ID TRY1_BOVIN Reviewed; 246 AA. AC P00760; A6H6Y3; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 02-SEP-2008, sequence version 3. DT 04-NOV-2026, entry version 237. DE RecName: Full=Serine protease 1 {ECO:0000250|UniProtKB:P07477}; DE EC=3.4.21.4; DE AltName: Full=Anionic trypsin I {ECO:0000250|UniProtKB:P00762}; DE AltName: Full=Anionic trypsin-I {ECO:0000250|UniProtKB:P00762}; DE AltName: Full=Beta-trypsin; DE AltName: Full=Cationic trypsin; DE AltName: Full=Pretrypsinogen I {ECO:0000250|UniProtKB:P00762}; DE AltName: Full=Trypsin I {ECO:0000250|UniProtKB:P07477}; DE AltName: Full=Trypsin-I; DE Contains: DE RecName: Full=Alpha-trypsin chain 1; DE Contains: DE RecName: Full=Alpha-trypsin chain 2; DE Flags: Precursor; GN Name=PRSS1; Synonyms=TRP1, TRY1 {ECO:0000250|UniProtKB:P07477}, TRYP1; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Fetal pancreas; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 4-246. RC TISSUE=Pancreas; RA Okajima T., Maniwa M., Nagao S., Fujikawa H., Goto S.; RL Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases. RN [3] RP PROTEIN SEQUENCE OF 18-246, AND DISULFIDE BONDS. RX PubMed=5967094; DOI=10.1016/0006-291x(66)90162-8; RA Mikes O., Holeysovsky V., Tomasek V., Sorm F.; RT "Covalent structure of bovine trypsinogen. The position of the remaining RT amides."; RL Biochem. Biophys. Res. Commun. 24:346-352(1966). RN [4] RP SEQUENCE REVISION. RX PubMed=4399051; DOI=10.1098/rstb.1970.0010; RA Hartley B.S.; RT "Homologies in serine proteinases."; RL Philos. Trans. R. Soc. Lond., B, Biol. Sci. 257:77-87(1970). RN [5] RP SEQUENCE REVISION. RX PubMed=1092332; DOI=10.1021/bi00678a003; RA Titani K., Ericsson L.H., Neurath H., Walsh K.A.; RT "Amino acid sequence of dogfish trypsin."; RL Biochemistry 14:1358-1366(1975). RN [6] RP ABSENCE OF SULFATED TYROSINE. RX PubMed=17087724; DOI=10.1111/j.1742-4658.2006.05501.x; RA Sahin-Toth M., Kukor Z., Nemoda Z.; RT "Human cationic trypsinogen is sulfated on Tyr154."; RL FEBS J. 273:5044-5050(2006). RN [7] RP DISULFIDE BONDS. RX PubMed=5892911; DOI=10.1016/s0022-2836(65)80340-0; RA Kauffman D.L.; RT "The disulphide bridges of trypsin."; RL J. Mol. Biol. 12:929-932(1965). RN [8] RP INTERACTION WITH HUMAN SERPINA1. RX PubMed=11057674; DOI=10.1038/35038119; RA Huntington J.A., Read R.J., Carrell R.W.; RT "Structure of a serpin-protease complex shows inhibition by deformation."; RL Nature 407:923-926(2000). RN [9] RP X-RAY CRYSTALLOGRAPHY OF CALCIUM-BINDING SITE. RX PubMed=512; DOI=10.1016/s0022-2836(75)80005-2; RA Bode W., Schwager P.; RT "The refined crystal structure of bovine beta-trypsin at 1.8-A resolution. RT II. Crystallographic refinement, calcium binding site, benzamidine binding RT site and active site at pH 7.0."; RL J. Mol. Biol. 98:693-717(1975). RN [10] RP X-RAY CRYSTALLOGRAPHY. RX PubMed=556951; DOI=10.1021/bi00623a016; RA Kossiakoff A.A., Chambers J.L., Kay L.M., Stroud R.M.; RT "Structure of bovine trypsinogen at 1.9-A resolution."; RL Biochemistry 16:654-664(1977). RN [11] RP X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH V.HEDERIFOLIA TRYPSIN INHIBITOR, AND RP DISULFIDE BONDS. RX PubMed=17640870; DOI=10.1074/jbc.m703871200; RA Conners R., Konarev A.V., Forsyth J., Lovegrove A., Marsh J., RA Joseph-Horne T., Shewry P., Brady R.L.; RT "An unusual helix-turn-helix protease inhibitory motif in a novel trypsin RT inhibitor from seeds of Veronica (Veronica hederifolia L.)."; RL J. Biol. Chem. 282:27760-27768(2007). RN [12] RP X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH THE SNAKE VENOM PROTEASE INHIBITOR RP TEXTILININ-1, DISULFIDE BONDS, AND METAL-BINDING SITES GLU-75; ASN-77; RP VAL-80 AND GLU-85. RX PubMed=23335990; DOI=10.1371/journal.pone.0054104; RA Millers E.K., Johnson L.A., Birrell G.W., Masci P.P., Lavin M.F., RA de Jersey J., Guddat L.W.; RT "The structure of human microplasmin in complex with textilinin-1, an RT aprotinin-like inhibitor from the Australian brown snake."; RL PLoS ONE 8:E54104-E54104(2013). RN [13] {ECO:0000312|PDB:6MRQ} RP X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH VENOM SCORPION CYCLOTIDE TRYPSIN RP INHIBITOR TOPI1, ACTIVITY REGULATION, AND DISULFIDE BONDS. RC TISSUE=Telson; RX PubMed=32787139; DOI=10.1021/acs.jmedchem.0c00686; RA Mourao C.B.F., Brand G.D., Fernandes J.P.C., Prates M.V., Bloch C. Jr., RA Barbosa J.A.R.G., Freitas S.M., Restano-Cassulini R., Possani L.D., RA Schwartz E.F.; RT "Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom RT Peptide that Resembles Plant Cyclotides."; RL J. Med. Chem. 63:9500-9511(2020). CC -!