ID   P3_HUMAN                Reviewed;         477 AA.
AC   P09131; Q5HY79; Q9BSL2;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-SEP-2026, entry version 191.
DE   RecName: Full=P3 protein;
DE   AltName: Full=Solute carrier family 10 member 3;
GN   Name=SLC10A3; Synonyms=DXS253E, P3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3186440; DOI=10.1093/nar/16.20.9527;
RA   Alcalay M., Toniolo D.;
RT   "CpG islands of the X chromosome are gene associated.";
RL   Nucleic Acids Res. 16:9527-9543(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8733135; DOI=10.1093/hmg/5.5.659;
RA   Chen E.Y., Zollo M., Mazzarella R.A., Ciccodicola A., Chen C.-N., Zuo L.,
RA   Heiner C., Burough F.W., Ripetto M., Schlessinger D., D'Urso M.;
RT   "Long-range sequence analysis in Xq28: thirteen known and six candidate
RT   genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.";
RL   Hum. Mol. Genet. 5:659-668(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: The ubiquitous expression and the conservation of the
CC       sequence in distant animal species suggest that the gene codes for a
CC       protein with housekeeping functions.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P09131-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P09131-2; Sequence=VSP_043669;
CC   -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS)
CC       (TC 2.A.28) family. {ECO:0000305}.
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DR   EMBL; X12458; CAA30998.1; -; Genomic_DNA.
DR   EMBL; L44140; AAA92651.1; -; Genomic_DNA.
DR   EMBL; BX664739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471172; EAW72697.1; -; Genomic_DNA.
DR   EMBL; CH471172; EAW72698.1; -; Genomic_DNA.
DR   EMBL; CH471172; EAW72699.1; -; Genomic_DNA.
DR   EMBL; BC004966; AAH04966.1; -; mRNA.
DR   CCDS; CCDS14755.1; -. [P09131-1]
DR   CCDS; CCDS48195.1; -. [P09131-2]
DR   PIR; S01696; S01696.
DR   RefSeq; NP_001135863.1; NM_001142391.3. [P09131-2]
DR   RefSeq; NP_001135864.1; NM_001142392.3. [P09131-1]
DR   RefSeq; NP_062822.1; NM_019848.5. [P09131-1]
DR   RefSeq; XP_011529503.1; XM_011531201.3. [P09131-1]
DR   RefSeq; XP_054183925.1; XM_054327950.1. [P09131-1]
DR   AlphaFoldDB; P09131; -.
DR   SMR; P09131; -.
DR   BioGRID; 113889; 28.
DR   FunCoup; P09131; 6.
DR   IntAct; P09131; 7.
DR   STRING; 9606.ENSP00000263512; -.
DR   TCDB; 2.A.28.1.8; the bile acid:na(+) symporter (bass) family.
DR   GlyGen; P09131; 1 site.
DR   iPTMnet; P09131; -.
DR   PhosphoSitePlus; P09131; -.
DR   SwissPalm; P09131; -.
DR   BioMuta; SLC10A3; -.
DR   DMDM; 129356; -.
DR   MassIVE; P09131; -.
DR   PaxDb; 9606-ENSP00000263512; -.
DR   PeptideAtlas; P09131; -.
DR   ProteomicsDB; 52201; -. [P09131-1]
DR   ProteomicsDB; 52202; -. [P09131-2]
DR   Antibodypedia; 17715; 62 antibodies from 17 providers.
DR   DNASU; 8273; -.
DR   Ensembl; ENST00000263512.5; ENSP00000263512.4; ENSG00000126903.17. [P09131-1]
DR   Ensembl; ENST00000369649.8; ENSP00000358663.4; ENSG00000126903.17. [P09131-2]
DR   Ensembl; ENST00000393587.4; ENSP00000377212.4; ENSG00000126903.17. [P09131-1]
DR   Ensembl; ENST00000651600.1; ENSP00000499188.1; ENSG00000126903.17. [P09131-1]
DR   Ensembl; ENST00000882890.1; ENSP00000552949.1; ENSG00000126903.17. [P09131-1]
DR   Ensembl; ENST00000882891.1; ENSP00000552950.1; ENSG00000126903.17. [P09131-1]
DR   Ensembl; ENST00000882892.1; ENSP00000552951.1; ENSG00000126903.17. [P09131-1]
DR   Ensembl; ENST00000882893.1; ENSP00000552952.1; ENSG00000126903.17. [P09131-1]
DR   Ensembl; ENST00000882894.1; ENSP00000552953.1; ENSG00000126903.17. [P09131-1]
DR   Ensembl; ENST00000882895.1; ENSP00000552954.1; ENSG00000126903.17. [P09131-1]
DR   Ensembl; ENST00000922672.1; ENSP00000592731.1; ENSG00000126903.17. [P09131-1]
DR   Ensembl; ENST00000922673.1; ENSP00000592732.1; ENSG00000126903.17. [P09131-1]
DR   Ensembl; ENST00000922674.1; ENSP00000592733.1; ENSG00000126903.17. [P09131-1]
DR   GeneID; 8273; -.
