ID   COGA_PARCM              Reviewed;          20 AA.
AC   P20732;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   02-SEP-2026, entry version 71.
DE   RecName: Full=Collagenolytic protease 36 kDa A;
DE            EC=3.4.21.32;
DE   Flags: Fragment;
OS   Paralithodes camtschaticus (Red king crab) (Maja camtschatica).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Communostraca;
OC   Malacostraca; Eumalacostraca; Stomatocarida; Decapoda; Pleocyemata;
OC   Anomura; Paguroidea; Lithodidae; Paralithodes.
OX   NCBI_TaxID=6741;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Hepatopancreas;
RX   PubMed=2154979; DOI=10.1016/0006-291x(90)91024-m;
RA   Klimova O.A., Borukhov S.I., Solovyeva N.I., Balaevskaya T.O.,
RA   Strongin A.Y.;
RT   "The isolation and properties of collagenolytic proteases from crab
RT   hepatopancreas.";
RL   Biochem. Biophys. Res. Commun. 166:1411-1420(1990).
CC   -!- FUNCTION: This enzyme is a serine protease capable of degrading the
CC       native triple helix of collagen.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of proteins, with broad specificity for peptide
CC         bonds. Native collagen is cleaved about 75% of the length of the
CC         molecule from the N-terminus. Low activity on small molecule
CC         substrates of both trypsin and chymotrypsin.; EC=3.4.21.32;
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00274}.
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DR   PIR; B34817; B34817.
DR   AlphaFoldDB; P20732; -.
PE   1: Evidence at protein level;
KW   Collagen degradation; Direct protein sequencing; Hydrolase; Protease;
KW   Serine protease.
FT   CHAIN           1..>20
FT                   /note="Collagenolytic protease 36 kDa A"
FT                   /id="PRO_0000088667"
FT   DOMAIN          1..>20
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         20
SQ   SEQUENCE   20 AA;  2116 MW;  45A172721B801016 CRC64;
     IVGGTEVTPG EIPYQLSLQD
//