ID   TRPC_ACIAD              Reviewed;         268 AA.
AC   P00911; Q6F9N1;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 2.
DT   10-JUN-2026, entry version 143.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; OrderedLocusNames=ACIAD2463;
OS   Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Moraxellales; Moraxellaceae; Acinetobacter.
OX   NCBI_TaxID=62977;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6599977; DOI=10.1093/oxfordjournals.molbev.a040331;
RA   Kaplan J.B., Goncharoff P., Seibold A.M., Nichols B.P.;
RT   "Nucleotide sequence of the Acinetobacter calcoaceticus trpGDC gene
RT   cluster.";
RL   Mol. Biol. Evol. 1:456-472(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33305 / BD413 / ADP1;
RX   PubMed=15514110; DOI=10.1093/nar/gkh910;
RA   Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L.,
RA   Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N.,
RA   Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT   "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1,
RT   a versatile and naturally transformation competent bacterium.";
RL   Nucleic Acids Res. 32:5766-5779(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG69233.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M36636; AAA21905.1; -; Genomic_DNA.
DR   EMBL; CR543861; CAG69233.1; ALT_INIT; Genomic_DNA.
DR   PIR; A01133; GWKECC.
DR   RefSeq; WP_004928449.1; NC_005966.1.
DR   AlphaFoldDB; P00911; -.
DR   SMR; P00911; -.
DR   STRING; 202950.GCA_001485005_01535; -.
DR   GeneID; 45234768; -.
DR   KEGG; aci:ACIAD2463; -.
DR   eggNOG; COG0134; Bacteria.
DR   HOGENOM; CLU_034247_2_0_6; -.
DR   OrthoDB; 9804217at2; -.
DR   BioCyc; ASP62977:ACIAD_RS11255-MONOMER; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000000430; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:TreeGrafter.
DR   GO; GO:0000162; P:L-tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   FunFam; 3.20.20.70:FF:000024; Indole-3-glycerol phosphate synthase; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   NCBIfam; NF001373; PRK00278.1-6; 1.
DR   NCBIfam; NF001377; PRK00278.2-4; 1.
DR   PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR   PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..268
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154205"
FT   CONFLICT        72
FT                   /note="A -> V (in Ref. 1; AAA21905)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   268 AA;  30189 MW;  50C41B42DBDE68AE CRC64;
     MIQIQNTILG KIVDRKHEEL ADRLKQRNLK DVEQWVKEAP PVRGFAQSLR SKRPGVIAEI
     KKASPSKGVI RADFNPAEIA QQYEQAGAAC LSVLTDVDFF QGADENIAIA RQHCSLPALR
     KDFLIDPYNV VEARALQADC ILLIVACLSD QQLEEMSKTA FEYDLDVLVE VHDEQELERA
     LKLSEQCLLG VNNRNLKTFD VDLNTSLRLK KLLDPSRLLV TESGIATPQD VQLMQEHDIH
     SFLVGESFMK QPRPDQAFTE LFGVPKLV
//