ID COX2_HUMAN Reviewed; 227 AA. AC P00403; Q37526; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 04-NOV-2026, entry version 240. DE RecName: Full=Cytochrome c oxidase subunit 2; DE EC=7.1.1.9; DE AltName: Full=Cytochrome c oxidase polypeptide II; GN Name=MT-CO2; GN Synonyms=COII, COX2 {ECO:0000303|PubMed:29154948}, COXII, MTCO2; OS Homo sapiens (Human). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=7219534; DOI=10.1038/290457a0; RA Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R., RA Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H., RA Smith A.J.H., Staden R., Young I.G.; RT "Sequence and organization of the human mitochondrial genome."; RL Nature 290:457-465(1981). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2550900; DOI=10.1093/nar/17.16.6734; RA Power M.D., Kiefer M.C., Barr P.J., Reeves R.; RT "Nucleotide sequence of human mitochondrial cytochrome c oxidase II cDNA."; RL Nucleic Acids Res. 17:6734-6734(1989). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=226894; DOI=10.1038/282189a0; RA Barrell B.G., Bankier A.T., Drouin J.; RT "A different genetic code in human mitochondria."; RL Nature 282:189-194(1979). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Placenta; RX PubMed=7530363; DOI=10.1073/pnas.92.2.532; RA Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.; RT "Recent African origin of modern humans revealed by complete sequences of RT hominoid mitochondrial DNAs."; RL Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-30 AND THR-148. RX PubMed=8277847; DOI=10.1093/oxfordjournals.molbev.a040068; RA Ruvolo M., Zehr S., von Dornum M., Pan D., Chang B., Lin J.; RT "Mitochondrial COII sequences and modern human origins."; RL Mol. Biol. Evol. 10:1115-1135(1993). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12949126; DOI=10.1093/molbev/msg230; RA Moilanen J.S., Finnila S., Majamaa K.; RT "Lineage-specific selection in human mtDNA: lack of polymorphisms in a RT segment of MTND5 gene in haplogroup J."; RL Mol. Biol. Evol. 20:2132-2142(2003). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=11130070; DOI=10.1038/35047064; RA Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.; RT "Mitochondrial genome variation and the origin of modern humans."; RL Nature 408:708-713(2000). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12840039; DOI=10.1101/gr.686603; RA Ingman M., Gyllensten U.; RT "Mitochondrial genome variation and evolutionary history of Australian and RT New Guinean aborigines."; RL Genome Res. 13:1600-1606(2003). RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=14760490; DOI=10.1007/s00414-004-0427-6; RA Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T., RA Irwin J.A., Parsons T.J.; RT "Single nucleotide polymorphisms over the entire mtDNA genome that increase RT the power of forensic testing in Caucasians."; RL Int. J. Legal Med. 118:137-146(2004). RN [10] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-227. RC TISSUE=Endometrial adenocarcinoma; RA Swanson K.V., Griffiss J.; RT "Gonococcal microcolony formation on HEC-1-B cells alters selective RT mitochondrial transcripts."; RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases. RN [11] RP NUCLEOTIDE SEQUENCE [MRNA] OF 42-227. RC TISSUE=Fetal liver; RA Dmitrenko V.V., Kavsan V.M.; RT "Nucleotide sequence of mitochondrial cytochrome C oxidase II from human RT fetal liver."; RL Submitted (SEP-1990) to the EMBL/GenBank/DDBJ databases. RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [13] RP INTERACTION WITH COX20. RX PubMed=23125284; DOI=10.1093/hmg/dds473; RA Szklarczyk R., Wanschers B.F., Nijtmans L.G., Rodenburg R.J., Zschocke J., RA Dikow N., van den Brand M.A., Hendriks-Franssen M.G., Gilissen C., RA Veltman J.A., Nooteboom M., Koopman W.J., Willems P.H., Smeitink J.A., RA Huynen M.A., van den Heuvel L.P.; RT "A mutation in the FAM36A gene, the human ortholog of COX20, impairs RT cytochrome c oxidase assembly and is associated with ataxia and muscle RT hypotonia."; RL Hum. Mol. Genet. 22:656-667(2013). RN [14] RP INTERACTION WITH COX20. RX PubMed=24403053; DOI=10.1093/hmg/ddu003; RA Bourens M., Boulet A., Leary S.C., Barrientos A.; RT "Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the RT assembly of cytochrome c oxidase."; RL Hum. Mol. Genet. 