- CATALYTIC ACTIVITY: CC Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Note=Binds 1 Ca(2+) ion per subunit.; CC -!- ACTIVITY REGULATION: Is inhibited by scorpion cyclotide trypsin CC inhibitor TopI1. {ECO:0000269|PubMed:32787139}. CC -!- SUBUNIT: Interacts with SERPINA1. {ECO:0000269|PubMed:11057674}. CC -!- INTERACTION: CC P00760; P00974; NbExp=4; IntAct=EBI-986385, EBI-1032263; CC P00760; P01009: SERPINA1; Xeno; NbExp=5; IntAct=EBI-986385, EBI-986224; CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space. CC -!- TISSUE SPECIFICITY: Synthesized in the acinar cells of the pancreas. CC -!- PTM: Autocatalytic cleavage after Lys-23 leads to beta-trypsin by CC releasing a terminal hexapeptide. Subsequent cleavage after Lys-148 CC leads to alpha-trypsin. Further cleavage after Lys-193 yields CC pseudotrypsin. A cleavage may also occur after Arg-122. CC -!- PTM: Not sulfated on tyrosine residue(s). CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE- CC ProRule:PRU00274}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC134797; AAI34798.1; -; mRNA. DR EMBL; BC146041; AAI46042.1; -; mRNA. DR EMBL; D38507; BAA07516.1; -; mRNA. DR PIR; A90164; TRBOTR. DR RefSeq; NP_001107199.1; NM_001113727.2. DR PDB; 1AQ7; X-ray; 2.20 A; A=24-246. DR PDB; 1AUJ; X-ray; 2.10 A; A=24-246. DR PDB; 1AZ8; X-ray; 1.80 A; A=24-246. DR PDB; 1BJU; X-ray; 1.80 A; A=24-246. DR PDB; 1BJV; X-ray; 1.80 A; A=24-246. DR PDB; 1BTP; X-ray; 2.20 A; A=18-246. DR PDB; 1BTW; X-ray; 1.70 A; A=18-246. DR PDB; 1BTX; X-ray; 1.70 A; A=18-246. DR PDB; 1BTY; X-ray; 1.50 A; A=18-246. DR PDB; 1BTZ; X-ray; 2.00 A; A=18-246. DR PDB; 1C1N; X-ray; 1.40 A; A=24-246. DR PDB; 1C1O; X-ray; 1.40 A; A=24-246. DR PDB; 1C1P; X-ray; 1.37 A; A=24-246. DR PDB; 1C1Q; X-ray; 1.37 A; A=24-246. DR PDB; 1C1R; X-ray; 1.37 A; A=24-246. DR PDB; 1C1S; X-ray; 1.63 A; A=24-246. DR PDB; 1C1T; X-ray; 1.37 A; A=24-246. DR PDB; 1C2D; X-ray; 1.65 A; A=24-246. DR PDB; 1C2E; X-ray; 1.65 A; A=24-246. DR PDB; 1C2F; X-ray; 1.70 A; A=24-246. DR PDB; 1C2G; X-ray; 1.65 A; A=24-246. DR PDB; 1C2H; X-ray; 1.40 A; A=24-246. DR PDB; 1C2I; X-ray; 1.47 A; A=24-246. DR PDB; 1C2J; X-ray; 1.40 A; A=24-246. DR PDB; 1C2K; X-ray; 1.65 A; A=24-246. DR PDB; 1C2L; X-ray; 1.50 A; A=24-246. DR PDB; 1C2M; X-ray; 1.40 A; A=24-246. DR PDB; 1C5P; X-ray; 1.43 A; A=24-246. DR PDB; 1C5Q; X-ray; 1.43 A; A=24-246. DR PDB; 1C5R; X-ray; 1.47 A; A=24-246. DR PDB; 1C5S; X-ray; 1.36 A; A=24-246. DR PDB; 1C5T; X-ray; 1.37 A; A=24-246. DR PDB; 1C5U; X-ray; 1.37 A; A=24-246. DR PDB; 1C5V; X-ray; 1.48 A; A=24-246. DR PDB; 1C9T; X-ray; 3.30 A; A/B/C/D/E/F=24-246. DR PDB; 1CE5; X-ray; 1.90 A; A=24-246. DR PDB; 1D6R; X-ray; 2.30 A; A=24-246. DR PDB; 1EB2; X-ray; 2.00 A; A=24-246. DR PDB; 1EJM; X-ray; 1.85 A; A/C/E=24-246. DR PDB; 1EZX; X-ray; 2.60 A; C=4-246. DR PDB; 1F0T; X-ray; 1.80 A; A=4-246. DR PDB; 1F0U; X-ray; 1.90 A; A=4-246. DR PDB; 1F2S; X-ray; 1.79 A; E=24-246. DR PDB; 1G36; X-ray; 1.90 A; A=24-246. DR PDB; 1G3B; X-ray; 1.80 A; A=19-246. DR PDB; 1G3C; X-ray; 1.80 A; A=19-246. DR PDB; 1G3D; X-ray; 1.80 A; A=19-246. DR PDB; 1G3E; X-ray; 1.80 A; A=19-246. DR PDB; 1G9I; X-ray; 2.20 A; E=24-246. DR PDB; 1GBT; X-ray; 2.00 A; A=24-246. DR PDB; 1GHZ; X-ray; 1.39 A; A=24-246. DR PDB; 1GI0; X-ray; 1.42 A; A=24-246. DR PDB; 1GI1; X-ray; 1.42 A; A=24-246. DR PDB; 1GI2; X-ray; 1.38 A; A=24-246. DR PDB; 1GI3; X-ray; 1.44 A; A=24-246. DR PDB; 1GI4; X-ray; 1.37 A; A=24-246. DR PDB; 1GI5; X-ray; 1.60 A; A=24-246. DR PDB; 1GI6; X-ray; 1.49 A; A=24-246. DR PDB; 1GJ6; X-ray; 1.50 A; A=24-246. DR PDB; 1HJ9; X-ray; 0.95 A; A=24-246. DR PDB; 1J8A; X-ray; 1.21 A; A=24-246. DR PDB; 1JIR; X-ray; 2.00 A; A=24-246. DR PDB; 1JRS; X-ray; 1.80 A; A=24-246. DR PDB; 1JRT; X-ray; 1.70 A; A=24-246. DR PDB; 1K1I; X-ray; 2.20 A; A=24-246. DR PDB; 1K1J; X-ray; 2.20 A; A=24-246. DR PDB; 1K1L; X-ray; 2.50 A; A=24-246. DR PDB; 1K1M; X-ray; 2.20 A; A=24-246. DR PDB; 1K1N; X-ray; 2.00 A; A=24-246. DR PDB; 1K1O; X-ray; 2.00 A; A=24-246. DR PDB; 1K1P; X-ray; 1.90 A; A=24-246. DR PDB; 1LQE; X-ray; 2.20 A; A=4-246. DR PDB; 1MAX; X-ray; 1.80 A; A=24-246. DR PDB; 1MAY; X-ray; 1.80 A; A=24-246. DR PDB; 1MTS; X-ray; 1.90 A; A=24-246. DR PDB; 1MTU; X-ray; 1.90 A; A=24-246. DR PDB; 1MTV; X-ray; 1.90 A; A=24-246. DR PDB; 1MTW; X-ray; 1.90 A; A=24-246. DR PDB; 1N6X; X-ray; 1.40 A; A=24-246. DR PDB; 1N6Y; X-ray; 1.40 A; A=24-246. DR PDB; 1NC6; X-ray; 1.90 A; A=24-246. DR PDB; 1NTP; Neutron; 1.80 A; A=24-246. DR PDB; 