ID   LIMS4_HUMAN             Reviewed;         117 AA.
AC   P0CW20; C9K0W2;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   02-SEP-2026, entry version 98.
DE   RecName: Full=LIM and senescent cell antigen-like-containing domain protein 4;
DE   AltName: Full=LIM and senescent cell antigen-like-containing domain protein 3-like;
GN   Name=LIMS4 {ECO:0000312|HGNC:HGNC:39941}; Synonyms=LIMS3L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- INTERACTION:
CC       P0CW20; Q03989: ARID5A; NbExp=3; IntAct=EBI-10196832, EBI-948603;
CC       P0CW20; P41182: BCL6; NbExp=6; IntAct=EBI-10196832, EBI-765407;
CC       P0CW20; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-10196832, EBI-12809220;
CC       P0CW20; O43186: CRX; NbExp=3; IntAct=EBI-10196832, EBI-748171;
CC       P0CW20; Q8IW50-3: FAM219A; NbExp=3; IntAct=EBI-10196832, EBI-13358054;
CC       P0CW20; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-10196832, EBI-745707;
CC       P0CW20; Q96G42: KLHDC7B; NbExp=3; IntAct=EBI-10196832, EBI-9478422;
CC       P0CW20; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10196832, EBI-1052037;
CC       P0CW20; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-10196832, EBI-6257312;
CC       P0CW20; P0CI26: TRIM49C; NbExp=3; IntAct=EBI-10196832, EBI-12889036;
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DR   EMBL; AC108938; AAY24131.1; -; Genomic_DNA.
DR   EMBL; AC112229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS54387.1; -.
DR   RefSeq; NP_001192217.1; NM_001205288.2.
DR   AlphaFoldDB; P0CW20; -.
DR   BMRB; P0CW20; -.
DR   SMR; P0CW20; -.
DR   BioGRID; 125178; 13.
DR   BioGRID; 940351; 11.
DR   FunCoup; P0CW20; 1.
DR   IntAct; P0CW20; 11.
DR   iPTMnet; P0CW20; -.
DR   PhosphoSitePlus; P0CW20; -.
DR   BioMuta; LIMS4; -.
DR   DMDM; 334350996; -.
DR   jPOST; P0CW20; -.
DR   MassIVE; P0CW20; -.
DR   Pumba; P0CW20; -.
DR   Antibodypedia; 77119; 15 antibodies from 2 providers.
DR   DNASU; 96626; -.
DR   Ensembl; ENST00000413601.3; ENSP00000404432.2; ENSG00000256671.7.
DR   Ensembl; ENST00000437679.3; ENSP00000405165.2; ENSG00000256977.13.
DR   GeneID; 100288695; -.
DR   KEGG; hsa:100288695; -.
DR   KEGG; hsa:96626; -.
DR   UCSC; uc002tff.4; human.
DR   AGR; HGNC:30047; -.
DR   AGR; HGNC:39941; -.
DR   CTD; 100288695; -.
DR   CTD; 96626; -.
DR   DisGeNET; 96626; -.
DR   GeneCards; LIMS4; -.
DR   HGNC; HGNC:39941; LIMS4.
DR   HPA; ENSG00000256671; Tissue enhanced (blood).
DR   VEuPathDB; HostDB:ENSG00000256671; -.
DR   GeneTree; ENSGT00940000153518; -.
DR   HOGENOM; CLU_2084116_0_0_1; -.
DR   InParanoid; P0CW20; -.
DR   OrthoDB; 20689at2759; -.
DR   PAN-GO; P0CW20; 0 GO annotations based on evolutionary models.
DR   PathwayCommons; P0CW20; -.
DR   SignaLink; P0CW20; -.
DR   SIGNOR; P0CW20; -.
DR   Agora; ENSG00000256671; -.
DR   BioGRID-ORCS; 100288695; 117 hits in 658 CRISPR screens.
DR   BioGRID-ORCS; 96626; 215 hits in 958 CRISPR screens.
DR   ChiTaRS; LIMS4; human.
DR   Pharos; P0CW20; Tdark.
DR   PRO; PR:P0CW20; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; P0CW20; protein.
DR   Bgee; ENSG00000256671; Expressed in descending thoracic aorta and 94 other cell types or tissues.
DR   ExpressionAtlas; P0CW20; baseline.
DR   Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR   InterPro; IPR017351; PINCH-1-4-like.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24210:SF12; LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR24210; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00412; LIM; 1.
DR   SMART; SM00132; LIM; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE   1: Evidence at protein level;
KW   LIM domain; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..117
FT                   /note="LIM and senescent cell antigen-like-containing
FT                   domain protein 4"
FT                   /id="PRO_0000409553"
FT   DOMAIN          70..117
FT                   /note="LIM zinc-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ   SEQUENCE   117 AA;  13251 MW;  F260926C06DA51CE CRC64;
     MAFSGRARPC IIPENEEIPR AALNTVHEAN GTEDERAVSK LQRRHSDVKV YKEFCDFYAK
     FNMANALASA TCERCKGGFA PAETIVNSNG ELYHEQCFVC AQCFQQFPEG LFYEERT
//