23:2901-2913(2014). RN [15] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [16] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [17] RP IDENTIFICATION IN A COMPLEX WITH TMEM177; COA6; COX20; COX18; SCO1 AND RP SCO2, AND INTERACTION WITH TMEM177 AND COX20. RX PubMed=29154948; DOI=10.1016/j.bbamcr.2017.11.010; RA Lorenzi I., Oeljeklaus S., Aich A., Ronsoer C., Callegari S., Dudek J., RA Warscheid B., Dennerlein S., Rehling P.; RT "The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis."; RL Biochim. Biophys. Acta 1865:323-333(2017). RN [18] RP INTERACTION WITH COX20. RX PubMed=28330871; DOI=10.1074/jbc.m117.778514; RA Bourens M., Barrientos A.; RT "Human mitochondrial cytochrome c oxidase assembly factor COX18 acts RT transiently as a membrane insertase within the subunit 2 maturation RT module."; RL J. Biol. Chem. 292:7774-7783(2017). RN [19] RP INTERACTION WITH COX16. RX PubMed=29355485; DOI=10.1016/j.bbabio.2018.01.004; RA Cerqua C., Morbidoni V., Desbats M.A., Doimo M., Frasson C., Sacconi S., RA Baldoin M.C., Sartori G., Basso G., Salviati L., Trevisson E.; RT "COX16 is required for assembly of cytochrome c oxidase in human cells and RT is involved in copper delivery to COX2."; RL Biochim. Biophys. Acta 1859:244-252(2018). RN [20] RP INTERACTION WITH COX16. RX PubMed=29381136; DOI=10.7554/elife.32572; RA Aich A., Wang C., Chowdhury A., Ronsoer C., Pacheu-Grau D., RA Richter-Dennerlein R., Dennerlein S., Rehling P.; RT "COX16 promotes COX2 metallation and assembly during respiratory complex IV RT biogenesis."; RL Elife 7:0-0(2018). RN [21] RP INTERACTION WITH COX11, AND SUBCELLULAR LOCATION. RX PubMed=35750769; DOI=10.1038/s41467-022-31413-1; RA Nyvltova E., Dietz J.V., Seravalli J., Khalimonchuk O., Barrientos A.; RT "Coordination of metal center biogenesis in human cytochrome c oxidase."; RL Nat. Commun. 13:3615-3615(2022). RN [22] RP STRUCTURE BY ELECTRON MICROSCOPY, AND SUBUNIT. RX PubMed=28844695; DOI=10.1016/j.cell.2017.07.050; RA Guo R., Zong S., Wu M., Gu J., Yang M.; RT "Architecture of human mitochondrial respiratory megacomplex I2III2IV2."; RL Cell 170:1247-1257(2017). RN [23] RP STRUCTURE BY ELECTRON MICROSCOPY. RX PubMed=30030519; DOI=10.1038/s41422-018-0071-1; RA Zong S., Wu M., Gu J., Liu T., Guo R., Yang M.; RT "Structure of the intact 14-subunit human cytochrome c oxidase."; RL Cell Res. 28:1026-1034(2018). RN [24] RP VARIANTS ALA-11; PRO-123 AND MET-187. RX PubMed=1757091; DOI=10.1007/bf00206061; RA Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R., RA Utthanaphol P., Byrne E.; RT "Normal variants of human mitochondrial DNA and translation products: the RT building of a reference data base."; RL Hum. Genet. 88:139-145(1991). RN [25] RP VARIANT COLORECTAL CANCER MET-142. RX PubMed=9806551; DOI=10.1038/3108; RA Polyak K., Li Y., Zhu H., Lengauer C., Willson J.K.V., Markowitz S.D., RA Trush M.A., Kinzler K.W., Vogelstein B.; RT "Somatic mutations of the mitochondrial genome in human colorectal RT tumours."; RL Nat. Genet. 20:291-293(1998). RN [26] RP VARIANT MT-C4D LYS-29, AND CHARACTERIZATION OF VARIANT MT-C4D LYS-29. RX PubMed=10486321; DOI=10.1086/302590; RA Rahman S., Taanman J.-W., Cooper J.M., Nelson I., Hargreaves I., RA Meunier B., Hanna M.G., Garcia J.J., Capaldi R.A., Lake B.D., Leonard J.V., RA Schapira A.H.V.; RT "A missense mutation of cytochrome oxidase subunit II causes defective RT assembly and myopathy."; RL Am. J. Hum. Genet. 65:1030-1039(1999). CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the CC mitochondrial electron transport chain which drives oxidative CC phosphorylation. The respiratory chain contains 3 multisubunit CC complexes succinate dehydrogenase (complex II, CII), ubiquinol- CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to CC transfer electrons derived from NADH and succinate to molecular oxygen, CC creating an electrochemical gradient over the inner membrane that CC drives transmembrane transport and the ATP synthase. Cytochrome c CC oxidase is the component of the respiratory chain that catalyzes the CC reduction of oxygen to water. Electrons originating from reduced CC cytochrome c in the intermembrane space (IMS) are transferred via the CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 CC to the active site in subunit 1, a binuclear center (BNC) formed by CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 CC water molecules using 4 electrons from cytochrome c in the IMS and 4 CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00410}. CC -!- CATALYTIC ACTIVITY: CC Reaction=4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)- CC [cytochrome c] + 2 H2O + 4 H(+)(out); Xref=Rhea:RHEA:11436, CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, CC ChEBI:CHEBI:29034; EC=7.1.1.9; CC Evidence={ECO:0000250|UniProtKB:P00410}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11437; CC Evidence={ECO:0000250|UniProtKB:P00410}; CC -!