ID   DBHA_ECOL6              Reviewed;          90 AA.
AC   P0ACF1; P02342;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   04-NOV-2026, entry version 100.
DE   RecName: Full=DNA-binding protein HU-alpha;
DE   AltName: Full=HU-2;
DE   AltName: Full=NS2;
GN   Name=hupA; OrderedLocusNames=c4957;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; AE014075; AAN83385.1; -; Genomic_DNA.
DR   RefSeq; WP_001044513.1; NC_004431.1.
DR   AlphaFoldDB; P0ACF1; -.
DR   SMR; P0ACF1; -.
DR   STRING; 199310.c4957; -.
DR   GeneID; 67175032; -.
DR   GeneID; 93777894; -.
DR   KEGG; ecc:c4957; -.
DR   eggNOG; COG0776; Bacteria.
DR   HOGENOM; CLU_105066_3_1_6; -.
DR   OMA; AAWAPKF; -.
DR   BioCyc; ECOL199310:C4957-MONOMER; -.
DR   Proteomes; UP000001410; Chromosome.
DR   AbasyAtlas; P0ACF1; -.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-ARBA.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-ARBA.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-ARBA.
DR   CDD; cd13831; HU; 1.
DR   FunFam; 4.10.520.10:FF:000001; DNA-binding protein HU; 1.
DR   Gene3D; 4.10.520.10; IHF-like DNA-binding proteins; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   NCBIfam; NF008023; hupA; 1.
DR   PANTHER; PTHR33175; DNA-BINDING PROTEIN HU; 1.
DR   PANTHER; PTHR33175:SF12; DNA-BINDING PROTEIN HU-ALPHA; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; IHF-like DNA-binding proteins; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   DNA condensation; DNA-binding; Reference proteome.
FT   CHAIN           1..90
FT                   /note="DNA-binding protein HU-alpha"
FT                   /id="PRO_0000104937"
SQ   SEQUENCE   90 AA;  9535 MW;  6B5B8536FDBD13DC CRC64;
     MNKTQLIDVI AEKAELSKTQ AKAALESTLA AITESLKEGD AVQLVGFGTF KVNHRAERTG
     RNPQTGKEIK IAAANVPAFV SGKALKDAVK
//