ID   HVM61_MOUSE             Reviewed;         116 AA.
AC   P18532;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   04-NOV-2026, entry version 129.
DE   RecName: Full=Ig heavy chain V region 1B43;
DE   Flags: Precursor;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/cJ;
RX   PubMed=2499654; DOI=10.1084/jem.169.6.2007;
RA   Levy N.S., Malipiero U.V., Lebecque S.G., Gearhart P.J.;
RT   "Early onset of somatic mutation in immunoglobulin VH genes during the
RT   primary immune response.";
RL   J. Exp. Med. 169:2007-2019(1989).
CC   -!- MISCELLANEOUS: This sequence belongs to the VH3660 subfamily.
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DR   PIR; JT0508; HVMS1B.
DR   PDB; 1KCS; X-ray; 2.50 A; H=19-116.
DR   PDB; 1KCV; X-ray; 1.80 A; H=19-116.
DR   PDB; 2F58; X-ray; 2.80 A; H=19-116.
DR   PDB; 3F58; X-ray; 2.80 A; H=19-116.
DR   AlphaFoldDB; P18532; -.
DR   MDRepo; P18532; -.
DR   SMR; P18532; -.
DR   FunCoup; P18532; 615.
DR   InParanoid; P18532; -.
DR   OMA; DWHWIRH; -.
DR   EvolutionaryTrace; P18532; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P18532; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-ARBA.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0016064; P:immunoglobulin mediated immune response; IBA:GO_Central.
DR   FunFam; 2.60.40.10:FF:002253; Ig heavy chain V region 36-60; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR050199; IgHV.
DR   PANTHER; PTHR23266; IMMUNOGLOBULIN HEAVY CHAIN; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin;
KW   Reference proteome; Signal.
FT   SIGNAL          1..18
FT   CHAIN           19..116
FT                   /note="Ig heavy chain V region 1B43"
FT                   /id="PRO_0000015242"
FT   REGION          19..48
FT                   /note="Framework-1"
FT   REGION          49..53
FT                   /note="Complementarity-determining-1"
FT   REGION          54..67
FT                   /note="Framework-2"
FT   REGION          68..84
FT                   /note="Complementarity-determining-2"
FT   REGION          85..116
FT                   /note="Framework-3"
FT   DISULFID        40..114
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         116
FT   STRAND          21..25
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   STRAND          28..30
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   STRAND          36..45
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   TURN            47..49
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   STRAND          50..58
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   STRAND          64..71
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   STRAND          76..78
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   TURN            80..85
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   STRAND          86..91
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   TURN            92..95
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   STRAND          96..101
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   HELIX           106..108
FT                   /evidence="ECO:0007829|PDB:1KCV"
FT   STRAND          110..116
FT                   /evidence="ECO:0007829|PDB:1KCV"
SQ   SEQUENCE   116 AA;  13158 MW;  1CB547253681FF74 CRC64;
     MRVLILLCLF TAFPGILSDV QLQESGPDLV KPSQSLSLTC TVTGYSITSG YSWHWIRQFP
     GNKLEWMGYI HYSGNTSYNP SLKSRISITR DTSKNQFFLQ LNSVTTEDTA TYYCAR
//