- COFACTOR: CC Name=Cu cation; Xref=ChEBI:CHEBI:23378; CC Evidence={ECO:0000269|PubMed:30030519}; CC Note=Binds a dinuclear copper A center per subunit. CC {ECO:0000269|PubMed:30030519}; CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a CC multisubunit enzyme composed of 14 subunits. The complex is composed of CC a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in CC the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or CC COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, CC COX7A2 (or COX7A1), COX7B, COX7C, COX8A and COXFA4, which are encoded CC in the nuclear genome (PubMed:30030519). The complex exists as a CC monomer or a dimer and forms supercomplexes (SCs) in the inner CC mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CC CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, CC complex III, CIII), resulting in different assemblies (supercomplex CC SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:28844695). CC Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2 CC (PubMed:29154948). Interacts with TMEM177 in a COX20-dependent manner CC (PubMed:29154948). Interacts with COX20 (PubMed:23125284, CC PubMed:24403053, PubMed:28330871, PubMed:29154948). Interacts with CC COX16 (PubMed:29355485, PubMed:29381136). Interacts with assembly CC factor COX11; during cytochrome c oxidase assembly (PubMed:35750769). CC {ECO:0000269|PubMed:23125284, ECO:0000269|PubMed:24403053, CC ECO:0000269|PubMed:28330871, ECO:0000269|PubMed:28844695, CC ECO:0000269|PubMed:29154948, ECO:0000269|PubMed:29355485, CC ECO:0000269|PubMed:29381136, ECO:0000269|PubMed:30030519, CC ECO:0000269|PubMed:35750769}. CC -!- INTERACTION: CC P00403; Q9NZ94-2: NLGN3; NbExp=4; IntAct=EBI-2105756, EBI-16423037; CC P00403; P49281-3: SLC11A2; NbExp=2; IntAct=EBI-2105756, EBI-10828817; CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000269|PubMed:30030519, ECO:0000305|PubMed:35750769}; Multi-pass CC membrane protein {ECO:0000269|PubMed:30030519}. CC -!- DISEASE: Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A CC disorder of the mitochondrial respiratory chain with heterogeneous CC clinical manifestations, ranging from isolated myopathy to severe CC multisystem disease affecting several tissues and organs. Features CC include hypertrophic cardiomyopathy, hepatomegaly and liver CC dysfunction, hypotonia, muscle weakness, exercise intolerance, CC developmental delay, delayed motor development and intellectual CC disability. Some affected individuals manifest a fatal hypertrophic CC cardiomyopathy resulting in neonatal death. A subset of patients CC manifest Leigh syndrome. {ECO:0000269|PubMed:10486321}. Note=The CC disease is caused by variants affecting the gene represented in this CC entry. CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; V00662; CAA24029.1; -; Genomic_DNA. DR EMBL; J01415; AAB58946.1; -; Genomic_DNA. DR EMBL; X15759; CAA33766.1; -; mRNA. DR EMBL; M25171; AAA31850.1; -; Genomic_DNA. DR EMBL; D38112; BAA07293.1; -; Genomic_DNA. DR EMBL; U12690; AAA20843.1; -; Genomic_DNA. DR EMBL; U12691; AAA20844.1; -; Genomic_DNA. DR EMBL; U12692; AAA20845.1; -; Genomic_DNA. DR EMBL; U12693; AAA20846.1; -; Genomic_DNA. DR EMBL; U12694; AAA20847.1; -; Genomic_DNA. DR EMBL; AF004339; AAB63450.1; -; Genomic_DNA. DR EMBL; AY339402; AAP89039.1; -; Genomic_DNA. DR EMBL; AY339403; AAP89052.1; -; Genomic_DNA. DR EMBL; AY339404; AAP89065.1; -; Genomic_DNA. DR EMBL; AY339405; AAP89078.1; -; Genomic_DNA. DR EMBL; AY339406; AAP89091.1; -; Genomic_DNA. DR EMBL; AY339407; AAP89104.1; -; Genomic_DNA. DR EMBL; AY339408; AAP89117.1; -; Genomic_DNA. DR EMBL; AY339409; AAP89130.1; -; Genomic_DNA. DR EMBL; AY339410; AAP89143.1; -; Genomic_DNA. DR EMBL; AY339411; AAP89156.1; -; Genomic_DNA. DR EMBL; AY339412; AAP89169.1; -; Genomic_DNA. DR EMBL; AY339413; AAP89182.1; -; Genomic_DNA. DR EMBL; AY339414; AAP89195.1; -; Genomic_DNA. DR EMBL; AY339415; AAP89208.1; -; Genomic_DNA. DR EMBL; AY339416; AAP89221.1; -; Genomic_DNA. DR EMBL; AY339417; AAP89234.1; -; Genomic_DNA. DR EMBL; AY339418; AAP89247.1; -; Genomic_DNA. DR EMBL; AY339419; AAP89260.1; -; Genomic_DNA. DR EMBL; AY339420; AAP89273.1; -; Genomic_DNA. DR EMBL; AY339421; AAP89286.1; -; Genomic_DNA. DR EMBL; AY339422; AAP89299.1; -; Genomic_DNA. DR EMBL; AY339423; AAP89312.1; -; Genomic_DNA. DR EMBL; AY339424; AAP89325.1; -; Genomic_DNA. DR EMBL; AY339425; AAP89338.1; -; Genomic_DNA. DR EMBL; AY339426; AAP89351.1; -; Genomic_DNA. DR EMBL; AY339427; AAP89364.1; -; Genomic_DNA. DR EMBL; AY339428; AAP89377.1; -; Genomic_DNA. DR EMBL; AY339429; AAP89390.1; -; Genomic_DNA. DR EMBL; AY339430; AAP89403.1; -; Genomic_DNA. DR EMBL; AY339431; AAP89416.1; -; Genomic_DNA. DR EMBL; AY339432; AAP89429.1; -; Genomic_DNA. DR EMBL; AY339433; AAP89442.1; -; Genomic_DNA. DR EMBL; AY339434; AAP89455.1; -; Genomic_DNA. DR EMBL; AY339435; AAP89468.1; -; Genomic_DNA. DR EMBL; AY339436; AAP89481.1; -; Genomic_DNA. DR EMBL; AY339437; AAP89494.1; -; Genomic_DNA. DR EMBL; AY339438; AAP89507.1; -; Genomic_DNA. DR