ID   HXA7_MOUSE              Reviewed;         229 AA.
AC   P02830; A2RS54; Q544P0;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   02-SEP-2026, entry version 194.
DE   RecName: Full=Homeobox protein Hox-A7;
DE   AltName: Full=Homeobox protein Hox-1.1;
DE   AltName: Full=Homeobox protein M6-12;
DE            Short=M6;
GN   Name=Hoxa7; Synonyms=Hox-1.1, Hoxa-7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2885847; DOI=10.1073/pnas.84.15.5306;
RA   Kessel M., Schulze F., Fibi M., Gruss P.;
RT   "Primary structure and nuclear localization of a murine homeodomain
RT   protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:5306-5310(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BALB/cJ;
RX   PubMed=7890170; DOI=10.1016/0378-1119(94)00850-r;
RA   Parikh H., Shah S., Hilt D., Peterkofsky A.;
RT   "Organization, sequence and regulation of expression of the murine Hoxa-7
RT   gene.";
RL   Gene 154:237-242(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Colon;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE OF 126-229.
RX   PubMed=2986010; DOI=10.1038/314713a0;
RA   Colberg-Poley A.M., Voss S.D., Chowdhury K., Gruss P.;
RT   "Structural analysis of murine genes containing homoeo box sequences and
RT   their expression in embryonal carcinoma cells.";
RL   Nature 314:713-718(1985).
RN   [6]
RP   NUCLEOTIDE SEQUENCE OF 129-197.
RX   PubMed=2877873; DOI=10.1002/j.1460-2075.1986.tb04486.x;
RA   Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P.;
RT   "Sequential expression of murine homeo box genes during F9 EC cell
RT   differentiation.";
RL   EMBO J. 5:2209-2215(1986).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; M17192; AAA37833.1; -; mRNA.
DR   EMBL; U15972; AAC52160.1; -; Genomic_DNA.
DR   EMBL; AK033500; BAC28323.1; -; mRNA.
DR   EMBL; BC131978; AAI31979.1; -; mRNA.
DR   EMBL; BC132643; AAI32644.1; -; mRNA.
DR   CCDS; CCDS20145.1; -.
DR   PIR; A03314; A03314.
DR   PIR; A28329; A28329.
DR   RefSeq; NP_001406196.1; NM_001419267.1.
DR   RefSeq; NP_001406197.1; NM_001419268.1.
DR   RefSeq; NP_001406198.1; NM_001419269.1.
DR   RefSeq; NP_034585.1; NM_010455.3.
DR   AlphaFoldDB; P02830; -.
DR   SMR; P02830; -.
DR   BioGRID; 200372; 1.
DR   FunCoup; P02830; 1108.
DR   IntAct; P02830; 1.
DR   STRING; 10090.ENSMUSP00000048648; -.
DR   PhosphoSitePlus; P02830; -.
DR   PaxDb; 10090-ENSMUSP00000048648; -.
DR   ProteomicsDB; 267021; -.
DR   Pumba; P02830; -.
DR   Antibodypedia; 12389; 176 antibodies from 29 providers.
DR   DNASU; 15404; -.
DR   Ensembl; ENSMUST00000048715.9; ENSMUSP00000048648.7; ENSMUSG00000038236.9.
DR   GeneID; 15404; -.
DR   KEGG; mmu:15404; -.
DR   UCSC; uc009byj.1; mouse.
DR   AGR; MGI:96179; -.
DR   CTD; 3204; -.
DR   MGI; MGI:96179; Hoxa7.
DR   VEuPathDB; HostDB:ENSMUSG00000038236; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000161013; -.
DR   HOGENOM; CLU_061398_1_1_1; -.
DR   InParanoid; P02830; -.
DR   OMA; YRMYPWM; -.
DR   OrthoDB; 6159439at2759; -.
DR   PhylomeDB; P02830; -.
DR   BioGRID-ORCS; 15404; 4 hits in 80 CRISPR screens.
DR   PRO; PR:P02830; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; P02830; protein.
DR   Bgee; ENSMUSG00000038236; Expressed in embryonic post-anal tail and 108 other cell types or tissues.
DR   ExpressionAtlas; P02830; baseline and differential.
DR   GO; GO:0031965; C:nuclear membrane; ISO:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; ISO:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0003677; F:DNA binding; IDA:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; ISO:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR   GO; GO:0001953; P:negative regulation of cell-matrix adhesion; ISO:GO_Central.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISO:GO_Central.
DR   GO; GO:0045617; P:negative regulation of keratinocyte differentiation; ISO:MGI.
DR   GO; GO:0002686; P:negative regulation of leukocyte migration; ISO:GO_Central.
DR   GO; GO:0045656; P:negative regulation of monocyte differentiation; ISO:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048863; P:stem cell differentiation; IDA:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   FunFam; 1.10.10.60:FF:000017; Homeobox protein antennapedia; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR050296; Antp_homeobox.
DR   InterPro; IPR001356; HD.
DR   InterPro; IPR020479; HD_metazoa.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR009057; Homeodomain-like_sf.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   PANTHER; PTHR45659:SF12; HOMEOBOX PROTEIN HOX-A7; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..229
FT                   /note="Homeobox protein Hox-A7"
FT                   /id="PRO_0000200072"
FT   DNA_BIND        129..188
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          186..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           118..123
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        213..229
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        43..45
FT                   /note="GAG -> APA (in Ref. 1; AAA37833)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   229 AA;  25682 MW;  D36E6BD61D8D5C6F CRC64;
     MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GPGAGAFAST VPGLYNVNSP
     LYQSPFASGY GLGADAYNLP CASYDQNIPG LCSDLAKGAC DKADEGVLHG PAEASFRIYP
     WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF NRYLTRRRRI EIAHALCLTE RQIKIWFQNR
     RMKWKKEHKD ESQAPTAAPE DAVPSVSTAA DKADEEEEEE EEEEEEEEE
//