ID   HLAH_HUMAN              Reviewed;         362 AA.
AC   P01893;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 3.
DT   04-NOV-2026, entry version 179.
DE   RecName: Full=Putative HLA class I histocompatibility antigen, alpha chain H;
DE   AltName: Full=HLA-12.4;
DE   AltName: Full=HLA-AR;
DE   AltName: Full=MHC class I antigen H;
DE   Flags: Precursor;
GN   Name=HLA-H; Synonyms=HLAH;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6461010; DOI=10.1073/pnas.79.3.893;
RA   Malissen M., Malissen B., Jordan B.R.;
RT   "Exon/intron organization and complete nucleotide sequence of an HLA
RT   gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:893-897(1982).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- INTERACTION:
CC       P01893; P11142: HSPA8; NbExp=2; IntAct=EBI-3197925, EBI-351896;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA36218.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; J00191; AAA36218.1; ALT_INIT; Genomic_DNA.
DR   PIR; A02189; HLHU12.
DR   AlphaFoldDB; P01893; -.
DR   SMR; P01893; -.
DR   FunCoup; P01893; 289.
DR   IntAct; P01893; 15.
DR   NDEx; IQUERY-CP-HLA-H; 1 NDEx IQuery Curated Pathway.
DR   GlyCosmos; P01893; 1 site, No reported glycans.
DR   GlyGen; P01893; 2 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; P01893; -.
DR   PhosphoSitePlus; P01893; -.
DR   SwissPalm; P01893; -.
DR   BioMuta; HGNC:4965; -.
DR   jPOST; P01893; -.
DR   MassIVE; P01893; -.
DR   ProteomicsDB; 51507; -.
DR   Pumba; P01893; -.
DR   AGR; HGNC:4965; -.
DR   GeneCards; HLA-H; -.
DR   HGNC; HGNC:4965; HLA-H.
DR   MIM; 142800; gene.
DR   InParanoid; P01893; -.
DR   PAN-GO; P01893; 9 GO annotations based on evolutionary models.
DR   PhylomeDB; P01893; -.
DR   PathwayCommons; P01893; -.
DR   Reactome; R-HSA-1236974; ER-Phagosome pathway.
DR   Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway.
DR   Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   Reactome; R-HSA-6798695; Neutrophil degranulation.
DR   Reactome; R-HSA-877300; Interferon gamma signaling.
DR   Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR   Reactome; R-HSA-9705671; SARS-CoV-2 activates/modulates innate and adaptive immune responses.
DR   Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
DR   SignaLink; P01893; -.
DR   ChiTaRS; HLA-H; human.
DR   Pharos; P01893; Tbio.
DR   PRO; PR:P01893; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; P01893; protein.
DR   GO; GO:0035577; C:azurophil granule membrane; TAS:Reactome.
DR   GO; GO:0009986; C:cell surface; IMP:UniProtKB.
DR   GO; GO:0031901; C:early endosome membrane; TAS:Reactome.
DR   GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR   GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome.
DR   GO; GO:0030881; F:beta-2-microglobulin binding; IMP:UniProtKB.
DR   GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IBA:GO_Central.
DR   GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IBA:GO_Central.
DR   CDD; cd21026; IgC1_MHC_Ia_HLA-B; 1.
DR   FunFam; 2.60.40.10:FF:000014; H-2 class I histocompatibility antigen, alpha chain; 1.
DR   FunFam; 3.30.500.10:FF:000001; H-2 class I histocompatibility antigen, alpha chain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR050208; MHC_class-I_related.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   InterPro; IPR010579; MHC_I_a_C.
DR   PANTHER; PTHR16675:SF256; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN H-RELATED; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   5: Uncertain;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I;
KW   Proteomics identification; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..362
FT                   /note="Putative HLA class I histocompatibility antigen,
FT                   alpha chain H"
FT                   /id="PRO_0000018888"
FT   TOPO_DOM        25..308
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        333..362
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          209..297
FT                   /note="Ig-like C1-type"
FT   REGION          25..114
FT                   /note="Alpha-1"
FT   REGION          115..206
FT                   /note="Alpha-2"
FT   REGION          207..298
FT                   /note="Alpha-3"
FT   REGION          299..308
FT                   /note="Connecting peptide"
FT   REGION          337..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..356
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        227..283
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   362 AA;  40892 MW;  8ADFD2388FEC4645 CRC64;
     MVLMAPRTLL LLLSGALALT QTWARSHSMR YFYTTMSRPG AGEPRFISVG YVDDTQFVRF
     DSDDASPREE PRAPWMEREG PKYWDRNTQI CKAQAQTERE NLRIALRYYN QSEGGSHTMQ
     VMYGCDVGPD GPFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAARRAEQR
     RVYLEGEFVE WLRRYLENGK ETLQRADPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP
     SSQPTVPIVG IVAGLVLLVA VVTGAVVAAV MWRKKSSDRK GGSYSQAASS NSAQGSDVSL
     TA
//