EMBL; AY339439; AAP89520.1; -; Genomic_DNA. DR EMBL; AY339440; AAP89533.1; -; Genomic_DNA. DR EMBL; AY339441; AAP89546.1; -; Genomic_DNA. DR EMBL; AY339442; AAP89559.1; -; Genomic_DNA. DR EMBL; AY339443; AAP89572.1; -; Genomic_DNA. DR EMBL; AY339444; AAP89585.1; -; Genomic_DNA. DR EMBL; AY339445; AAP89598.1; -; Genomic_DNA. DR EMBL; AY339446; AAP89611.1; -; Genomic_DNA. DR EMBL; AY339447; AAP89624.1; -; Genomic_DNA. DR EMBL; AY339448; AAP89637.1; -; Genomic_DNA. DR EMBL; AY339449; AAP89650.1; -; Genomic_DNA. DR EMBL; AY339450; AAP89663.1; -; Genomic_DNA. DR EMBL; AY339451; AAP89676.1; -; Genomic_DNA. DR EMBL; AY339452; AAP89689.1; -; Genomic_DNA. DR EMBL; AY339453; AAP89702.1; -; Genomic_DNA. DR EMBL; AY339454; AAP89715.1; -; Genomic_DNA. DR EMBL; AY339455; AAP89728.1; -; Genomic_DNA. DR EMBL; AY339456; AAP89741.1; -; Genomic_DNA. DR EMBL; AY339457; AAP89754.1; -; Genomic_DNA. DR EMBL; AY339458; AAP89767.1; -; Genomic_DNA. DR EMBL; AY339459; AAP89780.1; -; Genomic_DNA. DR EMBL; AY339460; AAP89793.1; -; Genomic_DNA. DR EMBL; AY339461; AAP89806.1; -; Genomic_DNA. DR EMBL; AY339462; AAP89819.1; -; Genomic_DNA. DR EMBL; AY339463; AAP89832.1; -; Genomic_DNA. DR EMBL; AY339464; AAP89845.1; -; Genomic_DNA. DR EMBL; AY339465; AAP89858.1; -; Genomic_DNA. DR EMBL; AY339466; AAP89871.1; -; Genomic_DNA. DR EMBL; AY339467; AAP89884.1; -; Genomic_DNA. DR EMBL; AY339468; AAP89897.1; -; Genomic_DNA. DR EMBL; AY339469; AAP89910.1; -; Genomic_DNA. DR EMBL; AY339470; AAP89923.1; -; Genomic_DNA. DR EMBL; AY339471; AAP89936.1; -; Genomic_DNA. DR EMBL; AY339472; AAP89949.1; -; Genomic_DNA. DR EMBL; AY339473; AAP89962.1; -; Genomic_DNA. DR EMBL; AY339474; AAP89975.1; -; Genomic_DNA. DR EMBL; AY339475; AAP89988.1; -; Genomic_DNA. DR EMBL; AY339476; AAP90001.1; -; Genomic_DNA. DR EMBL; AY339477; AAP90014.1; -; Genomic_DNA. DR EMBL; AY339478; AAP90027.1; -; Genomic_DNA. DR EMBL; AY339479; AAP90040.1; -; Genomic_DNA. DR EMBL; AY339480; AAP90053.1; -; Genomic_DNA. DR EMBL; AY339481; AAP90066.1; -; Genomic_DNA. DR EMBL; AY339482; AAP90079.1; -; Genomic_DNA. DR EMBL; AY339483; AAP90092.1; -; Genomic_DNA. DR EMBL; AY339484; AAP90105.1; -; Genomic_DNA. DR EMBL; AY339485; AAP90118.1; -; Genomic_DNA. DR EMBL; AY339486; AAP90131.1; -; Genomic_DNA. DR EMBL; AY339487; AAP90144.1; -; Genomic_DNA. DR EMBL; AY339488; AAP90157.1; -; Genomic_DNA. DR EMBL; AY339489; AAP90170.1; -; Genomic_DNA. DR EMBL; AY339490; AAP90183.1; -; Genomic_DNA. DR EMBL; AY339492; AAP90209.1; -; Genomic_DNA. DR EMBL; AY339493; AAP90222.1; -; Genomic_DNA. DR EMBL; AY339494; AAP90235.1; -; Genomic_DNA. DR EMBL; AY339495; AAP90248.1; -; Genomic_DNA. DR EMBL; AY339496; AAP90261.1; -; Genomic_DNA. DR EMBL; AY339498; AAP90287.1; -; Genomic_DNA. DR EMBL; AY339499; AAP90300.1; -; Genomic_DNA. DR EMBL; AY339500; AAP90313.1; -; Genomic_DNA. DR EMBL; AY339501; AAP90326.1; -; Genomic_DNA. DR EMBL; AY339502; AAP90339.1; -; Genomic_DNA. DR EMBL; AY339503; AAP90352.1; -; Genomic_DNA. DR EMBL; AY339504; AAP90365.1; -; Genomic_DNA. DR EMBL; AY339505; AAP90378.1; -; Genomic_DNA. DR EMBL; AY339506; AAP90391.1; -; Genomic_DNA. DR EMBL; AY339507; AAP90404.1; -; Genomic_DNA. DR EMBL; AY339508; AAP90417.1; -; Genomic_DNA. DR EMBL; AY339509; AAP90430.1; -; Genomic_DNA. DR EMBL; AY339510; AAP90443.1; -; Genomic_DNA. DR EMBL; AY339511; AAP90456.1; -; Genomic_DNA. DR EMBL; AY339512; AAP90469.1; -; Genomic_DNA. DR EMBL; AY339513; AAP90482.1; -; Genomic_DNA. DR EMBL; AY339514; AAP90495.1; -; Genomic_DNA. DR EMBL; AY339515; AAP90508.1; -; Genomic_DNA. DR EMBL; AY339516; AAP90521.1; -; Genomic_DNA. DR EMBL; AY339517; AAP90534.1; -; Genomic_DNA. DR EMBL; AY339518; AAP90547.1; -; Genomic_DNA. DR EMBL; AY339519; AAP90560.1; -; Genomic_DNA. DR EMBL; AY339520; AAP90573.1; -; Genomic_DNA. DR EMBL; AY339521; AAP90586.1; -; Genomic_DNA. DR EMBL; AY339522; AAP90599.1; -; Genomic_DNA. DR EMBL; AY339523; AAP90612.1; -; Genomic_DNA. DR EMBL; AY339524; AAP90625.1; -; Genomic_DNA. DR EMBL; AY339525; AAP90638.1; -; Genomic_DNA. DR EMBL; AY339526; AAP90651.1; -; Genomic_DNA. DR EMBL; AY339527; AAP90664.1; -; Genomic_DNA. DR EMBL; AY339528; AAP90677.1; -; Genomic_DNA. DR EMBL; AY339529; AAP90690.1; -; Genomic_DNA. DR EMBL; AY339530; AAP90703.1; -; Genomic_DNA. DR EMBL; AY339531; AAP90716.1; -; Genomic_DNA. DR EMBL; AY339532; AAP90729.1; -; Genomic_DNA. DR EMBL; AY339533; AAP90742.1; -; Genomic_DNA. DR EMBL; AY339534; AAP90755.1; -; Genomic_DNA. DR EMBL; AY339535; AAP90768.1; -; Genomic_DNA. DR EMBL; AY339536; AAP90781.1; -; Genomic_DNA. DR EMBL; AY339537; AAP90794.1; -; Genomic_DNA. DR EMBL; AY339538; AAP90807.1; -; Genomic_DNA. DR EMBL; AY339539; AAP90820.1; -; Genomic_DNA. DR EMBL; AY339540; AAP90833.1; -; Genomic_DNA. DR EMBL; AY339541; AAP90846.1; -; Genomic_DNA. DR