ID   KV3A8_MOUSE             Reviewed;         111 AA.
AC   P01660;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   02-SEP-2026, entry version 129.
DE   RecName: Full=Ig kappa chain V-III region PC 3741/TEPC 111;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   PROTEIN SEQUENCE (PC 3741).
RX   PubMed=103003; DOI=10.1038/276785a0;
RA   Weigert M., Gatmaitan L., Loh E., Schilling J., Hood L.E.;
RT   "Rearrangement of genetic information may produce immunoglobulin
RT   diversity.";
RL   Nature 276:785-790(1978).
RN   [2]
RP   PROTEIN SEQUENCE (TEPC 111).
RX   PubMed=99744; DOI=10.1073/pnas.75.8.3913;
RA   McKean D.J., Bell M., Potter M.;
RT   "Mechanisms of antibody diversity: multiple genes encode structurally
RT   related mouse kappa variable regions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 75:3913-3917(1978).
CC   -!- MISCELLANEOUS: The PC 3741 and TEPC 111 sequences are identical.
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DR   PIR; A93204; KVMS37.
DR   PDB; 1EJO; X-ray; 2.30 A; L=1-111.
DR   PDB; 1I8I; X-ray; 2.40 A; A=1-111.
DR   PDB; 1I8K; X-ray; 1.80 A; A=1-111.
DR   PDB; 1J05; X-ray; 1.50 A; A/L=1-111.
DR   PDB; 1MOE; X-ray; 2.60 A; A/B=1-111.
DR   PDB; 1QFW; X-ray; 3.50 A; L=1-111, M=1-111.
DR   PDB; 2R29; X-ray; 3.00 A; L=1-111.
DR   PDB; 2R69; X-ray; 3.80 A; L=1-111.
DR   PDB; 2R6P; EM; 24.00 A; E/G=1-111.
DR   PDB; 2VL5; X-ray; 2.10 A; B/D=1-111.
DR   PDB; 3BSZ; X-ray; 3.38 A; L/M=1-111.
DR   PDB; 4NJA; X-ray; 2.20 A; L=3-111.
DR   AlphaFoldDB; P01660; -.
DR   MDRepo; P01660; -.
DR   SMR; P01660; -.
DR   FunCoup; P01660; 779.
DR   MINT; P01660; -.
DR   jPOST; P01660; -.
DR   InParanoid; P01660; -.
DR   EvolutionaryTrace; P01660; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01660; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-ARBA.
DR   GO; GO:0019814; C:immunoglobulin complex; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-ARBA.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   CDD; cd04980; IgV_L_kappa; 1.
DR   FunFam; 2.60.40.10:FF:000350; Immunoglobulin kappa chain variable 18-36; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR050150; IgV_Light_Chain.
DR   PANTHER; PTHR23267; IMMUNOGLOBULIN LIGHT CHAIN; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PDBsum; 1EJO; -.
DR   PDBsum; 1I8I; -.
DR   PDBsum; 1I8K; -.
DR   PDBsum; 1J05; -.
DR   PDBsum; 1MOE; -.
DR   PDBsum; 1QFW; -.
DR   PDBsum; 2R29; -.
DR   PDBsum; 2R69; -.
DR   PDBsum; 2R6P; -.
DR   PDBsum; 2VL5; -.
DR   PDBsum; 3BSZ; -.
DR   PDBsum; 4NJA; -.
PE   1: Evidence at protein level;
KW   3D-structure; Adaptive immunity; Direct protein sequencing; Disulfide bond;
KW   Immunity; Immunoglobulin; Reference proteome.
FT   CHAIN           1..>111
FT                   /note="Ig kappa chain V-III region PC 3741/TEPC 111"
FT                   /id="PRO_0000059783"
FT   REGION          1..23
FT                   /note="Framework-1"
FT   REGION          24..38
FT                   /note="Complementarity-determining-1"
FT   REGION          39..53
FT                   /note="Framework-2"
FT   REGION          54..60
FT                   /note="Complementarity-determining-2"
FT   REGION          61..92
FT                   /note="Framework-3"
FT   REGION          93..101
FT                   /note="Complementarity-determining-3"
FT   REGION          102..111
FT                   /note="Framework-4"
FT   DISULFID        23..92
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         111
FT   STRAND          4..7
FT                   /evidence="ECO:0007829|PDB:1J05"
FT   STRAND          9..12
FT                   /evidence="ECO:0007829|PDB:1J05"
FT   STRAND          15..17
FT                   /evidence="ECO:0007829|PDB:2R29"
FT   STRAND          19..27
FT                   /evidence="ECO:0007829|PDB:1J05"
FT   STRAND          32..35
FT                   /evidence="ECO:0007829|PDB:2R29"
FT   STRAND          37..42
FT                   /evidence="ECO:0007829|PDB:1J05"
FT   STRAND          44..46
FT                   /evidence="ECO:0007829|PDB:1QFW"
FT   STRAND          48..53
FT                   /evidence="ECO:0007829|PDB:1J05"
FT   TURN            54..56
FT                   /evidence="ECO:0007829|PDB:1J05"
FT   STRAND          66..71
FT                   /evidence="ECO:0007829|PDB:1J05"
FT   STRAND          74..81
FT                   /evidence="ECO:0007829|PDB:1J05"
FT   HELIX           84..86
FT                   /evidence="ECO:0007829|PDB:1J05"
FT   STRAND          88..94
FT                   /evidence="ECO:0007829|PDB:1J05"
FT   STRAND          96..99
FT                   /evidence="ECO:0007829|PDB:1J05"
FT   STRAND          106..109
FT                   /evidence="ECO:0007829|PDB:1J05"
SQ   SEQUENCE   111 AA;  12099 MW;  EC46C9D259213BE4 CRC64;
     DIVLTQSPAS LAVSLGQRAT ISCRASESVD SYGNSFMHWY QQKPGQPPKL LIYRASNLES
     GIPARFSGSG SRTDFTLTIN PVEADDVATY YCQQSNEDPY TFGGGTKLEI K
//