ID   E1BS_ADE02              Reviewed;         175 AA.
AC   P03247;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 2.
DT   02-SEP-2026, entry version 113.
DE   RecName: Full=E1B protein, small T-antigen;
DE   AltName: Full=E1B 19 kDa protein;
DE            Short=E1B-19K;
DE   AltName: Full=E1B-175R;
GN   Name=E1B;
OS   Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Polisuviricotina;
OC   Pharingeaviricetes; Rowavirales; Adenoviridae; Mastadenovirus;
OC   Mastadenovirus hylobatidae; Mastadenovirus caesari; Human mastadenovirus C.
OX   NCBI_TaxID=10515;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7142161; DOI=10.1016/s0021-9258(18)33473-2;
RA   Gingeras T.R., Sciaky D., Gelinas R.E., Bing-Dong J., Yen C.E., Kelly M.M.,
RA   Bullock P.A., Parsons B.L., O'Neill K.E., Roberts R.J.;
RT   "Nucleotide sequences from the adenovirus-2 genome.";
RL   J. Biol. Chem. 257:13475-13491(1982).
RN   [2]
RP   ALTERNATIVE SPLICING (ISOFORMS E1B-495R AND E1B-155R).
RX   PubMed=6323739; DOI=10.1128/jvi.50.2.387-396.1984;
RA   Anderson C.W., Schmitt R.C., Smart J.E., Lewis J.B.;
RT   "Early region 1B of adenovirus 2 encodes two coterminal proteins of 495 and
RT   155 amino acid residues.";
RL   J. Virol. 50:387-396(1984).
RN   [3]
RP   ALTERNATIVE SPLICING (ISOFORMS E1B-495R; E1B-175R; E1B-155R; E1B-92R AND
RP   E1B-82R).
RX   PubMed=3989911; DOI=10.1128/jvi.54.2.383-391.1985;
RA   Virtanen A., Pettersson U.;
RT   "Organization of early region 1B of human adenovirus type 2: identification
RT   of four differentially spliced mRNAs.";
RL   J. Virol. 54:383-391(1985).
RN   [4]
RP   ALTERNATIVE SPLICING (ISOFORMS E1B-495R; E1B-175R; E1B-155R; E1B-92R AND
RP   E1B-82R).
RX   PubMed=2960832; DOI=10.1128/jvi.61.12.3879-3888.1987;
RA   Lewis J.B., Anderson C.W.;
RT   "Identification of adenovirus type 2 early region 1B proteins that share
RT   the same amino terminus as do the 495R and 155R proteins.";
RL   J. Virol. 61:3879-3888(1987).
CC   -!- FUNCTION: Putative adenovirus Bcl-2 homolog that inhibits apoptosis
CC       induced by TNF or FAS pathways, as well as p53-mediated apoptosis.
CC       Without E1B 19K function, virus production is compromised because of
CC       premature death of host cell. Interacts with Bax protein in cell
CC       lysates (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       P03247; O60238: BNIP3L; Xeno; NbExp=7; IntAct=EBI-849856, EBI-849893;
CC   -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000250}. Host nucleus
CC       envelope {ECO:0000250}. Host nucleus lamina {ECO:0000250}.
CC       Note=Associated with the plasma and nuclear membranes, and with the
CC       insoluble nuclear lamina. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC         Comment=At least five different polypeptides are generated by
CC         alternative splicing of a common mRNA precursor.;
CC       Name=E1B-175R; Synonyms=E1B-19K;
CC         IsoId=P03247-1; Sequence=Displayed;
CC       Name=E1B-495R; Synonyms=E1B-55K;
CC         IsoId=P03244-1; Sequence=External;
CC       Name=E1B-155R; Synonyms=E1B-18K;
CC         IsoId=P03244-2; Sequence=External;
CC       Name=E1B-92R; Synonyms=E1B-16K;
CC         IsoId=P03244-3; Sequence=External;
CC       Name=E1B-82R; Synonyms=E1B-15K;
CC         IsoId=P03244-4; Sequence=External;
CC   -!- SIMILARITY: Belongs to the adenoviridae E1B 19 kDa protein family.
CC       {ECO:0000305}.
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DR   EMBL; J01917; AAA92200.1; -; Genomic_DNA.
DR   PIR; B03814; Q1AD22.
DR   RefSeq; AP_000162.1; AC_000007.1. [P03247-1]
DR   RefSeq; NP_040510.1; NC_001405.1.
DR   AlphaFoldDB; P03247; -.
DR   IntAct; P03247; 5.
DR   MINT; P03247; -.
DR   GeneID; 2652981; -.
DR   Proteomes; UP000008167; Segment.
DR   GO; GO:0044165; C:host cell endoplasmic reticulum; IDA:UniProtKB.
DR   GO; GO:0044199; C:host cell nuclear envelope; IDA:UniProtKB.
DR   GO; GO:0044203; C:host cell nuclear lamina; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033668; P:symbiont-mediated suppression of host apoptosis; IDA:UniProtKB.
DR   InterPro; IPR002924; Adenovir_t-Ag_E1B_19kDa.
DR   InterPro; IPR002475; Bcl2-like.
DR   Pfam; PF01691; Adeno_E1B_19K; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Apoptosis; Early protein; Host cell membrane;
KW   Host membrane; Host nucleus; Host-virus interaction;
KW   Inhibition of host apoptosis by viral BCL2-like protein; Membrane;
KW   Modulation of host cell apoptosis by virus; Reference proteome.
FT   CHAIN           1..175
FT                   /note="E1B protein, small T-antigen"
FT                   /id="PRO_0000221710"
FT   REGION          147..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   175 AA;  20514 MW;  2FF4279D0CC700B6 CRC64;
     MEAWECLEDF SAVRNLLEQS SNSTSWFWRF LWGSSQAKLV CRIKEDYKWE FEELLKSCGE
     LFDSLNLGHQ ALFQEKVIKT LDFSTPGRAA AAVAFLSFIK DKWSEETHLS GGYLLDFLAM
     HLWRAVVRHK NRLLLLSSVR PAIIPTEEQQ QEEARRRRRQ EQSPWNPRAG LDPRE
//