ID MS2B_DROME Reviewed; 90 AA. AC P10334; A0JQ48; A4V091; O76300; O76302; O77456; O97184; O97185; O97456; AC O97460; Q4V3V8; Q95NY1; Q95NY2; Q95NY3; Q9V432; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1989, sequence version 1. DT 04-NOV-2026, entry version 158. DE RecName: Full=Accessory gland-specific peptide 26Ab; DE AltName: Full=Male accessory gland secretory protein 355B; DE Flags: Precursor; GN Name=Acp26Ab {ECO:0000312|FlyBase:FBgn0002856}; GN Synonyms=msp355b {ECO:0000303|PubMed:3142802}, Mst26Ab, mst355b GN {ECO:0000303|PubMed:3142802}; GN ORFNames=CG9024 {ECO:0000312|FlyBase:FBgn0002856}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida; OC Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota; OC Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Canton-S; RX PubMed=3142802; DOI=10.1101/gad.2.9.1063; RA Monsma S.A., Wolfner M.F.; RT "Structure and expression of a Drosophila male accessory gland gene whose RT product resembles a peptide pheromone precursor."; RL Genes Dev. 2:1063-1073(1988). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=NC-001, NC-002, NC-003, NC-004, NC-005, NC-006, NC-007, NC-008, RC NC-009, and NC-010; RX PubMed=1361475; DOI=10.1093/genetics/132.3.755; RA Aguade M., Miyashita N., Langley C.H.; RT "Polymorphism and divergence in the Mst26A male accessory gland gene region RT in Drosophila."; RL Genetics 132:755-770(1992). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS HIS-64; VAL-80; ILE-89 AND RP GLU-90. RC STRAIN=La10, La105, La106, La108, La116, La118, La120, La125, La13, RC La14, La15, La25, La27, La28, La3, La31, La32, La36, La37, La46, La54, RC La58, La60, La62, Ma11, Ma18, Ma20, Ma21, Ma23, Ma24, Ma3, Ma31, Ma35, RC Ma37, Ma43, Ma50, Ma53, Ma56, Ma57, Ma6, Ma60, Ma74, Mo13a, Mo29b, RC Mo34a, Mo36a, Mo37a, Mo40b, Mo47a, Mo52b, Mo79b, and Mo80b; RX PubMed=9799260; DOI=10.1093/genetics/150.3.1079; RA Aguade M.; RT "Different forces drive the evolution of the Acp26Aa and Acp26Ab accessory RT gland genes in the Drosophila melanogaster species complex."; RL Genetics 150:1079-1089(1998). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS HIS-64; ARG-77; VAL-80; RP ILE-89 AND GLU-90. RC STRAIN=AF1, AF10, AF2, AF3, AF4, AF5, AF6, AF7, AF8, AF9, Au1, Au10, RC Au2, Au3, Au4, Au5, Au6, Au7, Au8, Au9, NC-001, NC-002, NC-003, RC NC-004, NC-005, NC-006, NC-007, NC-008, NC-010, NC-098, Ny1, Ny2, Ny3, RC Ny4, Ny5, Ny6, Ny7, Ny8, TW1, TW10, TW11, TW2, TW3, TW4, TW5, TW6, RC TW7, TW8, and TW9; RX PubMed=9718731; DOI=10.1093/oxfordjournals.molbev.a026002; RA Tsaur S.-C., Ting C.-T., Wu C.-I.; RT "Positive selection driving the evolution of a gene of male reproduction, RT Acp26Aa, of Drosophila: II. Divergence versus polymorphism."; RL Mol. Biol. Evol. 15:1040-1046(1998). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., RA Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [6] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Kapadia B., RA Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.; RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases. RN [8] RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION. RX PubMed=2257979; DOI=10.1016/0012-1606(90)90368-s; RA Monsma S.A., Harada H.A., Wolfner M.F.; RT "Synthesis of two Drosophila male accessory gland proteins and their fate RT after transfer to the female during mating."; RL Dev. Biol. 142:465-475(1990). CC -!