ID GAST_BOVIN Reviewed; 104 AA. AC P01352; Q28114; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1991, sequence version 2. DT 02-SEP-2026, entry version 145. DE RecName: Full=Gastrin; DE Contains: DE RecName: Full=Big gastrin; DE AltName: Full=Gastrin-34; DE Short=G34; DE Contains: DE RecName: Full=Gastrin; DE Flags: Precursor; GN Name=GAST; Synonyms=GAS; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Liver; RX PubMed=2608050; DOI=10.1210/mend-3-10-1585; RA Lund T., Olsen J., Rehfeld J.F.; RT "Cloning and sequencing of the bovine gastrin gene."; RL Mol. Endocrinol. 3:1585-1588(1989). RN [2] RP NUCLEOTIDE SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-59. RX PubMed=1773057; DOI=10.3109/10425179109020769; RA Kim S.J., Uhm K.N., Kang Y.K., Yoo O.J.; RT "Bovine and feline gastrin cDNA sequences and the amino acid and nucleotide RT sequence homologies among mammalian species."; RL DNA Seq. 1:181-187(1991). RN [3] RP PROTEIN SEQUENCE OF 76-92, PYROGLUTAMATE FORMATION AT GLN-76, SULFATION AT RP TYR-87, AND AMIDATION AT PHE-92. RX PubMed=5665711; DOI=10.1038/219614a0; RA Agarwal K.L., Beacham J., Bentley P.H., Gregory R.A., Kenner G.W., RA Sheppard R.C., Tracy H.J.; RT "Isolation, structure and synthesis of ovine and bovine gastrins."; RL Nature 219:614-615(1968). CC -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete CC hydrochloric acid and the pancreas to secrete its digestive enzymes. It CC also stimulates smooth muscle contraction and increases blood CC circulation and water secretion in the stomach and intestine. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M31657; AAA30537.1; -; Genomic_DNA. DR EMBL; X16581; CAA34598.1; -; mRNA. DR PIR; S14400; GMBO. DR RefSeq; NP_776340.1; NM_173915.2. DR AlphaFoldDB; P01352; -. DR FunCoup; P01352; 56. DR STRING; 9913.ENSBTAP00000023489; -. DR PaxDb; 9913-ENSBTAP00000023489; -. DR Ensembl; ENSBTAT00000023489.5; ENSBTAP00000023489.3; ENSBTAG00000017663.5. DR Ensembl; ENSBTAT00085016428; ENSBTAP00085007356; ENSBTAG00085026439. DR Ensembl; ENSBTAT00090085292; ENSBTAP00090048660; ENSBTAG00090040138. DR GeneID; 280800; -. DR KEGG; bta:280800; -. DR CTD; 2520; -. DR VEuPathDB; HostDB:ENSBTAG00000017663; -. DR VGNC; VGNC:29264; GAST. DR eggNOG; ENOG502SA9S; Eukaryota. DR GeneTree; ENSGT00390000014792; -. DR HOGENOM; CLU_2249245_0_0_1; -. DR InParanoid; P01352; -. DR OMA; WKPRSQL; -. DR OrthoDB; 9924917at2759; -. DR Reactome; R-BTA-416476; G alpha (q) signalling events. DR Reactome; R-BTA-881907; Gastrin-CREB signalling pathway via PKC and MAPK. DR Proteomes; UP000009136; Chromosome 19. DR Bgee; ENSBTAG00000017663; Expressed in abomasum and 45 other cell types or tissues. DR GO; GO:0005576; C:extracellular region; IDA:AgBase. DR GO; GO:0005179; F:hormone activity; IBA:GO_Central. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0032094; P:response to food; IDA:AgBase. DR InterPro; IPR039236; GAST. DR InterPro; IPR001651; Gastrin/CCK. DR InterPro; IPR013152; Gastrin/cholecystokinin_CS. DR PANTHER; PTHR19309; GASTRIN; 1. DR PANTHER; PTHR19309:SF0; GASTRIN; 1. DR Pfam; PF00918; Gastrin; 1. DR PROSITE; PS00259; GASTRIN; 1. PE 1: Evidence at protein level; KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing; KW Hormone; Phosphoprotein; Pyrrolidone carboxylic acid; Reference proteome; KW Secreted; Signal; Sulfation. FT SIGNAL 1..21 FT PROPEP 22..58 FT /id="PRO_0000010609" FT PEPTIDE 59..92 FT /note="Big gastrin" FT /id="PRO_0000010610" FT PEPTIDE 76..92 FT /note="Gastrin" FT /evidence="ECO:0000269|PubMed:1773057" FT /id="PRO_0000010611" FT PROPEP 96..104 FT /id="PRO_0000010612" FT REGION 27..77 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 59 FT /note="Pyrrolidone carboxylic acid" FT /evidence="ECO:0000269|PubMed:1773057" FT MOD_RES 76 FT /note="Pyrrolidone carboxylic acid" FT /evidence="ECO:0000269|PubMed:5665711" FT MOD_RES 87 FT /note="Sulfotyrosine" FT /evidence="ECO:0000269|PubMed:5665711" FT MOD_RES 92 FT /note="Phenylalanine amide" FT /evidence="ECO:0000269|PubMed:5665711" FT MOD_RES 96 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P01353" FT CONFLICT 32 FT /note="A -> L (in Ref. 1; AAA30537)" FT /evidence="ECO:0000305" FT CONFLICT 37 FT /note="G -> R (in Ref. 1; AAA30537)" FT /evidence="ECO:0000305" FT CONFLICT 48 FT /note="N -> T (in Ref. 1; AAA30537)" FT /evidence="ECO:0000305" FT CONFLICT 74 FT /note="K -> N (in Ref. 1; AAA30537)" FT /evidence="ECO:0000305" FT CONFLICT 81 FT /note="E -> G (in Ref. 1; AAA30537)" FT /evidence="ECO:0000305" FT CONFLICT 96 FT /note="S -> M (in Ref. 1; AAA30537)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="E -> G (in Ref. 1; AAA30537)" FT /evidence="ECO:0000305" SQ SEQUENCE 104 AA; 11573 MW; 54D03BF200F299F2 CRC64; MQRLCAHVLI LVLALAAFCE ASWKPHSHLQ DAPVAPGANR GQEPLRMNRL GPASNPRRQL GLQDPPHMVA DLSKKQGPWV EEEEAAYGWM DFGRRSAEEG DQHP //