1O2H; X-ray; 1.77 A; A=24-246. DR PDB; 1O2I; X-ray; 1.50 A; A=24-246. DR PDB; 1O2J; X-ray; 1.65 A; A=24-246. DR PDB; 1O2K; X-ray; 1.63 A; A=24-246. DR PDB; 1O2L; X-ray; 1.68 A; A=24-246. DR PDB; 1O2M; X-ray; 1.69 A; A=24-246. DR PDB; 1O2N; X-ray; 1.50 A; A=24-246. DR PDB; 1O2O; X-ray; 1.63 A; A=24-246. DR PDB; 1O2P; X-ray; 1.47 A; A=24-246. DR PDB; 1O2Q; X-ray; 1.50 A; A=24-246. DR PDB; 1O2R; X-ray; 1.45 A; A=24-246. DR PDB; 1O2S; X-ray; 1.65 A; A=24-246. DR PDB; 1O2T; X-ray; 1.62 A; A=24-246. DR PDB; 1O2U; X-ray; 1.41 A; A=24-246. DR PDB; 1O2V; X-ray; 1.50 A; A=24-246. DR PDB; 1O2W; X-ray; 1.38 A; A=24-246. DR PDB; 1O2X; X-ray; 1.46 A; A=24-246. DR PDB; 1O2Y; X-ray; 1.45 A; A=24-246. DR PDB; 1O2Z; X-ray; 1.65 A; A=24-246. DR PDB; 1O30; X-ray; 1.55 A; A=24-246. DR PDB; 1O31; X-ray; 1.66 A; A=24-246. DR PDB; 1O32; X-ray; 1.78 A; A=24-246. DR PDB; 1O33; X-ray; 1.46 A; A=24-246. DR PDB; 1O34; X-ray; 1.50 A; A=24-246. DR PDB; 1O35; X-ray; 1.41 A; A=24-246. DR PDB; 1O36; X-ray; 1.70 A; A=24-246. DR PDB; 1O37; X-ray; 1.45 A; A=24-246. DR PDB; 1O38; X-ray; 1.38 A; A=24-246. DR PDB; 1O39; X-ray; 1.59 A; A=24-246. DR PDB; 1O3A; X-ray; 2.00 A; A=24-246. DR PDB; 1O3B; X-ray; 1.75 A; A=24-246. DR PDB; 1O3C; X-ray; 1.64 A; A=24-246. DR PDB; 1O3D; X-ray; 1.33 A; A=24-246. DR PDB; 1O3E; X-ray; 1.64 A; A=24-246. DR PDB; 1O3F; X-ray; 1.55 A; A=24-246. DR PDB; 1O3G; X-ray; 1.55 A; A=24-246. DR PDB; 1O3H; X-ray; 1.53 A; A=24-246. DR PDB; 1O3I; X-ray; 1.51 A; A=24-246. DR PDB; 1O3J; X-ray; 1.40 A; A=24-246. DR PDB; 1O3K; X-ray; 1.43 A; A=24-246. DR PDB; 1O3L; X-ray; 1.40 A; A=24-246. DR PDB; 1O3M; X-ray; 1.55 A; A=24-246. DR PDB; 1O3N; X-ray; 1.55 A; A=24-246. DR PDB; 1O3O; X-ray; 1.55 A; A=24-246. DR PDB; 1OPH; X-ray; 2.30 A; B=4-246. DR PDB; 1OX1; X-ray; 2.00 A; A=24-246. DR PDB; 1OYQ; X-ray; 1.90 A; A=24-246. DR PDB; 1P2I; X-ray; 1.65 A; A=24-246. DR PDB; 1P2J; X-ray; 1.35 A; A=24-246. DR PDB; 1P2K; X-ray; 1.60 A; A=24-246. DR PDB; 1PPC; X-ray; 1.80 A; E=24-246. DR PDB; 1PPE; X-ray; 2.00 A; E=24-246. DR PDB; 1PPH; X-ray; 1.90 A; E=24-246. DR PDB; 1QA0; X-ray; 1.80 A; A=24-246. DR PDB; 1QB1; X-ray; 1.80 A; A=24-246. DR PDB; 1QB6; X-ray; 1.80 A; A=24-246. DR PDB; 1QB9; X-ray; 1.80 A; A=24-246. DR PDB; 1QBN; X-ray; 1.80 A; A=24-246. DR PDB; 1QBO; X-ray; 1.80 A; A=24-246. DR PDB; 1QCP; X-ray; 1.80 A; A=24-246. DR PDB; 1QL7; X-ray; 2.10 A; A=24-246. DR PDB; 1QL8; X-ray; 3.00 A; A=24-246. DR PDB; 1RXP; X-ray; 1.70 A; A=24-246. DR PDB; 1S0Q; X-ray; 1.02 A; A=24-246. DR PDB; 1S0R; X-ray; 1.02 A; A=24-246. DR PDB; 1SBW; X-ray; 1.80 A; A=24-246. DR PDB; 1SFI; X-ray; 1.65 A; A=24-246. DR PDB; 1SMF; X-ray; 2.10 A; E=24-246. DR PDB; 1TAB; X-ray; 2.30 A; E=24-246. DR PDB; 1TAW; X-ray; 1.80 A; A=24-246. DR PDB; 1TGB; X-ray; 1.80 A; A=18-246. DR PDB; 1TGC; X-ray; 1.80 A; A=18-246. DR PDB; 1TGN; X-ray; 1.65 A; A=18-246. DR PDB; 1TGS; X-ray; 1.80 A; Z=18-246. DR PDB; 1TGT; X-ray; 1.70 A; A=18-246. DR PDB; 1TIO; X-ray; 1.93 A; A=24-246. DR PDB; 1TLD; X-ray; 1.50 A; A=24-246. DR PDB; 1TNG; X-ray; 1.80 A; A=18-246. DR PDB; 1TNH; X-ray; 1.80 A; A=18-246. DR PDB; 1TNI; X-ray; 1.90 A; A=18-246. DR PDB; 1TNJ; X-ray; 1.80 A; A=18-246. DR PDB; 1TNK; X-ray; 1.80 A; A=18-246. DR PDB; 1TNL; X-ray; 1.90 A; A=18-246. DR PDB; 1TPA; X-ray; 1.90 A; E=24-246. DR PDB; 1TPO; X-ray; 1.70 A; A=24-246. DR PDB; 1TPP; X-ray; 1.40 A; A=24-246. DR PDB; 1TPS; X-ray; 1.90 A; A=24-246. DR PDB; 1TX7; X-ray; 1.75 A; A=24-246. DR PDB; 1TX8; X-ray; 1.70 A; A=24-246. DR PDB; 1TYN; X-ray; 2.00 A; A=24-246. DR PDB; 1UTN; X-ray; 1.15 A; A=4-246. DR PDB; 1UTO; X-ray; 1.15 A; A=4-246. DR PDB; 1UTP; X-ray; 1.30 A; A=4-246. DR PDB; 1UTQ; X-ray; 1.15 A; A=4-246. DR PDB; 1V2J; X-ray; 1.90 A; T=24-246. DR PDB; 1V2K; X-ray; 2.00 A; T=24-246. DR PDB; 1V2L; X-ray; 1.60 A; T=24-246. DR PDB; 1V2M; X-ray; 1.65 A; T=24-246. DR PDB; 1V2N; X-ray; 1.80 A; T=24-246. DR PDB; 1V2O; X-ray; 1.62 A; T=24-246. DR PDB; 1V2P; X-ray; 1.92 A; T=24-246. DR PDB; 1V2Q; X-ray; 2.30 A; T=24-246. DR PDB; 1V2R; X-ray; 1.70 A; T=24-246. DR PDB; 1V2S; X-ray; 1.72 A; T=24-246. DR PDB; 1V2T; X-ray; 1.90 A; T=24-246. DR PDB; 1V2U; X-ray; 1.80 A; T=24-246. DR PDB; 1V2V; X-ray; 1.80 A; T=24-246. DR PDB; 1V2W; X-ray; 1.75 A; T=24-246. DR PDB; 1XUF; X-ray; 1.90 A; A=24-246. DR PDB; 1XUG; X-ray; 1.50 A; A=24-246. DR PDB; 1XUH; X-ray; 2.20 A; A=24-246. DR PDB; 1XUI; X-ray; 1.50 A; A=24-246. DR PDB; 1XUJ; X-ray; 1.92 A; A=24-246. DR PDB; 1XUK; X-ray; 1.80 A; A=24-246. DR PDB; 1Y3U; X-ray; 1.80 A; A=24-246. DR PDB; 1Y3V; X-ray; 1.60 A; A=24-246. DR