ID HXC8_MOUSE Reviewed; 242 AA. AC P09025; DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1989, sequence version 2. DT 04-NOV-2026, entry version 200. DE RecName: Full=Homeobox protein Hox-C8; DE AltName: Full=Homeobox protein Hox-3.1; DE AltName: Full=Homeobox protein M31; GN Name=Hoxc8; Synonyms=Hox-3.1, Hoxc-8; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2895723; DOI=10.1101/gad.2.1.125; RA le Mouellic H., Condamine H., Brulet P.; RT "Pattern of transcription of the homeo gene Hox-3.1 in the mouse embryo."; RL Genes Dev. 2:125-135(1988). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2900757; DOI=10.1002/j.1460-2075.1988.tb02948.x; RA Breier G., Dressler G.R., Gruss P.; RT "Primary structure and developmental expression pattern of Hox 3.1, a RT member of the murine Hox 3 homeobox gene cluster."; RL EMBO J. 7:1329-1336(1988). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=CD-1; RX PubMed=1696731; DOI=10.1073/pnas.87.16.6428; RA Awgulewitsch A., Bieberich C., Bogarad L., Shashikant C., Ruddle F.H.; RT "Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox- RT 3.1 intergenic region."; RL Proc. Natl. Acad. Sci. U.S.A. 87:6428-6432(1990). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-216. RX PubMed=3007994; DOI=10.1038/320328a0; RA Awgulewitsch A., Utset M.F., Hart C.P., McGinnis W., Ruddle F.H.; RT "Spatial restriction in expression of a mouse homoeo box locus within the RT central nervous system."; RL Nature 320:328-335(1986). RN [5] RP NUCLEOTIDE SEQUENCE OF 149-215. RX PubMed=2877873; DOI=10.1002/j.1460-2075.1986.tb04486.x; RA Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P.; RT "Sequential expression of murine homeo box genes during F9 EC cell RT differentiation."; RL EMBO J. 5:2209-2215(1986). RN [6] RP INTERACTION WITH PBX1. RX PubMed=7791786; DOI=10.1128/mcb.15.7.3786; RA Lu Q., Knoepfler P.S., Scheele J., Wright D.D., Kamps M.P.; RT "Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the RT products of multiple murine Hox genes, some of which are themselves RT oncogenes."; RL Mol. Cell. Biol. 15:3786-3795(1995). CC -!- FUNCTION: Sequence-specific transcription factor which is part of a CC developmental regulatory system that provides cells with specific CC positional identities on the anterior-posterior axis. CC -!- SUBUNIT: Interacts with HOMEZ (By similarity). Forms a DNA-binding CC heterodimer with transcription factor PBX1 (PubMed:7791786). CC {ECO:0000250|UniProtKB:P31273, ECO:0000269|PubMed:7791786}. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- DEVELOPMENTAL STAGE: Initially found in all tissues of the posterior CC region in 8.5 and 9.5 dpc. Embryos, it eventually become specifically CC located in neural tissue. CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X07439; CAA30319.1; -; mRNA. DR EMBL; X07646; CAA30486.1; -; mRNA. DR EMBL; M35603; AAA37857.1; -; Genomic_DNA. DR EMBL; X03659; CAA27294.1; ALT_SEQ; Genomic_DNA. DR CCDS; CCDS27894.1; -. DR PIR; B25180; A25180. DR PIR; B36023; WJMSX3. DR PIR; S13785; S13785. DR RefSeq; NP_034596.1; NM_010466.2. DR SMR; P09025; -. DR BioGRID; 200389; 3. DR IntAct; P09025; 1. DR STRING; 10090.ENSMUSP00000001703; -. DR iPTMnet; P09025; -. DR PhosphoSitePlus; P09025; -. DR PaxDb; 10090-ENSMUSP00000001703; -. DR ProteomicsDB; 267025; -. DR DNASU; 15426; -. DR Ensembl; ENSMUST00000001703.8; ENSMUSP00000001703.7; ENSMUSG00000001657.8. DR GeneID; 15426; -. DR KEGG; mmu:15426; -. DR UCSC; uc012aaf.1; mouse. DR CTD; 3224; -. DR VEuPathDB; HostDB:ENSMUSG00000001657; -. DR AGR; MGI:96198; -. DR MGI; MGI:96198; Hoxc8. DR eggNOG; KOG0489; Eukaryota. DR GeneTree; ENSGT00940000161194; -. DR HOGENOM; CLU_061398_1_0_1; -. DR InParanoid; P09025; -. DR OMA; ACAQQSW; -. DR OrthoDB; 6159439at2759; -. DR PhylomeDB; P09025; -. DR Reactome; R-MMU-9762293; Regulation of CDH11 gene transcription. DR PRO; PR:P09025; -. DR Bgee; ENSMUSG00000001657; Expressed in epididymis and 141 other cell types or tissues. DR CDD; cd00086; homeodomain; 1. DR FunFam; 1.10.10.60:FF:000072; Homeobox protein Hox-B8; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR050948; Antp_homeobox_TF. DR InterPro; IPR001356; HD. DR InterPro; IPR020479; HD_metazoa. DR InterPro; IPR001827; Homeobox_Antennapedia_CS. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR009057; Homeodomain-like_sf. DR InterPro; IPR000047; HTH_motif. DR PANTHER; PTHR46166; HOMEOBOX DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR46166:SF4; HOMEOBOX PROTEIN HOX-C8; 1. DR Pfam; PF00046; Homeodomain; 1. DR PRINTS; PR00024; HOMEOBOX. DR PRINTS; PR00031; HTHREPRESSR. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00032; ANTENNAPEDIA; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR GO; GO:0015630; C:microtubule cytoskeleton; ISO:GO_Central. DR GO; GO:0005654; C:nucleoplasm; ISO:GO_Central. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:GO_Central. DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI. DR GO; GO:0030182; P:neuron differentiation; IMP:MGI. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0048705; P:skeletal system morphogenesis; IMP:MGI. DR Proteomes; UP000000589; Chromosome 15. DR Antibodypedia; 27310; 296 antibodies from 35 providers. DR RNAct; P09025; protein. DR BioGRID-ORCS; 15426; 2 hits in 79 CRISPR screens. DR AlphaFoldDB; P09025; -. DR FunCoup; P09025; 1378. PE 1: Evidence at protein level; KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome; KW Transcription; Transcription regulation. FT CHAIN 1..242 FT /note="Homeobox protein Hox-C8" FT /id="PRO_0000200181" FT DNA_BIND 149..208 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 114..154 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 206..242 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 138..143 FT /note="Antp-type hexapeptide" FT COMPBIAS 116..136 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 206..220 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 221..242 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CONFLICT 151 FT /note="S -> T (in Ref. 4; CAA27294)" FT /evidence="ECO:0000305" FT CONFLICT 181 FT /note="E -> Q (in Ref. 4; CAA27294)" FT /evidence="ECO:0000305" SQ SEQUENCE 242 AA; 27740 MW; 4A2A53BDA4CFA878 CRC64; MSSYFVNPLF SKYKGGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ HASHHVQDFF HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY GAQQEASVVQ YPDCKSSANT NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALGLTE RQVKIWFQNR RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN KD //