ID MAL_HUMAN Reviewed; 153 AA. AC P21145; Q6FH77; DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1991, sequence version 1. DT 04-NOV-2026, entry version 199. DE RecName: Full=Myelin and lymphocyte protein; DE AltName: Full=T-lymphocyte maturation-associated protein; GN Name=MAL; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=3494249; DOI=10.1073/pnas.84.7.1997; RA Alonso M.A., Weissman S.M.; RT "cDNA cloning and sequence of MAL, a hydrophobic protein associated with RT human T-cell differentiation."; RL Proc. Natl. Acad. Sci. U.S.A. 84:1997-2001(1987). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. RX PubMed=8088843; DOI=10.1006/geno.1994.1294; RA Rancano C., Rubio T., Alonso M.A.; RT "Alternative splicing of human T-cell-specific MAL mRNA and its correlation RT with the exon/intron organization of the gene."; RL Genomics 21:447-450(1994). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Lymphocyte, and Placenta; RX PubMed=8132541; DOI=10.1016/s0021-9258(17)37174-0; RA Rancano C., Rubio T., Correas I., Alonso M.A.; RT "Genomic structure and subcellular localization of MAL, a human T-cell- RT specific proteolipid protein."; RL J. Biol. Chem. 269:8159-8164(1994). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP VARIANT HLD28 ASP-109, INVOLVEMENT IN HLD28, CHARACTERIZATION OF HLD28 RP ASP-109, INTERACTION WITH PLP1, AND SUBCELLULAR LOCATION. RX PubMed=35217805; DOI=10.1038/s41431-022-01050-9; RA Elpidorou M., Poulter J.A., Szymanska K., Baron W., Junger K., Boldt K., RA Ueffing M., Green L., Livingston J.H., Sheridan E.G., Johnson C.A.; RT "Missense mutation of MAL causes a rare leukodystrophy similar to RT Pelizaeus-Merzbacher disease."; RL Eur. J. Hum. Genet. 30:860-864(2022). CC -!- FUNCTION: May be involved in vesicular trafficking from the Golgi CC apparatus to the cell membrane. Plays a role in the maintenance of the CC myelin sheath, and in axon-glia and glia-glia interactions. CC {ECO:0000250|UniProtKB:O09198}. CC -!- SUBUNIT: Interacts with PLP1. {ECO:0000269|PubMed:35217805}. CC -!- INTERACTION: CC P21145; Q16671: AMHR2; NbExp=3; IntAct=EBI-3932027, EBI-6423788; CC P21145; Q13520: AQP6; NbExp=3; IntAct=EBI-3932027, EBI-13059134; CC P21145; Q9BXK5: BCL2L13; NbExp=5; IntAct=EBI-3932027, EBI-747430; CC P21145; Q06187: BTK; NbExp=5; IntAct=EBI-3932027, EBI-624835; CC P21145; Q7KYR7-4: BTN2A1; NbExp=3; IntAct=EBI-3932027, EBI-17841208; CC P21145; Q9BXU9: CALN1; NbExp=3; IntAct=EBI-3932027, EBI-12187137; CC P21145; Q6UXG3: CD300LG; NbExp=3; IntAct=EBI-3932027, EBI-10254587; CC P21145; P09693: CD3G; NbExp=3; IntAct=EBI-3932027, EBI-3862428; CC P21145; P25942: CD40; NbExp=3; IntAct=EBI-3932027, EBI-525714; CC P21145; P19397: CD53; NbExp=3; IntAct=EBI-3932027, EBI-6657396; CC P21145; Q07108: CD69; NbExp=3; IntAct=EBI-3932027, EBI-2836595; CC P21145; O95500: CLDN14; NbExp=3; IntAct=EBI-3932027, EBI-11742599; CC P21145; P56880: CLDN20; NbExp=3; IntAct=EBI-3932027, EBI-23801559; CC P21145; O95471: CLDN7; NbExp=3; IntAct=EBI-3932027, EBI-740744; CC