ID   CRO_RANTE               Reviewed;         324 AA.
AC   P02532;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   02-SEP-2026, entry version 104.
DE   RecName: Full=Rho crystallin;
OS   Rana temporaria (European common frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=8407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=8186748;
RA   Dolgilevich S.M., Mikaelian A.S., Kniazeva M.V., Snegovaia I.Y.,
RA   Simirskii V.N., Aleinikova K.S., Gause G.G. Jr.;
RT   "Rho-crystallins from frog eye lens: structure and expression.";
RL   Dokl. Akad. Nauk 335:373-377(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 100-324.
RC   TISSUE=Lens;
RX   PubMed=6609843; DOI=10.1016/0014-5793(84)80508-6;
RA   Tomarev S.I., Zinovieva R.D., Dolgilevich S.M., Luchin S.V., Krayev A.S.,
RA   Skryabin K.G., Gause G.G. Jr.;
RT   "A novel type of crystallin in the frog eye lens. 35-kDa polypeptide is not
RT   homologous to any of the major classes of lens crystallins.";
RL   FEBS Lett. 171:297-302(1984).
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
CC   -!- CAUTION: Was originally called epsilon crystallin. {ECO:0000305}.
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DR   EMBL; S70451; AAB30820.1; -; mRNA.
DR   EMBL; X00659; CAA25277.1; ALT_SEQ; mRNA.
DR   PIR; A02938; CYFGE.
DR   AlphaFoldDB; P02532; -.
DR   SMR; P02532; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd19108; AKR_AKR1C1-35; 1.
DR   FunFam; 3.20.20.100:FF:000003; Aldo-keto reductase family 1 member C3; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR044482; AKR1C.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR036812; NAD(P)_OxRdtase_dom_sf.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Eye lens protein.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..324
FT                   /note="Rho crystallin"
FT                   /id="PRO_0000124614"
FT   BINDING         218..281
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   324 AA;  37015 MW;  19D72B345982869F CRC64;
     MTLTKETRVT LNDGNMMPIL GLGTYASPHV PKSLAEEAVK IAIDVGYRHI DCAFITGNEM
     HIGNGIRSKI SDGTVKREDI FYTGKLWCTY FSPEMVRKGL ERSLRDVGMD YLDLFLMHWP
     VSLKPSGASD PSDKDKPFIY DNVDLCATWE ALEARKDAGL VRSLGVSNFN RRQLERILNK
     PGLKYKPVCN QVECHVYLNQ NKLHSYCKSK DIVLVTYSVL GSHRDRNWVD LSLPVLLDDP
     ILNKVAAKYN RTSAEIAMRF ILQKGIVVLA KSFTPARIKQ NLGVFEFELK PEDMKSLESL
     DRNLHYGPFR EVKQHPEYPF HDEY
//