ID   YECD_ECOLI              Reviewed;         188 AA.
AC   P0ADI7; P37347; P76287;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   02-SEP-2026, entry version 119.
DE   RecName: Full=Isochorismatase family protein YecD;
DE            EC=3.-.-.-;
GN   Name=yecD; OrderedLocusNames=b1867, JW5307;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=2129559; DOI=10.1093/nar/18.23.7109;
RA   Eriani G., Dirheimer G., Gangloff J.;
RT   "Aspartyl-tRNA synthetase from Escherichia coli: cloning and
RT   characterisation of the gene, homologies of its translated amino acid
RT   sequence with asparaginyl- and lysyl-tRNA synthetases.";
RL   Nucleic Acids Res. 18:7109-7118(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA   Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA   Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA   Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA   Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA   Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA   Horiuchi T.;
RT   "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 40.1-50.0 min region on the linkage map.";
RL   DNA Res. 3:379-392(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=7984428; DOI=10.1093/nar/22.22.4756;
RA   Borodovsky M., Rudd K.E., Koonin E.V.;
RT   "Intrinsic and extrinsic approaches for detecting genes in a bacterial
RT   genome.";
RL   Nucleic Acids Res. 22:4756-4767(1994).
RN   [6]
RP   X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS).
RX   PubMed=14649299; DOI=10.1023/a:1026177202925;
RA   Abergel C., Coutard B., Byrne D., Chenivesse S., Claude J.-B.,
RA   Deregnaucourt C., Fricaux T., Gianesini-Boutreux C., Jeudy S., Lebrun R.,
RA   Maza C., Notredame C., Poirot O., Suhre K., Varagnol M., Claverie J.-M.;
RT   "Structural genomics of highly conserved microbial genes of unknown
RT   function in search of new antibacterial targets.";
RL   J. Struct. Funct. Genomics 4:141-157(2003).
CC   -!- SIMILARITY: Belongs to the isochorismatase family. {ECO:0000305}.
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DR   EMBL; X53863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U00096; AAC74937.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15678.1; -; Genomic_DNA.
DR   PIR; C64949; C64949.
DR   RefSeq; NP_416381.2; NC_000913.3.
DR   RefSeq; WP_000891621.1; NZ_CP009789.1.
DR   PDB; 1J2R; X-ray; 1.30 A; A/B/C/D=1-188.
DR   AlphaFoldDB; P0ADI7; -.
DR   SMR; P0ADI7; -.
DR   BioGRID; 4259332; 10.
DR   FunCoup; P0ADI7; 127.
DR   STRING; 511145.b1867; -.
DR   jPOST; P0ADI7; -.
DR   PaxDb; 511145-b1867; -.
DR   EnsemblBacteria; AAC74937; AAC74937; b1867.
DR   GeneID; 946384; -.
DR   KEGG; ecj:JW5307; -.
DR   KEGG; eco:b1867; -.
DR   KEGG; ecoc:C3026_10630; -.
DR   PATRIC; fig|511145.12.peg.1946; -.
DR   EchoBASE; EB2280; -.
DR   eggNOG; COG1335; Bacteria.
DR   HOGENOM; CLU_068979_8_2_6; -.
DR   InParanoid; P0ADI7; -.
DR   OMA; CGIATNI; -.
DR   OrthoDB; 9807387at2; -.
DR   PhylomeDB; P0ADI7; -.
DR   BioCyc; EcoCyc:EG12378-MONOMER; -.
DR   EvolutionaryTrace; P0ADI7; -.
DR   PRO; PR:P0ADI7; -.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR   CDD; cd00431; cysteine_hydrolases; 1.
DR   FunFam; 3.40.50.850:FF:000005; Isochorismatase hydrolase; 1.
DR   Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR   InterPro; IPR000868; Isochorismatase-like_dom.
DR   InterPro; IPR050272; Isochorismatase-like_hydrls.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   NCBIfam; NF008517; PRK11440.1; 1.
DR   PANTHER; PTHR43540:SF7; ISOCHORISMATASE FAMILY PROTEIN YECD; 1.
DR   PANTHER; PTHR43540; PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED; 1.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
DR   PDBsum; 1J2R; -.
PE   1: Evidence at protein level;
KW   3D-structure; Hydrolase; Reference proteome.
FT   CHAIN           1..188
FT                   /note="Isochorismatase family protein YecD"
FT                   /id="PRO_0000201831"
FT   CONFLICT        180..188
FT                   /note="SVEEILNAL -> TWKRSSTRYDLHRSTAMVAS (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   HELIX           6..8
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   STRAND          9..14
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   TURN            18..20
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   HELIX           21..23
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   STRAND          26..28
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   HELIX           30..46
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   STRAND          51..56
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   HELIX           73..75
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   HELIX           77..80
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   TURN            81..84
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   HELIX           85..87
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   HELIX           88..90
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   STRAND          96..107
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   HELIX           112..118
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   STRAND          123..129
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   TURN            131..133
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   HELIX           134..144
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   STRAND          148..160
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   HELIX           161..170
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   HELIX           172..175
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   STRAND          176..179
FT                   /evidence="ECO:0007829|PDB:1J2R"
FT   HELIX           181..187
FT                   /evidence="ECO:0007829|PDB:1J2R"
SQ   SEQUENCE   188 AA;  20452 MW;  3850DE203370249E CRC64;
     MLELNAKTTA LVVIDLQEGI LPFAGGPHTA DEVVNRAGKL AAKFRASGQP VFLVRVGWSA
     DYAEALKQPV DAPSPAKVLP ENWWQHPAAL GATDSDIEII KRQWGAFYGT DLELQLRRRG
     IDTIVLCGIS TNIGVESTAR NAWELGFNLV IAEDACSAAS AEQHNNSINH IYPRIARVRS
     VEEILNAL
//