ID NEBU_HUMAN Reviewed; 8525 AA. AC P20929; F8WCL5; F8WCP0; Q15346; Q53QQ2; Q53TG8; DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot. DT 29-MAY-2024, sequence version 6. DT 04-NOV-2026, entry version 223. DE RecName: Full=Nebulin; GN Name=NEB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), AND VARIANTS ASN-1027; HIS-1301; RP MET-1491; CYS-3603; THR-6102 AND VAL-8402. RX PubMed=7739042; DOI=10.1016/s0022-2836(95)80052-2; RA Labeit S., Kolmerer B.; RT "The complete primary structure of human nebulin and its correlation to RT muscle structure."; RL J. Mol. Biol. 248:308-315(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 7964-8185. RX PubMed=1682316; DOI=10.1016/s0021-9258(18)54843-2; RA Jin J.P., Wang K.; RT "Cloning, expression, and protein interaction of human nebulin fragments RT composed of varying numbers of sequence modules."; RL J. Biol. Chem. 266:21215-21223(1991). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1811-1939. RX PubMed=3397062; DOI=10.1016/0888-7543(88)90009-2; RA Zeviani M., Darras B.T., Rizzuto R., Salviati G., Betto R., Bonilla E., RA Miranda A.F., Du J., Samitt C., Dickson G., Walsh F.S., Dimauro S., RA Francke U., Schon E.A.; RT "Cloning and expression of human nebulin cDNAs and assignment of the gene RT to chromosome 2q31-q32."; RL Genomics 2:249-256(1988). RN [5] RP INTERACTION WITH TTN. RX PubMed=12482578; DOI=10.1016/s0014-5793(02)03655-4; RA Ma K., Wang K.; RT "Interaction of nebulin SH3 domain with titin PEVK and myopalladin: RT implications for the signaling and assembly role of titin and nebulin."; RL FEBS Lett. 532:273-278(2002). RN [6] RP SUBUNIT, AND INTERACTION WITH DES. RX PubMed=23615443; DOI=10.1091/mbc.e12-11-0840; RA Baker L.K., Gillis D.C., Sharma S., Ambrus A., Herrmann H., Conover G.M.; RT "Nebulin binding impedes mutant desmin filament assembly."; RL Mol. Biol. Cell 24:1918-1932(2013). RN [7] RP TISSUE SPECIFICITY. RX PubMed=23985323; DOI=10.1091/mbc.e13-04-0202; RA Eulitz S., Sauer F., Pelissier M.C., Boisguerin P., Molt S., Schuld J., RA Orfanos Z., Kley R.A., Volkmer R., Wilmanns M., Kirfel G., RA van der Ven P.F., Fuerst D.O.; RT "Identification of Xin-repeat proteins as novel ligands of the SH3 domains RT of nebulin and nebulette and analysis of their interaction during myofibril RT formation and remodeling."; RL Mol. Biol. Cell 24:3215-3226(2013). RN [8] RP STRUCTURE BY NMR OF 8466-8525. RX PubMed=9514727; DOI=10.1006/jmbi.1997.1521; RA Politou A.S., Millevoi S., Gautel M., Kolmerer B., Pastore A.; RT "SH3 in muscles: solution structure of the SH3 domain from nebulin."; RL J. Mol. Biol. 276:189-202(1998). RN [9] RP INVOLVEMENT IN NEM2, AND INVOLVEMENT IN AMC6. RX PubMed=10051637; DOI=10.1073/pnas.96.5.2305; RA Pelin K., Hilpelae P., Donner K., Sewry C., Akkari P.A., Wilton S.D., RA Wattanasirichaigoon D., Bang M.-L., Centner T., Hanefeld F., Odent S., RA Fardeau M., Urtizberea J.A., Muntoni F., Dubowitz V., Beggs A.H., RA Laing N.G., Labeit S., de la Chapelle A., Wallgren-Pettersson C.; RT "Mutations in the nebulin gene associated with autosomal recessive nemaline RT myopathy."; RL Proc. Natl. Acad. Sci. U.S.A. 96:2305-2310(1999). RN [10] RP INVOLVEMENT IN AMC6. RX PubMed=21798101; DOI=10.1186/2044-5040-1-23; RA Lawlor M.W., Ottenheijm C.A., Lehtokari V.L., Cho K., Pelin K., RA Wallgren-Pettersson C., Granzier H., Beggs A.H.; RT "Novel mutations in NEB cause abnormal nebulin expression and markedly RT impaired muscle force generation in severe nemaline myopathy."; RL Skelet. Muscle 1:23-23(2011). RN [11] RP INTERACTION WITH SVIL. RX PubMed=18639526; DOI=10.1016/j.bbrc.2008.07.036; RA Lee M.-A., Joo Y.M., Lee Y.M., Kim H.S., Kim J.-H., Choi J.-K., Ahn S.-J., RA Min B.-I., Kim C.-R.; RT "Archvillin anchors in the Z-line of skeletal muscle via the nebulin C- RT terminus."; RL Biochem. Biophys. Res. Commun. 374:320-324(2008). RN [12] RP VARIANT AMC6 974-ARG--ILE-6669 DEL, AND INVOLVEMENT IN AMC6. RX PubMed=26578207; DOI=10.1186/s13023-015-0364-0; RA Todd E.J., Yau K.S., Ong R., Slee J., McGillivray G., Barnett C.P., RA Haliloglu G., Talim B., Akcoren Z., Kariminejad A., Cairns A., Clarke N.F., RA Freckmann M.L., Romero N.B., Williams D., Sewry C.A., Colley A., Ryan M.M., RA Kiraly-Borri C., Sivadorai P., Allcock R.J., Beeson D., Maxwell S., RA Davis M.R., Laing N.G., Ravenscroft G.; RT "Next generation sequencing in a large cohort of patients presenting with RT neuromuscular disease before or at birth."; RL Orphanet J. Rare Dis. 10:148-148(2015). RN [13] RP VARIANTS AMC6 6262-TYR--ILE-8525 DEL AND 6327-TYR--ILE-8525 DEL, AND RP INVOLVEMENT IN AMC6. RX PubMed=29274205; DOI=10.1002/ajmg.a.38577; RA Ahmed A.A., Skaria P., Safina N.P., Thiffault I., Kats A., Taboada E., RA Habeebu S., Saunders C.; RT "Arthrogryposis and pterygia as lethal end manifestations of genetically RT defined congenital myopathies."; RL Am. J. Med. Genet. A 176:359-367(2018). CC -!- FUNCTION: This giant muscle protein may be involved in maintaining the CC structural integrity of sarcomeres and the membrane system associated CC with the myofibrils. Binds and stabilize F-actin. CC -!- SUBUNIT: Monomer and homooligomer (PubMed:23615443). Interacts with CC TTN/titin (PubMed:12482578). Interacts with SVIL (PubMed:18639526). CC Interacts (via nebulin repeats 160-164) with DES (PubMed:23615443). CC {ECO:0000269|PubMed:12482578, ECO:0000269|PubMed:18639526, CC ECO:0000269|PubMed:23615443}. CC -!