ID   STE2_LACKL              Reviewed;         426 AA.
AC   P12384;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   02-SEP-2026, entry version 76.
DE   RecName: Full=Pheromone alpha factor receptor;
GN   Name=STE2;
OS   Lachancea kluyveri (Yeast) (Saccharomyces kluyveri).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=4934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=XM8-2;
RX   PubMed=2836861; DOI=10.1073/pnas.85.11.3855;
RA   Marsh L., Herskowitz I.;
RT   "STE2 protein of Saccharomyces kluyveri is a member of the rhodopsin/beta-
RT   adrenergic receptor family and is responsible for recognition of the
RT   peptide ligand alpha factor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:3855-3859(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Marsh L.;
RL   Submitted (AUG-1988) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for the peptide pheromone alpha factor, the mating
CC       factor of yeast.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G protein-coupled receptor 4 family.
CC       {ECO:0000305}.
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DR   EMBL; J03265; AAA34961.1; -; Genomic_DNA.
DR   PIR; A94801; A30212.
DR   AlphaFoldDB; P12384; -.
DR   SMR; P12384; -.
DR   GO; GO:0038038; C:G protein-coupled receptor homodimeric complex; IEA:TreeGrafter.
DR   GO; GO:0004932; F:mating-type factor pheromone receptor activity; IEA:InterPro.
DR   CDD; cd14939; 7tmD_STE2; 1.
DR   Gene3D; 1.10.287.920; Pheromone alpha factor receptor; 1.
DR   InterPro; IPR000366; GPCR_STE2.
DR   InterPro; IPR027458; STE2_TM1-TM2_sf.
DR   PANTHER; PTHR28009; PHEROMONE ALPHA FACTOR RECEPTOR; 1.
DR   PANTHER; PTHR28009:SF1; PHEROMONE ALPHA FACTOR RECEPTOR; 1.
DR   Pfam; PF02116; STE2; 1.
DR   PRINTS; PR00250; GPCRSTE2.
PE   3: Inferred from homology;
KW   G protein-coupled receptor; Membrane; Pheromone response; Receptor;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..426
FT                   /note="Pheromone alpha factor receptor"
FT                   /id="PRO_0000195069"
FT   TRANSMEM        50..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        13
FT                   /note="Y -> N (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   426 AA;  47078 MW;  72E4635966ECAC02 CRC64;
     MSGKQDLSPL GLYSSYDPTK GLISYTSLYG SGTTVTFEEL QIFVNKKITQ GILFGTRIGA
     AGLAIIVLWM VSKNRKTPIF IINQISLFLI LLHSSLFLRY LLGDYASVVF NFTLFSQSIS
     RNDVHVYGAT NMIQVLLVAA VEISLIFQVR VIFKGDSYKG VGRILTSISA VLGFTTVVMY
     FITAVKSMTS VYSDLTKTSD RYFFNIASIL LSSSVNFMTL LLTVKLILAV RSRRFLGLKQ
     FDSFHVLLIM SFQTLIFPSI LFILAYALNP NQGTDTLTSI ATLLVTLSLP LSSMWATSAN
     NSSHPSSINT QFRQRNYDDV SFKTGITSFY SESSKPSSKY RHTNNLYDLY PVSRTSNSRC
     NGYPNDGSKL APNPNCVGHN GSTMSVNDKN GAHATCVQNN VTLNTDSTLN YSNVDTQDTS
     KILMTT
//