ID ACP_RHIME Reviewed; 78 AA. AC P19372; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 02-SEP-2026, entry version 148. DE RecName: Full=Acyl carrier protein AcpP {ECO:0000255|HAMAP-Rule:MF_01217}; DE Short=ACP {ECO:0000255|HAMAP-Rule:MF_01217}; GN Name=acpP {ECO:0000255|HAMAP-Rule:MF_01217}; OrderedLocusNames=R01143; GN ORFNames=SMc00573; OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium OS meliloti). OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria; OC Hyphomicrobiales; Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium. OX NCBI_TaxID=266834; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PHOSPHOPANTETHEINYLATION AT SER-37. RC STRAIN=1021; RX PubMed=10784042; DOI=10.1099/00221287-146-4-839; RA Lopez-Lara I.M., Geiger O.; RT "Expression and purification of four different rhizobial acyl carrier RT proteins."; RL Microbiology 146:839-849(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1021; RX PubMed=11481430; DOI=10.1073/pnas.161294398; RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T., RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., RA Thebault P., Vandenbol M., Weidner S., Galibert F.; RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium RT meliloti strain 1021."; RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1021; RX PubMed=11474104; DOI=10.1126/science.1060966; RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., RA Wong K., Yeh K.-C., Batut J.; RT "The composite genome of the legume symbiont Sinorhizobium meliloti."; RL Science 293:668-672(2001). RN [4] RP PROTEIN SEQUENCE OF 2-78. RC STRAIN=1021; RX PubMed=2144277; DOI=10.1128/jb.172.9.5440-5444.1990; RA Platt M.K., Miller K.J., Lane W.S., Kennedy E.P.; RT "Isolation and characterization of the constitutive acyl carrier protein RT from Rhizobium meliloti."; RL J. Bacteriol. 172:5440-5444(1990). CC -!- FUNCTION: Carrier of the growing fatty acid chain in fatty acid CC biosynthesis. CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP- CC Rule:MF_01217}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01217}. CC -!- PTM: 4'-phosphopantetheine is transferred from CoA to a specific serine CC of apo-ACP by AcpS. This modification is essential for activity because CC fatty acids are bound in thioester linkage to the sulfhydryl of the CC prosthetic group. CC -!- SIMILARITY: Belongs to the acyl carrier protein (ACP) family. CC {ECO:0000255|HAMAP-Rule:MF_01217}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF159244; AAF24181.1; -; Genomic_DNA. DR EMBL; AL591688; CAC45722.1; -; Genomic_DNA. DR PIR; A36728; A36728. DR RefSeq; WP_003531676.1; NC_003047.1. DR AlphaFoldDB; P19372; -. DR SMR; P19372; -. DR EnsemblBacteria; CAC45722; CAC45722; SMc00573. DR GeneID; 48972423; -. DR KEGG; sme:SMc00573; -. DR PATRIC; fig|266834.11.peg.2552; -. DR eggNOG; COG0236; Bacteria. DR HOGENOM; CLU_108696_5_1_5; -. DR OrthoDB; 9804551at2; -. DR UniPathway; UPA00094; -. DR PRO; PR:P19372; -. DR Proteomes; UP000001976; Chromosome. DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter. DR GO; GO:0000035; F:acyl binding; IEA:TreeGrafter. DR GO; GO:0000036; F:acyl carrier activity; IEA:UniProtKB-UniRule. DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:TreeGrafter. DR FunFam; 1.10.1200.10:FF:000001; Acyl carrier protein; 1. DR Gene3D; 1.10.1200.10; ACP-like; 1. DR HAMAP; MF_01217; Acyl_carrier; 1. DR InterPro; IPR003231; ACP. DR InterPro; IPR036736; ACP-like_sf. DR InterPro; IPR009081; PP-bd_ACP. DR InterPro; IPR006162; Ppantetheine_attach_site. DR NCBIfam; TIGR00517; acyl_carrier; 1. DR NCBIfam; NF002148; PRK00982.1-2; 1. DR NCBIfam; NF002149; PRK00982.1-3; 1. DR NCBIfam; NF002150; PRK00982.1-4; 1. DR NCBIfam; NF002151; PRK00982.1-5; 1. DR PANTHER; PTHR20863; ACYL CARRIER PROTEIN; 1. DR PANTHER; PTHR20863:SF76; CARRIER DOMAIN-CONTAINING PROTEIN; 1. DR Pfam; PF00550; PP-binding; 1. DR SUPFAM; SSF47336; ACP-like; 1. DR PROSITE; PS50075; CARRIER; 1. DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1. PE 1: Evidence at protein level; KW Cytoplasm; Direct protein sequencing; Fatty acid biosynthesis; KW Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; KW Phosphopantetheine; Phosphoprotein; Reference proteome. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000269|PubMed:2144277" FT CHAIN 2..78 FT /note="Acyl carrier protein AcpP" FT /id="PRO_0000180176" FT DOMAIN 2..77 FT /note="Carrier" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258" FT MOD_RES 37 FT /note="O-(pantetheine 4'-phosphoryl)serine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258, FT ECO:0000269|PubMed:10784042" SQ SEQUENCE 78 AA; 8340 MW; 5B8EF6618C374760 CRC64; MSDIAERVKK IVIDHLGVDA EKVSEGASFI DDLGADSLDT VELVMAFEEE FGVEIPDDAA DSILTVGDAV KFIEKAQA //