ID   CALCA_RAT               Reviewed;         128 AA.
AC   P01256;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   04-NOV-2026, entry version 164.
DE   RecName: Full=Calcitonin gene-related peptide 1;
DE            Short=CGRP1 {ECO:0000250|UniProtKB:P06881};
DE   AltName: Full=Alpha-type CGRP;
DE   AltName: Full=Calcitonin gene-related peptide I;
DE            Short=CGRP-I;
DE   Flags: Precursor;
GN   Name=Calca {ECO:0000312|RGD:2254}; Synonyms=Calc;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3872459; DOI=10.1073/pnas.82.7.1994;
RA   Jonas V., Lin C.R., Kawashima E., Semon D., Swanson L.W., Mermod J.-J.,
RA   Evans R.M., Rosenfeld M.G.;
RT   "Alternative RNA processing events in human calcitonin/calcitonin gene-
RT   related peptide gene expression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6283379; DOI=10.1038/298240a0;
RA   Amara S.G., Jonas V., Rosenfeld M.G., Ong E.S., Evans R.M.;
RT   "Alternative RNA processing in calcitonin gene expression generates mRNAs
RT   encoding different polypeptide products.";
RL   Nature 298:240-244(1982).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2994212; DOI=10.1126/science.2994212;
RA   Amara S.G., Arriza J.L., Leff S.E., Swanson L.W., Evans R.M.,
RA   Rosenfeld M.G.;
RT   "Expression in brain of a messenger RNA encoding a novel neuropeptide
RT   homologous to calcitonin gene-related peptide.";
RL   Science 229:1094-1097(1985).
CC   -!- FUNCTION: CGRP1/CALCA is a peptide hormone that induces vasodilation
CC       mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of
CC       vessels including the coronary, cerebral and systemic vasculature. Its
CC       abundance in the CNS also points toward a neurotransmitter or
CC       neuromodulator role. It also elevates platelet cAMP. CGRP1 can also
CC       bind and activate CALCR-RAMP1 (AMYR1) receptor complex.
CC       {ECO:0000250|UniProtKB:P06881}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P06881}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Calcitonin-gene related peptide I;
CC         IsoId=P01256-1; Sequence=Displayed;
CC       Name=Calcitonin;
CC         IsoId=P01257-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L29188; AAB59682.1; -; Genomic_DNA.
DR   EMBL; L00109; AAB59682.1; JOINED; Genomic_DNA.
DR   EMBL; L00110; AAB59682.1; JOINED; Genomic_DNA.
DR   EMBL; V01231; CAA24541.1; -; mRNA.
DR   EMBL; M11597; AAA40847.1; -; mRNA.
DR   PIR; A01524; TCRTR.
DR   PIR; B44173; B44173.
DR   RefSeq; NP_001029127.1; NM_001033955.1.
DR   RefSeq; NP_001029128.1; NM_001033956.1.
DR   BioGRID; 246427; 3.
DR   BindingDB; P01256; -.
DR   ChEMBL; CHEMBL5735; -.
DR   GeneID; 24241; -.
DR   KEGG; rno:24241; -.
DR   CTD; 796; -.
DR   AGR; RGD:2254; -.
DR   RGD; 2254; Calca.
DR   OMA; ALMKDYV; -.
DR   OrthoDB; 9929923at2759; -.
DR   Gene3D; 6.10.250.2190; -; 1.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505:SF3; CALCITONIN GENE-RELATED PEPTIDE 2; 1.
DR   PANTHER; PTHR10505; CALCITONIN-RELATED; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   Proteomes; UP000002494; Unplaced.
DR   ABCD; P01256; 1 sequenced antibody.
DR   AlphaFoldDB; P01256; -.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT   PROPEP          26..80
FT                   /id="PRO_0000004065"
FT   PEPTIDE         83..119
FT                   /note="Calcitonin gene-related peptide 1"
FT                   /id="PRO_0000004066"
FT   PROPEP          125..128
FT                   /id="PRO_0000004067"
FT   MOD_RES         119
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        84..89
FT                   /evidence="ECO:0000250|UniProtKB:P06881"
FT   CONFLICT        40
FT                   /note="Missing (in Ref. 2; AAB59682/CAA24541 and 3;
FT                   AAA40847)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        51
FT                   /note="Missing (in Ref. 2; AAB59682/CAA24541 and 3;
FT                   AAA40847)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        70
FT                   /note="Q -> EEQ (in Ref. 2; AAB59682/CAA24541 and 3;
FT                   AAA40847)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        99
FT                   /note="S -> R (in Ref. 3; AAA40847)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   128 AA;  13948 MW;  75D14869C17078D3 CRC64;
     MGFLKFSPFL VVSILLLYQA CGLQAVPLRS TLESSPGMAA TLSEEEARLL LAALVQNYMQ
     MKVRELEQEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR SGGVVKDNFV PTNVGSEAFG
     RRRRDLQA
//