ID   GRP_CHICK               Reviewed;         164 AA.
AC   P01295; A0A3Q2U7K9;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 2.
DT   02-SEP-2026, entry version 106.
DE   RecName: Full=Gastrin-releasing peptide;
DE            Short=GRP;
DE   AltName: Full=Proventricular peptide;
DE   Contains:
DE     RecName: Full=Neuromedin-C;
DE     AltName: Full=GRP-10;
DE   Flags: Precursor;
GN   Name=GRP;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1] {ECO:0000312|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000312|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA   Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA   Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA   Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA   McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA   Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA   Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA   Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA   Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA   Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA   Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA   Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA   Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA   Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA   Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA   Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA   Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA   Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA   Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA   Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA   Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA   Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA   Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA   Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA   Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA   Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA   Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA   Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide unique
RT   perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2]
RP   PROTEIN SEQUENCE OF 28-54.
RX   PubMed=7215543; DOI=10.1016/0014-5793(80)80398-x;
RA   McDonald T.J., Joernvall H., Ghatei M., Bloom S.R., Mutt V.;
RT   "Characterization of an avian gastric (proventricular) peptide having
RT   sequence homology with the porcine gastrin-releasing peptide and the
RT   amphibian peptides bombesin and alytesin.";
RL   FEBS Lett. 122:45-48(1980).
RN   [3]
RP   PROTEIN SEQUENCE OF 28-54, AMIDATION AT MET-54, AND FUNCTION.
RX   PubMed=2297533; DOI=10.1016/0167-4781(90)90023-u;
RA   Campbell B.J., Young J., Dimaline R., Dockray G.J.;
RT   "Isolation, sequence and biosynthetic significance of a novel fragment of
RT   gastrin-releasing peptide from chicken proventriculus.";
RL   Biochim. Biophys. Acta 1048:66-71(1990).
CC   -!- FUNCTION: Stimulates the release of gastrin and other gastrointestinal
CC       hormones (By similarity). Stimulates pancreatic protein and fluid
CC       secretion, and increases acid secretion from the avian proventriculus
CC       (PubMed:2297533). {ECO:0000250|UniProtKB:P63153,
CC       ECO:0000269|PubMed:2297533}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07492}.
CC       Cytoplasmic vesicle, secretory vesicle lumen
CC       {ECO:0000250|UniProtKB:Q863C3}.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
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DR   EMBL; AC191339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A01563; RHCHA.
DR   AlphaFoldDB; P01295; -.
DR   STRING; 9031.ENSGALP00000070188; -.
DR   PaxDb; 9031-ENSGALP00000070188; -.
DR   VEuPathDB; HostDB:geneid_425213; -.
DR   eggNOG; ENOG502S4DG; Eukaryota.
DR   HOGENOM; CLU_144892_0_0_1; -.
DR   InParanoid; P01295; -.
DR   OrthoDB; 9879745at2759; -.
DR   PRO; PR:P01295; -.
DR   Proteomes; UP000000539; Chromosome Z.
DR   Bgee; ENSGALG00000040959; Expressed in spermatocyte and 8 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0034774; C:secretory granule lumen; ISS:UniProtKB.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:2000987; P:positive regulation of behavioral fear response; IBA:GO_Central.
DR   GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISS:UniProtKB.
DR   GO; GO:1900738; P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR000874; Bombesin.
DR   PANTHER; PTHR16866; GASTRIN-RELEASING PEPTIDE; 1.
DR   PANTHER; PTHR16866:SF2; GASTRIN-RELEASING PEPTIDE; 1.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Cytoplasmic vesicle;
KW   Direct protein sequencing; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000269|PubMed:2297533,
FT                   ECO:0000269|PubMed:7215543"
FT   PEPTIDE         28..54
FT                   /note="Gastrin-releasing peptide"
FT                   /evidence="ECO:0000269|PubMed:2297533,
FT                   ECO:0000269|PubMed:7215543"
FT                   /id="PRO_0000223263"
FT   PEPTIDE         45..54
FT                   /note="Neuromedin-C"
FT                   /evidence="ECO:0000269|PubMed:2297533"
FT                   /id="PRO_0000003045"
FT   PROPEP          58..164
FT                   /evidence="ECO:0000269|PubMed:2297533,
FT                   ECO:0000269|PubMed:7215543"
FT                   /id="PRO_0000455541"
FT   MOD_RES         54
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:2297533"
SQ   SEQUENCE   164 AA;  17807 MW;  BE0365CB506B481A CRC64;
     MGGGGPRRPG TLPLLALLAL LAAHGGAAPL QPGGSPALTK IYPRGSHWAV GHLMGKKSTG
     DFPYAYEEEN KIPLSASPEN IKQLDDYLQR EEMSKHLLQL LEGNENKSAH FSKGGLPWHT
     RNSWETDDSS SWKDVSRTRC VSAFLTVTFC SKVAYQLCPT SALS
//