ID   HXA3_MOUSE              Reviewed;         443 AA.
AC   P02831; Q4V9Z8; Q61197;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   02-SEP-2026, entry version 200.
DE   RecName: Full=Homeobox protein Hox-A3;
DE   AltName: Full=Homeobox protein Hox-1.5;
DE   AltName: Full=Homeobox protein MO-10;
GN   Name=Hoxa3; Synonyms=Hox-1.5, Hoxa-3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ;
RA   Hofmann M., Boehm T.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 54-280.
RC   STRAIN=ICR X Swiss Webster;
RX   PubMed=8710855; DOI=10.1073/pnas.93.16.8247;
RA   Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.;
RT   "Sequence and expression of the murine Hoxd-3 homeobox gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:8247-8252(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 185-258.
RA   Ruddle F.H., Hart C.P., McGinnis W.;
RT   "Structural and functional aspects of the mammalian homeo-box sequences.";
RL   Trends Genet. 1:48-51(1985).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-258.
RX   PubMed=6091896; DOI=10.1016/0092-8674(84)90262-9;
RA   McGinnis W., Hart C.P., Gehring W.J., Ruddle F.H.;
RT   "Molecular cloning and chromosome mapping of a mouse DNA sequence
RT   homologous to homeotic genes of Drosophila.";
RL   Cell 38:675-680(1984).
RN   [6]
RP   DNA-BINDING.
RX   PubMed=2879282; DOI=10.1073/pnas.83.24.9532;
RA   Fainsod A., Bogarad L.D., Ruusala T., Lubin M., Crothers D.M., Ruddle F.H.;
RT   "The homeo domain of a murine protein binds 5' to its own homeo box.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:9532-9536(1986).
RN   [7]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=2444477; DOI=10.1016/0012-1606(87)90465-9;
RA   Fainsod A., Awgulewitsch A., Ruddle F.H.;
RT   "Expression of the murine homeo box gene Hox 1.5 during embryogenesis.";
RL   Dev. Biol. 124:125-133(1987).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Binds 5' to its
CC       own homeobox.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed in a spatially restricted manner in
CC       embryos 8.5 dpc, expression is limited to the CNS with an anterior
CC       boundary in the hindbrain and extending posteriorly through caudal
CC       regions of the spinal cord. The same spatial expression is seen in
CC       embryos 9.5 to 12.5 dpc. {ECO:0000269|PubMed:2444477}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; Y11717; CAA72404.1; -; mRNA.
DR   EMBL; BC096612; AAH96612.1; -; mRNA.
DR   EMBL; U56399; AAC52778.1; -; mRNA.
DR   EMBL; K02591; AAA37822.1; -; Genomic_DNA.
DR   CCDS; CCDS20140.1; -.
DR   PIR; I49746; I49746.
DR   RefSeq; NP_034582.1; NM_010452.4.
DR   RefSeq; XP_011239527.1; XM_011241225.4.
DR   RefSeq; XP_017176891.1; XM_017321402.2.
DR   RefSeq; XP_017176892.1; XM_017321403.2.
DR   RefSeq; XP_017176893.1; XM_017321404.3.
DR   AlphaFoldDB; P02831; -.
DR   SMR; P02831; -.
DR   BioGRID; 200368; 2.
DR   FunCoup; P02831; 2062.
DR   STRING; 10090.ENSMUSP00000110077; -.
DR   GlyGen; P02831; 4 sites, 1 N-linked glycan (1 site).
DR   iPTMnet; P02831; -.
DR   PhosphoSitePlus; P02831; -.
DR   PaxDb; 10090-ENSMUSP00000110077; -.
DR   Pumba; P02831; -.
DR   Antibodypedia; 12366; 205 antibodies from 23 providers.
DR   DNASU; 15400; -.
DR   Ensembl; ENSMUST00000114434.9; ENSMUSP00000110077.3; ENSMUSG00000079560.14.
DR   GeneID; 15400; -.
DR   KEGG; mmu:15400; -.
DR   UCSC; uc009bya.2; mouse.
DR   AGR; MGI:96175; -.
DR   CTD; 3200; -.
DR   MGI; MGI:96175; Hoxa3.
DR   VEuPathDB; HostDB:ENSMUSG00000079560; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000159522; -.
DR   HOGENOM; CLU_051508_1_0_1; -.
DR   InParanoid; P02831; -.
DR   OMA; PDYDPHP; -.
DR   OrthoDB; 6159439at2759; -.
DR   PhylomeDB; P02831; -.
DR   BioGRID-ORCS; 15400; 6 hits in 78 CRISPR screens.
DR   PRO; PR:P02831; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; P02831; protein.
DR   Bgee; ENSMUSG00000079560; Expressed in ascending aorta and 155 other cell types or tissues.
DR   ExpressionAtlas; P02831; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; ISO:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0071837; F:HMG box domain binding; IPI:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0048645; P:animal organ formation; IMP:MGI.
DR   GO; GO:0009887; P:animal organ morphogenesis; IMP:MGI.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR   GO; GO:0001974; P:blood vessel remodeling; IMP:MGI.
DR   GO; GO:0051216; P:cartilage development; IGI:MGI.
DR   GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR   GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IMP:MGI.
DR   GO; GO:0060017; P:parathyroid gland development; IGI:MGI.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0010159; P:specification of animal organ position; IGI:MGI.
DR   GO; GO:0048538; P:thymus development; IMP:MGI.
DR   GO; GO:0030878; P:thyroid gland development; IMP:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   FunFam; 1.10.10.60:FF:000094; Homeobox protein Hox-A3; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR001356; HD.
DR   InterPro; IPR020479; HD_metazoa.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR009057; Homeodomain-like_sf.
DR   PANTHER; PTHR45664:SF13; HOMEOBOX PROTEIN HOX-A3; 1.
DR   PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR01217; PRICHEXTENSN.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..443
FT                   /note="Homeobox protein Hox-A3"
FT                   /id="PRO_0000200044"
FT   DNA_BIND        192..251
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          74..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           156..161
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        80..126
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..197
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..267
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..310
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..327
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        185
FT                   /note="S -> G (in Ref. 4 and 5)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        195
FT                   /note="A -> G (in Ref. 4 and 5)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        201..202
FT                   /note="SA -> RP (in Ref. 4 and 5)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        218
FT                   /note="C -> M (in Ref. 4 and 5)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   443 AA;  46430 MW;  6C0E184B0F6F2D40 CRC64;
     MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA CSLQSPASAG
     GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP PAPQPPQPPP QPPAPTPAAP
     PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP TVGKQIFPWM KESRQNTKQK TSGSSSGESC
     AGDKSPPGQA SSKRARTAYT SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF
     QNRRMKYKKD QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK
     PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL QGNGSYGTPH
     LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG TGPLGSGHHH GPGPGEPHPT
     YTDLTAHHPS QGRIQEAPKL THL
//