ID DEOR_ECOLI Reviewed; 252 AA. AC P0ACK5; P06217; DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1988, sequence version 1. DT 02-SEP-2026, entry version 129. DE RecName: Full=Deoxyribose operon repressor; GN Name=deoR; Synonyms=nucR; OrderedLocusNames=b0840, JW0824; OS Escherichia coli (strain K12). OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; OC Enterobacterales; Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=K12; RX PubMed=2994018; DOI=10.1093/nar/13.16.5927; RA Valentin-Hansen P., Hoejrup P., Short S.; RT "The primary structure of the DeoR repressor from Escherichia coli K-12."; RL Nucleic Acids Res. 13:5927-5936(1985). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=8905232; DOI=10.1093/dnares/3.3.137; RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H., RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., RA Horiuchi T.; RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to RT the 12.7-28.0 min region on the linkage map."; RL DNA Res. 3:137-155(1996). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., RA Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1462(1997). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 RT and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [5] RP SUBUNIT. RX PubMed=2653814; DOI=10.1002/j.1460-2075.1989.tb03380.x; RA Mortensen L., Dandanell G., Hammer K.; RT "Purification and characterization of the deoR repressor of Escherichia RT coli."; RL EMBO J. 8:325-331(1989). CC -!- FUNCTION: This protein is one of the repressors that regulate the CC expression of deoCABD genes, which encode nucleotide and deoxy CC ribonucleotide catabolizing enzymes. It also negatively regulates the CC expression of nupG (a transport protein) and tsx (a pore-forming CC protein). The inducer is deoxyribose-5-phosphate. CC -!- SUBUNIT: Homooctamer. {ECO:0000305|PubMed:2653814}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X02837; CAA26598.1; -; Genomic_DNA. DR EMBL; U00096; AAC73927.1; -; Genomic_DNA. DR EMBL; AP009048; BAA35543.1; -; Genomic_DNA. DR PIR; A24076; RPECDO. DR RefSeq; NP_415361.1; NC_000913.3. DR RefSeq; WP_000450121.1; NZ_CP009789.1. DR PDB; 7L6L; X-ray; 1.75 A; A/B/C/D/E/F=70-252. DR AlphaFoldDB; P0ACK5; -. DR SMR; P0ACK5; -. DR BioGRID; 4262826; 140. DR DIP; DIP-9430N; -. DR FunCoup; P0ACK5; 23. DR IntAct; P0ACK5; 4. DR STRING; 511145.b0840; -. DR jPOST; P0ACK5; -. DR PaxDb; 511145-b0840; -. DR EnsemblBacteria; AAC73927; AAC73927; b0840. DR GeneID; 75170909; -. DR GeneID; 945453; -. DR KEGG; ecj:JW0824; -. DR KEGG; eco:b0840; -. DR KEGG; ecoc:C3026_05255; -. DR PATRIC; fig|1411691.4.peg.1438; -. DR EchoBASE; EB0219; -. DR eggNOG; COG1349; Bacteria. DR HOGENOM; CLU_060699_4_0_6; -. DR InParanoid; P0ACK5; -. DR OMA; CFHFHEV; -. DR OrthoDB; 9797223at2; -. DR PhylomeDB; P0ACK5; -. DR BioCyc; EcoCyc:PD01196; -. DR PRO; PR:P0ACK5; -. DR Proteomes; UP000000625; Chromosome. DR AbasyAtlas; P0ACK5; -. DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:EcoCyc. DR GO; GO:0098531; F:ligand-modulated transcription factor activity; IBA:GO_Central. DR GO; GO:2000143; P:negative regulation of DNA-templated transcription initiation; IMP:EcoCyc. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central. DR FunFam; 3.40.50.1360:FF:000011; Deoxyribose operon repressor; 1. DR Gene3D; 3.40.50.1360; -; 1. DR InterPro; IPR050313; Carb_Metab_HTH_regulators. DR InterPro; IPR014036; DeoR-like_C. DR InterPro; IPR001034; DeoR_HTH. DR InterPro; IPR037171; NagB/RpiA_transferase-like. DR InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS. DR NCBIfam; NF007961; PRK10681.1; 1. DR PANTHER; PTHR30363:SF8; DEOXYRIBOSE OPERON REPRESSOR; 1. DR PANTHER; PTHR30363; HTH-TYPE TRANSCRIPTIONAL REGULATOR SRLR-RELATED; 1. DR Pfam; PF00455; DeoRC; 1. DR Pfam; PF08220; HTH_DeoR; 1. DR SMART; SM01134; DeoRC; 1. DR SMART; SM00420; HTH_DEOR; 1. DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1. DR PROSITE; PS00894; HTH_DEOR_1; 1. DR PROSITE; PS51000; HTH_DEOR_2; 1. DR PDBsum; 7L6L; -. PE 1: Evidence at protein level; KW 3D-structure; DNA-binding; Reference proteome; Repressor; Transcription; KW Transcription regulation. FT CHAIN 1..252 FT /note="Deoxyribose operon repressor" FT /id="PRO_0000050244" FT DOMAIN 5..57 FT /note="HTH deoR-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00349" FT DNA_BIND 22..41 FT /note="H-T-H motif" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00349" FT HELIX 76..87 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 95..98 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 100..103 FT /evidence="ECO:0007829|PDB:7L6L" FT HELIX 104..110 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 117..121 FT /evidence="ECO:0007829|PDB:7L6L" FT HELIX 124..131 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 136..140 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 143..146 FT /evidence="ECO:0007829|PDB:7L6L" FT HELIX 148..150 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 151..153 FT /evidence="ECO:0007829|PDB:7L6L" FT HELIX 161..163 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 167..171 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 174..177 FT /evidence="ECO:0007829|PDB:7L6L" FT TURN 178..180 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 181..185 FT /evidence="ECO:0007829|PDB:7L6L" FT HELIX 187..189 FT /evidence="ECO:0007829|PDB:7L6L" FT HELIX 190..199 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 201..206 FT /evidence="ECO:0007829|PDB:7L6L" FT HELIX 209..211 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 217..221 FT /evidence="ECO:0007829|PDB:7L6L" FT HELIX 223..225 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 227..230 FT /evidence="ECO:0007829|PDB:7L6L" FT HELIX 234..236 FT /evidence="ECO:0007829|PDB:7L6L" FT HELIX 237..246 FT /evidence="ECO:0007829|PDB:7L6L" FT STRAND 249..251 FT /evidence="ECO:0007829|PDB:7L6L" SQ SEQUENCE 252 AA; 28548 MW; 69D20CEC86080233 CRC64; METRREERIG QLLQELKRSD KLHLKDAAAL LGVSEMTIRR DLNNHSAPVV LLGGYIVLEP RSASHYLLSD QKSRLVEEKR RAAKLAATLV EPDQTLFFDC GTTTPWIIEA IDNEIPFTAV CYSLNTFLAL KEKPHCRAFL CGGEFHASNA IFKPIDFQQT LNNFCPDIAF YSAAGVHVSK GATCFNLEEL PVKHWAMSMA QKHVLVVDHS KFGKVRPARM GDLKRFDIVV SDCCPEDEYV KYAQTQRIKL MY //