- FUNCTION: This protein is transferred from male to female during mating CC and may affect egglaying and behavior after mating. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space. Cytoplasm CC {ECO:0000269|PubMed:2257979}. CC -!- TISSUE SPECIFICITY: Main cells and secondary cells of the accessory CC glands of 1 day old virgin males (at protein level) (PubMed:2257979). CC In 5 day old virgin males, only detected in the secondary cells (at CC protein level) (PubMed:2257979). Reappears in the main cells after CC mating (at protein level) (PubMed:2257979). First detected in adult CC males 3-4 hr after eclosion, levels increase reaching a peak at day 3-5 CC which is maintained until at least day 10 of adulthood (at protein CC level) (PubMed:2257979). In unmated male adults, levels are maintained CC for the first 6 days of adulthood and then gradually decrease for at CC least the next 8 days (PubMed:2257979). No expression in females CC (PubMed:3142802). {ECO:0000269|PubMed:2257979, CC ECO:0000269|PubMed:3142802}. CC -!- INDUCTION: Up-regulated in response to mating. CC {ECO:0000269|PubMed:2257979}. CC -!- SEQUENCE CAUTION: CC Sequence=ABK57075.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y00219; CAA68367.1; -; Genomic_DNA. DR EMBL; X70888; CAA50233.1; -; Genomic_DNA. DR EMBL; X70889; CAA50235.1; -; Genomic_DNA. DR EMBL; X70890; CAA50237.1; -; Genomic_DNA. DR EMBL; X70891; CAA50239.1; -; Genomic_DNA. DR EMBL; X70892; CAA50241.1; -; Genomic_DNA. DR EMBL; X70893; CAA50243.1; -; Genomic_DNA. DR EMBL; X70894; CAA50245.1; -; Genomic_DNA. DR EMBL; X70895; CAA50247.1; -; Genomic_DNA. DR EMBL; X70896; CAA50249.1; -; Genomic_DNA. DR EMBL; X70897; CAA50251.1; -; Genomic_DNA. DR EMBL; AJ231350; CAB37195.1; -; Genomic_DNA. DR EMBL; AJ231351; CAB37197.1; -; Genomic_DNA. DR EMBL; AJ231352; CAB37199.1; -; Genomic_DNA. DR EMBL; AJ231353; CAB37201.1; -; Genomic_DNA. DR EMBL; AJ231354; CAB37203.1; -; Genomic_DNA. DR EMBL; AJ231355; CAB37205.1; -; Genomic_DNA. DR EMBL; AJ231356; CAB37207.1; -; Genomic_DNA. DR EMBL; AJ231357; CAB37209.1; -; Genomic_DNA. DR EMBL; AJ231358; CAB37211.1; -; Genomic_DNA. DR EMBL; AJ231359; CAB37213.1; -; Genomic_DNA. DR EMBL; AJ231360; CAB37215.1; -; Genomic_DNA. DR EMBL; AJ231361; CAB37217.1; -; Genomic_DNA. DR EMBL; AJ231362; CAB37219.1; -; Genomic_DNA. DR EMBL; AJ231363; CAB37221.1; -; Genomic_DNA. DR EMBL; AJ231364; CAB37223.1; -; Genomic_DNA. DR EMBL; AJ231365; CAB37225.1; -; Genomic_DNA. DR EMBL; AJ231366; CAB37227.1; -; Genomic_DNA. DR EMBL; AJ231367; CAB37229.1; -; Genomic_DNA. DR EMBL; AJ231368; CAB37231.1; -; Genomic_DNA. DR EMBL; AJ231369; CAB37233.1; -; Genomic_DNA. DR EMBL; AJ231370; CAB37235.1; -; Genomic_DNA. DR EMBL; AJ231371; CAB37237.1; -; Genomic_DNA. DR EMBL; AJ231372; CAB37239.1; -; Genomic_DNA. DR EMBL; AJ231373; CAB37241.1; -; Genomic_DNA. DR EMBL; AJ231374; CAB37624.1; -; Genomic_DNA. DR EMBL; AJ231375; CAB37243.1; -; Genomic_DNA. DR EMBL; AJ231376; CAB37245.1; -; Genomic_DNA. DR