DR   KEGG; hsa:8273; -.
DR   MANE-Select; ENST00000651600.1; ENSP00000499188.1; NM_019848.5; NP_062822.1.
DR   UCSC; uc004flp.4; human. [P09131-1]
DR   AGR; HGNC:22979; -.
DR   ClinPGx; PA134886398; -.
DR   CTD; 8273; -.
DR   DisGeNET; 8273; -.
DR   GeneCards; SLC10A3; -.
DR   HGNC; HGNC:22979; SLC10A3.
DR   HPA; ENSG00000126903; Low tissue specificity.
DR   MIM; 312090; gene.
DR   OpenTargets; ENSG00000126903; -.
DR   VEuPathDB; HostDB:ENSG00000126903; -.
DR   eggNOG; KOG2718; Eukaryota.
DR   GeneTree; ENSGT00950000182808; -.
DR   HOGENOM; CLU_034788_2_0_1; -.
DR   InParanoid; P09131; -.
DR   OMA; IQLMDPH; -.
DR   OrthoDB; 203097at2759; -.
DR   PAN-GO; P09131; 2 GO annotations based on evolutionary models.
DR   PhylomeDB; P09131; -.
DR   PathwayCommons; P09131; -.
DR   SignaLink; P09131; -.
DR   Agora; ENSG00000126903; -.
DR   BioGRID-ORCS; 8273; 9 hits in 775 CRISPR screens.
DR   GeneWiki; SLC10A3; -.
DR   GenomeRNAi; 8273; -.
DR   Pharos; P09131; Tbio.
DR   PRO; PR:P09131; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; P09131; protein.
DR   Bgee; ENSG00000126903; Expressed in right coronary artery and 146 other cell types or tissues.
DR   ExpressionAtlas; P09131; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0008508; F:bile acid:sodium symporter activity; IBA:GO_Central.
DR   GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR   FunFam; 1.20.1530.20:FF:000014; Solute carrier family 10 member 3; 1.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR   InterPro; IPR004710; Bilac:Na_transpt.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR057103; NTCP5_P3_N.
DR   NCBIfam; TIGR00841; bass; 1.
DR   PANTHER; PTHR10361:SF3; P3 PROTEIN; 1.
DR   PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR   Pfam; PF24690; NTCP5_P3_N; 1.
DR   Pfam; PF01758; SBF; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Proteomics identification;
KW   Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..477
FT                   /note="P3 protein"
FT                   /id="PRO_0000052343"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         120..148
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_043669"
FT   VARIANT         354
FT                   /note="V -> I (in dbSNP:rs35381503)"
FT                   /id="VAR_050229"
SQ   SEQUENCE   477 AA;  50333 MW;  49CB363EB3B66A1D CRC64;
     MVLMQDKGSS QQWPGLGGEG GGTGPLSMLR AALLLISLPW GAQGTASTSL STAGGHTVPP
     TGGRYLSIGD GSVMEFEFPE DSEGIIVISS QYPGQANRTA PGPMLRVTSL DTEVLTIKNV
     SAITWGGGGG FVVSIHSGLA GLAPLHIQLV DAHEAPPTLI EERRDFCIKV SPAEDTPATL
     SADLAHFSEN PILYLLLPLI FVNKCSFGCK VELEVLKGLM QSPQPMLLGL LGQFLVMPLY
     AFLMAKVFML PKALALGLII TCSSPGGGGS YLFSLLLGGD VTLAISMTFL STVAATGFLP
     LSSAIYSRLL SIHETLHVPI SKILGTLLFI AIPIAVGVLI KSKLPKFSQL LLQVVKPFSF
     VLLLGGLFLA YRMGVFILAG IRLPIVLVGI TVPLVGLLVG YCLATCLKLP VAQRRTVSIE
     VGVQNSLLAL AMLQLSLRRL QADYASQAPF IVALSGTSEM LALVIGHFIY SSLFPVP
//