EMBL; AY339543; AAP90872.1; -; Genomic_DNA. DR EMBL; AY339544; AAP90885.1; -; Genomic_DNA. DR EMBL; AY339545; AAP90898.1; -; Genomic_DNA. DR EMBL; AY339546; AAP90911.1; -; Genomic_DNA. DR EMBL; AY339547; AAP90924.1; -; Genomic_DNA. DR EMBL; AY339548; AAP90937.1; -; Genomic_DNA. DR EMBL; AY339549; AAP90950.1; -; Genomic_DNA. DR EMBL; AY339550; AAP90963.1; -; Genomic_DNA. DR EMBL; AY339551; AAP90976.1; -; Genomic_DNA. DR EMBL; AY339552; AAP90989.1; -; Genomic_DNA. DR EMBL; AY339553; AAP91002.1; -; Genomic_DNA. DR EMBL; AY339555; AAP91028.1; -; Genomic_DNA. DR EMBL; AY339556; AAP91041.1; -; Genomic_DNA. DR EMBL; AY339557; AAP91054.1; -; Genomic_DNA. DR EMBL; AY339558; AAP91067.1; -; Genomic_DNA. DR EMBL; AY339559; AAP91080.1; -; Genomic_DNA. DR EMBL; AY339560; AAP91093.1; -; Genomic_DNA. DR EMBL; AY339561; AAP91106.1; -; Genomic_DNA. DR EMBL; AY339562; AAP91119.1; -; Genomic_DNA. DR EMBL; AY339563; AAP91132.1; -; Genomic_DNA. DR EMBL; AY339564; AAP91145.1; -; Genomic_DNA. DR EMBL; AY339565; AAP91158.1; -; Genomic_DNA. DR EMBL; AY339566; AAP91171.1; -; Genomic_DNA. DR EMBL; AY339567; AAP91184.1; -; Genomic_DNA. DR EMBL; AY339568; AAP91197.1; -; Genomic_DNA. DR EMBL; AY339569; AAP91210.1; -; Genomic_DNA. DR EMBL; AY339570; AAP91223.1; -; Genomic_DNA. DR EMBL; AY339571; AAP91236.1; -; Genomic_DNA. DR EMBL; AY339572; AAP91249.1; -; Genomic_DNA. DR EMBL; AY339573; AAP91262.1; -; Genomic_DNA. DR EMBL; AY339574; AAP91275.1; -; Genomic_DNA. DR EMBL; AY339575; AAP91288.1; -; Genomic_DNA. DR EMBL; AY339576; AAP91301.1; -; Genomic_DNA. DR EMBL; AY339577; AAP91314.1; -; Genomic_DNA. DR EMBL; AY339578; AAP91327.1; -; Genomic_DNA. DR EMBL; AY339579; AAP91340.1; -; Genomic_DNA. DR EMBL; AY339580; AAP91353.1; -; Genomic_DNA. DR EMBL; AY339581; AAP91366.1; -; Genomic_DNA. DR EMBL; AY339582; AAP91379.1; -; Genomic_DNA. DR EMBL; AY339583; AAP91392.1; -; Genomic_DNA. DR EMBL; AY339584; AAP91405.1; -; Genomic_DNA. DR EMBL; AY339585; AAP91418.1; -; Genomic_DNA. DR EMBL; AY339586; AAP91431.1; -; Genomic_DNA. DR EMBL; AY339587; AAP91444.1; -; Genomic_DNA. DR EMBL; AY339588; AAP91457.1; -; Genomic_DNA. DR EMBL; AY339589; AAP91470.1; -; Genomic_DNA. DR EMBL; AY339590; AAP91483.1; -; Genomic_DNA. DR EMBL; AY339591; AAP91496.1; -; Genomic_DNA. DR EMBL; AY339592; AAP91509.1; -; Genomic_DNA. DR EMBL; AY339593; AAP91522.1; -; Genomic_DNA. DR EMBL; AF346963; AAK17210.1; -; Genomic_DNA. DR EMBL; AF346964; AAK17223.1; -; Genomic_DNA. DR EMBL; AF346965; AAK17236.1; -; Genomic_DNA. DR EMBL; AF346966; AAK17249.1; -; Genomic_DNA. DR EMBL; AF346967; AAK17262.1; -; Genomic_DNA. DR EMBL; AF346970; AAK17301.1; -; Genomic_DNA. DR EMBL; AF346972; AAK17327.1; -; Genomic_DNA. DR EMBL; AF346973; AAK17340.1; -; Genomic_DNA. DR EMBL; AF346974; AAK17353.1; -; Genomic_DNA. DR EMBL; AF346975; AAK17366.1; -; Genomic_DNA. DR EMBL; AF346976; AAK17379.1; -; Genomic_DNA. DR EMBL; AF346977; AAK17392.1; -; Genomic_DNA. DR EMBL; AF346978; AAK17405.1; -; Genomic_DNA. DR EMBL; AF346979; AAK17418.1; -; Genomic_DNA. DR EMBL; AF346980; AAK17431.1; -; Genomic_DNA. DR EMBL; AF346981; AAK17444.1; -; Genomic_DNA. DR EMBL; AF346982; AAK17457.1; -; Genomic_DNA. DR EMBL; AF346983; AAK17470.1; -; Genomic_DNA. DR EMBL; AF346984; AAK17483.1; -; Genomic_DNA. DR EMBL; AF346985; AAK17496.1; -; Genomic_DNA. DR EMBL; AF346986; AAK17509.1; -; Genomic_DNA. DR EMBL; AF346988; AAK17535.1; -; Genomic_DNA. DR EMBL; AF346989; AAK17548.1; -; Genomic_DNA. DR EMBL; AF346990; AAK17561.1; -; Genomic_DNA. DR EMBL; AF346991; AAK17574.1; -; Genomic_DNA. DR EMBL; AF346993; AAK17600.1; -; Genomic_DNA. DR EMBL; AF346994; AAK17613.1; -; Genomic_DNA. DR EMBL; AF346995; AAK17626.1; -; Genomic_DNA. DR EMBL; AF346998; AAK17665.1; -; Genomic_DNA. DR EMBL; AF346999; AAK17678.1; -; Genomic_DNA. DR EMBL; AF347000; AAK17691.1; -; Genomic_DNA. DR EMBL; AF347001; AAK17704.1; -; Genomic_DNA. DR EMBL; AF347002; AAK17717.1; -; Genomic_DNA. DR EMBL; AF347003; AAK17730.1; -; Genomic_DNA. DR EMBL; AF347004; AAK17743.1; -; Genomic_DNA. DR EMBL; AF347005; AAK17756.1; -; Genomic_DNA. DR EMBL; AF347006; AAK17769.1; -; Genomic_DNA. DR EMBL; AF347007; AAK17782.1; -; Genomic_DNA. DR EMBL; AF347009; AAK17808.1; -; Genomic_DNA. DR EMBL; AF347010; AAK17821.1; -; Genomic_DNA. DR EMBL; AF347011; AAK17834.1; -; Genomic_DNA. DR EMBL; AF347014; AAK17873.1; -; Genomic_DNA. DR EMBL; AF347015; AAK17886.1; -; Genomic_DNA. DR EMBL; AY289051; AAP47883.1; -; Genomic_DNA. DR EMBL; AY289053; AAP47909.1; -; Genomic_DNA. DR EMBL; AY289054; AAP47922.1; -; Genomic_DNA. DR EMBL; AY289056; AAP47948.1; -; Genomic_DNA. DR EMBL; AY289057; AAP47961.1; -; Genomic_DNA. DR EMBL; AY289058; AAP47974.1; -; Genomic_DNA. DR EMBL; AY289059; AAP47987.1; -; Genomic_DNA. DR