- INTERACTION: CC P20929; Q02410: APBA1; NbExp=2; IntAct=EBI-1049657, EBI-368690; CC P20929; Q99767: APBA2; NbExp=2; IntAct=EBI-1049657, EBI-81711; CC P20929; Q12959: DLG1; NbExp=3; IntAct=EBI-1049657, EBI-357481; CC P20929; Q92796: DLG3; NbExp=3; IntAct=EBI-1049657, EBI-80440; CC P20929; P78352: DLG4; NbExp=3; IntAct=EBI-1049657, EBI-80389; CC P20929; Q68DX3: FRMPD2; NbExp=3; IntAct=EBI-1049657, EBI-53993476; CC P20929; A4D2P6: GRID2IP; NbExp=2; IntAct=EBI-1049657, EBI-15893226; CC P20929; Q9Y3R0: GRIP1; NbExp=5; IntAct=EBI-1049657, EBI-5349621; CC P20929; Q9C0E4: GRIP2; NbExp=5; IntAct=EBI-1049657, EBI-949557; CC P20929; Q14005: IL16; NbExp=3; IntAct=EBI-1049657, EBI-2831580; CC P20929; O60662: KLHL41; NbExp=3; IntAct=EBI-1049657, EBI-5353084; CC P20929; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-1049657, EBI-739832; CC P20929; Q8N448: LNX2; NbExp=2; IntAct=EBI-1049657, EBI-2340947; CC P20929; Q96QZ7: MAGI1; NbExp=2; IntAct=EBI-1049657, EBI-924464; CC P20929; Q86UL8: MAGI2; NbExp=5; IntAct=EBI-1049657, EBI-311035; CC P20929; O75970: MPDZ; NbExp=3; IntAct=EBI-1049657, EBI-821405; CC P20929; Q86TC9: MYPN; NbExp=2; IntAct=EBI-1049657, EBI-2562606; CC P20929; Q86UT5: NHERF4; NbExp=2; IntAct=EBI-1049657, EBI-8744528; CC P20929; Q8NI35: PATJ; NbExp=9; IntAct=EBI-1049657, EBI-724390; CC P20929; Q5T2W1: PDZK1; NbExp=3; IntAct=EBI-1049657, EBI-349819; CC P20929; Q14160: SCRIB; NbExp=3; IntAct=EBI-1049657, EBI-357345; CC P20929; Q13424: SNTA1; NbExp=2; IntAct=EBI-1049657, EBI-717191; CC P20929; Q07889: SOS1; NbExp=3; IntAct=EBI-1049657, EBI-297487; CC P20929; O95425: SVIL; NbExp=4; IntAct=EBI-1049657, EBI-487145; CC P20929; Q07157: TJP1; NbExp=2; IntAct=EBI-1049657, EBI-79553; CC P20929; Q8WZ42: TTN; NbExp=6; IntAct=EBI-1049657, EBI-681210; CC P20929; Q9P202: WHRN; NbExp=3; IntAct=EBI-1049657, EBI-310886; CC P20929; Q702N8-1: XIRP1; NbExp=2; IntAct=EBI-1049657, EBI-61250262; CC P20929; A4UGR9: XIRP2; NbExp=3; IntAct=EBI-1049657, EBI-3220204; CC P20929-1; O75923: DYSF; NbExp=4; IntAct=EBI-55727352, EBI-2799016; CC P20929-1; O60662: KLHL41; NbExp=7; IntAct=EBI-55727352, EBI-5353084; CC P20929-4; O60662: KLHL41; NbExp=5; IntAct=EBI-9531519, EBI-5353084; CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere. Cytoplasm, CC cytoskeleton. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=2; CC IsoId=P20929-2; Sequence=Displayed; CC Name=1; CC IsoId=P20929-1; Sequence=VSP_062337, VSP_062338, VSP_062339, CC VSP_062340; CC Name=3; CC IsoId=P20929-3; Sequence=VSP_062339; CC Name=4; CC IsoId=P20929-4; Sequence=VSP_062336, VSP_062338, VSP_062339, CC VSP_062340; CC -!- TISSUE SPECIFICITY: Expressed in skeletal muscle (at protein level) CC (PubMed:23985323). Located in the thin filament of striated muscle CC (PubMed:9514727). {ECO:0000269|PubMed:23985323, CC ECO:0000269|PubMed:9514727}. CC -!- DISEASE: Nemaline myopathy 2 (NEM2) [MIM:256030]: A form of nemaline CC myopathy. Nemaline myopathies are muscular disorders characterized by CC muscle weakness of varying severity and onset, and abnormal thread-like CC or rod-shaped structures in muscle fibers on histologic examination. CC {ECO:0000269|PubMed:10051637}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- DISEASE: Arthrogryposis multiplex congenita 6 (AMC6) [MIM:619334]: A CC form of arthrogryposis multiplex congenita, a developmental condition CC characterized by multiple joint contractures resulting from reduced or CC absent fetal movements. AMC6 is an autosomal recessive lethal form. CC Death usually occurs in utero or in infancy. CC {ECO:0000269|PubMed:10051637, ECO:0000269|PubMed:21798101, CC ECO:0000269|PubMed:26578207, ECO:0000269|PubMed:29274205}. Note=The CC disease is caused by variants affecting the gene represented in this CC entry. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X83957; CAA58788.1; -; mRNA. DR EMBL; AC009497; AAY14651.1; -; Genomic_DNA. DR EMBL; AC107052; AAY14977.1; -; Genomic_DNA. DR EMBL; AC116650; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; M19669; AAA59917.1; -; mRNA. DR CCDS; CCDS46424.1; -. [P20929-4] DR CCDS; CCDS54407.1; -. [P20929-2] DR CCDS; CCDS54408.1; -. [P20929-3] DR PIR; A29979; A29979. DR PIR; B29979; B29979. DR PIR; S55024; S55024. DR RefSeq; NP_001157979.2; NM_001164507.2. [P20929-3] DR RefSeq; NP_001157980.2; NM_001164508.2. [P20929-2] DR RefSeq; NP_004534.3; NM_004543.5. [P20929-4] DR PDB; 1ARK; NMR; -; A=8466-8525. DR PDB; 1NEB; NMR; -; A=8466-8525. DR PDB; 6Y17; X-ray; 1.56 A; C/D=8466-8525. DR MDposit; P20929; -. DR SMR; P20929; -. DR BioGRID; 110783; 101. DR FunCoup; P20929; 96. DR IntAct; P20929; 123. DR NDEx; IQUERY-CP-NEB; 2 NDEx IQuery Curated Pathways. DR STRING; 9606.ENSP00000484342; -. DR CarbonylDB; P20929; -. DR GlyCosmos; P20929; 6 sites, 1 glycan. DR GlyGen; P20929; 2 sites, 1 O-linked glycan (2 sites). DR iPTMnet; P20929; -. DR PhosphoSitePlus; P20929; -. DR SwissPalm; P20929; -. DR BioMuta; NEB; -. DR DMDM; 313104310; -. DR jPOST; P20929; -. DR MassIVE; P20929; -. DR PaxDb; 9606-ENSP00000484342; -. DR PeptideAtlas; P20929; -. DR ProteomicsDB; 31194; -. DR ProteomicsDB; 31219; -. DR ProteomicsDB; 53825; -. [P20929-1] DR Antibodypedia; 1171; 130 antibodies from 28 providers. DR DNASU; 4703; -. DR Ensembl; ENST00000397345.8; ENSP00000380505.3; ENSG00000183091.21. [P20929-2] DR Ensembl; ENST00000409198.5; ENSP00000386259.1; ENSG00000183091.21. [P20929-4] DR Ensembl; ENST00000427231.7; ENSP00000416578.2; ENSG00000183091.21. [P20929-3] DR GeneID; 4703; -. DR KEGG; hsa:4703; -. DR MANE-Select; ENST00000397345.8; ENSP00000380505.3; NM_001164508.2; NP_001157980.2. DR UCSC; uc002txu.3; human. [P20929-2] DR AGR; HGNC:7720; -. DR ClinPGx; PA31530; -. DR CTD; 4703; -. DR DisGeNET; 4703; -. DR GeneCards; NEB; -. DR HGNC; HGNC:7720; NEB. DR HPA; ENSG00000183091; Group enriched (skeletal muscle, tongue). DR MalaCards; NEB; -. DR MIM; 161650; gene. DR MIM; 256030; phenotype. DR MIM; 619334; phenotype. DR OpenTargets; ENSG00000183091; -. DR Orphanet; 708123; Autosomal dominant distal nebulin myopathy. DR Orphanet; 399103; Autosomal recessive distal nebulin myopathy. DR Orphanet; 171439; Childhood-onset nemaline myopathy. DR Orphanet; 171433; Intermediate nemaline myopathy. DR Orphanet; 33108; Lethal multiple pterygium syndrome. DR Orphanet; 171430; Severe congenital nemaline myopathy. DR Orphanet; 171436; Typical nemaline myopathy. DR VEuPathDB; HostDB:ENSG00000183091; -. DR GeneTree; ENSGT00940000154533; -. DR HOGENOM; CLU_000024_0_0_1; -. DR InParanoid; P20929; -. DR OrthoDB; 9295290at2759; -. DR PAN-GO; P20929; 3 GO annotations based on evolutionary models. DR PathwayCommons; P20929; -. DR Reactome; R-HSA-390522; Striated Muscle Contraction. DR SignaLink; P20929; -. DR SIGNOR; P20929; -. DR Agora; ENSG00000183091; -. DR BioGRID-ORCS; 4703; 13 hits in 1141 CRISPR screens. DR ChiTaRS; NEB; human. DR EvolutionaryTrace; P20929; -. DR GenomeRNAi; 4703; -. DR Pharos; P20929; Tbio. DR PRO; PR:P20929; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; P20929; protein. DR Bgee; ENSG00000183091; Expressed in gluteal muscle and 126 other cell types or tissues. DR ExpressionAtlas; P20929; baseline and differential. DR GO; GO:0015629; C:actin cytoskeleton; TAS:ProtInc. