ID   ERLN_HUMAN              Reviewed;          62 AA.
AC   P0DI80;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 1.
DT   02-SEP-2026, entry version 74.
DE   RecName: Full=Endoregulin {ECO:0000250|UniProtKB:Q3U0I6};
DE            Short=ELN {ECO:0000250|UniProtKB:Q3U0I6};
DE   AltName: Full=Small integral membrane protein 6 {ECO:0000312|HGNC:HGNC:40032};
GN   Name=ERLN {ECO:0000312|HGNC:HGNC:40032}; Synonyms=C17orf110, SMIM6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [3]
RP   SUBUNIT.
RX   PubMed=36523160; DOI=10.1016/j.bpj.2022.12.014;
RA   Phillips T.A., Hauck G.T., Pribadi M.P., Cho E.E., Cleary S.R., Robia S.L.;
RT   "Micropeptide hetero-oligomerization adds complexity to the calcium pump
RT   regulatory network.";
RL   Biophys. J. 122:301-309(2023).
CC   -!- FUNCTION: Inhibits the activity of the calcium ATPases ATP2A2/SERCA2
CC       and ATP2A3/SERCA3 by decreasing their apparent affinity for Ca(2+).
CC       {ECO:0000250|UniProtKB:Q3U0I6}.
CC   -!- SUBUNIT: Homooligomer (PubMed:36523160). Can also form heterooligomers
CC       with other sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA)
CC       regulators ARLN, PLN, SLN and STRIT1/DWORF (PubMed:36523160). Monomer
CC       (By similarity). Interacts as a monomer with ATP2A2/SERCA2; the
CC       interaction results in inhibition of ATP2A2 Ca(2+) affinity (By
CC       similarity). {ECO:0000250|UniProtKB:Q3U0I6,
CC       ECO:0000269|PubMed:36523160}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q3U0I6}; Single-pass membrane protein
CC       {ECO:0000255}.
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DR   EMBL; AK131023; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC087749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS54166.1; -.
DR   RefSeq; NP_001156469.1; NM_001162997.2.
DR   AlphaFoldDB; P0DI80; -.
DR   SMR; P0DI80; -.
DR   STRING; 9606.ENSP00000463361; -.
DR   TCDB; 1.A.113.5.1; the small integral membrane protein (simp) family.
DR   BioMuta; SMIM6; -.
DR   MassIVE; P0DI80; -.
DR   PaxDb; 9606-ENSP00000463361; -.
DR   PeptideAtlas; P0DI80; -.
DR   ProteomicsDB; 52530; -.
DR   Antibodypedia; 74683; 4 antibodies from 4 providers.
DR   DNASU; 100130933; -.
DR   Ensembl; ENST00000556126.2; ENSP00000450581.2; ENSG00000259120.4.
DR   Ensembl; ENST00000579469.2; ENSP00000463361.1; ENSG00000259120.4.
DR   Ensembl; ENST00000911162.1; ENSP00000581221.1; ENSG00000259120.4.
DR   GeneID; 100130933; -.
DR   KEGG; hsa:100130933; -.
DR   MANE-Select; ENST00000579469.2; ENSP00000463361.1; NM_001162997.2; NP_001156469.1.
DR   UCSC; uc002joy.4; human.
DR   AGR; HGNC:40032; -.
DR   CTD; 100130933; -.
DR   GeneCards; ERLN; -.
DR   HGNC; HGNC:40032; ERLN.
DR   HPA; ENSG00000259120; Tissue enhanced (fallopian tube, kidney, stomach, testis).
DR   MIM; 620531; gene.
DR   OpenTargets; ENSG00000259120; -.
DR   VEuPathDB; HostDB:ENSG00000259120; -.
DR   eggNOG; ENOG502RWMW; Eukaryota.
DR   GeneTree; ENSGT00940000165228; -.
DR   HOGENOM; CLU_210527_0_0_1; -.
DR   InParanoid; P0DI80; -.
DR   OMA; LMTKQDI; -.
DR   OrthoDB; 9618375at2759; -.
DR   PAN-GO; P0DI80; 0 GO annotations based on evolutionary models.
DR   PhylomeDB; P0DI80; -.
DR   PathwayCommons; P0DI80; -.
DR   Agora; ENSG00000259120; -.
DR   BioGRID-ORCS; 100130933; 36 hits in 1131 CRISPR screens.
DR   Pharos; P0DI80; Tdark.
DR   PRO; PR:P0DI80; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P0DI80; protein.
DR   Bgee; ENSG00000259120; Expressed in sperm and 115 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   InterPro; IPR062148; ERLN.
DR   Pfam; PF29888; ERLN; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..62
FT                   /note="Endoregulin"
FT                   /id="PRO_0000412225"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   62 AA;  7017 MW;  CA605EB69C41AD08 CRC64;
     MDQLVFKETI WNDAFWQNPW DQGGLAVIIL FITAVLLLIL FAIVFGLLTS TENTQCEAGE
     EE
//