ID   XYLB_ACTM4              Reviewed;         466 AA.
AC   P12867; I0GZR9;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2012, sequence version 3.
DT   04-NOV-2026, entry version 106.
DE   RecName: Full=Xylulose kinase {ECO:0000255|HAMAP-Rule:MF_02220};
DE            Short=Xylulokinase {ECO:0000255|HAMAP-Rule:MF_02220};
DE            EC=2.7.1.17 {ECO:0000255|HAMAP-Rule:MF_02220};
GN   Name=xylB {ECO:0000255|HAMAP-Rule:MF_02220};
GN   OrderedLocusNames=AMIS_10360;
OS   Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 /
OS   JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=512565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 /
RC   NCIMB 12654 / NRRL B-3342 / UNCC 431;
RA   Ohnishi Y., Ishikawa J., Sekine M., Hosoyama A., Harada T., Narita H.,
RA   Hata T., Konno Y., Tutikane K., Fujita N., Horinouchi S., Hayakawa M.;
RT   "Complete genome sequence of Actinoplanes missouriensis 431 (= NBRC
RT   102363).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-61.
RC   STRAIN=ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 /
RC   NCIMB 12654 / NRRL B-3342 / UNCC 431;
RX   PubMed=2798103; DOI=10.1093/nar/17.18.7515;
RA   Amore R., Hollenberg C.P.;
RT   "Xylose isomerase from Actinoplanes missouriensis: primary structure of the
RT   gene and the protein.";
RL   Nucleic Acids Res. 17:7515-7515(1989).
CC   -!- FUNCTION: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-
CC       phosphate. {ECO:0000255|HAMAP-Rule:MF_02220}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:10964, ChEBI:CHEBI:15378, ChEBI:CHEBI:17140,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57737, ChEBI:CHEBI:456216;
CC         EC=2.7.1.17; Evidence={ECO:0000255|HAMAP-Rule:MF_02220};
CC   -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000255|HAMAP-
CC       Rule:MF_02220, ECO:0000305}.
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DR   EMBL; AP012319; BAL86256.1; -; Genomic_DNA.
DR   EMBL; X16042; CAA34165.1; -; Genomic_DNA.
DR   PIR; S05999; S05999.
DR   RefSeq; WP_014441153.1; NC_017093.1.
DR   AlphaFoldDB; P12867; -.
DR   SMR; P12867; -.
DR   STRING; 512565.AMIS_10360; -.
DR   KEGG; ams:AMIS_10360; -.
DR   PATRIC; fig|512565.3.peg.1042; -.
DR   eggNOG; COG1070; Bacteria.
DR   HOGENOM; CLU_009281_12_0_11; -.
DR   OMA; AAAKWYS; -.
DR   OrthoDB; 9805576at2; -.
DR   Proteomes; UP000007882; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004856; F:D-xylulokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005998; P:xylulose catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07809; ASKHA_NBD_FGGY_BaXK-like; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   HAMAP; MF_02220; XylB; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018485; FGGY_C.
DR   InterPro; IPR050406; FGGY_Carb_Kinase.
DR   InterPro; IPR018484; FGGY_N.
DR   InterPro; IPR006000; Xylulokinase.
DR   NCBIfam; TIGR01312; XylB; 1.
DR   PANTHER; PTHR43095; SUGAR KINASE; 1.
DR   PANTHER; PTHR43095:SF5; XYLULOSE KINASE; 1.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   PIRSF; PIRSF000538; GlpK; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS00933; FGGY_KINASES_1; 1.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase; Xylose metabolism.
FT   CHAIN           1..466
FT                   /note="Xylulose kinase"
FT                   /id="PRO_0000059545"
FT   ACT_SITE        226
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02220"
FT   BINDING         71..72
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02220"
FT   SITE            8
FT                   /note="Important for activity"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02220"
FT   CONFLICT        60..61
FT                   /note="DD -> EF (in Ref. 2; CAA34165)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   466 AA;  47866 MW;  8FA3AFD953F03739 CRC64;
     MALVAGIDSS TQSCKVVIRD AETGALVRQG RASHPDGTEV HPDAWWSALQ SAIEEAGGLD
     DVAAASVAGQ QHGMVALDEN GEVVRPALLW NDTRSAGAAA DLIAELGGGE KWAEAVGIVP
     VASFTLTKLR WLARNEPANA AKVAAVCLPH DWLTWKLSGS TDIADIKTDR SDASGTLYWS
     AKTNEYRRDL LELGFGRDLV LPEVLGPTGI AGHLPNGAPL GPGAGDNAAA ALGTGALPGD
     VIVSIGTSGT VFVSSDVAPV DGRGTVAGFA DTTGRFLPIV VTLNAARVLD AAAKLLGVDH
     DELSRLALSA PAGADGMVLV PYLEGERTPN RPDATGAIHG LTLKTSDPAH LARAAVEGML
     CALADGLDAL VAHGAEANRI VLVGGGARSE AVRRIAPALF GKPVLVPPPG EYVADGAARQ
     AAWVARGGDT PPAWSAASPE VYEDDPVPLI REQYAAAQNA VIDRTR
//