ID   RIPS_MOMCO              Reviewed;          30 AA.
AC   P20655;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   02-SEP-2026, entry version 75.
DE   RecName: Full=Ribosome-inactivating protein momorcochin-S;
DE            EC=3.2.2.22;
DE   AltName: Full=rRNA N-glycosidase;
DE   Flags: Fragment;
OS   Momordica cochinchinensis (Spiny bitter cucumber) (Muricia
OS   cochinchinensis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Cucurbitales; Cucurbitaceae; Momordiceae; Momordica.
OX   NCBI_TaxID=3674;
RN   [1]
RP   PROTEIN SEQUENCE, AND GLYCOSYLATION.
RC   TISSUE=Seed;
RX   PubMed=2597699; DOI=10.1016/0304-4165(89)90178-5;
RA   Bolognesi A., Barbieri L., Carnicelli D., Abbondanza A., Cenini P.,
RA   Falasca A.I., Dinota A., Stirpe F.;
RT   "Purification and properties of a new ribosome-inactivating protein with
RT   RNA N-glycosidase activity suitable for immunotoxin preparation from the
RT   seeds of Momordica cochinchinensis.";
RL   Biochim. Biophys. Acta 993:287-292(1989).
CC   -!- FUNCTION: Inactivates eukaryotic 60S ribosomal subunits.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endohydrolysis of the N-glycosidic bond at one specific
CC         adenosine on the 28S rRNA.; EC=3.2.2.22;
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:2597699}.
CC   -!- SIMILARITY: Belongs to the ribosome-inactivating protein family. Type 1
CC       RIP subfamily. {ECO:0000305}.
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DR   PIR; S07065; S07065.
DR   AlphaFoldDB; P20655; -.
DR   SMR; P20655; -.
DR   GO; GO:0030598; F:rRNA N-glycosylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0017148; P:negative regulation of translation; IEA:InterPro.
DR   InterPro; IPR036041; Ribosome-inact_prot_sf.
DR   SUPFAM; SSF56371; Ribosome inactivating proteins (RIP); 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Hydrolase; Plant defense;
KW   Protein synthesis inhibitor; Toxin.
FT   CHAIN           1..>30
FT                   /note="Ribosome-inactivating protein momorcochin-S"
FT                   /id="PRO_0000221410"
FT   NON_TER         30
SQ   SEQUENCE   30 AA;  3323 MW;  5B93CE73B9E3E221 CRC64;
     DVTFSLLGAN TKSYAAFITN FRKDVASEKK
//