EMBL; AJ231377; CAB37247.1; -; Genomic_DNA. DR EMBL; AJ231378; CAB37249.1; -; Genomic_DNA. DR EMBL; AJ231379; CAB37251.1; -; Genomic_DNA. DR EMBL; AJ231380; CAB37253.1; -; Genomic_DNA. DR EMBL; AJ231381; CAB37255.1; -; Genomic_DNA. DR EMBL; AJ231382; CAB37257.1; -; Genomic_DNA. DR EMBL; AJ231383; CAB37259.1; -; Genomic_DNA. DR EMBL; AJ231384; CAB37261.1; -; Genomic_DNA. DR EMBL; AJ231385; CAB37263.1; -; Genomic_DNA. DR EMBL; AJ231386; CAB37265.1; -; Genomic_DNA. DR EMBL; AJ231387; CAB37267.1; -; Genomic_DNA. DR EMBL; AJ231388; CAB37269.1; -; Genomic_DNA. DR EMBL; AJ231389; CAB37271.1; -; Genomic_DNA. DR EMBL; AJ231390; CAB37273.1; -; Genomic_DNA. DR EMBL; AJ231391; CAB37275.1; -; Genomic_DNA. DR EMBL; AJ231392; CAB37277.1; -; Genomic_DNA. DR EMBL; AJ231393; CAB37279.1; -; Genomic_DNA. DR EMBL; AJ231394; CAB37281.1; -; Genomic_DNA. DR EMBL; AJ231395; CAB37283.1; -; Genomic_DNA. DR EMBL; AJ231396; CAB37285.1; -; Genomic_DNA. DR EMBL; AJ231397; CAB37287.1; -; Genomic_DNA. DR EMBL; AJ231398; CAB37289.1; -; Genomic_DNA. DR EMBL; AJ231399; CAB37291.1; -; Genomic_DNA. DR EMBL; AJ231400; CAB37293.1; -; Genomic_DNA. DR EMBL; AJ231401; CAB37629.1; -; Genomic_DNA. DR EMBL; AF052470; AAC27996.1; -; Genomic_DNA. DR EMBL; AF052471; AAC27998.1; -; Genomic_DNA. DR EMBL; AF052472; AAC28000.1; -; Genomic_DNA. DR EMBL; AF052473; AAC28002.1; -; Genomic_DNA. DR EMBL; AF052474; AAC28004.1; -; Genomic_DNA. DR EMBL; AF052475; AAC28006.1; -; Genomic_DNA. DR EMBL; AF052476; AAC28008.1; -; Genomic_DNA. DR EMBL; AF052477; AAC28010.1; -; Genomic_DNA. DR EMBL; AF052478; AAC28012.1; -; Genomic_DNA. DR EMBL; AF052479; AAC28014.1; -; Genomic_DNA. DR EMBL; AF052480; AAC28016.1; -; Genomic_DNA. DR EMBL; AF052481; AAC28018.1; -; Genomic_DNA. DR EMBL; AF053250; AAC28791.1; -; Genomic_DNA. DR EMBL; AF053251; AAC28793.1; -; Genomic_DNA. DR EMBL; AF053252; AAC28795.1; -; Genomic_DNA. DR EMBL; AF053253; AAC28797.1; -; Genomic_DNA. DR EMBL; AF053254; AAC28799.1; -; Genomic_DNA. DR EMBL; AF053255; AAC28801.1; -; Genomic_DNA. DR EMBL; AF053256; AAC28803.1; -; Genomic_DNA. DR EMBL; AF053257; AAC28805.1; -; Genomic_DNA. DR EMBL; AF053258; AAC28807.1; -; Genomic_DNA. DR EMBL; AF053259; AAC28809.1; -; Genomic_DNA. DR EMBL; AF053260; AAC28811.1; -; Genomic_DNA. DR EMBL; AF053261; AAC28813.1; -; Genomic_DNA. DR EMBL; AF053262; AAC28815.1; -; Genomic_DNA. DR EMBL; AF053263; AAC28817.1; -; Genomic_DNA. DR EMBL; AF053264; AAC28819.1; -; Genomic_DNA. DR EMBL; AF053265; AAC28821.1; -; Genomic_DNA. DR EMBL; AF053266; AAC28823.1; -; Genomic_DNA. DR EMBL; AF053267; AAC28825.1; -; Genomic_DNA. DR EMBL; AF053268; AAC28827.1; -; Genomic_DNA. DR EMBL; AF053269; AAC28829.1; -; Genomic_DNA. DR EMBL; AF053270; AAC28831.1; -; Genomic_DNA. DR EMBL; AF053271; AAC28833.1; -; Genomic_DNA. DR EMBL; AF053272; AAC28835.1; -; Genomic_DNA. DR EMBL; AF053273; AAC28837.1; -; Genomic_DNA. DR EMBL; AF053274; AAC28839.1; -; Genomic_DNA. DR EMBL; AF053275; AAC28841.1; -; Genomic_DNA. DR EMBL; AF053276; AAC28843.1; -; Genomic_DNA. DR EMBL; AE014134; AAF52297.1; -; Genomic_DNA. DR EMBL; AE014134; AAN10560.1; -; Genomic_DNA. DR EMBL; BT023248; AAY55664.1; -; mRNA. DR EMBL; BT029418; ABK57075.1; ALT_INIT; mRNA. DR