EMBL; AY289060; AAP48000.1; -; Genomic_DNA. DR EMBL; AY289061; AAP48013.1; -; Genomic_DNA. DR EMBL; AY289062; AAP48026.1; -; Genomic_DNA. DR EMBL; AY289063; AAP48039.1; -; Genomic_DNA. DR EMBL; AY289064; AAP48052.1; -; Genomic_DNA. DR EMBL; AY289065; AAP48065.1; -; Genomic_DNA. DR EMBL; AY289066; AAP48078.1; -; Genomic_DNA. DR EMBL; AY289067; AAP48091.1; -; Genomic_DNA. DR EMBL; AY289068; AAP48104.1; -; Genomic_DNA. DR EMBL; AY289069; AAP48117.1; -; Genomic_DNA. DR EMBL; AY289071; AAP48143.1; -; Genomic_DNA. DR EMBL; AY289072; AAP48156.1; -; Genomic_DNA. DR EMBL; AY289073; AAP48169.1; -; Genomic_DNA. DR EMBL; AY289074; AAP48182.1; -; Genomic_DNA. DR EMBL; AY289075; AAP48195.1; -; Genomic_DNA. DR EMBL; AY289076; AAP48208.1; -; Genomic_DNA. DR EMBL; AY289077; AAP48221.1; -; Genomic_DNA. DR EMBL; AY289078; AAP48234.1; -; Genomic_DNA. DR EMBL; AY289079; AAP48247.1; -; Genomic_DNA. DR EMBL; AY289080; AAP48260.1; -; Genomic_DNA. DR EMBL; AY289081; AAP48273.1; -; Genomic_DNA. DR EMBL; AY289082; AAP48286.1; -; Genomic_DNA. DR EMBL; AY289083; AAP48299.1; -; Genomic_DNA. DR EMBL; AY289084; AAP48312.1; -; Genomic_DNA. DR EMBL; AY289085; AAP48325.1; -; Genomic_DNA. DR EMBL; AY289086; AAP48338.1; -; Genomic_DNA. DR EMBL; AY289087; AAP48351.1; -; Genomic_DNA. DR EMBL; AY289088; AAP48364.1; -; Genomic_DNA. DR EMBL; AY289089; AAP48377.1; -; Genomic_DNA. DR EMBL; AY289090; AAP48390.1; -; Genomic_DNA. DR EMBL; AY289091; AAP48403.1; -; Genomic_DNA. DR EMBL; AY289092; AAP48416.1; -; Genomic_DNA. DR EMBL; AY289093; AAP48428.1; -; Genomic_DNA. DR EMBL; AY289094; AAP48441.1; -; Genomic_DNA. DR EMBL; AY289095; AAP48454.1; -; Genomic_DNA. DR EMBL; AY289096; AAP48467.1; -; Genomic_DNA. DR EMBL; AY289099; AAP48506.1; -; Genomic_DNA. DR EMBL; AY289100; AAP48519.1; -; Genomic_DNA. DR EMBL; AY289102; AAP48545.1; -; Genomic_DNA. DR EMBL; AY495090; AAR92499.1; -; Genomic_DNA. DR EMBL; AY495091; AAR92512.1; -; Genomic_DNA. DR EMBL; AY495092; AAR92525.1; -; Genomic_DNA. DR EMBL; AY495093; AAR92538.1; -; Genomic_DNA. DR EMBL; AY495094; AAR92551.1; -; Genomic_DNA. DR EMBL; AY495095; AAR92564.1; -; Genomic_DNA. DR EMBL; AY495096; AAR92577.1; -; Genomic_DNA. DR EMBL; AY495097; AAR92590.1; -; Genomic_DNA. DR EMBL; AY495098; AAR92603.1; -; Genomic_DNA. DR EMBL; AY495099; AAR92616.1; -; Genomic_DNA. DR EMBL; AY495100; AAR92629.1; -; Genomic_DNA. DR EMBL; AY495101; AAR92642.1; -; Genomic_DNA. DR EMBL; AY495102; AAR92655.1; -; Genomic_DNA. DR EMBL; AY495103; AAR92668.1; -; Genomic_DNA. DR EMBL; AY495104; AAR92681.1; -; Genomic_DNA. DR EMBL; AY495105; AAR92694.1; -; Genomic_DNA. DR EMBL; AY495106; AAR92707.1; -; Genomic_DNA. DR EMBL; AY495107; AAR92720.1; -; Genomic_DNA. DR EMBL; AY495108; AAR92733.1; -; Genomic_DNA. DR EMBL; AY495109; AAR92746.1; -; Genomic_DNA. DR EMBL; AY495110; AAR92759.1; -; Genomic_DNA. DR EMBL; AY495111; AAR92772.1; -; Genomic_DNA. DR EMBL; AY495112; AAR92785.1; -; Genomic_DNA. DR EMBL; AY495113; AAR92798.1; -; Genomic_DNA. DR EMBL; AY495114; AAR92811.1; -; Genomic_DNA. DR EMBL; AY495115; AAR92824.1; -; Genomic_DNA. DR EMBL; AY495116; AAR92837.1; -; Genomic_DNA. DR EMBL; AY495117; AAR92850.1; -; Genomic_DNA. DR EMBL; AY495118; AAR92863.1; -; Genomic_DNA. DR EMBL; AY495119; AAR92876.1; -; Genomic_DNA. DR EMBL; AY495120; AAR92889.1; -; Genomic_DNA. DR EMBL; AY495121; AAR92902.1; -; Genomic_DNA. DR EMBL; AY495122; AAR92915.1; -; Genomic_DNA. DR EMBL; AY495123; AAR92928.1; -; Genomic_DNA. DR EMBL; AY495124; AAR92941.1; -; Genomic_DNA. DR EMBL; AY495125; AAR92954.1; -; Genomic_DNA. DR EMBL; AY495126; AAR92967.1; -; Genomic_DNA. DR EMBL; AY495127; AAR92980.1; -; Genomic_DNA. DR EMBL; AY495128; AAR92993.1; -; Genomic_DNA. DR EMBL; AY495129; AAR93006.1; -; Genomic_DNA. DR EMBL; AY495130; AAR93019.1; -; Genomic_DNA. DR EMBL; AY495131; AAR93032.1; -; Genomic_DNA. DR EMBL; AY495132; AAR93045.1; -; Genomic_DNA. DR EMBL; AY495133; AAR93058.1; -; Genomic_DNA. DR EMBL; AY495134; AAR93071.1; -; Genomic_DNA. DR EMBL; AY495135; AAR93084.1; -; Genomic_DNA. DR EMBL; AY495136; AAR93097.1; -; Genomic_DNA. DR EMBL; AY495137; AAR93110.1; -; Genomic_DNA. DR EMBL; AY495138; AAR93123.1; -; Genomic_DNA. DR EMBL; AY495139; AAR93136.1; -; Genomic_DNA. DR EMBL; AY495140; AAR93149.1; -; Genomic_DNA. DR EMBL; AY495141; AAR93162.1; -; Genomic_DNA. DR EMBL; AY495142; AAR93175.1; -; Genomic_DNA. DR EMBL; AY495143; AAR93188.1; -; Genomic_DNA. DR EMBL; AY495144; AAR93201.1; -; Genomic_DNA. DR EMBL; AY495145; AAR93214.1; -; Genomic_DNA. DR EMBL; AY495146; AAR93227.1; -; Genomic_DNA. DR EMBL; AY495147; AAR93240.1; -; Genomic_DNA. DR EMBL; AY495148; AAR93253.1; -; Genomic_DNA. DR EMBL; AY495149; AAR93266.1; -; Genomic_DNA. DR EMBL; AY495150; AAR93279.1; -; Genomic_DNA. DR EMBL; AY495151; AAR93292.1; -; Genomic_DNA. DR