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0030018; C:Z disc; IDA:UniProtKB. DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central. DR GO; GO:0008307; F:structural constituent of muscle; TAS:ProtInc. DR GO; GO:0071691; P:cardiac muscle thin filament assembly; IBA:GO_Central. DR GO; GO:0007517; P:muscle organ development; TAS:ProtInc. DR GO; GO:0030832; P:regulation of actin filament length; NAS:UniProtKB. DR GO; GO:0007525; P:somatic muscle development; NAS:UniProtKB. DR CDD; cd11933; SH3_Nebulin_C; 1. DR FunFam; 2.30.30.40:FF:000007; nebulin isoform X1; 1. DR Gene3D; 2.30.30.40; SH3 Domains; 1. DR InterPro; IPR055297; NEBU/NEBL. DR InterPro; IPR013998; Nebulin-like. DR InterPro; IPR000900; Nebulin_repeat. DR InterPro; IPR035629; Nebulin_SH3. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR11039; NEBULIN; 1. DR PANTHER; PTHR11039:SF37; NEBULIN; 1. DR Pfam; PF00880; Nebulin; 139. DR Pfam; PF14604; SH3_9; 1. DR PRINTS; PR00510; NEBULIN. DR SMART; SM00227; NEBU; 235. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF50044; SH3-domain; 1. DR PROSITE; PS51216; NEBULIN; 181. DR PROSITE; PS50002; SH3; 1. PE 1: Evidence at protein level; KW 3D-structure; Actin-binding; Alternative splicing; Cytoplasm; Cytoskeleton; KW Disease variant; Muscle protein; Nemaline myopathy; KW Proteomics identification; Reference proteome; Repeat; SH3 domain. FT CHAIN 1..8525 FT /note="Nebulin" FT /id="PRO_0000096775" FT REPEAT 83..110 FT /note="Nebulin 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 112..146 FT /note="Nebulin 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 156..181 FT /note="Nebulin 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 182..216 FT /note="Nebulin 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 217..251 FT /note="Nebulin 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 252..286 FT /note="Nebulin 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 296..321 FT /note="Nebulin 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 323..357 FT /note="Nebulin 8" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 362..396 FT /note="Nebulin 9" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 403..431 FT /note="Nebulin 10" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 433..467 FT /note="Nebulin 11" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 501..535 FT /note="Nebulin 12" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 536..570 FT /note="Nebulin 13" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 572..606 FT /note="Nebulin 14" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 610..644 FT /note="Nebulin 15" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 680..714 FT /note="Nebulin 16" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 748..782 FT /note="Nebulin 17" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 783..817 FT /note="Nebulin 18" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 819..853 FT /note="Nebulin 19" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 857..891 FT /note="Nebulin 20" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 892..918 FT /note="Nebulin 21" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 923..957 FT /note="Nebulin 22" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 968..986 FT /note="Nebulin 23" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 992..1026 FT /note="Nebulin 24" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1027..1061 FT /note="Nebulin 25" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1063..1097 FT /note="Nebulin 26" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1101..1135 FT /note="Nebulin 27" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1136..1166 FT /note="Nebulin 28" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1167..1201 FT /note="Nebulin 29" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1212..1230 FT /note="Nebulin 30" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1236..1270 FT /note="Nebulin 31" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1271..1305 FT /note="Nebulin 32" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1307..1341 FT /note="Nebulin 33" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1345..1379 FT /note="Nebulin 34" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1380..1407 FT /note="Nebulin 35" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1411..1445 FT /note="Nebulin 36" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1456..1474 FT /note="Nebulin 37" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1480..1514 FT /note="Nebulin 38" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1515..1549 FT /note="Nebulin 39" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1551..1585 FT /note="Nebulin 40" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1589..1623 FT /note="Nebulin 41" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1624..1654 FT /note="Nebulin 42" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1655..1689 FT /note="Nebulin 43" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1697..1725 FT /note="Nebulin 44" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1730..1758 FT /note="Nebulin 45" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1759..1793 FT /note="Nebulin 46" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1795..1829 FT /note="Nebulin 47" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1833..1867 FT /note="Nebulin 48" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1868..1894 FT /note="Nebulin 49" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1899..1933 FT /note="Nebulin 50" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1949..1962 FT /note="Nebulin 51" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 1968..2002 FT /note="Nebulin 52" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2003..2037 FT /note="Nebulin 53" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2039..2073 FT /note="Nebulin 54" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2077..2111 FT /note="Nebulin 55" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2112..2138 FT /note="Nebulin 56" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2143..2177 FT /note="Nebulin 57" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2188..2206 FT /note="Nebulin 58" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2212..2246 FT /note="Nebulin 59" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2247..2281 FT /note="Nebulin 60" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2283..2317 FT /note="Nebulin 61" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2321..2355 FT /note="Nebulin 62" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2356..2382 FT /note="Nebulin 63" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2387..2421 FT /note="Nebulin 64" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2436..2449 FT /note="Nebulin 65" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2455..2489 FT /note="Nebulin 66" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2490..2524 FT /note="Nebulin 67" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2526..2560 FT /note="Nebulin 68" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2564..2598 FT /note="Nebulin 69" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2599..2625 FT /note="Nebulin 70" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2630..2664 FT /note="Nebulin 71" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2679..2692 FT /note="Nebulin 72" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2698..2732 FT /note="Nebulin 73" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2733..2767 FT /note="Nebulin 74" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2769..2803 FT /note="Nebulin 75" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2807..2841 FT /note="Nebulin 76" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2842..2868 FT /note="Nebulin 77" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2873..2907 FT /note="Nebulin 78" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2917..2935 FT /note="Nebulin 79" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2941..2975 FT /note="Nebulin 80" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 2976..3010 FT /note="Nebulin 81" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3012..3046 FT /note="Nebulin 82" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3050..3084 FT /note="Nebulin 83" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3085..3111 FT /note="Nebulin 84" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3116..3150 FT /note="Nebulin 85" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3158..3178 FT /note="Nebulin 86" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3184..3218 FT /note="Nebulin 87" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3219..3253 FT /note="Nebulin 88" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3255..3289 FT /note="Nebulin 89" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3293..3327 FT /note="Nebulin 90" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3328..3354 FT /note="Nebulin 91" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3359..3393 FT /note="Nebulin 92" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3401..3421 FT /note="Nebulin 93" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3427..3461 FT /note="Nebulin 94" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3462..3496 FT /note="Nebulin 95" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3498..3532 FT /note="Nebulin 96" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3536..3570 FT /note="Nebulin 97" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3571..3597 FT /note="Nebulin 98" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3602..3636 FT /note="Nebulin 99" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3643..3664 FT /note="Nebulin 100" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3670..3704 FT /note="Nebulin 101" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3705..3739 FT /note="Nebulin 102" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3741..3775 FT /note="Nebulin 103" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3779..3813 FT /note="Nebulin 104" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3814..3840 FT /note="Nebulin 105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3845..3879 FT /note="Nebulin 106" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3889..3907 FT /note="Nebulin 107" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3913..3947 FT /note="Nebulin 108" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3948..3982 FT /note="Nebulin 109" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 3984..4018 FT /note="Nebulin 110" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4022..4056 FT /note="Nebulin 111" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4057..4083 FT /note="Nebulin 112" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4088..4122 FT /note="Nebulin 113" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4132..4149 FT /note="Nebulin 114" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4156..4190 FT /note="Nebulin 115" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4191..4225 FT /note="Nebulin 116" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4227..4261 FT /note="Nebulin 117" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4265..4299 FT /note="Nebulin 118" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4300..4326 FT /note="Nebulin 119" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4331..4365 FT /note="Nebulin 120" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4375..4392 FT /note="Nebulin 121" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4399..4433 FT /note="Nebulin 122" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4434..4468 FT /note="Nebulin 123" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4470..4504 FT /note="Nebulin 124" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4508..4542 FT /note="Nebulin 125" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4543..4569 FT /note="Nebulin 126" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4574..4608 FT /note="Nebulin 127" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4618..4635 FT /note="Nebulin 128" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4642..4676 FT /note="Nebulin 129" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4677..4711 FT /note="Nebulin 130" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4713..4747 FT /note="Nebulin 131" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4751..4785 FT /note="Nebulin 132" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4786..4812 FT /note="Nebulin 133" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4817..4851 FT /note="Nebulin 134" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4861..4878 FT /note="Nebulin 135" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4885..4919 FT /note="Nebulin 136" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4920..4954 FT /note="Nebulin 137" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4956..4990 FT /note="Nebulin 138" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 4994..5028 FT /note="Nebulin 139" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5029..5055 FT /note="Nebulin 140" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5060..5094 FT /note="Nebulin 141" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5104..5121 FT /note="Nebulin 142" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5128..5162 FT /note="Nebulin 143" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5163..5197 FT /note="Nebulin 144" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5199..5233 FT /note="Nebulin 145" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5237..5271 FT /note="Nebulin 146" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5272..5298 FT /note="Nebulin 147" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5303..5337 FT /note="Nebulin 148" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5347..5364 FT /note="Nebulin 149" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5371..5405 FT /note="Nebulin 150" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5406..5440 FT /note="Nebulin 151" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5442..5476 FT /note="Nebulin 152" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5480..5514 FT /note="Nebulin 153" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5515..5541 FT /note="Nebulin 154" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5546..5580 FT /note="Nebulin 155" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5588..5607 FT /note="Nebulin 156" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5614..5648 FT /note="Nebulin 157" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5649..5683 FT /note="Nebulin 158" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5690..5718 FT /note="Nebulin 159" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5722..5756 FT /note="Nebulin 160" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5757..5783 FT /note="Nebulin 161" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5788..5822 FT /note="Nebulin 162" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5829..5853 FT /note="Nebulin 163" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5856..5890 FT /note="Nebulin 164" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5893..5924 FT /note="Nebulin 165" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5926..5960 FT /note="Nebulin 166" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5964..5998 FT /note="Nebulin 167" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 5999..6025 FT /note="Nebulin 168" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6030..6064 FT /note="Nebulin 169" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6071..6099 FT /note="Nebulin 170" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6100..6134 FT /note="Nebulin 171" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6135..6169 FT /note="Nebulin 172" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6171..6205 FT /note="Nebulin 173" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6209..6243 FT /note="Nebulin 174" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6244..6274 FT /note="Nebulin 175" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6275..6309 FT /note="Nebulin 176" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6316..6344 FT /note="Nebulin 177" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6345..6379 FT /note="Nebulin 178" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6380..6414 FT /note="Nebulin 179" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6416..6450 FT /note="Nebulin 180" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6458..6488 FT /note="Nebulin 181" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6489..6515 FT /note="Nebulin 182" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6532..6554 FT /note="Nebulin 183" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6561..6589 FT /note="Nebulin 184" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6590..6624 FT /note="Nebulin 185" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6626..6660 FT /note="Nebulin 186" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6661..6695 FT /note="Nebulin 187" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6697..6731 FT /note="Nebulin 188" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6732..6766 FT /note="Nebulin 189" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6767..6801 FT /note="Nebulin 190" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6808..6836 