ID NU3C_SYNY3 Reviewed; 120 AA. AC P19045; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1990, sequence version 1. DT 02-SEP-2026, entry version 137. DE RecName: Full=NAD(P)H-quinone oxidoreductase subunit 3; DE EC=7.1.1.-; DE AltName: Full=NAD(P)H dehydrogenase subunit 3; DE AltName: Full=NADH-plastoquinone oxidoreductase subunit 3; DE AltName: Full=NDH-1 subunit 3; DE Short=NDH-C; GN Name=ndhC; OrderedLocusNames=slr1279; OS Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa). OC Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Synechococcales; OC Merismopediaceae; Synechocystis. OX NCBI_TaxID=1111708; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=2499764; DOI=10.1007/bf00332231; RA Steinmueller K., Ley A.C., Steinmetz A.A., Sayre R.T., Bogorad L.; RT "Characterization of the ndhC-psbG-ORF157/159 operon of maize plastid DNA RT and of the cyanobacterium Synechocystis sp. PCC6803."; RL Mol. Gen. Genet. 216:60-69(1989). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 27184 / PCC 6803 / Kazusa; RX PubMed=8905231; DOI=10.1093/dnares/3.3.109; RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S., RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.; RT "Sequence analysis of the genome of the unicellular cyanobacterium RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire RT genome and assignment of potential protein-coding regions."; RL DNA Res. 3:109-136(1996). RN [3] RP PROTEIN SEQUENCE OF 1-6, CHARACTERIZATION AS A MEMBER OF THE RP NAD(P)H-QUINONE OXIDOREDUCTASE COMPLEX, AND SUBCOMPLEXES OF NDH-1. RX PubMed=15102833; DOI=10.1074/jbc.m401107200; RA Prommeenate P., Lennon A.M., Markert C., Hippler M., Nixon P.J.; RT "Subunit composition of NDH-1 complexes of Synechocystis sp. PCC 6803: RT identification of two new ndh gene products with nuclear-encoded homologues RT in the chloroplast Ndh complex."; RL J. Biol. Chem. 279:28165-28173(2004). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY, CHARACTERIZATION AS A MEMBER OF THE RP NAD(P)H-QUINONE OXIDOREDUCTASE COMPLEX, AND SUBCOMPLEXES OF NDH-1. RX PubMed=15548534; DOI=10.1074/jbc.m410914200; RA Battchikova N., Zhang P., Rudd S., Ogawa T., Aro E.-M.; RT "Identification of NdhL and Ssl1690 (NdhO) in NDH-1L and NDH-1M complexes RT of Synechocystis sp. PCC 6803."; RL J. Biol. Chem. 280:2587-2595(2005). CC -!- FUNCTION: NDH-1 shuttles electrons from an unknown electron donor, via CC FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory CC and/or the photosynthetic chain. The immediate electron acceptor for CC the enzyme in this species is believed to be plastoquinone. Couples the CC redox reaction to proton translocation, and thus conserves the redox CC energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in CC inorganic carbon-concentration (By similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a plastoquinone + NADH + (n+1) H(+)(in) = a plastoquinol + CC NAD(+) + n H(+)(out); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561, CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192; CC -!- CATALYTIC ACTIVITY: CC Reaction=a plastoquinone + NADPH + (n+1) H(+)(in) = a plastoquinol + CC NADP(+) + n H(+)(out); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561, CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192; CC -!- SUBUNIT: NDH-1 can be composed of about 15 different subunits; CC different subcomplexes with different compositions have been identified CC which probably have different functions. CC -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane {ECO:0000305}; Multi- CC pass membrane protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17439; CAA35484.1; -; Genomic_DNA. DR EMBL; BA000022; BAA18283.1; -; Genomic_DNA. DR PIR; S04435; S04435. DR AlphaFoldDB; P19045; -. DR SMR; P19045; -. DR IntAct; P19045; 3. DR STRING; 1148.gene:10499159; -. DR PaxDb; 1148-gene:10499159; -. DR EnsemblBacteria; BAA18283; BAA18283; BAA18283. DR KEGG; syn:slr1279; -. DR eggNOG; COG0838; Bacteria. DR InParanoid; P19045; -. DR PhylomeDB; P19045; -. DR Proteomes; UP000001425; Chromosome. DR GO; GO:0030964; C:NADH dehydrogenase complex; IBA:GO_Central. DR GO; GO:0031676; C:plasma membrane-derived thylakoid membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central. DR GO; GO:0019684; P:photosynthesis, light reaction; IEA:UniProtKB-UniRule. DR FunFam; 1.20.58.1610:FF:000001; NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic; 1. DR Gene3D; 1.20.58.1610; NADH:ubiquinone/plastoquinone oxidoreductase, chain 3; 1. DR HAMAP; MF_01394; NDH1_NuoA; 1. DR InterPro; IPR023043; NAD(P)H_OxRDtase_bac/plastid. DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3. DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf. DR PANTHER; PTHR11058; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1. DR PANTHER; PTHR11058:SF9; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1. DR Pfam; PF00507; Oxidored_q4; 1. PE 1: Evidence at protein level; KW Direct protein sequencing; Membrane; NAD; NADP; Plastoquinone; Quinone; KW Reference proteome; Thylakoid; Translocase; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1..120 FT /note="NAD(P)H-quinone oxidoreductase subunit 3" FT /id="PRO_0000117859" FT TRANSMEM 2..22 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 64..84 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 89..109 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 120 AA; 13662 MW; 39343E8AFEAD8184 CRC64; MFVLTGYEYF LGFLFICSLV PVLALTASKL LRPRDGGPER QTTYESGMEP IGGAWIQFNI RYYMFALVFV VFDVETVFLY PWAVAFNQLG LLAFVEALIF IAILVVALVY AWRKGALEWS //