EMBL; AY495152; AAR93305.1; -; Genomic_DNA. DR EMBL; AY495153; AAR93318.1; -; Genomic_DNA. DR EMBL; AY495154; AAR93331.1; -; Genomic_DNA. DR EMBL; AY495155; AAR93344.1; -; Genomic_DNA. DR EMBL; AY495156; AAR93357.1; -; Genomic_DNA. DR EMBL; AY495157; AAR93370.1; -; Genomic_DNA. DR EMBL; AY495158; AAR93383.1; -; Genomic_DNA. DR EMBL; AY495159; AAR93396.1; -; Genomic_DNA. DR EMBL; AY495160; AAR93409.1; -; Genomic_DNA. DR EMBL; AY495161; AAR93422.1; -; Genomic_DNA. DR EMBL; AY495162; AAR93435.1; -; Genomic_DNA. DR EMBL; AY495163; AAR93448.1; -; Genomic_DNA. DR EMBL; AY495164; AAR93461.1; -; Genomic_DNA. DR EMBL; AY495166; AAR93487.1; -; Genomic_DNA. DR EMBL; AY495167; AAR93500.1; -; Genomic_DNA. DR EMBL; AY495168; AAR93513.1; -; Genomic_DNA. DR EMBL; AY495169; AAR93526.1; -; Genomic_DNA. DR EMBL; AY495170; AAR93539.1; -; Genomic_DNA. DR EMBL; AY495172; AAR93565.1; -; Genomic_DNA. DR EMBL; AY495173; AAR93578.1; -; Genomic_DNA. DR EMBL; AY495174; AAR93591.1; -; Genomic_DNA. DR EMBL; AY495175; AAR93604.1; -; Genomic_DNA. DR EMBL; AY495176; AAR93617.1; -; Genomic_DNA. DR EMBL; AY495177; AAR93630.1; -; Genomic_DNA. DR EMBL; AY495178; AAR93643.1; -; Genomic_DNA. DR EMBL; AY495179; AAR93656.1; -; Genomic_DNA. DR EMBL; AY495180; AAR93669.1; -; Genomic_DNA. DR EMBL; AY495181; AAR93682.1; -; Genomic_DNA. DR EMBL; AY495182; AAR93695.1; -; Genomic_DNA. DR EMBL; AY495183; AAR93708.1; -; Genomic_DNA. DR EMBL; AY495184; AAR93721.1; -; Genomic_DNA. DR EMBL; AY495185; AAR93734.1; -; Genomic_DNA. DR EMBL; AY495186; AAR93747.1; -; Genomic_DNA. DR EMBL; AY495187; AAR93760.1; -; Genomic_DNA. DR EMBL; AY495188; AAR93773.1; -; Genomic_DNA. DR EMBL; AY495189; AAR93786.1; -; Genomic_DNA. DR EMBL; AY495190; AAR93799.1; -; Genomic_DNA. DR EMBL; AY495191; AAR93812.1; -; Genomic_DNA. DR EMBL; AY495192; AAR93825.1; -; Genomic_DNA. DR EMBL; AY495193; AAR93838.1; -; Genomic_DNA. DR EMBL; AY495194; AAR93851.1; -; Genomic_DNA. DR EMBL; AY495195; AAR93864.1; -; Genomic_DNA. DR EMBL; AY495196; AAR93877.1; -; Genomic_DNA. DR EMBL; AY495197; AAR93890.1; -; Genomic_DNA. DR EMBL; AY495198; AAR93903.1; -; Genomic_DNA. DR EMBL; AY495199; AAR93916.1; -; Genomic_DNA. DR EMBL; AY495200; AAR93929.1; -; Genomic_DNA. DR EMBL; AY495201; AAR93942.1; -; Genomic_DNA. DR EMBL; AY495202; AAR93955.1; -; Genomic_DNA. DR EMBL; AY495203; AAR93968.1; -; Genomic_DNA. DR EMBL; AY495204; AAR93981.1; -; Genomic_DNA. DR EMBL; AY495205; AAR93994.1; -; Genomic_DNA. DR EMBL; AY495206; AAR94007.1; -; Genomic_DNA. DR EMBL; AY495207; AAR94020.1; -; Genomic_DNA. DR EMBL; AY495208; AAR94033.1; -; Genomic_DNA. DR EMBL; AY495209; AAR94046.1; -; Genomic_DNA. DR EMBL; AY495210; AAR94059.1; -; Genomic_DNA. DR EMBL; AY495211; AAR94072.1; -; Genomic_DNA. DR EMBL; AY495212; AAR94085.1; -; Genomic_DNA. DR EMBL; AY495213; AAR94098.1; -; Genomic_DNA. DR EMBL; AY495214; AAR94111.1; -; Genomic_DNA. DR EMBL; AY495215; AAR94124.1; -; Genomic_DNA. DR EMBL; AY495216; AAR94137.1; -; Genomic_DNA. DR EMBL; AY495217; AAR94150.1; -; Genomic_DNA. DR EMBL; AY495218; AAR94163.1; -; Genomic_DNA. DR EMBL; AY495219; AAR94176.1; -; Genomic_DNA. DR EMBL; AY495220; AAR94189.1; -; Genomic_DNA. DR EMBL; AY495221; AAR94202.1; -; Genomic_DNA. DR EMBL; AY495223; AAR94228.1; -; Genomic_DNA. DR EMBL; AY495224; AAR94241.1; -; Genomic_DNA. DR EMBL; AY495225; AAR94254.1; -; Genomic_DNA. DR EMBL; AY495226; AAR94267.1; -; Genomic_DNA. DR EMBL; AY495227; AAR94280.1; -; Genomic_DNA. DR EMBL; AY495228; AAR94293.1; -; Genomic_DNA. DR EMBL; AY495229; AAR94306.1; -; Genomic_DNA. DR EMBL; AY495230; AAR94319.1; -; Genomic_DNA. DR EMBL; AY495231; AAR94332.1; -; Genomic_DNA. DR EMBL; AY495232; AAR94345.1; -; Genomic_DNA. DR EMBL; AY495233; AAR94358.1; -; Genomic_DNA. DR EMBL; AY495234; AAR94371.1; -; Genomic_DNA. DR EMBL; AY495235; AAR94384.1; -; Genomic_DNA. DR EMBL; AY495236; AAR94397.1; -; Genomic_DNA. DR EMBL; AY495237; AAR94410.1; -; Genomic_DNA. DR EMBL; AY495238; AAR94423.1; -; Genomic_DNA. DR EMBL; AY495239; AAR94436.1; -; Genomic_DNA. DR EMBL; AY495240; AAR94449.1; -; Genomic_DNA. DR EMBL; AY495241; AAR94462.1; -; Genomic_DNA. DR EMBL; AY495242; AAR94475.1; -; Genomic_DNA. DR EMBL; AY495243; AAR94488.1; -; Genomic_DNA. DR EMBL; AY495244; AAR94501.1; -; Genomic_DNA. DR EMBL; AY495245; AAR94514.1; -; Genomic_DNA. DR EMBL; AY495246; AAR94527.1; -; Genomic_DNA. DR EMBL; AY495247; AAR94540.1; -; Genomic_DNA. DR EMBL; AY495248; AAR94553.1; -; Genomic_DNA. DR EMBL; AY495249; AAR94566.1; -; Genomic_DNA. DR EMBL; AY495250; AAR94579.1; -; Genomic_DNA. DR EMBL; AY495251; AAR94592.1; -; Genomic_DNA. DR EMBL; AY495252; AAR94605.1; -; Genomic_DNA. DR EMBL; AY495253; AAR94618.1; -; Genomic_DNA. DR EMBL; AY495254; AAR94631.1; -; Genomic_DNA. DR EMBL; AY495255; AAR94644.1; -; Genomic_DNA. DR