FT /note="Nebulin 191" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6837..6871 FT /note="Nebulin 192" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6872..6906 FT /note="Nebulin 193" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6907..6941 FT /note="Nebulin 194" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6942..6976 FT /note="Nebulin 195" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 6977..7011 FT /note="Nebulin 196" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7012..7046 FT /note="Nebulin 197" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7053..7081 FT /note="Nebulin 198" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7082..7110 FT /note="Nebulin 199" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7125..7151 FT /note="Nebulin 200" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7152..7186 FT /note="Nebulin 201" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7188..7222 FT /note="Nebulin 202" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7223..7257 FT /note="Nebulin 203" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7258..7292 FT /note="Nebulin 204" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7297..7327 FT /note="Nebulin 205" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7328..7362 FT /note="Nebulin 206" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7365..7399 FT /note="Nebulin 207" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7402..7433 FT /note="Nebulin 208" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7436..7470 FT /note="Nebulin 209" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7479..7505 FT /note="Nebulin 210" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7514..7542 FT /note="Nebulin 211" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7543..7577 FT /note="Nebulin 212" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7578..7612 FT /note="Nebulin 213" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7619..7647 FT /note="Nebulin 214" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7650..7684 FT /note="Nebulin 215" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7687..7721 FT /note="Nebulin 216" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7731..7759 FT /note="Nebulin 217" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7760..7794 FT /note="Nebulin 218" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7795..7829 FT /note="Nebulin 219" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7830..7864 FT /note="Nebulin 220" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7867..7888 FT /note="Nebulin 221" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7892..7921 FT /note="Nebulin 222" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7930..7957 FT /note="Nebulin 223" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7961..7988 FT /note="Nebulin 224" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 7992..8013 FT /note="Nebulin 225" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 8016..8045 FT /note="Nebulin 226" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 8054..8075 FT /note="Nebulin 227" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 8078..8112 FT /note="Nebulin 228" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 8116..8143 FT /note="Nebulin 229" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 8147..8168 FT /note="Nebulin 230" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 8171..8205 FT /note="Nebulin 231" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 8209..8232 FT /note="Nebulin 232" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 8233..8267 FT /note="Nebulin 233" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 8269..8303 FT /note="Nebulin 234" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT REPEAT 8304..8330 FT /note="Nebulin 235" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00563" FT DOMAIN 8466..8525 FT /note="SH3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192" FT REGION 34..73 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 8313..8468 FT /note="Interaction with SVIL" FT /evidence="ECO:0000269|PubMed:18639526" FT REGION 8385..8422 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 8439..8463 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 48..64 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 8405..8419 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 8444..8459 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 2941..3183 FT /note="Missing (in isoform 4)" FT /id="VSP_062336" FT VAR_SEQ 2961..3203 FT /note="Missing (in isoform 1)" FT /id="VSP_062337" FT VAR_SEQ 4103..5560 FT /note="Missing (in isoform 1 and isoform 4)" FT /id="VSP_062338" FT VAR_SEQ 7105..7137 FT /note="RKYKSSAKMFLQHGCNEILRPDMLTALYNSHMW -> KKYRADYEQRKDKYH FT LVVDEPRHLLAKTAGDQI (in isoform 1, isoform 3 and isoform 4)" FT /id="VSP_062339" FT VAR_SEQ 7975..8129 FT /note="Missing (in isoform 1 and isoform 4)" FT /id="VSP_062340" FT VARIANT 146 FT /note="T -> A (in dbSNP:rs4077109)" FT /id="VAR_047692" FT VARIANT 191 FT /note="E -> Q (in dbSNP:rs35686968)" FT /id="VAR_047693" FT VARIANT 974..8525 FT /note="Missing (in AMC6)" FT /evidence="ECO:0000269|PubMed:26578207" FT /id="VAR_085714" FT VARIANT 1027 FT /note="K -> N (in dbSNP:rs6735208)" FT /evidence="ECO:0000269|PubMed:7739042" FT /id="VAR_047694" FT VARIANT 1301 FT /note="Y -> H (in dbSNP:rs6711382)" FT /evidence="ECO:0000269|PubMed:7739042" FT /id="VAR_047695" FT VARIANT 1469 FT /note="E -> D (in dbSNP:rs34800215)" FT /id="VAR_047696" FT VARIANT 1479 FT /note="V -> I (in dbSNP:rs34577613)" FT /id="VAR_047697" FT VARIANT 1491 FT /note="V -> M (in dbSNP:rs7426114)" FT /evidence="ECO:0000269|PubMed:7739042" FT /id="VAR_047698" FT VARIANT 1969 FT /note="Y -> H (in dbSNP:rs34532796)" FT /id="VAR_047699" FT VARIANT 2613 FT /note="K -> N (in dbSNP:rs13013209)" FT /id="VAR_047700" FT VARIANT 2773 FT /note="R -> Q (in dbSNP:rs35974308)" FT /id="VAR_047701" FT VARIANT 2912 FT /note="S -> P (in dbSNP:rs6713162)" FT /id="VAR_047702" FT VARIANT 2952 FT /note="V -> G (in dbSNP:rs13024542)" FT /id="VAR_047703" FT VARIANT 3603 FT /note="W -> C (in dbSNP:rs10172023)" FT /evidence="ECO:0000269|PubMed:7739042" FT /id="VAR_047704" FT VARIANT 5588 FT /note="S -> T (in dbSNP:rs35227368)" FT /id="VAR_047705" FT VARIANT 5972 FT /note="P -> L (in dbSNP:rs4327235)" FT /id="VAR_047706" FT VARIANT 6038 FT /note="N -> S (in dbSNP:rs16830236)" FT /id="VAR_047707" FT VARIANT 6102 FT /note="R -> T (in dbSNP:rs2288210)" FT /evidence="ECO:0000269|PubMed:7739042" FT /id="VAR_047708" FT VARIANT 6262..8525 FT /note="Missing (in AMC6)" FT /evidence="ECO:0000269|PubMed:29274205" FT /id="VAR_085715" FT VARIANT 6327..8525 FT /note="Missing (in AMC6)" FT /evidence="ECO:0000269|PubMed:29274205" FT /id="VAR_085716" FT VARIANT 6731 FT /note="D -> V (in dbSNP:rs2288200)" FT /id="VAR_024240" FT VARIANT 7164 FT /note="R -> P (in dbSNP:rs16830171)" FT /id="VAR_047709" FT VARIANT 7635 FT /note="G -> E (in dbSNP:rs3732309)" FT /id="VAR_021888" FT VARIANT 7832 FT /note="T -> I (in dbSNP:rs34368668)" FT /id="VAR_056953" FT VARIANT 8402 FT /note="I -> V (in dbSNP:rs1061305)" FT /evidence="ECO:0000269|PubMed:7739042" FT /id="VAR_056954" FT CONFLICT 727 FT /note="E -> D (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT CONFLICT 781 FT /note="K -> R (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT CONFLICT 1290 FT /note="N -> S (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT CONFLICT 1389 FT /note="S -> T (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT CONFLICT 1549 FT /note="A -> R (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT CONFLICT 1939 FT /note="P -> L (in Ref. 4; AAA59917)" FT /evidence="ECO:0000305" FT CONFLICT 2023 FT /note="M -> I (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT CONFLICT 2613 FT /note="K -> Y (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT CONFLICT 4039 FT /note="G -> E (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT CONFLICT 4081 FT /note="D -> Y (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT CONFLICT 6739 FT /note="T -> P (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT CONFLICT 6833 FT /note="K -> E (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT CONFLICT 8145 FT /note="A -> P (in Ref. 1; CAA58788)" FT /evidence="ECO:0000305" FT STRAND 8471..8475 FT /evidence="ECO:0007829|PDB:6Y17" FT STRAND 8480..8484 FT /evidence="ECO:0007829|PDB:1ARK" FT STRAND 8492..8508 FT /evidence="ECO:0007829|PDB:6Y17" FT TURN 8509..8511 FT /evidence="ECO:0007829|PDB:6Y17" FT STRAND 8514..8518 FT /evidence="ECO:0007829|PDB:6Y17" FT HELIX 8519..8521 FT /evidence="ECO:0007829|PDB:6Y17" FT STRAND 8522..8524 FT /evidence="ECO:0007829|PDB:6Y17" SQ SEQUENCE 8525 AA; 986665 MW; CB81263B60987A7B CRC64; MADDEDYEEV VEYYTEEVVY EEVPGETITK IYETTTTRTS DYEQSETSKP ALAQPALAQP ASAKPVERRK VIRKKVDPSK FMTPYIAHSQ KMQDLFSPNK YKEKFEKTKG QPYASTTDTP ELRRIKKVQD QLSEVKYRMD GDVAKTICHV DEKAKDIEHA KKVSQQVSKV LYKQNWEDTK DKYLLPPDAP ELVQAVKNTA MFSKKLYTED WEADKSLFYP YNDSPELRRV AQAQKALSDV AYKKGLAEQQ AQFTPLADPP DIEFAKKVTN QVSKQKYKED YENKIKGKWS ETPCFEVANA RMNADNISTR KYQEDFENMK DQIYFMQTET PEYKMNKKAG VAASKVKYKE DYEKNKGKAD YNVLPASENP QLRQLKAAGD ALSDKLYKEN YEKTKAKSIN YCETPKFKLD TVLQNFSSDK KYKDSYLKDI LGHYVGSFED PYHSHCMKVT AQNSDKNYKA EYEEDRGKGF FPQTITQEYE AIKKLDQCKD HTYKVHPDKT KFTQVTDSPV LLQAQVNSKQ LSDLNYKAKH ESEKFKCHIP PDTPAFIQHK VNAYNLSDNL YKQDWEKSKA KKFDIKVDAI PLLAAKANTK NTSDVMYKKD YEKNKGKMIG VLSINDDPKM LHSLKVAKNQ SDRLYKENYE KTKAKSMNYC ETPKYQLDTQ LKNFSEARYK DLYVKDVLGH YVGSMEDPYH THCMKVAAQN SDKSYKAEYE EDKGKCYFPQ TITQEYEAIK KLDQCKDHTY KVHPDKTKFT AVTDSPVLLQ AQLNTKQLSD LNYKAKHEGE KFKCHIPADA PQFIQHRVNA YNLSDNVYKQ DWEKSKAKKF DIKVDAIPLL AAKANTKNTS DVMYKKDYEK SKGKMIGALS INDDPKMLHS LKTAKNQSDR EYRKDYEKSK TIYTAPLDML QVTQAKKSQA IASDVDYKHI LHSYSYPPDS INVDLAKKAY ALQSDVEYKA DYNSWMKGCG WVPFGSLEME KAKRASDILN EKKYRQHPDT LKFTSIEDAP ITVQSKINQA QRSDIAYKAK GEEIIHKYNL PPDLPQFIQA KVNAYNISEN MYKADLKDLS KKGYDLRTDA IPIRAAKAAR QAASDVQYKK DYEKAKGKMV GFQSLQDDPK LVHYMNVAKI QSDREYKKDY EKTKSKYNTP HDMFNVVAAK KAQDVVSNVN YKHSLHHYTY LPDAMDLELS KNMMQIQSDN VYKEDYNNWM KGIGWIPIGS LDVEKVKKAG DALNEKKYRQ HPDTLKFTSI VDSPVMVQAK QNTKQVSDIL YKAKGEDVKH KYTMSPDLPQ FLQAKCNAYN ISDVCYKRDW YDLIAKGNNV LGDAIPITAA KASRNIASDY KYKEAYEKSK GKHVGFRSLQ DDPKLVHYMN VAKLQSDREY KKNYENTKTS YHTPGDMVSI TAAKMAQDVA TNVNYKQPLH HYTYLPDAMS LEHTRNVNQI QSDNVYKDEY NSFLKGIGWI PIGSLEVEKV KKAGDALNER KYRQHPDTVK FTSVPDSMGM VLAQHNTKQL SDLNYKVEGE KLKHKYTIDP ELPQFIQAKV NALNMSDAHY KADWKKTIAK GYDLRPDAIP IVAAKSSRNI ASDCKYKEAY EKAKGKQVGF LSLQDDPKLV HYMNVAKIQS DREYKKGYEA SKTKYHTPLD MVSVTAAKKS QEVATNANYR QSYHHYTLLP DALNVEHSRN AMQIQSDNLY KSDFTNWMKG IGWVPIESLE VEKAKKAGEI LSEKKYRQHP EKLKFTYAMD TMEQALNKSN KLNMDKRLYT EKWNKDKTTI HVMPDTPDIL LSRVNQITMS DKLYKAGWEE EKKKGYDLRP DAIAIKAARA SRDIASDYKY KKAYEQAKGK HIGFRSLEDD PKLVHFMQVA KMQSDREYKK GYEKSKTSFH TPVDMLSVVA AKKSQEVATN ANYRNVIHTY NMLPDAMSFE LAKNMMQIQS DNQYKADYAD FMKGIGWLPL GSLEAEKNKK AMEIISEKKY RQHPDTLKYS TLMDSMNMVL AQNNAKIMNE HLYKQAWEAD KTKVHIMPDI PQIILAKANA INMSDKLYKL SLEESKKKGY DLRPDAIPIK AAKASRDIAS DYKYKYNYEK GKGKMVGFRS LEDDPKLVHS MQVAKMQSDR EYKKNYENTK TSYHTPADML SVTAAKDAQA NITNTNYKHL IHKYILLPDA MNIELTRNMN RIQSDNEYKQ DYNEWYKGLG WSPAGSLEVE KAKKATEYAS DQKYRQHPSN FQFKKLTDSM DMVLAKQNAH TMNKHLYTID WNKDKTKIHV MPDTPDILQA KQNQTLYSQK LYKLGWEEAL KKGYDLPVDA ISVQLAKASR DIASDYKYKQ GYRKQLGHHV GFRSLQDDPK LVLSMNVAKM QSEREYKKDF EKWKTKFSSP VDMLGVVLAK KCQELVSDVD YKNYLHQWTC LPDQNDVVQA KKVYELQSEN LYKSDLEWLR GIGWSPLGSL EAEKNKRASE IISEKKYRQP PDRNKFTSIP DAMDIVLAKT NAKNRSDRLY REAWDKDKTQ IHIMPDTPDI VLAKANLINT SDKLYRMGYE ELKRKGYDLP VDAIPIKAAK ASREIASEYK YKEGFRKQLG HHIGARNIED DPKMMWSMHV AKIQSDREYK KDFEKWKTKF SSPVDMLGVV LAKKCQTLVS DVDYKNYLHQ WTCLPDQSDV IHARQAYDLQ SDNLYKSDLQ WLKGIGWMTS GSLEDEKNKR ATQILSDHVY RQHPDQFKFS SLMDSIPMVL AKNNAITMNH RLYTEAWDKD KTTVHIMPDT PEVLLAKQNK VNYSEKLYKL GLEEAKRKGY DMRVDAIPIK AAKASRDIAS EFKYKEGYRK QLGHHIGARA IRDDPKMMWS MHVAKIQSDR EYKKDFEKWK TKFSSPVDML GVVLAKKCQT LVSDVDYKNY LHQWTCLPDQ SDVIHARQAY DLQSDNMYKS DLQWMRGIGW VSIGSLDVEK CKRATEILSD KIYRQPPDRF KFTSVTDSLE QVLAKNNAIT MNKRLYTEAW DKDKTQIHIM PDTPEIMLAR MNKINYSESL YKLANEEAKK KGYDLRSDAI