PDB; 1Y3W; X-ray; 1.80 A; A=24-246. DR PDB; 1Y3X; X-ray; 1.70 A; A=24-246. DR PDB; 1Y3Y; X-ray; 1.75 A; A=24-246. DR PDB; 1Y59; X-ray; 1.20 A; T=24-246. DR PDB; 1Y5A; X-ray; 1.40 A; T=24-246. DR PDB; 1Y5B; X-ray; 1.65 A; T=24-246. DR PDB; 1Y5U; X-ray; 1.60 A; T=24-246. DR PDB; 1YP9; X-ray; 2.10 A; A=24-246. DR PDB; 1YYY; X-ray; 2.10 A; 1=24-246. DR PDB; 1ZR0; X-ray; 1.80 A; A/C=24-246. DR PDB; 1ZZZ; X-ray; 1.90 A; A=10-246. DR PDB; 2A7H; X-ray; 2.10 A; A=24-246. DR PDB; 2AGE; X-ray; 1.15 A; X=24-246. DR PDB; 2AGG; X-ray; 1.28 A; X=24-246. DR PDB; 2AGI; X-ray; 1.14 A; X=24-246. DR PDB; 2AH4; X-ray; 1.13 A; X=24-246. DR PDB; 2AYW; X-ray; 0.97 A; A=24-246. DR PDB; 2BLV; X-ray; 1.20 A; A=24-246. DR PDB; 2BLW; X-ray; 1.20 A; A=24-246. DR PDB; 2BTC; X-ray; 1.50 A; E=24-246. DR PDB; 2BY5; X-ray; 1.30 A; X=4-246. DR PDB; 2BY6; X-ray; 1.30 A; X=4-246. DR PDB; 2BY7; X-ray; 1.30 A; X=4-246. DR PDB; 2BY8; X-ray; 1.30 A; X=4-246. DR PDB; 2BY9; X-ray; 1.30 A; X=4-246. DR PDB; 2BYA; X-ray; 1.30 A; X=4-246. DR PDB; 2BZA; X-ray; 1.90 A; A=24-246. DR PDB; 2CMY; X-ray; 2.25 A; A=24-246. DR PDB; 2D8W; X-ray; 2.00 A; A=24-246. DR PDB; 2F3C; X-ray; 2.50 A; E=24-246. DR PDB; 2FI3; X-ray; 1.58 A; E=24-246. DR PDB; 2FI4; X-ray; 1.58 A; E=24-246. DR PDB; 2FI5; X-ray; 1.58 A; E=24-246. DR PDB; 2FTL; X-ray; 1.62 A; E=24-246. DR PDB; 2FTM; X-ray; 1.65 A; A=24-246. DR PDB; 2FX4; X-ray; 1.65 A; A=24-246. DR PDB; 2FX6; X-ray; 1.57 A; A=24-246. DR PDB; 2G55; X-ray; 1.82 A; A=24-246. DR PDB; 2G5N; X-ray; 1.51 A; A=24-246. DR PDB; 2G5V; X-ray; 1.45 A; A=24-246. DR PDB; 2G81; X-ray; 1.55 A; E=24-246. DR PDB; 2G8T; X-ray; 1.41 A; A=24-246. DR PDB; 2ILN; X-ray; 2.00 A; A/B=24-246. DR PDB; 2J9N; X-ray; 1.50 A; A=24-246. DR PDB; 2O9Q; X-ray; 1.70 A; A=24-246. DR PDB; 2OTV; X-ray; 1.56 A; A=24-246. DR PDB; 2OXS; X-ray; 1.32 A; A=24-246. DR PDB; 2PLX; X-ray; 1.56 A; A=24-246. DR PDB; 2PTC; X-ray; 1.90 A; E=24-246. DR PDB; 2PTN; X-ray; 1.55 A; A=24-246. DR PDB; 2QN5; X-ray; 3.00 A; T=24-246. DR PDB; 2QYI; X-ray; 2.60 A; A/C=24-246. DR PDB; 2TGA; X-ray; 1.80 A; A=18-246. DR PDB; 2TGD; X-ray; 2.10 A; A=18-246. DR PDB; 2TGP; X-ray; 1.90 A; Z=18-246. DR PDB; 2TGT; X-ray; 1.70 A; A=18-246. DR PDB; 2TIO; X-ray; 1.93 A; A=24-246. DR PDB; 2TLD; X-ray; 2.60 A; E=24-246. DR PDB; 2TPI; X-ray; 2.10 A; Z=18-246. DR PDB; 2UUY; X-ray; 1.15 A; A=24-246. DR PDB; 2XTT; X-ray; 0.93 A; B=24-246. DR PDB; 2ZDK; X-ray; 1.67 A; A=24-246. DR PDB; 2ZDL; X-ray; 1.80 A; A=24-246. DR PDB; 2ZDM; X-ray; 1.93 A; A=24-246. DR PDB; 2ZDN; X-ray; 1.98 A; A=24-246. DR PDB; 2ZFS; X-ray; 1.51 A; A=24-246. DR PDB; 2ZFT; X-ray; 1.76 A; A=24-246. DR PDB; 2ZHD; X-ray; 1.94 A; A=24-246. DR PDB; 2ZQ1; X-ray; 1.68 A; A=24-246. DR PDB; 2ZQ2; X-ray; 1.40 A; A=24-246. DR PDB; 3A7T; X-ray; 1.75 A; A=24-246. DR PDB; 3A7V; X-ray; 1.75 A; A=24-246. DR PDB; 3A7W; X-ray; 1.75 A; A=24-246. DR PDB; 3A7X; X-ray; 1.75 A; A=24-246. DR PDB; 3A7Y; X-ray; 1.81 A; A=24-246. DR PDB; 3A7Z; X-ray; 1.80 A; A=24-246. DR PDB; 3A80; X-ray; 1.75 A; A=24-246. DR PDB; 3A81; X-ray; 1.78 A; A=24-246. DR PDB; 3A82; X-ray; 1.75 A; A=24-246. DR PDB; 3A83; X-ray; 1.78 A; A=24-246. DR PDB; 3A84; X-ray; 1.75 A; A=24-246. DR PDB; 3A85; X-ray; 1.75 A; A=24-246. DR PDB; 3A86; X-ray; 1.75 A; A=24-246. DR PDB; 3A87; X-ray; 1.75 A; A=24-246. DR PDB; 3A88; X-ray; 1.75 A; A=24-246. DR PDB; 3A89; X-ray; 1.80 A; A=24-246. DR PDB; 3A8A; X-ray; 1.40 A; A=24-246. DR PDB; 3A8B; X-ray; 1.75 A; A=24-246. DR PDB; 3A8C; X-ray; 1.85 A; A=24-246. DR PDB; 3A8D; X-ray; 1.75 A; A=24-246. DR PDB; 3AAS; X-ray; 1.75 A; A=24-246. DR PDB; 3AAU; X-ray; 1.80 A; A=24-246. DR PDB; 3AAV; X-ray; 1.70 A; A/B=24-246. DR PDB; 3ATI; X-ray; 1.71 A; A=24-246. DR PDB; 3ATK; X-ray; 1.74 A; A=24-246. DR PDB; 3ATL; X-ray; 1.74 A; A=24-246. DR PDB; 3ATM; X-ray; 1.72 A; A=24-246. DR PDB; 3BTD; X-ray; 1.90 A; E=24-246. DR PDB; 3BTE; X-ray; 1.85 A; E=24-246. DR PDB; 3BTF; X-ray; 1.80 A; E=24-246. DR PDB; 3BTG; X-ray; 1.90 A; E=24-246. DR PDB; 3BTH; X-ray; 1.75 A; E=24-246. DR PDB; 3BTK; X-ray; 1.85 A; E=24-246. DR PDB; 3BTM; X-ray; 1.80 A; E=24-246. DR PDB; 3BTQ; X-ray; 1.90 A; E=24-246. DR PDB; 3BTT; X-ray; 1.90 A; E=24-246. DR PDB; 3BTW; X-ray; 2.05 A; E=24-246. DR PDB; 3D65; X-ray; 1.64 A; E=24-246. DR PDB; 3E8L; X-ray; 2.48 A; A/B=24-246. DR PDB; 3GY2; X-ray; 1.57 A; A=24-246. DR PDB; 3GY3; X-ray; 1.70 A; A=24-246. DR PDB; 3GY4; X-ray; 1.55 A; A=24-246. DR PDB; 3GY5; X-ray; 1.57 A; A=24-246. DR PDB; 3GY6; X-ray; 1.70 A; A=24-246. DR PDB; 3GY7; X-ray; 1.55 A; A=24-246. DR PDB; 3GY8; X-ray; 