P21145; O95484: CLDN9; NbExp=3; IntAct=EBI-3932027, EBI-18341636; CC P21145; Q8WTT0: CLEC4C; NbExp=4; IntAct=EBI-3932027, EBI-12913226; CC P21145; Q9BQT9: CLSTN3; NbExp=3; IntAct=EBI-3932027, EBI-11291074; CC P21145; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-3932027, EBI-18013275; CC P21145; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-3932027, EBI-6942903; CC P21145; P78310: CXADR; NbExp=3; IntAct=EBI-3932027, EBI-747931; CC P21145; Q9Y4D2: DAGLA; NbExp=3; IntAct=EBI-3932027, EBI-12808806; CC P21145; Q92838: EDA; NbExp=7; IntAct=EBI-3932027, EBI-529425; CC P21145; P54849: EMP1; NbExp=3; IntAct=EBI-3932027, EBI-4319440; CC P21145; P22794: EVI2A; NbExp=3; IntAct=EBI-3932027, EBI-2870359; CC P21145; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-3932027, EBI-18304435; CC P21145; Q96LA5-2: FCRL2; NbExp=3; IntAct=EBI-3932027, EBI-17263163; CC P21145; Q8N539: FIBCD1; NbExp=6; IntAct=EBI-3932027, EBI-10200808; CC P21145; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-3932027, EBI-12142257; CC P21145; P48165: GJA8; NbExp=3; IntAct=EBI-3932027, EBI-17458373; CC P21145; P08034: GJB1; NbExp=3; IntAct=EBI-3932027, EBI-17565645; CC P21145; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-3932027, EBI-13345167; CC P21145; Q96CP6: GRAMD1A; NbExp=3; IntAct=EBI-3932027, EBI-1384139; CC P21145; Q6UXU4-2: GSG1L; NbExp=3; IntAct=EBI-3932027, EBI-18632127; CC P21145; P31937: HIBADH; NbExp=3; IntAct=EBI-3932027, EBI-11427100; CC P21145; Q13651: IL10RA; NbExp=3; IntAct=EBI-3932027, EBI-1031656; CC P21145; Q6UXL0: IL20RB; NbExp=3; IntAct=EBI-3932027, EBI-14022792; CC P21145; Q86YT9-2: JAML; NbExp=3; IntAct=EBI-3932027, EBI-17244059; CC P21145; Q09470: KCNA1; NbExp=3; IntAct=EBI-3932027, EBI-8286599; CC P21145; Q16322: KCNA10; NbExp=3; IntAct=EBI-3932027, EBI-12265328; CC P21145; Q86W47: KCNMB4; NbExp=3; IntAct=EBI-3932027, EBI-19112227; CC P21145; P26715: KLRC1; NbExp=6; IntAct=EBI-3932027, EBI-9018187; CC P21145; Q5T700: LDLRAD1; NbExp=7; IntAct=EBI-3932027, EBI-10173166; CC P21145; Q9H0V9: LMAN2L; NbExp=3; IntAct=EBI-3932027, EBI-9091707; CC P21145; Q8N386: LRRC25; NbExp=3; IntAct=EBI-3932027, EBI-11304917; CC P21145; Q9HBL6: LRTM1; NbExp=3; IntAct=EBI-3932027, EBI-12825005; CC P21145; Q8N8F7: LSMEM1; NbExp=3; IntAct=EBI-3932027, EBI-10200825; CC P21145; Q96JQ5: MS4A4A; NbExp=3; IntAct=EBI-3932027, EBI-12820341; CC P21145; Q6IBW4-4: NCAPH2; NbExp=3; IntAct=EBI-3932027, EBI-10247000; CC P21145; Q8IVV8: NKAIN4; NbExp=3; IntAct=EBI-3932027, EBI-17791123; CC P21145; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-3932027, EBI-748927; CC P21145; P35372-10: OPRM1; NbExp=3; IntAct=EBI-3932027, EBI-12807478; CC P21145; Q96FX8: PERP; NbExp=3; IntAct=EBI-3932027, EBI-17183069; CC P21145; O15496: PLA2G10; NbExp=3; IntAct=EBI-3932027, EBI-726466; CC P21145; Q99946-2: PRRT1; NbExp=3; IntAct=EBI-3932027, EBI-12211089; CC P21145; Q16849-3: PTPRN; NbExp=3; IntAct=EBI-3932027, EBI-10200782; CC P21145; O60894: RAMP1; NbExp=3; IntAct=EBI-3932027, EBI-962893; CC