##gff-version 3
P10279	UniProtKB	Signal peptide	1	24	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2904126;Dbxref=PMID:2904126	
P10279	UniProtKB	Chain	25	241	.	.	.	ID=PRO_0000025627;Note=Major prion protein	
P10279	UniProtKB	Propeptide	242	264	.	.	.	ID=PRO_0000025628;Note=Removed in mature form;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P10279	UniProtKB	Repeat	54	62	.	.	.	Note=1	
P10279	UniProtKB	Repeat	63	70	.	.	.	Note=2	
P10279	UniProtKB	Repeat	71	78	.	.	.	Note=3	
P10279	UniProtKB	Repeat	79	86	.	.	.	Note=4	
P10279	UniProtKB	Repeat	87	94	.	.	.	Note=5	
P10279	UniProtKB	Repeat	95	103	.	.	.	Note=6	
P10279	UniProtKB	Region	25	241	.	.	.	Note=Interaction with GRB2%2C ERI3 and SYN1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04925	
P10279	UniProtKB	Region	25	41	.	.	.	Note=Interaction with ADGRG6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04925	
P10279	UniProtKB	Region	28	119	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P10279	UniProtKB	Region	54	103	.	.	.	Note=6 X 8 AA tandem repeats of P-H-G-G-G-W-G-Q	
P10279	UniProtKB	Compositional bias	55	107	.	.	.	Note=Gly residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P10279	UniProtKB	Binding site	72	72	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Binding site	73	73	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Binding site	74	74	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Binding site	80	80	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Binding site	81	81	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Binding site	82	82	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Binding site	88	88	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Binding site	89	89	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Binding site	90	90	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Binding site	96	96	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Binding site	98	98	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Binding site	99	99	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P10279	UniProtKB	Lipidation	241	241	.	.	.	Note=GPI-anchor amidated alanine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P10279	UniProtKB	Glycosylation	192	192	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P10279	UniProtKB	Glycosylation	208	208	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P10279	UniProtKB	Disulfide bond	190	225	.	.	.	.	
P10279	UniProtKB	Natural variant	60	60	.	.	.	Note=W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10	
P10279	UniProtKB	Natural variant	71	78	.	.	.	Note=In allele 2. Missing	
P10279	UniProtKB	Natural variant	84	99	.	.	.	Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15477588;Dbxref=PMID:15477588	
P10279	UniProtKB	Natural variant	92	99	.	.	.	Note=Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1362024,ECO:0000269|PubMed:15477588;Dbxref=PMID:1362024,PMID:15477588	
P10279	UniProtKB	Natural variant	94	94	.	.	.	Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10	
P10279	UniProtKB	Natural variant	98	98	.	.	.	Note=G->GGWGQPHGG;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6	
P10279	UniProtKB	Natural variant	154	154	.	.	.	Note=S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1362024,ECO:0000269|Ref.10;Dbxref=PMID:1362024	
P10279	UniProtKB	Natural variant	211	211	.	.	.	Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18625065;Dbxref=PMID:18625065	
P10279	UniProtKB	Natural variant	234	234	.	.	.	Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10	
P10279	UniProtKB	Sequence conflict	106	108	.	.	.	Note=THG->SHS;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P10279	UniProtKB	Sequence conflict	218	218	.	.	.	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P10279	UniProtKB	Turn	3	8	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SKH	
P10279	UniProtKB	Helix	9	21	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SKH	
P10279	UniProtKB	Beta strand	24	26	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SKH	
P10279	UniProtKB	Beta strand	109	111	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2HH0	
P10279	UniProtKB	Helix	136	138	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1DWY	
P10279	UniProtKB	Beta strand	139	141	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1DWY	
P10279	UniProtKB	Helix	142	144	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4YX2	
P10279	UniProtKB	Helix	146	149	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4YX2	
P10279	UniProtKB	Helix	155	164	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4YX2	
P10279	UniProtKB	Helix	165	167	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4YX2	
P10279	UniProtKB	Helix	177	179	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4YX2	
P10279	UniProtKB	Beta strand	180	182	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4YX2	
P10279	UniProtKB	Helix	183	204	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4YX2	
P10279	UniProtKB	Helix	211	233	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4YX2