ID   HBAT_HUMAN              Reviewed;         142 AA.
AC   P09105; Q13723; Q1W6G5;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   10-JUN-2026, entry version 191.
DE   RecName: Full=Hemoglobin subunit theta-1;
DE   AltName: Full=Hemoglobin theta-1 chain;
DE   AltName: Full=Theta-1-globin;
GN   Name=HBQ1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3422341; DOI=10.1038/331094a0;
RA   Hsu S.-L., Marks J., Shaw J.-P., Tam M., Higgs D.R., Shen C.C.,
RA   Shen C.-K.J.;
RT   "Structure and expression of the human theta 1 globin gene.";
RL   Nature 331:94-96(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3408475; DOI=10.1007/bf00561460;
RA   Gonzalez-Redondo J.M., Han I.S., Gu Y.C., Huisman T.H.J.;
RT   "Nucleotide sequence of the human theta 1-globin gene.";
RL   Biochem. Genet. 26:207-211(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16728641; DOI=10.1126/science.1126431;
RA   De Gobbi M., Viprakasit V., Hughes J.R., Fisher C., Buckle V.J., Ayyub H.,
RA   Gibbons R.J., Vernimmen D., Yoshinaga Y., de Jong P., Cheng J.-F.,
RA   Rubin E.M., Wood W.G., Bowden D., Higgs D.R.;
RT   "A regulatory SNP causes a human genetic disease by creating a new
RT   transcriptional promoter.";
RL   Science 312:1215-1217(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA   Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA   Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT   "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT   the short arm of human chromosome 16.";
RL   Hum. Mol. Genet. 10:339-352(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
RC   TISSUE=Liver;
RX   PubMed=2569721; DOI=10.1093/nar/17.14.5687;
RA   Kim J.H., Yu C.Y., Bailey A.D., Hardison R., Shen C.-K.J.;
RT   "Unique sequence organization and erythroid cell-specific nuclear factor-
RT   binding of mammalian theta 1 globin promoters.";
RL   Nucleic Acids Res. 17:5687-5700(1989).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- INTERACTION:
CC       P09105; O43865: AHCYL1; NbExp=6; IntAct=EBI-10193656, EBI-2371423;
CC       P09105; P69905: HBA2; NbExp=3; IntAct=EBI-10193656, EBI-714680;
CC       P09105; P68871: HBB; NbExp=3; IntAct=EBI-10193656, EBI-715554;
CC       P09105; P02042: HBD; NbExp=6; IntAct=EBI-10193656, EBI-6152722;
CC       P09105; P02100: HBE1; NbExp=3; IntAct=EBI-10193656, EBI-6190240;
CC       P09105; P69892: HBG2; NbExp=3; IntAct=EBI-10193656, EBI-3910089;
CC       P09105; P02008: HBZ; NbExp=3; IntAct=EBI-10193656, EBI-719843;
CC       P09105; Q9GZT8: NIF3L1; NbExp=2; IntAct=EBI-10193656, EBI-740897;
CC       P09105; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10193656, EBI-741158;
CC       P09105; Q8TAC1: RFESD; NbExp=9; IntAct=EBI-10193656, EBI-10271664;
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; X06482; CAA29776.1; -; Genomic_DNA.
DR   EMBL; M33022; AAA52640.1; -; Genomic_DNA.
DR   EMBL; DQ431198; ABD95912.1; -; Genomic_DNA.
DR   EMBL; AE006462; AAK61217.1; -; Genomic_DNA.
DR   EMBL; BC056686; AAH56686.1; -; mRNA.
DR   EMBL; M91453; AAA58362.1; -; Genomic_DNA.
DR   CCDS; CCDS10400.1; -.
DR   PIR; I52337; HTHU.
DR   RefSeq; NP_005322.1; NM_005331.5.
DR   AlphaFoldDB; P09105; -.
DR   SMR; P09105; -.
DR   BioGRID; 109299; 28.
DR   FunCoup; P09105; 12.