P21145; P31431: SDC4; NbExp=3; IntAct=EBI-3932027, EBI-3913237; CC P21145; Q16585: SGCB; NbExp=3; IntAct=EBI-3932027, EBI-5663627; CC P21145; A0PJX4: SHISA3; NbExp=3; IntAct=EBI-3932027, EBI-10171518; CC P21145; Q96DD7: SHISA4; NbExp=3; IntAct=EBI-3932027, EBI-18035902; CC P21145; Q14973: SLC10A1; NbExp=3; IntAct=EBI-3932027, EBI-3923031; CC P21145; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-3932027, EBI-17295964; CC P21145; Q9BZL3: SMIM3; NbExp=6; IntAct=EBI-3932027, EBI-741850; CC P21145; O43278-2: SPINT1; NbExp=3; IntAct=EBI-3932027, EBI-12078338; CC P21145; Q16623: STX1A; NbExp=4; IntAct=EBI-3932027, EBI-712466; CC P21145; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-3932027, EBI-726331; CC P21145; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-3932027, EBI-19027521; CC P21145; Q495A1: TIGIT; NbExp=3; IntAct=EBI-3932027, EBI-4314807; CC P21145; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-3932027, EBI-13351685; CC P21145; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-3932027, EBI-2821497; CC P21145; Q8WUU8: TMEM174; NbExp=3; IntAct=EBI-3932027, EBI-10276729; CC P21145; Q6UWW9: TMEM207; NbExp=3; IntAct=EBI-3932027, EBI-13301303; CC P21145; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-3932027, EBI-10314986; CC P21145; Q9NV96-2: TMEM30A; NbExp=3; IntAct=EBI-3932027, EBI-12921610; CC P21145; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-3932027, EBI-18178701; CC P21145; O43557: TNFSF14; NbExp=5; IntAct=EBI-3932027, EBI-524131; CC P21145; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-3932027, EBI-12195249; CC P21145; Q93009: USP7; NbExp=3; IntAct=EBI-3932027, EBI-302474; CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell CC membrane {ECO:0000269|PubMed:35217805}. Note=Found in lipid rafts. CC {ECO:0000250|UniProtKB:O09198}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=A; CC IsoId=P21145-1; Sequence=Displayed; CC Name=B; CC IsoId=P21145-2; Sequence=VSP_003164; CC Name=C; CC IsoId=P21145-3; Sequence=VSP_003163; CC Name=D; CC IsoId=P21145-4; Sequence=VSP_003162; CC -!- DEVELOPMENTAL STAGE: Expressed in the intermediate and late stages of CC T-cell differentiation. CC -!- PTM: Lipoprotein. CC -!- DISEASE: Leukodystrophy, hypomyelinating, 28 (HLD28) [MIM:620978]: A CC form of hypomyelinating leukodystrophy, a group of heterogeneous CC disorders characterized by persistent deficit of myelin observed on CC brain imaging. HLD28 is an autosomal recessive form characterized by CC developmental delay and nystagmus in infancy, followed by significant CC learning disabilities and progressive motor deterioration within the CC first decade. {ECO:0000269|PubMed:35217805}. Note=The disease may be CC caused by variants affecting the gene represented in this entry. CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}. CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and CC Haematology; CC URL="https://atlasgeneticsoncology.org/gene/46222/MAL"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M15800; AAA36196.1; -; mRNA. DR