ID   LCP1_DROME              Reviewed;         130 AA.
AC   P02839; Q24290; Q9V4S9;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2001, sequence version 3.
DT   02-SEP-2026, entry version 165.
DE   RecName: Full=Larval cuticle protein 1;
DE   AltName: Full=Larval cuticle protein I;
DE   Flags: Precursor;
GN   Name=Lcp1; ORFNames=CG11650;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=Canton-S, and Oregon-R; TISSUE=Larva;
RX   PubMed=6817923; DOI=10.1016/0092-8674(82)90466-4;
RA   Snyder M., Hunkapiller M., Yuen D., Silvert D., Fristrom J., Davidson N.;
RT   "Cuticle protein genes of Drosophila: structure, organization and evolution
RT   of four clustered genes.";
RL   Cell 29:1027-1040(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC   -!- FUNCTION: Component of the larval cuticle.
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DR   EMBL; V00202; CAA23487.1; -; Genomic_DNA.
DR   EMBL; AE013599; AAF59096.1; -; Genomic_DNA.
DR   PIR; A03328; UCFF1L.
DR   PIR; A25299; A25299.
DR   RefSeq; NP_001260801.1; NM_001273872.2.
DR   RefSeq; NP_476619.1; NM_057271.4.
DR   AlphaFoldDB; P02839; -.
DR   SMR; P02839; -.
DR   BioGRID; 61670; 7.
DR   DIP; DIP-18177N; -.
DR   FunCoup; P02839; 30.
DR   IntAct; P02839; 1.
DR   STRING; 7227.FBpp0305735; -.
DR   PaxDb; 7227-FBpp0305735; -.
DR   PeptideAtlas; P02839; -.
DR   DNASU; 35817; -.
DR   EnsemblMetazoa; FBtr0088763; FBpp0087841; FBgn0002531.
DR   EnsemblMetazoa; FBtr0333557; FBpp0305735; FBgn0002531.
DR   GeneID; 35817; -.
DR   KEGG; dme:Dmel_CG11650; -.
DR   AGR; FB:FBgn0002531; -.
DR   CTD; 3936; -.
DR   FlyBase; FBgn0002531; Lcp1.
DR   VEuPathDB; VectorBase:FBgn0002531; -.
DR   eggNOG; ENOG502TD3C; Eukaryota.
DR   HOGENOM; CLU_065450_3_1_1; -.
DR   InParanoid; P02839; -.
DR   OMA; QGKFGWI; -.
DR   OrthoDB; 6343684at2759; -.
DR   PhylomeDB; P02839; -.
DR   BioGRID-ORCS; 35817; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 35817; -.
DR   PRO; PR:P02839; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0002531; Expressed in saliva-secreting gland and 13 other cell types or tissues.
DR   ExpressionAtlas; P02839; baseline and differential.
DR   GO; GO:0062129; C:chitin-based extracellular matrix; IDA:FlyBase.
DR   GO; GO:0008010; F:structural constituent of chitin-based larval cuticle; IDA:FlyBase.
DR   GO; GO:0040003; P:chitin-based cuticle development; ISM:FlyBase.
DR   GO; GO:0008363; P:larval chitin-based cuticle development; IC:FlyBase.
DR   InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR   InterPro; IPR050468; Cuticle_Struct_Prot.
DR   InterPro; IPR000618; Insect_cuticle.
DR   PANTHER; PTHR10380; CUTICLE PROTEIN; 1.
DR   PANTHER; PTHR10380:SF237; CUTICULAR PROTEIN 65AU, ISOFORM A-RELATED; 1.
DR   Pfam; PF00379; Chitin_bind_4; 1.
DR   PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR   PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE   1: Evidence at protein level;
KW   Cuticle; Direct protein sequencing; Reference proteome; Signal.
FT   SIGNAL          1..16
FT   CHAIN           17..130
FT                   /note="Larval cuticle protein 1"
FT                   /id="PRO_0000006387"
FT   DOMAIN          43..104
FT                   /note="Chitin-binding type R&R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT   CONFLICT        37
FT                   /note="Q -> R (in Ref. 1; CAA23487)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   130 AA;  13921 MW;  0A20F5B9D2DC3F4B CRC64;
     MFKFVMICAV LGLAVANPPV PHSLGRSEDV HADVLSQSDD VRADGFDSSL HTSNGIEQAA
     SGDAHGNIHG NFGWISPEGE HVEVKYVANE NGYQPSGAWI PTPPPIPEAI ARAVAWLESH
     PPAPEHPRHH
//