DR   IntAct; P09105; 27.
DR   NDEx; MUSIC2-C5421-HBQ1; Osteosarcoma (U2OS) cell map - Steroidogenesis and lipid metabolism (4 proteins).
DR   STRING; 9606.ENSP00000199708; -.
DR   iPTMnet; P09105; -.
DR   PhosphoSitePlus; P09105; -.
DR   BioMuta; HBQ1; -.
DR   DMDM; 122330; -.
DR   jPOST; P09105; -.
DR   MassIVE; P09105; -.
DR   PaxDb; 9606-ENSP00000199708; -.
DR   PeptideAtlas; P09105; -.
DR   ProteomicsDB; 52199; -.
DR   Pumba; P09105; -.
DR   Antibodypedia; 22527; 152 antibodies from 26 providers.
DR   DNASU; 3049; -.
DR   Ensembl; ENST00000199708.3; ENSP00000199708.2; ENSG00000086506.3.
DR   GeneID; 3049; -.
DR   KEGG; hsa:3049; -.
DR   MANE-Select; ENST00000199708.3; ENSP00000199708.2; NM_005331.5; NP_005322.1.
DR   UCSC; uc002cfz.4; human.
DR   AGR; HGNC:4833; -.
DR   ClinPGx; PA29208; -.
DR   CTD; 3049; -.
DR   DisGeNET; 3049; -.
DR   GeneCards; HBQ1; -.
DR   HGNC; HGNC:4833; HBQ1.
DR   HPA; ENSG00000086506; Group enriched (bone marrow, brain).
DR   MIM; 142240; gene.
DR   OpenTargets; ENSG00000086506; -.
DR   VEuPathDB; HostDB:ENSG00000086506; -.
DR   eggNOG; KOG3378; Eukaryota.
DR   GeneTree; ENSGT00940000162598; -.
DR   HOGENOM; CLU_003827_10_2_1; -.
DR   InParanoid; P09105; -.
DR   OMA; FFKLLCH; -.
DR   OrthoDB; 8751793at2759; -.
DR   PAN-GO; P09105; 6 GO annotations based on evolutionary models.
DR   PhylomeDB; P09105; -.
DR   PathwayCommons; P09105; -.
DR   SignaLink; P09105; -.
DR   Agora; ENSG00000086506; -.
DR   BioGRID-ORCS; 3049; 17 hits in 1149 CRISPR screens.
DR   GeneWiki; HBQ1; -.
DR   GenomeRNAi; 3049; -.
DR   Pharos; P09105; Tbio.
DR   PRO; PR:P09105; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; P09105; protein.
DR   Bgee; ENSG00000086506; Expressed in blood and 108 other cell types or tissues.
DR   ExpressionAtlas; P09105; baseline and differential.
DR   GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR   GO; GO:0048821; P:erythrocyte development; IBA:GO_Central.
DR   GO; GO:0015671; P:oxygen transport; IBA:GO_Central.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   FunFam; 1.10.490.10:FF:000002; Hemoglobin subunit alpha; 1.
DR   Gene3D; 1.10.490.10; Globins; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR050056; Hemoglobin_oxygen_transport.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   PANTHER; PTHR11442; HEMOGLOBIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR11442:SF15; HEMOGLOBIN SUBUNIT THETA-1; 1.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; Globin-like; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Heme; Iron; Metal-binding; Oxygen transport; Proteomics identification;
KW   Reference proteome; Transport.
FT   CHAIN           1..142
FT                   /note="Hemoglobin subunit theta-1"
FT                   /id="PRO_0000052846"
FT   DOMAIN          2..142
FT                   /note="Globin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         59
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         88
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   142 AA;  15508 MW;  9D4F103D758694D6 CRC64;
     MALSAEDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KTYFSHLDLS PGSSQVRAHG
     QKVADALSLA VERLDDLPHA LSALSHLHAC QLRVDPASFQ LLGHCLLVTL ARHYPGDFSP
     ALQASLDKFL SHVISALVSE YR
//