1.75 A; A=24-246. DR PDB; 3I29; X-ray; 2.40 A; A=24-246. DR PDB; 3ITI; X-ray; 1.55 A; A=24-246. DR PDB; 3LJJ; X-ray; 1.55 A; A=24-246. DR PDB; 3LJO; X-ray; 1.50 A; A=24-246. DR PDB; 3M35; X-ray; 2.20 A; A=24-246. DR PDB; 3M7Q; X-ray; 1.70 A; A=24-246. DR PDB; 3MFJ; X-ray; 0.80 A; A=24-246. DR PDB; 3MI4; X-ray; 0.80 A; A=24-246. DR PDB; 3NK8; X-ray; 1.15 A; A=24-246. DR PDB; 3NKK; X-ray; 1.12 A; A=24-246. DR PDB; 3OTJ; Other; 2.15 A; E=24-246. DR PDB; 3PLB; X-ray; 1.18 A; A=24-246. DR PDB; 3PLK; X-ray; 1.53 A; A=24-246. DR PDB; 3PLP; X-ray; 1.63 A; A=24-246. DR PDB; 3PM3; X-ray; 1.53 A; A=24-246. DR PDB; 3PMJ; X-ray; 1.45 A; A=24-246. DR PDB; 3PTB; X-ray; 1.70 A; A=24-246. DR PDB; 3PTN; X-ray; 1.70 A; A=24-246. DR PDB; 3PWB; X-ray; 1.63 A; A=24-246. DR PDB; 3PWC; X-ray; 1.60 A; A=24-246. DR PDB; 3PYH; X-ray; 2.00 A; A=24-246. DR PDB; 3Q00; X-ray; 1.70 A; A=24-246. DR PDB; 3QK1; X-ray; 2.08 A; A=24-246. DR PDB; 3RDZ; X-ray; 2.26 A; A/B=24-246. DR PDB; 3RU4; X-ray; 1.68 A; T=24-246. DR PDB; 3RXA; X-ray; 1.70 A; A=24-246. DR PDB; 3RXB; X-ray; 1.70 A; A=24-246. DR PDB; 3RXC; X-ray; 1.70 A; A=24-246. DR PDB; 3RXD; X-ray; 1.70 A; A=24-246. DR PDB; 3RXE; X-ray; 1.70 A; A=24-246. DR PDB; 3RXF; X-ray; 1.70 A; A=24-246. DR PDB; 3RXG; X-ray; 1.70 A; A=24-246. DR PDB; 3RXH; X-ray; 1.70 A; A=24-246. DR PDB; 3RXI; X-ray; 1.60 A; A=24-246. DR PDB; 3RXJ; X-ray; 1.70 A; A=24-246. DR PDB; 3RXK; X-ray; 1.60 A; A=24-246. DR PDB; 3RXL; X-ray; 1.70 A; A=24-246. DR PDB; 3RXM; X-ray; 1.70 A; A=24-246. DR PDB; 3RXO; X-ray; 1.60 A; A=24-246. DR PDB; 3RXP; X-ray; 1.60 A; A=24-246. DR PDB; 3RXQ; X-ray; 1.68 A; A=24-246. DR PDB; 3RXR; X-ray; 1.72 A; A=24-246. DR PDB; 3RXS; X-ray; 1.74 A; A=24-246. DR PDB; 3RXT; X-ray; 1.70 A; A=24-246. DR PDB; 3RXU; X-ray; 1.68 A; A=24-246. DR PDB; 3RXV; X-ray; 1.70 A; A=24-246. DR PDB; 3T25; X-ray; 1.70 A; A=24-246. DR PDB; 3T26; X-ray; 1.70 A; A=24-246. DR PDB; 3T27; X-ray; 1.95 A; A=24-246. DR PDB; 3T28; X-ray; 2.80 A; A=24-246. DR PDB; 3T29; X-ray; 1.75 A; A=24-246. DR PDB; 3TPI; X-ray; 1.90 A; Z=18-246. DR PDB; 3UNQ; X-ray; 1.62 A; A=24-246. DR PDB; 3UNS; X-ray; 1.80 A; A=24-246. DR PDB; 3UOP; X-ray; 1.69 A; A=24-246. DR PDB; 3UPE; X-ray; 1.54 A; A=24-246. DR PDB; 3UQO; X-ray; 1.80 A; A=24-246. DR PDB; 3UQV; X-ray; 2.40 A; A=24-246. DR PDB; 3UUZ; X-ray; 2.10 A; A/B=24-246. DR PDB; 3UWI; X-ray; 1.43 A; A=24-246. DR PDB; 3UY9; X-ray; 3.22 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=24-246. DR PDB; 3V0X; X-ray; 1.90 A; A=24-246. DR PDB; 3V12; X-ray; 1.80 A; A=24-246. DR PDB; 3V13; X-ray; 1.63 A; A=24-246. DR PDB; 3VEQ; X-ray; 2.25 A; B=24-246. DR PDB; 3VPK; X-ray; 1.94 A; A=24-246. DR PDB; 4AB8; X-ray; 1.60 A; A=24-246. DR PDB; 4AB9; X-ray; 1.20 A; A=24-246. DR PDB; 4ABA; X-ray; 1.25 A; A=24-246. DR PDB; 4ABB; X-ray; 1.25 A; A=24-246. DR PDB; 4ABD; X-ray; 1.25 A; A=24-246. DR PDB; 4ABE; X-ray; 1.30 A; A=24-246. DR PDB; 4ABF; X-ray; 1.30 A; A=24-246. DR PDB; 4ABG; X-ray; 1.52 A; A=24-246. DR PDB; 4ABH; X-ray; 1.25 A; A=24-246. DR PDB; 4ABI; X-ray; 1.55 A; A=24-246. DR PDB; 4ABJ; X-ray; 1.45 A; A=24-246. DR PDB; 4AOQ; X-ray; 2.00 A; A/B/C=24-246. DR PDB; 4AOR; X-ray; 1.70 A; A/B/C=24-246. DR PDB; 4B1T; X-ray; 1.78 A; A/C=24-246. DR PDB; 4B2A; X-ray; 1.89 A; A/C=24-246. DR PDB; 4B2B; X-ray; 1.36 A; A/C=24-246. DR PDB; 4B2C; X-ray; 1.43 A; A/C=24-246. DR PDB; 4GUX; X-ray; 1.80 A; A/B/C=1-246. DR PDB; 4HGC; X-ray; 1.29 A; A=24-246. DR PDB; 4I8G; X-ray; 0.80 A; A=24-246. DR PDB; 4I8H; X-ray; 0.75 A; A=24-246. DR PDB; 4I8J; X-ray; 0.87 A; A=24-246. DR PDB; 4I8K; X-ray; 0.85 A; A=24-246. DR PDB; 4I8L; X-ray; 0.87 A; A=24-246. DR PDB; 4J2Y; X-ray; 2.00 A; B=24-246. DR PDB; 4KTS; X-ray; 1.30 A; A=24-246. DR PDB; 4KTU; X-ray; 1.35 A; A=24-246. DR PDB; 4MTB; X-ray; 1.22 A; A=24-246. DR PDB; 4NCY; X-ray; 1.42 A; A=24-246. DR PDB; 4NIV; X-ray; 1.00 A; A=24-246. DR PDB; 4NIW; X-ray; 1.31 A; A=24-246. DR PDB; 4NIX; X-ray; 1.30 A; A=24-246. DR PDB; 4NIY; X-ray; 2.84 A; A/B/C/D=24-246. DR PDB; 4TPI; X-ray; 2.20 A; Z=18-246. DR PDB; 4TPY; X-ray; 1.30 A; A=24-246. DR PDB; 4U2W; X-ray; 1.00 A; A=24-246. DR PDB; 4XOJ; X-ray; 0.91 A; A=1-246. DR PDB; 4Y0Y; X-ray; 1.25 A; E=24-246. DR PDB; 4Y0Z; X-ray; 1.37 A; E=24-246. DR PDB; 4Y10; X-ray; 1.37 A; E=24-246. DR PDB; 4Y11; X-ray; 1.30 A; E=24-246. DR PDB; 4YTA; X-ray; 1.20 A; A=24-246. DR PDB; 5EG4; X-ray; 1.32 A; A=24-246. DR PDB; 5F6M; X-ray; 1.10 A; A=24-246. DR PDB; 5FXL; X-ray; 1.78 A; A=1-246. DR PDB; 5GIB; X-ray; 2.70 A; A/B=24-246. DR PDB; 5GXP; X-ray; 2.80 A; A/B=24-246. DR