PIR; S02854; S02854. DR PIR; S30412; S30412. DR RefSeq; NP_001285646.1; NM_001298717.1. DR RefSeq; NP_476645.1; NM_057297.3. DR RefSeq; NP_599099.1; NM_134272.1. DR AlphaFoldDB; P10334; -. DR FunCoup; P10334; 46. DR STRING; 7227.FBpp0078788; -. DR PaxDb; 7227-FBpp0078788; -. DR PeptideAtlas; P10334; -. DR DNASU; 33816; -. DR EnsemblMetazoa; FBtr0079156; FBpp0078787; FBgn0002856. DR EnsemblMetazoa; FBtr0079157; FBpp0078788; FBgn0002856. DR EnsemblMetazoa; FBtr0342618; FBpp0309554; FBgn0002856. DR GeneID; 33816; -. DR KEGG; dme:Dmel_CG9024; -. DR AGR; FB:FBgn0002856; -. DR CTD; 33816; -. DR FlyBase; FBgn0002856; Acp26Ab. DR VEuPathDB; VectorBase:FBgn0002856; -. DR HOGENOM; CLU_187897_0_0_1; -. DR InParanoid; P10334; -. DR OMA; CIFTYIC; -. DR OrthoDB; 7860727at2759; -. DR PhylomeDB; P10334; -. DR BioGRID-ORCS; 33816; 0 hits in 1 CRISPR screen. DR GenomeRNAi; 33816; -. DR PRO; PR:P10334; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0002856; Expressed in spermatid in male reproductive gland and 27 other cell types or tissues. DR ExpressionAtlas; P10334; baseline and differential. DR GO; GO:0005737; C:cytoplasm; EXP:UniProtKB. DR GO; GO:0005576; C:extracellular region; HDA:FlyBase. DR GO; GO:0007320; P:insemination; HEP:FlyBase. DR GO; GO:0007618; P:mating; IEP:FlyBase. DR InterPro; IPR008392; Acp26Ab. DR Pfam; PF05777; Acp26Ab; 1. PE 1: Evidence at protein level; KW Behavior; Cytoplasm; Reference proteome; Secreted; Signal. FT SIGNAL 1..21 FT /evidence="ECO:0000255" FT CHAIN 22..90 FT /note="Accessory gland-specific peptide 26Ab" FT /id="PRO_0000021759" FT VARIANT 64 FT /note="Q -> H (in strain: AF1, AF2, AF3, AF5, AF6, AF7, FT AF8, AF9, AF10, Au4, Au7, Au8, La3, La10, La13, La14, La15, FT La28, La31, La32, La36, La37, La54, La58, La60, La62, FT La105, La106, La116, La118, La120, La125, Ma3, Ma6, Ma11, FT Ma18, Ma20, Ma21, Ma23, Ma24, Ma31, Ma35, Ma37, Ma43, Ma50, FT Ma53, Ma56, Ma57, Ma60, Ma74, Mo29b, Mo40b, Mo52b, NC-003, FT NC-004, NC-006, NC-008, NC-009, Ny2, Ny3, Ny4, Ny5, TW1, FT TW2, TW5, TW6, TW7, TW8, TW10 and TW11)" FT /evidence="ECO:0000269|PubMed:9718731, FT ECO:0000269|PubMed:9799260" FT VARIANT 77 FT /note="P -> R (in strain: TW9)" FT /evidence="ECO:0000269|PubMed:9718731" FT VARIANT 80 FT /note="I -> V (in strain: La3, La10, La13, La15, La27, FT La28, La31, La62, La105, La106, La116, La118, La120, Ma3, FT Ma6, Ma18, Ma23, Ma31, Ma37, Ma43, Ma56, Ma57, Ma60, Ma74, FT Mo13a, Mo29b, Mo34a, Mo40b, Mo52b, NC-002, NC-003, NC-004, FT NC-006, NC-008, Ny2, Ny4, TW2, TW4, TW5, TW8, TW10 and FT TW11)" FT /evidence="ECO:0000269|PubMed:9718731, FT ECO:0000269|PubMed:9799260" FT VARIANT 89 FT /note="M -> I (in strain: Au4 and Ma60)" FT /evidence="ECO:0000269|PubMed:9718731, FT ECO:0000269|PubMed:9799260" FT VARIANT 90 FT /note="A -> E (in strain: AF1, AF2, AF3, AF5, AF6, AF7, FT AF8, AF9, AF10, La14, La31, La32, La60, La106, La118, FT La125, Ma6, Ma21, Ma24, Ma31, Ma37, Ma50, Ma56, Ma57, Ma74, FT TW1 and TW6)" FT /evidence="ECO:0000269|PubMed:9718731, FT ECO:0000269|PubMed:9799260" SQ SEQUENCE 90 AA; 10162 MW; 1FDFDC7951F9BDFF CRC64; MNYFAVICIF SCICLWQFSD AAPFISVQSS SQSRSQKVMN GMLRTLYDYS VQDSVNDATG HLIQTHKADF NSDVMSPDEI ESVRQQLNMA //