ID   NEU4_ONCKE              Reviewed;         158 AA.
AC   P16042; Q91174;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   02-SEP-2026, entry version 95.
DE   RecName: Full=Vasotocin-neurophysin VT 2;
DE   Contains:
DE     RecName: Full=Vasotocin;
DE              Short=VT;
DE   Contains:
DE     RecName: Full=Neurophysin VT 2;
DE   Flags: Precursor;
OS   Oncorhynchus keta (Chum salmon) (Salmo keta).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8018;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=2298304; DOI=10.1016/0014-5793(90)80129-7;
RA   Heierhorst J., Mahlmann S., Morley S.D., Coe I.R., Sherwood N.M.,
RA   Richter D.;
RT   "Molecular cloning of two distinct vasotocin precursor cDNAs from chum
RT   salmon (Oncorhynchus keta) suggests an ancient gene duplication.";
RL   FEBS Lett. 260:301-304(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Tsugaruishi; TISSUE=Brain;
RX   PubMed=2045542; DOI=10.1007/bf00571256;
RA   Hyodo S., Kato Y., Ono M., Urano A.;
RT   "Cloning and sequence analyses of cDNAs encoding vasotocin and isotocin
RT   precursors of chum salmon, Oncorhynchus keta: evolutionary relationships of
RT   neurohypophysial hormone precursors.";
RL   J. Comp. Physiol. B 160:601-608(1991).
CC   -!- FUNCTION: Vasotocin is an antidiuretic hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Seven disulfide bonds are present in neurophysin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; X17328; CAA35206.1; -; mRNA.
DR   EMBL; D10943; BAA01737.1; ALT_SEQ; mRNA.
DR   PIR; B34132; B34132.
DR   AlphaFoldDB; P16042; -.
DR   SMR; P16042; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030141; C:secretory granule; IEA:TreeGrafter.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   FunFam; 2.60.9.10:FF:000001; oxytocin-neurophysin 1; 1.
DR   Gene3D; 2.60.9.10; Neurohypophysial hormone domain; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; NEUROPHYSIN; 1.
DR   PANTHER; PTHR11681:SF13; VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN PRECURSOR; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; Neurophysin II; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT   PEPTIDE         20..28
FT                   /note="Vasotocin"
FT                   /id="PRO_0000020568"
FT   CHAIN           32..158
FT                   /note="Neurophysin VT 2"
FT                   /id="PRO_0000020569"
FT   MOD_RES         28
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        20..25
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        41..85
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        44..58
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        52..75
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        59..65
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        92..105
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        99..117
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        106..111
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   158 AA;  16670 MW;  F8002437A89611C4 CRC64;
     MPHSTLLLCV IGLLAFSSAC YIQNCPRGGK RALQDTGIRQ CMTCGPGDQG HCFGPSICCG
     EGLGCWMGSP ETARCFEENY LPTPCQTGGR PCGSDAGRCA APGVCCDSES CVLDPDCLSE
     SRYHSPADHS AGATSDSPGE LLLRLLHFAT RGQSEYKQ
//