PDB; 5JYI; X-ray; 1.91 A; A=1-246. DR PDB; 5K7R; EM; 1.70 A; A=24-246. DR PDB; 5LGO; X-ray; 1.12 A; A=24-246. DR PDB; 5LH4; X-ray; 1.37 A; A=24-246. DR PDB; 5LH8; X-ray; 1.54 A; A=24-246. DR PDB; 5MN1; X-ray; 0.79 A; A=24-246. DR PDB; 5MNA; X-ray; 1.44 A; A=24-246. DR PDB; 5MNB; X-ray; 0.94 A; A=24-246. DR PDB; 5MNC; X-ray; 0.92 A; A=24-246. DR PDB; 5MNE; X-ray; 1.01 A; A=24-246. DR PDB; 5MNF; X-ray; 0.99 A; A=24-246. DR PDB; 5MNG; X-ray; 0.86 A; A=24-246. DR PDB; 5MNH; X-ray; 0.93 A; A=24-246. DR PDB; 5MNK; X-ray; 0.80 A; A=24-246. DR PDB; 5MNL; X-ray; 1.04 A; A=24-246. DR PDB; 5MNM; X-ray; 0.98 A; A=24-246. DR PDB; 5MNN; X-ray; 0.86 A; A=24-246. DR PDB; 5MNO; X-ray; 0.96 A; A=24-246. DR PDB; 5MNP; X-ray; 1.01 A; A=24-246. DR PDB; 5MNQ; X-ray; 1.34 A; A=24-246. DR PDB; 5MNX; Neutron; 1.42 A; A=24-246. DR PDB; 5MNY; Neutron; 1.43 A; A=24-246. DR PDB; 5MNZ; Neutron; 1.45 A; A=24-246. DR PDB; 5MO0; Neutron; 1.50 A; A=24-246. DR PDB; 5MO1; Neutron; 1.49 A; A=24-246. DR PDB; 5MO2; Neutron; 1.50 A; A=24-246. DR PDB; 5MON; Other; 0.94 A; A=24-246. DR PDB; 5MOO; Other; 1.44 A; A=24-246. DR PDB; 5MOP; Other; 0.99 A; A=24-246. DR PDB; 5MOQ; Other; 0.93 A; A=24-246. DR PDB; 5MOR; Other; 0.98 A; A=24-246. DR PDB; 5MOS; Other; 0.96 A; A=24-246. DR PDB; 5PTP; X-ray; 1.34 A; A=24-246. DR PDB; 5T3H; X-ray; 1.55 A; A=24-246. DR PDB; 6AVL; X-ray; 2.00 A; A=24-246. DR PDB; 6B6N; X-ray; 2.00 A; A=24-246. DR PDB; 6B6O; X-ray; 2.40 A; A=24-246. DR PDB; 6B6P; X-ray; 2.00 A; A=24-246. DR PDB; 6B6Q; X-ray; 2.00 A; A=24-246. DR PDB; 6B6R; X-ray; 2.00 A; A=24-246. DR PDB; 6B6S; X-ray; 2.00 A; A=24-246. DR PDB; 6B6T; X-ray; 2.00 A; A=24-246. DR PDB; 6BFP; X-ray; 1.29 A; A=24-246. DR PDB; 6BVH; X-ray; 1.93 A; A=24-246. DR PDB; 6DWF; X-ray; 1.94 A; A/B/C/D/E/F=24-246. DR PDB; 6DWH; X-ray; 2.00 A; A/B/C/D/E/F=24-246. DR PDB; 6DWR; X-ray; 1.32 A; A=24-246. DR PDB; 6DWU; X-ray; 3.96 A; AA/AC/AE/AG/AI/AK/AM/AO/AQ/AS/AU/BA/BC/BE/BG/BI/BK/BM/BO/BQ/BS/BU/CA/CC/CE/CG/CI/CK/CM/CO=24-246. DR PDB; 6DZF; X-ray; 2.20 A; A=24-246. DR PDB; 6E5M; X-ray; 1.61 A; A=24-246. DR PDB; 6EAT; X-ray; 1.15 A; A=24-246. DR PDB; 6EAU; X-ray; 1.18 A; A=24-246. DR PDB; 6EAV; X-ray; 1.39 A; A=24-246. DR PDB; 6EAW; X-ray; 1.29 A; A=24-246. DR PDB; 6EAX; X-ray; 1.19 A; A=24-246. DR PDB; 6FID; X-ray; 2.20 A; A=24-246. DR PDB; 6MRQ; X-ray; 1.29 A; A=24-246. DR PDB; 6QIH; X-ray; 1.42 A; A=24-246. DR PDB; 6QL0; X-ray; 1.63 A; A=1-246. DR PDB; 6SUX; X-ray; 1.16 A; A=24-246. DR PDB; 6SV0; X-ray; 1.16 A; A=24-246. DR PDB; 6SV6; X-ray; 1.15 A; A=24-246. DR PDB; 6SV8; X-ray; 1.15 A; A=24-246. DR PDB; 6SV9; X-ray; 1.15 A; A=24-246. DR PDB; 6SVB; X-ray; 1.15 A; A=24-246. DR PDB; 6SVD; X-ray; 1.15 A; A=24-246. DR PDB; 6SVG; X-ray; 1.16 A; A=24-246. DR PDB; 6SVI; X-ray; 1.16 A; A=24-246. DR PDB; 6SVJ; X-ray; 1.16 A; A=24-246. DR PDB; 6SVN; X-ray; 1.16 A; A=24-246. DR PDB; 6SVR; X-ray; 1.16 A; A=24-246. DR PDB; 6SVU; X-ray; 1.15 A; A=24-246. DR PDB; 6SVV; X-ray; 1.15 A; A=24-246. DR PDB; 6SVW; X-ray; 1.16 A; A=24-246. DR PDB; 6SVX; X-ray; 1.16 A; A=24-246. DR PDB; 6SVZ; X-ray; 1.15 A; A=24-246. DR PDB; 6SW0; X-ray; 1.15 A; A=24-246. DR PDB; 6SWV; X-ray; 1.43 A; AAA=1-246. DR PDB; 6SY3; X-ray; 0.95 A; A=1-246. DR PDB; 6T0M; X-ray; 1.51 A; A=1-246. DR PDB; 6T0P; X-ray; 1.19 A; A=1-246. DR PDB; 6T5W; X-ray; 1.13 A; A=1-246. DR PDB; 6T9U; X-ray; 1.07 A; A=1-246. DR PDB; 6T9V; X-ray; 1.13 A; A=1-246. DR PDB; 6U22; X-ray; 1.42 A; A=24-246. DR PDB; 6VXY; X-ray; 1.40 A; A=24-246. DR PDB; 6XYG; X-ray; 1.50 A; A=24-246. DR PDB; 6XYK; X-ray; 1.50 A; A=24-246. DR PDB; 6YDY; X-ray; 1.45 A; A=1-246. DR PDB; 6YIS; X-ray; 1.19 A; A=1-246. DR PDB; 6YIT; X-ray; 1.25 A; A=24-246. DR PDB; 6YIU; X-ray; 1.36 A; A=24-246. DR PDB; 6YIV; X-ray; 0.95 A; A=24-246. DR PDB; 6YIW; X-ray; 0.97 A; A=24-246. DR PDB; 6YIX; X-ray; 1.31 A; A=24-246. DR PDB; 6YIY; X-ray; 1.11 A; A=24-246. DR PDB; 6YZA; X-ray; 1.30 A; A=24-246. DR PDB; 6YZC; X-ray; 1.42 A; A=24-246. DR PDB; 6ZFJ; X-ray; 1.00 A; A=24-246. DR PDB; 6ZFK; X-ray; 1.10 A; A=24-246. DR PDB; 6ZQ2; X-ray; 1.29 A; A=24-246. DR PDB; 7AL8; X-ray; 2.85 A; B/E/H/K/N/Q/T/U=24-246. DR PDB; 7AYS; X-ray; 2.10 A; A=24-246. DR PDB; 7BRV; X-ray; 1.55 A; A=24-246. DR PDB; 7BRW; X-ray; 1.60 A; A=24-246. DR PDB; 7BRX; X-ray; 1.35 A; A=24-246. DR PDB; 7BRY; X-ray; 1.65 A; A=24-246. DR PDB; 7BRZ; X-ray; 1.30 A; A=24-246. DR PDB; 7BS0; X-ray; 1.85 A; A=24-246. DR PDB; 7BS1; X-ray; 1.50 A; A=24-246. DR PDB; 7BS2; X-ray; 1.80 A; A=24-246. DR PDB; 7BS3; X-ray; 1.28 A; A=24-246. DR PDB; 