ID   ZFP58_MOUSE             Reviewed;         489 AA.
AC   P16372; Q3TS54; Q6P8L3; Q7M6X1; Q8BRV1;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 2.
DT   02-SEP-2026, entry version 182.
DE   RecName: Full=Zinc finger protein 58;
DE            Short=Zfp-58;
DE   AltName: Full=Regulator of sex-limitation candidate 5;
DE   AltName: Full=Zinc finger protein Mfg-1;
GN   Name=Zfp58; Synonyms=Mfg-1, Rslcan5, Zfp817;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=14563677; DOI=10.1101/gad.1135703;
RA   Krebs C.J., Larkins L.K., Price R., Tullis K.M., Miller R.D., Robins D.M.;
RT   "Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes
RT   that control sexually dimorphic liver gene expression.";
RL   Genes Dev. 17:2664-2674(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Aorta, Egg, Placenta, and Vein;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 99-239, FUNCTION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=2512579; DOI=10.1073/pnas.86.23.9417;
RA   Passananti C., Felsani A., Caruso M., Amati P.;
RT   "Mouse genes coding for 'zinc-finger'-containing proteins: characterization
RT   and expression in differentiated cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:9417-9421(1989).
CC   -!- FUNCTION: May have a role during differentiation processes.
CC       {ECO:0000269|PubMed:2512579}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in liver, testis and, at considerably
CC       lower levels, in brain, spleen and heart. {ECO:0000269|PubMed:2512579}.
CC   -!- DEVELOPMENTAL STAGE: Expression increases upon differentiation and is
CC       not related to the cell cycle. {ECO:0000269|PubMed:2512579}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH61200.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; BK001635; DAA01860.1; -; mRNA.
DR   EMBL; AK041250; BAC30880.1; -; mRNA.
DR   EMBL; AK162259; BAE36821.1; -; mRNA.
DR   EMBL; AK167399; BAE39488.1; -; mRNA.
DR   EMBL; CH466661; EDL10303.1; -; Genomic_DNA.
DR   EMBL; CH466661; EDL10304.1; -; Genomic_DNA.
DR   EMBL; BC061200; AAH61200.1; ALT_SEQ; mRNA.
DR   EMBL; BC139150; AAI39151.1; -; mRNA.
DR   EMBL; BC139151; AAI39152.1; -; mRNA.
DR   EMBL; M28513; AAA39531.1; -; mRNA.
DR   CCDS; CCDS26616.1; -.
DR   PIR; A39240; A39240.
DR   RefSeq; NP_001007576.1; NM_001007575.2.
DR   AlphaFoldDB; P16372; -.
DR   SMR; P16372; -.
DR   BioGRID; 232010; 32.
DR   FunCoup; P16372; 1.
DR   STRING; 10090.ENSMUSP00000075487; -.
DR   iPTMnet; P16372; -.
DR   PhosphoSitePlus; P16372; -.
DR   PaxDb; 10090-ENSMUSP00000075487; -.
DR   ProteomicsDB; 299548; -.
DR   DNASU; 238693; -.
DR   Ensembl; ENSMUST00000076123.12; ENSMUSP00000075487.6; ENSMUSG00000071291.11.
DR   Ensembl; ENSMUST00000171518.8; ENSMUSP00000132285.2; ENSMUSG00000071291.11.
DR   GeneID; 238693; -.
DR   KEGG; mmu:238693; -.
DR   UCSC; uc007rax.2; mouse.
DR   AGR; MGI:99205; -.
DR   CTD; 238693; -.
DR   MGI; MGI:99205; Zfp58.
DR   VEuPathDB; HostDB:ENSMUSG00000071291; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000153165; -.
DR   HOGENOM; CLU_476683_0_0_1; -.
DR   InParanoid; P16372; -.
DR   OMA; AYNCEEC; -.
DR   OrthoDB; 6077919at2759; -.
DR   PhylomeDB; P16372; -.
DR   Reactome; R-MMU-212436; Generic Transcription Pathway.
DR   BioGRID-ORCS; 238693; 1 hit in 78 CRISPR screens.
DR   PRO; PR:P16372; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; P16372; protein.
DR   Bgee; ENSMUSG00000071291; Expressed in animal zygote and 65 other cell types or tissues.
DR   ExpressionAtlas; P16372; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   FunFam; 3.30.160.60:FF:001956; ZFP37 zinc finger protein; 1.
DR   FunFam; 3.30.160.60:FF:000380; zinc finger protein 2 isoform X2; 1.
DR   FunFam; 3.30.160.60:FF:002005; Zinc finger protein 200; 1.
DR   FunFam; 3.30.160.60:FF:002343; Zinc finger protein 33A; 3.
DR   FunFam; 3.30.160.60:FF:000690; Zinc finger protein 354C; 2.
DR   FunFam; 3.30.160.60:FF:002254; Zinc finger protein 540; 1.
DR   FunFam; 3.30.160.60:FF:001437; Zinc finger protein 594; 1.
DR   FunFam; 3.30.160.60:FF:001630; Zinc finger protein 888; 1.
DR   FunFam; 3.30.160.60:FF:001671; Zinc finger protein 94; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 15.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24376; ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR24376:SF253; ZINC FINGER PROTEIN 748; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 11.
DR   Pfam; PF13465; zf-H2C2_2; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 14.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..489
FT                   /note="Zinc finger protein 58"
FT                   /id="PRO_0000047302"
FT   DOMAIN          2..73
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         78..100
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         106..128
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         134..156
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         162..184
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         190..212
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         218..240
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         246..268
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         274..296
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         302..324
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         330..352
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         358..380
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         386..408
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         410..432
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         438..460
FT                   /note="C2H2-type 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         466..488
FT                   /note="C2H2-type 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   CONFLICT        190
FT                   /note="Y -> YKCEECGKAFSTSSNLSEHKRIHTGEKPI (in Ref. 5;
FT                   AAA39531)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   489 AA;  57232 MW;  32A9FFF460AEE061 CRC64;
     MLSFWDVAID FSPEERECLE PDQWDLYRDV MLENYSHLDF LGLALSKPFL VTFLEQRQGP
     WDVKRQAAAA VHPGKTVNKC KDFSKAFFCK SLLTQHQRIR TGEKAFKCEE CGKAFNNRSN
     LSEHKRIHTG EKPYKCEECG KAFRIRSKLS THQRVHTGEK PYKCEECGKA FNSHSNLSEH
     KRIHTGEKPY KCEECGKAFS TRSTYYRHQK NHTGKKPYKC EECAKEFSYP SLLKVHQRIH
     SAEKSYKCEE CGKPFYCPLL LKKHQIIHSA EKPYKCAECG KAFHYPSLLK RHQRIHAGKK
     PCKCKDCDRA FYSSAFLKRH QRIHSEENSY KCGECGKRFC SFPHLQYHQR FHSGEKPYKC
     EQCGKTFSTL SYLPWHKLRH SGEKSYKCEK CGKMFYSTLD LKKHQKIHEY KCGECHYGFP
     NYAALTAHQR VHTGEKPHVC EQCGKDFSRI DSLNQHQLVH TGEKPYKCEK CGKCFYRSSS
     LKRHQGIHS
//