ID   AACC4_SALSP             Reviewed;         261 AA.
AC   P08988;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   02-SEP-2026, entry version 70.
DE   RecName: Full=Aminoglycoside N(3)-acetyltransferase IV;
DE            EC=2.3.1.81;
DE   AltName: Full=ACC(3)-IV;
DE   AltName: Full=Aminocyclitol 3-N-acetyltransferase type IV;
GN   Name=aacC4;
OS   Salmonella sp.
OG   Plasmid pWP7b.
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=599;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6318050; DOI=10.1007/bf00327434;
RA   Braeu B., Pilz U., Piepersberg W.;
RT   "Genes for gentamicin-(3)-N-acetyltransferases III and IV: I. Nucleotide
RT   sequence of the AAC(3)-IV gene and possible involvement of an IS140 element
RT   in its expression.";
RL   Mol. Gen. Genet. 193:179-187(1984).
RN   [2]
RP   SEQUENCE REVISION.
RA   Piepersberg W.;
RL   Submitted (SEP-1985) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Resistance to antibiotics containing the 2-deoxy-streptamine
CC       ring including gentamicin, kanamycin, tobramycin, neomycin and
CC       apramycin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3)-acetyl-
CC         2-deoxystreptamine antibiotic + CoA + H(+); Xref=Rhea:RHEA:12665,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:57921, ChEBI:CHEBI:77452; EC=2.3.1.81;
CC   -!- SIMILARITY: Belongs to the antibiotic N-acetyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; X01385; CAA25642.1; -; Genomic_DNA.
DR   PIR; S09647; S09647.
DR   AlphaFoldDB; P08988; -.
DR   SMR; P08988; -.
DR   KEGG; ag:CAA25642; -.
DR   GO; GO:0046353; F:aminoglycoside 3-N-acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR   InterPro; IPR003679; Amioglycoside_AcTrfase.
DR   InterPro; IPR028345; Antibiotic_NAT-like.
DR   NCBIfam; NF033081; AAC_3_IV; 1.
DR   PANTHER; PTHR11104; AMINOGLYCOSIDE N3-ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR11104:SF0; SPBETA PROPHAGE-DERIVED AMINOGLYCOSIDE N(3')-ACETYLTRANSFERASE-LIKE PROTEIN YOKD; 1.
DR   Pfam; PF02522; Antibiotic_NAT; 1.
DR   SUPFAM; SSF110710; TTHA0583/YokD-like; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic resistance; Plasmid; Transferase.
FT   CHAIN           1..261
FT                   /note="Aminoglycoside N(3)-acetyltransferase IV"
FT                   /id="PRO_0000068548"
SQ   SEQUENCE   261 AA;  28491 MW;  7E8CBBFC6DFC111E CRC64;
     MQYEWRKAEL IGQLLNLGVT PGGVLLVHSS FRSVRPLEDG PLGLIEALRA ALGPGGTLVM
     PSWSGLDDEP FDPATSPVTP DLGVVSDTFW RLPNVKRSAH PFAFAAAGPQ AEQIISDPLP
     LPPHSPASPV ARVHELDGQV LLLGVGHDAN TTLHLAELMA KVPYGVPRHC TILQDGKLVR
     VDYLENDHCC ERFALADRWL KEKSLQKEGP VGHAFARLIR SRDIVATALG QLGRDPLIFL
     HPPEGGMRRM RCRSPVDWLS S
//