7BS4; X-ray; 1.04 A; A=24-246. DR PDB; 7BS5; X-ray; 1.17 A; A=24-246. DR PDB; 7BS6; X-ray; 1.04 A; A=24-246. DR PDB; 7BS7; X-ray; 1.04 A; A=24-246. DR PDB; 7BS8; X-ray; 1.37 A; A=24-246. DR PDB; 7BS9; X-ray; 1.05 A; A=24-246. DR PDB; 7BSA; X-ray; 1.22 A; A=24-246. DR PDB; 7JR1; X-ray; 2.05 A; A/B/C/D/E/F=24-246. DR PDB; 7JR2; X-ray; 1.85 A; A/B/C/D/E/F=24-246. DR PDB; 7JWX; X-ray; 2.38 A; A/B/C/D=24-246. DR PDB; 7PH1; X-ray; 1.18 A; E=24-246. DR PDB; 7Q0W; X-ray; 1.20 A; A=24-246. DR PDB; 7Q0X; X-ray; 1.09 A; A=24-246. DR PDB; 7VO7; X-ray; 2.25 A; A/B=24-246. DR PDB; 7WA0; X-ray; 1.77 A; A=24-246. DR PDB; 7WA2; X-ray; 1.52 A; A=24-246. DR PDB; 7WB6; X-ray; 1.48 A; A=24-246. DR PDB; 7WB7; X-ray; 1.45 A; A=24-246. DR PDB; 7WB8; X-ray; 1.38 A; A=24-246. DR PDB; 7WB9; X-ray; 1.56 A; A=24-246. DR PDB; 7WBA; X-ray; 1.45 A; A=24-246. DR PDB; 7Z25; X-ray; 1.35 A; A=24-246. DR PDB; 7Z2I; X-ray; 1.09 A; A=24-246. DR PDB; 8ADT; X-ray; 1.40 A; A=24-246. DR PDB; 8IYV; X-ray; 2.10 A; A=24-246. DR PDB; 8IZH; X-ray; 2.30 A; A=24-246. DR PDB; 8IZI; X-ray; 2.10 A; A=24-246. DR PDB; 8IZK; X-ray; 2.00 A; A=24-246. DR PDB; 8KDU; X-ray; 2.30 A; A=24-246. DR PDB; 8UO7; X-ray; 2.20 A; A=24-246. DR PDB; 8UTL; X-ray; 1.56 A; A=24-246. DR PDB; 8WK1; X-ray; 2.00 A; A/C=24-246. DR PDB; 8XNI; X-ray; 2.30 A; A=1-246. DR PDB; 8XNJ; X-ray; 2.40 A; A=24-246. DR PDB; 9AVX; X-ray; 1.50 A; A=24-246. DR PDB; 9AVY; X-ray; 1.50 A; A=24-246. DR PDB; 9AVZ; X-ray; 1.50 A; A=24-246. DR PDB; 9AW0; X-ray; 1.50 A; A=24-246. DR PDB; 9AW1; X-ray; 1.50 A; A=24-246. DR PDB; 9AW2; X-ray; 1.50 A; A=24-246. DR PDB; 9AW4; X-ray; 1.50 A; A=24-246. DR PDB; 9AW8; X-ray; 1.50 A; A=24-246. DR PDB; 9AW9; X-ray; 1.50 A; A=24-246. DR PDB; 9AWA; X-ray; 1.50 A; A=24-246. DR PDB; 9AWB; X-ray; 1.50 A; A=24-246. DR PDB; 9AWC; X-ray; 1.49 A; A=24-246. DR PDB; 9AWD; X-ray; 1.49 A; A=24-246. DR PDB; 9AWF; X-ray; 1.50 A; A=24-246. DR PDB; 9AWG; X-ray; 1.49 A; A=24-246. DR PDB; 9AWH; X-ray; 1.50 A; A=24-246. DR PDB; 9AWI; X-ray; 1.48 A; A=24-246. DR PDB; 9AWL; X-ray; 1.50 A; A=24-246. DR PDB; 9AWM; X-ray; 1.50 A; A=24-246. DR PDB; 9AWN; X-ray; 1.48 A; A=24-246. DR PDB; 9AWO; X-ray; 1.50 A; A=24-246. DR PDB; 9AWP; X-ray; 1.50 A; A=24-246. DR PDB; 9AWQ; X-ray; 1.49 A; A=24-246. DR PDB; 9AWR; X-ray; 1.49 A; A=24-246. DR PDB; 9AWS; X-ray; 1.50 A; A=24-246. DR PDB; 9AWU; X-ray; 1.48 A; A=24-246. DR PDB; 9AWV; X-ray; 1.49 A; A=24-246. DR PDB; 9AWZ; X-ray; 1.49 A; A=24-246. DR PDB; 9BKF; X-ray; 1.20 A; A=24-246. DR PDB; 9BKG; X-ray; 1.57 A; A=24-246. DR PDB; 9BOK; X-ray; 1.35 A; A=24-246. DR PDB; 9BOM; X-ray; 1.35 A; A=24-246. DR PDB; 9KK4; X-ray; 2.35 A; A=24-246. DR PDB; 9KK5; X-ray; 2.00 A; A=24-246. DR PDB; 9P77; X-ray; 1.30 A; B=1-246. DR PDB; 9P7B; X-ray; 1.50 A; A=1-246. DR AlphaFoldDB; P00760; -. DR EMDB; EMD-8220; -. DR MDposit; P00760; -. DR MDRepo; P00760; -. DR SASBDB; P00760; -. DR SMR; P00760; -. DR BioGRID; 542655; 1. DR CORUM; P00760; -. DR FunCoup; P00760; 85. DR IntAct; P00760; 5. DR STRING; 9913.ENSBTAP00000004737; -. DR BindingDB; P00760; -. DR ChEMBL; CHEMBL3769; -. DR DrugCentral; P00760; -. DR MEROPS; S01.151; -. DR PaxDb; 9913-ENSBTAP00000004737; -. DR PeptideAtlas; P00760; -. DR PRIDE; P00760; -. DR Ensembl; ENSBTAT00000004737.5; ENSBTAP00000004737.4; ENSBTAG00000067483.1. DR Ensembl; ENSBTAT00000033479.6; ENSBTAP00000033392.4; ENSBTAG00000060741.1. DR Ensembl; ENSBTAT00085038710; ENSBTAP00085039320; ENSBTAG00085006581. DR Ensembl; ENSBTAT00085040153; ENSBTAP00085016531; ENSBTAG00085014275. DR Ensembl; ENSBTAT00090005362; ENSBTAP00090008941; ENSBTAG00090009641. DR Ensembl; ENSBTAT00090018238; ENSBTAP00090008948; ENSBTAG00090009643. DR GeneID; 615026; -. DR GeneID; 780933; -. DR KEGG; bta:615026; -. DR KEGG; bta:780933; -. DR CTD; 5644; -. DR VEuPathDB; HostDB:ENSBTAG00000050323; -. DR VEuPathDB; HostDB:ENSBTAG00000052726; -. DR eggNOG; KOG3627; Eukaryota. DR GeneTree; ENSGT01050000244883; -. DR HOGENOM; CLU_006842_7_0_1; -. DR InParanoid; P00760; -. DR OMA; AAGWGHQ; -. DR OrthoDB; 10059102at2759; -. DR BRENDA; 3.4.21.4; 908. DR SABIO-RK; P00760; -. DR EvolutionaryTrace; P00760; -. DR PRO; PR:P00760; -. DR Proteomes; UP000009136; Chromosome 4. DR Bgee; ENSBTAG00000050323; Expressed in urinary bladder and 32 other cell types or tissues. DR GO; GO:0005576; C:extracellular region; IBA:GO_Central. DR GO; GO:0097180; C:serine protease inhibitor complex; IDA:CAFA. DR GO; GO:0004175; F:endopeptidase activity; IDA:CAFA. DR GO; GO:0004252; F:serine-type endopeptidase activity; IDA:CAFA. DR GO; GO:0097655; F:serpin family protein binding; IDA:CAFA. DR GO; GO:0006508; P:proteolysis; IDA:CAFA. DR CDD; cd00190; Tryp_SPc; 1. DR DisProt; DP00728; -. DR FunFam; 2.40.10.10:FF:000008; Cationic trypsin; 1. DR FunFam; 2.40.10.10:FF:000124; Cationic trypsin; 1. DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR001314; Peptidase_S1A. DR InterPro; IPR050127; Serine_Proteases_S1. DR InterPro; IPR001254; Trypsin_dom. DR InterPro; IPR018114; TRYPSIN_HIS. DR InterPro; IPR033116; TRYPSIN_SER. DR PANTHER; PTHR24264:SF15; RIKEN CDNA 2210010C04 GENE; 1. DR PANTHER; PTHR24264; TRYPSIN-RELATED; 1. DR Pfam; PF00089; Trypsin; 1. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00020; Tryp_SPc; 1. DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1. DR PROSITE; PS50240; TRYPSIN_DOM; 1. DR PROSITE; PS00134; TRYPSIN_HIS; 1. DR PROSITE; PS00135; TRYPSIN_SER; 1. DR PCDDB; P00760; -. PE 1: Evidence at protein level; KW 3D-structure; Calcium; Digestion; Direct protein sequencing; KW Disulfide bond; Hydrolase; Metal-binding; Protease; Reference proteome; KW Secreted; Serine protease; Signal; Zymogen. FT SIGNAL 1..17 FT /evidence="ECO:0000269|PubMed:5967094" FT PROPEP 18..23 FT /note="Activation peptide" FT /id="PRO_0000028185" FT CHAIN 24..246 FT /note="Serine protease 1" FT /id="PRO_0000028186" FT CHAIN 24..148 FT /note="Alpha-trypsin chain 1" FT /id="PRO_0000028187" FT CHAIN 149..246 FT /note="Alpha-trypsin chain 2" FT /id="PRO_0000028188" FT DOMAIN 24..244 FT /note="Peptidase S1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274" FT ACT_SITE 63 FT /note="Charge relay system" FT ACT_SITE 107 FT /note="Charge relay system" FT ACT_SITE 200 FT /note="Charge relay system" FT BINDING 75 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT BINDING 77 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT BINDING 80 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT BINDING 85 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT BINDING 194..195 FT /ligand="substrate" FT BINDING 197..198 FT /ligand="substrate" FT BINDING 200 FT /ligand="substrate" FT DISULFID 30..160 FT /evidence="ECO:0000269|PubMed:32787139, FT ECO:0007744|PDB:6MRQ" FT DISULFID 48..64 FT /evidence="ECO:0000269|PubMed:32787139, FT ECO:0007744|PDB:6MRQ" FT DISULFID 132..233 FT /evidence="ECO:0000269|PubMed:32787139, FT ECO:0007744|PDB:6MRQ" FT DISULFID 139..206 FT /evidence="ECO:0000269|PubMed:32787139, FT ECO:0007744|PDB:6MRQ" FT DISULFID 171..185 FT /evidence="ECO:0000269|PubMed:32787139, FT ECO:0007744|PDB:6MRQ" FT DISULFID 196..220 FT /evidence="ECO:0000269|PubMed:32787139, FT ECO:0007744|PDB:6MRQ" FT TURN 23..26 FT /evidence="ECO:0007829|PDB:1TGS" FT TURN 32..34 FT /evidence="ECO:0007829|PDB:1TGS" FT STRAND 38..54 FT /evidence="ECO:0007829|PDB:4I8H" FT STRAND 57..60 FT /evidence="ECO:0007829|PDB:4I8H" FT HELIX 62..64 FT /evidence="ECO:0007829|PDB:4I8H" FT STRAND 70..74 FT /evidence="ECO:0007829|PDB:4I8H" FT STRAND 76..80 FT /evidence="ECO:0007829|PDB:1C2D" FT STRAND 81..84 FT /evidence="ECO:0007829|PDB:1EJM" FT STRAND 86..95 FT /evidence="ECO:0007829|PDB:4I8H" FT TURN 101..103 FT /evidence="ECO:0007829|PDB:4I8H" FT STRAND 109..115 FT /evidence="ECO:0007829|PDB:4I8H" FT HELIX 116..119 FT /evidence="ECO:0007829|PDB:5MN1" FT STRAND 121..123 FT /evidence="ECO:0007829|PDB:4I8H" FT STRAND 138..145 FT /evidence="ECO:0007829|PDB:4I8H" FT STRAND 149..151 FT /evidence="ECO:0007829|PDB:4I8H" FT STRAND 159..165 FT /evidence="ECO:0007829|PDB:4I8H" FT HELIX 168..174 FT /evidence="ECO:0007829|PDB:4I8H" FT TURN 176..178 FT /evidence="ECO:0007829|PDB:4I8H" FT TURN 180..182 FT /evidence="ECO:0007829|PDB:1V2J" FT STRAND 183..187 FT /evidence="ECO:0007829|PDB:4I8H" FT TURN 189..191 FT /evidence="ECO:0007829|PDB:1TGN" FT STRAND 192..194 FT /evidence="ECO:0007829|PDB:2AH4" FT TURN 197..201 FT /evidence="ECO:0007829|PDB:9BOK" FT STRAND 203..206 FT /evidence="ECO:0007829|PDB:4I8H" FT STRAND 209..216 FT /evidence="ECO:0007829|PDB:4I8H" FT STRAND 218..222 FT /evidence="ECO:0007829|PDB:4I8H" FT STRAND 227..231 FT /evidence="ECO:0007829|PDB:4I8H" FT HELIX 232..235 FT /evidence="ECO:0007829|PDB:4I8H" FT HELIX 236..245 FT /evidence="ECO:0007829|PDB:4I8H" SQ SEQUENCE 246 AA; 25785 MW; 092E3D8ACCCCC4D3 CRC64; MKTFIFLALL GAAVAFPVDD DDKIVGGYTC GANTVPYQVS LNSGYHFCGG SLINSQWVVS AAHCYKSGIQ VRLGEDNINV VEGNEQFISA SKSIVHPSYN SNTLNNDIML IKLKSAASLN SRVASISLPT SCASAGTQCL ISGWGNTKSS GTSYPDVLKC LKAPILSDSS CKSAYPGQIT SNMFCAGYLE GGKDSCQGDS GGPVVCSGKL QGIVSWGSGC AQKNKPGVYT KVCNYVSWIK QTIASN //