ID NU1C_MARPO Reviewed; 368 AA. AC P06255; DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1988, sequence version 1. DT 04-NOV-2026, entry version 105. DE RecName: Full=NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic {ECO:0000255|HAMAP-Rule:MF_01350}; DE EC=7.1.1.- {ECO:0000255|HAMAP-Rule:MF_01350}; DE AltName: Full=NAD(P)H dehydrogenase subunit 1 {ECO:0000255|HAMAP-Rule:MF_01350}; DE Short=NDH subunit 1 {ECO:0000255|HAMAP-Rule:MF_01350}; DE AltName: Full=NADH-plastoquinone oxidoreductase subunit 1 {ECO:0000255|HAMAP-Rule:MF_01350}; GN Name=ndhA {ECO:0000255|HAMAP-Rule:MF_01350}; Synonyms=ndh1; OS Marchantia polymorpha (Common liverwort) (Marchantia aquatica). OG Plastid; Chloroplast. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Marchantiophyta; OC Marchantiopsida; Marchantiidae; Marchantiales; Marchantiaceae; Marchantia. OX NCBI_TaxID=3197; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tak-1; RX DOI=10.1038/322572a0; RA Ohyama K., Fukuzawa H., Kohchi T., Shirai H., Sano T., Sano S., Umesono K., RA Shiki Y., Takeuchi M., Chang Z., Aota S., Inokuchi H., Ozeki H.; RT "Chloroplast gene organization deduced from complete sequence of liverwort RT Marchantia polymorpha chloroplast DNA."; RL Nature 322:572-574(1986). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=3199437; DOI=10.1016/0022-2836(88)90004-6; RA Kohchi T., Shirai H., Fukuzawa H., Sano T., Komano T., Umesono K., RA Inokuchi H., Ozeki H., Ohyama K.; RT "Structure and organization of Marchantia polymorpha chloroplast genome. RT IV. Inverted repeat and small single copy regions."; RL J. Mol. Biol. 203:353-372(1988). CC -!- FUNCTION: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN CC and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain CC and possibly in a chloroplast respiratory chain. The immediate electron CC acceptor for the enzyme in this species is believed to be CC plastoquinone. Couples the redox reaction to proton translocation, and CC thus conserves the redox energy in a proton gradient. CC {ECO:0000255|HAMAP-Rule:MF_01350}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a plastoquinone + NADH + (n+1) H(+)(in) = a plastoquinol + CC NAD(+) + n H(+)(out); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561, CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192; CC Evidence={ECO:0000255|HAMAP-Rule:MF_01350}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a plastoquinone + NADPH + (n+1) H(+)(in) = a plastoquinol + CC NADP(+) + n H(+)(out); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561, CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192; CC Evidence={ECO:0000255|HAMAP-Rule:MF_01350}; CC -!- SUBUNIT: NDH is composed of at least 16 different subunits, 5 of which CC are encoded in the nucleus. {ECO:0000255|HAMAP-Rule:MF_01350}. CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane CC {ECO:0000255|HAMAP-Rule:MF_01350}; Multi-pass membrane protein CC {ECO:0000255|HAMAP-Rule:MF_01350}. CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. CC {ECO:0000255|HAMAP-Rule:MF_01350}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X04465; CAA28139.1; -; Genomic_DNA. DR PIR; A00413; DELVN1. DR RefSeq; NP_039353.1; NC_001319.1. DR AlphaFoldDB; P06255; -. DR SMR; P06255; -. DR GeneID; 2702580; -. DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule. DR GO; GO:0019684; P:photosynthesis, light reaction; IEA:UniProtKB-UniRule. DR HAMAP; MF_01350; NDH1_NuoH; 1. DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO. DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS. DR NCBIfam; NF004741; nuoH; 1. DR NCBIfam; NF004744; nuoH; 1. DR PANTHER; PTHR11432; NADH DEHYDROGENASE SUBUNIT 1; 1. DR PANTHER; PTHR11432:SF3; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1; 1. DR Pfam; PF00146; NADHdh; 1. DR PROSITE; PS00667; COMPLEX1_ND1_1; 1. DR PROSITE; PS00668; COMPLEX1_ND1_2; 1. PE 3: Inferred from homology; KW Chloroplast; Membrane; NAD; NADP; Plastid; Plastoquinone; Quinone; KW Thylakoid; Translocase; Transmembrane; Transmembrane helix. FT CHAIN 1..368 FT /note="NAD(P)H-quinone oxidoreductase subunit 1, FT chloroplastic" FT /id="PRO_0000117510" FT TRANSMEM 27..47 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 97..117 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 130..150 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 166..186 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 204..224 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 249..269 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 270..290 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 305..325 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 348..368 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" SQ SEQUENCE 368 AA; 41510 MW; EB37938FB4B75C0B CRC64; MISNINLEDK FFSFFFTLGF SKEFFNFLWI IFSILILMLG VTIGVLVLVW LERKISAAIQ QRIGPEYAGP LGIIQALADG IKLFLKEDIV PAQGDVWLFN IGPILVLIPV FLSYLVIPFE YNVILANFSI GVFFWIAVSS VVPLGLLMAG YGSNNKYSFL GGLRAAAQSI SYEIPLALSV LSIALLSNSL STVDIVEAQS KYGFLSWNLW RQPIGFIVFF IASLAECERL PFDLPEAEEE LVAGYQTEYS GMKFAFFYLA SYLNLLVSSL FVTILYLGGW HFSIPFFSLF KNFEWNLMSN GISEVISIII GIVITLVKSY LFLFISIMTR WTLPRIRIDQ LLNLGWKFLL PIALGNLLLT TSFQLFLL //