EMBL; X76678; CAA54100.1; -; mRNA. DR EMBL; X76679; CAA54101.1; -; mRNA. DR EMBL; X76680; CAA54102.1; -; mRNA. DR EMBL; X76681; CAA54103.1; -; mRNA. DR EMBL; X76220; CAA53809.1; -; Genomic_DNA. DR EMBL; X76221; CAA53809.1; JOINED; Genomic_DNA. DR EMBL; X76222; CAA53809.1; JOINED; Genomic_DNA. DR EMBL; X76223; CAA53809.1; JOINED; Genomic_DNA. DR EMBL; AK311844; BAG34786.1; -; mRNA. DR EMBL; CR541879; CAG46677.1; -; mRNA. DR EMBL; AC103563; AAY24121.1; -; Genomic_DNA. DR EMBL; CH471219; EAX10705.1; -; Genomic_DNA. DR EMBL; BC000458; AAH00458.1; -; mRNA. DR EMBL; BC003006; AAH03006.1; -; mRNA. DR CCDS; CCDS2006.1; -. [P21145-1] DR CCDS; CCDS2007.1; -. [P21145-2] DR CCDS; CCDS2008.1; -. [P21145-3] DR CCDS; CCDS2009.1; -. [P21145-4] DR PIR; A29472; A29472. DR RefSeq; NP_002362.1; NM_002371.4. [P21145-1] DR RefSeq; NP_071883.1; NM_022438.3. [P21145-2] DR RefSeq; NP_071884.1; NM_022439.3. [P21145-3] DR RefSeq; NP_071885.1; NM_022440.3. [P21145-4] DR AlphaFoldDB; P21145; -. DR SMR; P21145; -. DR BioGRID; 110292; 81. DR CORUM; P21145; -. DR FunCoup; P21145; 75. DR IntAct; P21145; 85. DR NDEx; IQUERY-CP-MAL; 1 NDEx IQuery Curated Pathway. DR STRING; 9606.ENSP00000310880; -. DR TCDB; 1.A.64.2.2; the plasmolipin (plasmolipin) family. DR BioMuta; MAL; -. DR DMDM; 126719; -. DR PaxDb; 9606-ENSP00000310880; -. DR PeptideAtlas; P21145; -. DR ProteomicsDB; 53849; -. [P21145-1] DR ProteomicsDB; 53851; -. [P21145-3] DR Antibodypedia; 32290; 235 antibodies from 32 providers. DR DNASU; 4118; -. DR Ensembl; ENST00000309988.9; ENSP00000310880.4; ENSG00000172005.12. [P21145-1] DR Ensembl; ENST00000349807.3; ENSP00000322860.3; ENSG00000172005.12. [P21145-4] DR Ensembl; ENST00000353004.7; ENSP00000306568.4; ENSG00000172005.12. [P21145-2] DR Ensembl; ENST00000354078.7; ENSP00000304924.3; ENSG00000172005.12. [P21145-3] DR GeneID; 4118; -. DR KEGG; hsa:4118; -. DR MANE-Select; ENST00000309988.9; ENSP00000310880.4; NM_002371.4; NP_002362.1. DR UCSC; uc002stx.3; human. [P21145-1] DR AGR; HGNC:6817; -. DR ClinPGx; PA30565; -. DR CTD; 4118; -. DR DisGeNET; 4118; -. DR GeneCards; MAL; -. DR HGNC; HGNC:6817; MAL. DR HPA; ENSG00000172005; Tissue enhanced (cervix, esophagus, vagina). DR MalaCards; MAL; -. DR MIM; 188860; gene. DR MIM; 620978; phenotype. DR OpenTargets; ENSG00000172005; -. DR Orphanet; 280270; Pelizaeus-Merzbacher-like disease. DR VEuPathDB; HostDB:ENSG00000172005; -. DR eggNOG; KOG4788; Eukaryota. DR GeneTree; ENSGT00940000154987; -. DR HOGENOM; CLU_112950_0_0_1; -. DR InParanoid; P21145; -. DR OMA; AAVFTCR; -. DR OrthoDB; 9940869at2759; -. DR PAN-GO; P21145; 3 GO annotations based on evolutionary models. DR PhylomeDB; P21145; -. DR PathwayCommons; P21145; -. DR SignaLink; P21145; -. DR SIGNOR; P21145; -. DR Agora; ENSG00000172005; -. DR BioGRID-ORCS; 4118; 18 hits in 1152 CRISPR screens. DR ChiTaRS; MAL; human. DR GeneWiki; MAL_(gene); -. DR GenomeRNAi; 4118; -. DR Pharos; P21145; Tbio. DR