PIVAAKASRD IISDYKYKDG YCKQLGHHIG ARNIEDDPKM MWSMHVAKIQ SDREYKKDFE KWKTKFSSPV DMLGVVLAKK CQTLVSDVDY KNYLHEWTCL PDQSDVIHAR QAYDLQSDNI YKSDLQWLRG IGWVPIGSMD VVKCKRATEI LSDNIYRQPP DKLKFTSVTD SLEQVLAKNN ALNMNKRLYT EAWDKDKTQI HIMPDTPEIM LARQNKINYS ETLYKLANEE AKKKGYDLRS DAIPIVAAKA SRDVISDYKY KDGYRKQLGH HIGARNIEDD PKMMWSMHVA KIQSDREYKK DFEKWKTKFS SPVDMLGVVL AKKCQTLVSD VDYKNYLHEW TCLPDQNDVI HARQAYDLQS DNIYKSDLQW LRGIGWVPIG SMDVVKCKRA AEILSDNIYR QPPDKLKFTS VTDSLEQVLA KNNALNMNKR LYTEAWDKDK TQVHIMPDTP EIMLARQNKI NYSESLYRQA MEEAKKEGYD LRSDAIPIVA AKASRDIASD YKYKEAYRKQ LGHHIGARAV HDDPKIMWSL HIAKVQSDRE YKKDFEKYKT RYSSPVDMLG IVLAKKCQTL VSDVDYKHPL HEWICLPDQN DIIHARKAYD LQSDNLYKSD LEWMKGIGWV PIDSLEVVRA KRAGELLSDT IYRQRPETLK FTSITDTPEQ VLAKNNALNM NKRLYTEAWD NDKKTIHVMP DTPEIMLAKL NRINYSDKLY KLALEESKKE GYDLRLDAIP IQAAKASRDI ASDYKYKEGY RKQLGHHIGA RNIKDDPKMM WSIHVAKIQS DREYKKEFEK WKTKFSSPVD MLGVVLAKKC QILVSDIDYK HPLHEWTCLP DQNDVIQARK AYDLQSDAIY KSDLEWLRGI GWVPIGSVEV EKVKRAGEIL SDRKYRQPAD QLKFTCITDT PEIVLAKNNA LTMSKHLYTE AWDADKTSIH VMPDTPDILL AKSNSANISQ KLYTKGWDES KMKDYDLRAD AISIKSAKAS RDIASDYKYK EAYEKQKGHH IGAQSIEDDP KIMCAIHAGK IQSEREYKKE FQKWKTKFSS PVDMLSILLA KKCQTLVTDI DYRNYLHEWT CMPDQNDIIQ AKKAYDLQSD SVYKADLEWL RGIGWMPEGS VEMNRVKVAQ DLVNERLYRT RPEALSFTSI VDTPEVVLAK ANSLQISEKL YQEAWNKDKS NITIPSDTPE MLQAHINALQ ISNKLYQKDW NDAKQKGYDI RADAIEIKHA KASREIASEY KYKEGYRKQL GHHMGFRTLQ DDPKSVWAIH AAKIQSDREY KKAYEKSKGI HNTPLDMMSI VQAKKCQVLV SDIDYRNYLH QWTCLPDQND VIQAKKAYDL QSDNLYKSDL EWLKGIGWLP EGSVEVMRVK NAQNLLNERL YRIKPEALKF TSIVDTPEVI QAKINAVQIS EPLYRDAWEK EKANVNVPAD TPLMLQSKIN ALQISNKRYQ QAWEDVKMTG YDLRADAIGI QHAKASRDIA SDYLYKTAYE KQKGHYIGCR SAKEDPKLVW AANVLKMQND RLYKKAYNDH KAKISIPVDM VSISAAKEGQ ALASDVDYRH YLHHWSCFPD QNDVIQARKA YDLQSDSVYK ADLEWLRGIG WMPEGSVEMN RVKVAQDLVN ERLYRTRPEA LSFTSIVDTP EVVLAKANSL QISEKLYQEA WNKDKSNITI PSDTPEMLQA HINALQISNK LYQKDWNDTK QKGYDIRADA IEIKHAKASR EIASEYKYKE GYRKQLGHHM GFRTLQDDPK SVWAIHAAKI QSDREYKKAY EKSKGIHNTP LDMMSIVQAK KCQVLVSDID YRNYLHQWTC LPDQNDVIQA KKAYDLQSDN LYKSDLEWLK GIGWLPEGSV EVMRVKNAQN LLNERLYRIK PEALKFTSIV DTPEVIQAKI NAVQISEPLY RNAWEKEKAN VNVPADTPLM LQSKINALQI SNKRYQQAWE DVKMTGYDLR ADAIGIQHAK ASRDIASDYL YKTAYEKQKG HYIGCRSAKE DPKLVWAANV LKMQNDRLYK KAYNDHKAKI SIPVDMVSIS AAKEGQALAS DVDYRHYLHH WSCFPDQNDV IQARKAYDLQ SDSVYKADLE WLRGIGWMPE GSVEMNRVKV AQDLVNERLY RTRPEALSFT SIVDTPEVVL AKANSLQISE KLYQEAWNKD KSNITIPSDT PEMLQAHINA LQISNKLYQK DWNDTKQKGY DIRADAIEIK HAKASREIAS EYKYKEGYRK QLGHHMGFRT LQDDPKSVWA IHAAKIQSDR EYKKAYEKSK GIHNTPLDMM SIVQAKKCQV LVSDIDYRNY LHQWTCLPDQ NDVIQAKKAY DLQSDNLYKS DLEWLKGIGW LPEGSVEVMR VKNAQNLLNE RLYRIKPEAL KFTSIVDTPE VIQAKINAVQ ISEPLYRDAW EKEKANVNVP ADTPLMLQSK INALQISNKR YQQAWEDVKM TGYDLRADAI GIQHAKASRD IASDYLYKTA YEKQKGHYIG CRSAKEDPKL VWAANVLKMQ NDRLYKKAYN DHKAKISIPV DMVSISAAKE GQALASDVDY RHYLHRWSCF PDQNDVIQAR KAYDLQSDAL YKADLEWLRG IGWMPQGSPE VLRVKNAQNI FCDSVYRTPV VNLKYTSIVD TPEVVLAKSN AENISIPKYR EVWDKDKTSI HIMPDTPEIN LARANALNVS NKLYREGWDE MKAGCDVRLD AIPIQAAKAS REIASDYKYK LDHEKQKGHY VGTLTARDDN KIRWALIADK LQNEREYRLD WAKWKAKIQS PVDMLSILHS KNSQALVSDM DYRNYLHQWT CMPDQNDVIQ AKKAYELQSD NVYKADLEWL RGIGWMPNDS VSVNHAKHAA DIFSEKKYRT KIETLNFTPV DDRVDYVTAK QSGEILDDIK YRKDWNATKS KYTLTETPLL HTAQEAARIL DQYLYKEGWE RQKATGYILP PDAVPFVHAH HCNDVQSELK YKAEHVKQKG HYVGVPTMRD DPKLVWFEHA GQIQNERLYK EDYHKTKAKI NIPADMVSVL AAKQGQTLVS DIDYRNYLHQ WMCHPDQNDV IQARKAYDLQ SDNVYRADLE WLRGIGWIPL DSVDHVRVTK NQEMMSQIKY KKNALENYPN FRSVVDPPEI VLAKINSVNQ SDVKYKETFN KAKGKYTFSP DTPHISHSKD MGKLYSTILY KGAWEGTKAY GYTLDERYIP IVGAKHADLV NSELKYKETY EKQKGHYLAG KVIGEFPGVV HCLDFQKMRS ALNYRKHYED TKANVHIPND MMNHVLAKRC QYILSDLEYR HYFHQWTSLL EEPNVIRVRN AQEILSDNVY KDDLNWLKGI GCYVWDTPQI LHAKKSYDLQ SQLQYTAAGK ENLQNYNLVT DTPLYVTAVQ SGINASEVKY KENYHQIKDK YTTVLETVDY DRTRNLKNLY SSNLYKEAWD RVKATSYILP SSTLSLTHAK NQKHLASHIK YREEYEKFKA LYTLPRSVDD DPNTARCLRV GKLNIDRLYR SVYEKNKMKI HIVPDMVEMV TAKDSQKKVS EIDYRLRLHE WICHPDLQVN DHVRKVTDQI SDIVYKDDLN WLKGIGCYVW DTPEILHAKH AYDLRDDIKY KAHMLKTRND YKLVTDTPVY VQAVKSGKQL SDAVYHYDYV HSVRGKVAPT TKTVDLDRAL HAYKLQSSNL YKTSLRTLPT GYRLPGDTPH FKHIKDTRYM SSYFKYKEAY EHTKAYGYTL GPKDVPFVHV RRVNNVTSER LYRELYHKLK DKIHTTPDTP EIRQVKKTQE AVSELIYKSD FFKMQGHMIS LPYTPQVIHC RYVGDITSDI KYKEDLQVLK GFGCFLYDTP DMVRSRHLRK LWSNYLYTDK ARKMRDKYKV VLDTPEYRKV QELKTHLSEL VYRAAGKKQK SIFTSVPDTP DLLRAKRGQK LQSQYLYVEL ATKERPHHHA GNQTTALKHA KDVKDMVSEK KYKIQYEKMK DKYTPVPDTP ILIRAKRAYW NASDLRYKET FQKTKGKYHT VKDALDIVYH RKVTDDISKI KYKENYMSQL GIWRSIPDRP EHFHHRAVTD TVSDVKYKED LTWLKGIGCY AYDTPDFTLA EKNKTLYSKY KYKEVFERTK SDFKYVADSP INRHFKYATQ LMNERKYKSS AKMFLQHGCN EILRPDMLTA LYNSHMWSQI KYRKNYEKSK DKFTSIVDTP EHLRTTKVNK QISDILYKLE YNKAKPRGYT TIHDTPMLLH VRKVKDEVSD LKYKEVYQRN KSNCTIEPDA VHIKAAKDAY KVNTNLDYKK QYEANKAHWK WTPDRPDFLQ AAKSSLQQSD FEYKLDREFL KGCKLSVTDD KNTVLALRNT LIESDLKYKE KHVKERGTCH AVPDTPQILL AKTVSNLVSE NKYKDHVKKH LAQGSYTTLP ETRDTVHVKE VTKHVSDTNY KKKFVKEKGK SNYSIMLEPP EVKHAMEVAK KQSDVAYRKD AKENLHYTTV ADRPDIKKAT QAAKQASEVE YRAKHRKEGS HGLSMLGRPD IEMAKKAAKL SSQVKYRENF DKEKGKTPKY NPKDSQLYKV MKDANNLASE VKYKADLKKL HKPVTDMKES LIMNHVLNTS QLASSYQYKK KYEKSKGHYH TIPDNLEQLH LKEATELQSI VKYKEKYEKE RGKPMLDFET PTYITAKESQ QMQSGKEYRK DYEESIKGRN LTGLEVTPAL LHVKYATKIA SEKEYRKDLE ESIRGKGLTE MEDTPDMLRA KNATQILNEK EYKRDLELEV KGRGLNAMAN ETPDFMRARN ATDIASQIKY KQSAEMEKAN FTSVVDTPEI IHAQQVKNLS SQKKYKEDAE KSMSYYETVL DTPEIQRVRE NQKNFSLLQY QCDLKNSKGK ITVVQDTPEI LRVKENQKNF SSVLYKEDVS PGTAIGKTPE MMRVKQTQDH ISSVKYKEAI GQGTPIPDLP EVKRVKETQK HISSVMYKEN LGTGIPTTVT PEIERVKRNQ ENFSSVLYKE NLGKGIPTPI TPEMERVKRN QENFSSILYK ENLSKGTPLP VTPEMERVKL NQENFSSVLY KENVGKGIPI PITPEMERVK HNQENFSSVL YKENLGTGIP IPITPEMQRV KHNQENLSSV LYKENMGKGT PLPVTPEMER VKHNQENISS VLYKENMGKG TPLPVTPEME RVKHNQENIS SVLYKENMGK GTPLAVTPEM ERVKHNQENI SSVLYKENVG KATATPVTPE MQRVKRNQEN ISSVLYKENL GKATPTPFTP EMERVKRNQE NFSSVLYKEN MRKATPTPVT PEMERAKRNQ ENISSVLYSD SFRKQIQGKA AYVLDTPEMR RVRETQRHIS TVKYHEDFEK HKGCFTPVVT DPITERVKKN MQDFSDINYR GIQRKVVEME QKRNDQDQET ITGLRVWRTN PGSVFDYDPA EDNIQSRSLH MINVQAQRRS REQSRSASAL SISGGEEKSE HSEAPDHHLS TYSDGGVFAV STAYKHAKTT ELPQQRSSSV ATQQTTVSSI PSHPSTAGKI FRAMYDYMAA DADEVSFKDG DAIINVQAID EGWMYGTVQR TGRTGMLPAN YVEAI //