ID   AST5_DROME              Reviewed;         201 AA.
AC   P10083; Q4V702; Q9W5G4;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-SEP-2026, entry version 211.
DE   RecName: Full=Achaete-scute complex protein T5;
DE   AltName: Full=Protein achaete;
GN   Name=ac; Synonyms=T5; ORFNames=CG3796;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Canton-S;
RX   PubMed=3111716; DOI=10.1016/0092-8674(87)90495-8;
RA   Villares R., Cabrera C.V.;
RT   "The achaete-scute gene complex of D. melanogaster: conserved domains in a
RT   subset of genes required for neurogenesis and their homology to myc.";
RL   Cell 50:415-424(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oregon-R;
RX   PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA   Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA   Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA   Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA   Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA   Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA   Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA   McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA   Glover D.M.;
RT   "From sequence to chromosome: the tip of the X chromosome of D.
RT   melanogaster.";
RL   Science 287:2220-2222(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.W.,
RA   Park S., Wan K.H., Yu C., Celniker S.E.;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: AS-C proteins are involved in the determination of the
CC       neuronal precursors in the peripheral nervous system and the central
CC       nervous system.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- INTERACTION:
CC       P10083; Q01070: E(spl)mgamma-HLH; NbExp=3; IntAct=EBI-152748, EBI-119159;
CC   -!- TISSUE SPECIFICITY: L(1)SC, SC and AC strongly label the presumptive
CC       stomatogastric nervous system, while ASE is more prominent in the
CC       presumptive procephalic lobe.
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DR   EMBL; M17120; AAA28312.1; -; Genomic_DNA.
DR   EMBL; AE014298; AAF45498.1; -; Genomic_DNA.
DR   EMBL; AL023873; CAA19641.1; -; Genomic_DNA.
DR   EMBL; BT022154; AAY51549.1; -; mRNA.
DR   PIR; A43731; A43731.
DR   RefSeq; NP_476824.1; NM_057476.3.
DR   AlphaFoldDB; P10083; -.
DR   SMR; P10083; -.
DR   BioGRID; 57554; 38.
DR   DIP; DIP-187N; -.
DR   FunCoup; P10083; 13.
DR   IntAct; P10083; 17.
DR   STRING; 7227.FBpp0070071; -.
DR   PaxDb; 7227-FBpp0070071; -.
DR   DNASU; 30981; -.
DR   EnsemblMetazoa; FBtr0070072; FBpp0070071; FBgn0000022.
DR   GeneID; 30981; -.
DR   KEGG; dme:Dmel_CG3796; -.
DR   AGR; FB:FBgn0000022; -.
DR   CTD; 11358; -.
DR   FlyBase; FBgn0000022; ac.
DR   VEuPathDB; VectorBase:FBgn0000022; -.
DR   eggNOG; KOG4029; Eukaryota.
DR   HOGENOM; CLU_063523_1_0_1; -.
DR   InParanoid; P10083; -.
DR   OMA; QHFYAWQ; -.
DR   OrthoDB; 5976910at2759; -.
DR   PhylomeDB; P10083; -.
DR   SignaLink; P10083; -.
DR   BioGRID-ORCS; 30981; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 30981; -.
DR   PRO; PR:P10083; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0000022; Expressed in stage 1 neuroblast (Drosophila) and 23 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; IPI:FlyBase.
DR   GO; GO:0003677; F:DNA binding; TAS:FlyBase.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:FlyBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IPI:FlyBase.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR   GO; GO:0007417; P:central nervous system development; TAS:FlyBase.
DR   GO; GO:0008407; P:chaeta morphogenesis; IMP:FlyBase.
DR   GO; GO:0061331; P:epithelial cell proliferation involved in Malpighian tubule morphogenesis; IMP:FlyBase.
DR   GO; GO:0061382; P:Malpighian tubule tip cell differentiation; IMP:FlyBase.
DR   GO; GO:0007399; P:nervous system development; TAS:FlyBase.
DR   GO; GO:0007400; P:neuroblast fate determination; TAS:FlyBase.
DR   GO; GO:0007422; P:peripheral nervous system development; IMP:FlyBase.
DR   GO; GO:0006963; P:positive regulation of antibacterial peptide biosynthetic process; IMP:FlyBase.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; ISS:FlyBase.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; TAS:FlyBase.
DR   GO; GO:0007423; P:sensory organ development; IMP:FlyBase.
DR   GO; GO:0007419; P:ventral cord development; NAS:FlyBase.
DR   CDD; cd19744; bHLH_TS_dAS-C_like; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR015660; MASH1/Ascl1a-like.
DR   PANTHER; PTHR13935:SF106; ACHAETE-SCUTE COMPLEX PROTEIN T5-RELATED; 1.
DR   PANTHER; PTHR13935; ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Differentiation; DNA-binding; Neurogenesis;
KW   Reference proteome.
FT   CHAIN           1..201
FT                   /note="Achaete-scute complex protein T5"
FT                   /id="PRO_0000127137"
FT   DOMAIN          24..90
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..10
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   201 AA;  22753 MW;  AAA906600CA764C0 CRC64;
     MALGSENHSV FNDDEESSSA FNGPSVIRRN ARERNRVKQV NNGFSQLRQH IPAAVIADLS
     NGRRGIGPGA NKKLSKVSTL KMAVEYIRRL QKVLHENDQQ KQKQLHLQQQ HLHFQQQQQH
     QHLYAWHQEL QLQSPTGSTS SCNSISSYCK PATSTIPGAT PPNNFHTKLE ASFEDYRNNS
     CSSGTEDEDI LDYISLWQDD L
//