PRO; PR:P21145; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; P21145; protein. DR Bgee; ENSG00000172005; Expressed in esophagus squamous epithelium and 179 other cell types or tissues. DR GO; GO:0016324; C:apical plasma membrane; IDA:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB. DR GO; GO:0045121; C:membrane raft; IDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; EXP:UniProtKB. DR GO; GO:0008289; F:lipid binding; TAS:UniProtKB. DR GO; GO:0016505; F:peptidase activator activity involved in apoptotic process; NAS:UniProtKB. DR GO; GO:0019911; F:structural constituent of myelin sheath; IDA:UniProtKB. DR GO; GO:0045176; P:apical protein localization; TAS:UniProtKB. DR GO; GO:0006915; P:apoptotic process; NAS:UniProtKB. DR GO; GO:0030154; P:cell differentiation; TAS:UniProtKB. DR GO; GO:0007417; P:central nervous system development; TAS:UniProtKB. DR GO; GO:0001766; P:membrane raft polarization; TAS:UniProtKB. DR GO; GO:0042552; P:myelination; IBA:GO_Central. DR GO; GO:0098737; P:protein insertion into plasma membrane; IMP:UniProtKB. DR InterPro; IPR013295; MAL. DR InterPro; IPR008253; Marvel. DR InterPro; IPR050578; MARVEL-like. DR PANTHER; PTHR22776; MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN; 1. DR PANTHER; PTHR22776:SF12; MYELIN AND LYMPHOCYTE PROTEIN; 1. DR Pfam; PF01284; MARVEL; 1. DR PRINTS; PR01884; MALPROTEIN. DR PROSITE; PS51225; MARVEL; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; Leukodystrophy; Lipoprotein; Membrane; KW Proteomics identification; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1..153 FT /note="Myelin and lymphocyte protein" FT /id="PRO_0000156805" FT TOPO_DOM 1..24 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 25..46 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 47..53 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 54..75 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 76..92 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 93..114 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 115..125 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 126..147 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 148..153 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT DOMAIN 18..151 FT /note="MARVEL" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581" FT VAR_SEQ 32..129 FT /note="Missing (in isoform D)" FT /evidence="ECO:0000305" FT /id="VSP_003162" FT VAR_SEQ 32..87 FT /note="Missing (in isoform C)" FT /evidence="ECO:0000305" FT /id="VSP_003163" FT VAR_SEQ 88..129 FT /note="Missing (in isoform B)" FT /evidence="ECO:0000305" FT /id="VSP_003164" FT VARIANT 109 FT /note="A -> D (in HLD28; uncertain significance; decreased FT interaction with PLP1; mislocalized to the endoplasmic FT reticulum)" FT /evidence="ECO:0000269|PubMed:35217805" FT /id="VAR_090116" SQ SEQUENCE 153 AA; 16714 MW; F821FC1C0ADBE775 CRC64; MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL VQGWVMFVSV FCFVATTTLI ILYIIGAHGG ETSWVTLDAA YHCTAALFYL SASVLEALAT ITMQDGFTYR HYHENIAAVV FSYIATLLYV VHAVFSLIRW KSS //