EMBL; AY495256; AAR94657.1; -; Genomic_DNA. DR EMBL; AY495257; AAR94670.1; -; Genomic_DNA. DR EMBL; AY495258; AAR94683.1; -; Genomic_DNA. DR EMBL; AY495259; AAR94696.1; -; Genomic_DNA. DR EMBL; AY495260; AAR94709.1; -; Genomic_DNA. DR EMBL; AY495261; AAR94722.1; -; Genomic_DNA. DR EMBL; AY495262; AAR94735.1; -; Genomic_DNA. DR EMBL; AY495263; AAR94748.1; -; Genomic_DNA. DR EMBL; AY495264; AAR94761.1; -; Genomic_DNA. DR EMBL; AY495265; AAR94774.1; -; Genomic_DNA. DR EMBL; AY495266; AAR94787.1; -; Genomic_DNA. DR EMBL; AY495267; AAR94800.1; -; Genomic_DNA. DR EMBL; AY495268; AAR94813.1; -; Genomic_DNA. DR EMBL; AY495269; AAR94826.1; -; Genomic_DNA. DR EMBL; AY495270; AAR94839.1; -; Genomic_DNA. DR EMBL; AY495271; AAR94852.1; -; Genomic_DNA. DR EMBL; AY495272; AAR94865.1; -; Genomic_DNA. DR EMBL; AY495273; AAR94878.1; -; Genomic_DNA. DR EMBL; AY495274; AAR94891.1; -; Genomic_DNA. DR EMBL; AY495275; AAR94904.1; -; Genomic_DNA. DR EMBL; AY495276; AAR94917.1; -; Genomic_DNA. DR EMBL; AY495277; AAR94930.1; -; Genomic_DNA. DR EMBL; AY495278; AAR94943.1; -; Genomic_DNA. DR EMBL; AY495279; AAR94956.1; -; Genomic_DNA. DR EMBL; AY495280; AAR94969.1; -; Genomic_DNA. DR EMBL; AY495281; AAR94982.1; -; Genomic_DNA. DR EMBL; AY495282; AAR94995.1; -; Genomic_DNA. DR EMBL; AY495283; AAR95008.1; -; Genomic_DNA. DR EMBL; AY495284; AAR95021.1; -; Genomic_DNA. DR EMBL; AY495285; AAR95034.1; -; Genomic_DNA. DR EMBL; AY495286; AAR95047.1; -; Genomic_DNA. DR EMBL; AY495287; AAR95060.1; -; Genomic_DNA. DR EMBL; AY495288; AAR95073.1; -; Genomic_DNA. DR EMBL; AY495289; AAR95086.1; -; Genomic_DNA. DR EMBL; AY495290; AAR95099.1; -; Genomic_DNA. DR EMBL; AY495291; AAR95112.1; -; Genomic_DNA. DR EMBL; AY495292; AAR95125.1; -; Genomic_DNA. DR EMBL; AY495293; AAR95138.1; -; Genomic_DNA. DR EMBL; AY495294; AAR95151.1; -; Genomic_DNA. DR EMBL; AY495295; AAR95164.1; -; Genomic_DNA. DR EMBL; AY495296; AAR95177.1; -; Genomic_DNA. DR EMBL; AY495297; AAR95190.1; -; Genomic_DNA. DR EMBL; AY495298; AAR95203.1; -; Genomic_DNA. DR EMBL; AY495299; AAR95216.1; -; Genomic_DNA. DR EMBL; AY495300; AAR95229.1; -; Genomic_DNA. DR EMBL; AY495301; AAR95242.1; -; Genomic_DNA. DR EMBL; AY495302; AAR95255.1; -; Genomic_DNA. DR EMBL; AY495303; AAR95268.1; -; Genomic_DNA. DR EMBL; AY495304; AAR95281.1; -; Genomic_DNA. DR EMBL; AY495305; AAR95294.1; -; Genomic_DNA. DR EMBL; AY495306; AAR95307.1; -; Genomic_DNA. DR EMBL; AY495307; AAR95320.1; -; Genomic_DNA. DR EMBL; AY495308; AAR95333.1; -; Genomic_DNA. DR EMBL; AY495309; AAR95346.1; -; Genomic_DNA. DR EMBL; AY495310; AAR95359.1; -; Genomic_DNA. DR EMBL; AY495311; AAR95372.1; -; Genomic_DNA. DR EMBL; AY495312; AAR95385.1; -; Genomic_DNA. DR EMBL; AY495313; AAR95398.1; -; Genomic_DNA. DR EMBL; AY495314; AAR95411.1; -; Genomic_DNA. DR EMBL; AY495315; AAR95424.1; -; Genomic_DNA. DR EMBL; AY495316; AAR95437.1; -; Genomic_DNA. DR EMBL; AY495317; AAR95450.1; -; Genomic_DNA. DR EMBL; AY495318; AAR95463.1; -; Genomic_DNA. DR EMBL; AY495319; AAR95476.1; -; Genomic_DNA. DR EMBL; AY495320; AAR95489.1; -; Genomic_DNA. DR EMBL; AY495321; AAR95502.1; -; Genomic_DNA. DR EMBL; AY495322; AAR95515.1; -; Genomic_DNA. DR EMBL; AY495323; AAR95528.1; -; Genomic_DNA. DR EMBL; AY495325; AAR95554.1; -; Genomic_DNA. DR EMBL; AY495326; AAR95567.1; -; Genomic_DNA. DR EMBL; AY495327; AAR95580.1; -; Genomic_DNA. DR EMBL; AY495328; AAR95593.1; -; Genomic_DNA. DR EMBL; AY495329; AAR95606.1; -; Genomic_DNA. DR EMBL; AY495330; AAR95619.1; -; Genomic_DNA. DR EMBL; X55654; CAA39187.1; -; mRNA. DR PIR; A00472; OBHU2. DR RefSeq; YP_003024029.1; NC_012920.1. DR PDB; 3VRJ; X-ray; 1.90 A; C=46-55. DR PDB; 5Z62; EM; 3.60 A; B=1-227. DR PDB; 9I6F; EM; 2.95 A; B=1-227. DR PDB; 9I7U; EM; 3.15 A; B=1-227. DR SMR; P00403; -. DR BioGRID; 110616; 240. DR ComplexPortal; CPX-6123; Mitochondrial respiratory chain complex IV. DR CORUM; P00403; -. DR IntAct; P00403; 94. DR STRING; 9606.ENSP00000354876; -. DR NDEx; IQUERY-CP-MT-CO2; 3 NDEx IQuery Curated Pathways. DR BindingDB; P00403; -. DR ChEMBL; CHEMBL6174; -. DR DrugBank; DB02659; Cholic Acid. DR DrugBank; DB04464; N-Formylmethionine. DR DrugBank; DB05412; Talmapimod. DR TCDB; 3.D.4.11.1; the proton-translocating cytochrome oxidase (cox) superfamily. DR GlyGen; P00403; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; P00403; -. DR PhosphoSitePlus; P00403; -. DR SwissPalm; P00403; -. DR MetOSite; P00403; -. DR BioMuta; MT-CO2; -. DR DMDM; 117020; -. DR PaxDb; 9606-ENSP00000354876; -. DR PeptideAtlas; P00403; -. DR PRIDE; P00403; -. DR ProteomicsDB; 51247; -. DR Pumba; P00403; -. DR TopDownProteomics; P00403; -. DR jPOST; P00403; -. DR MassIVE; P00403; -. DR DNASU; 4513; -. DR Ensembl; ENST00000361739.1; ENSP00000354876.1; ENSG00000198712.1. DR GeneID; 4513; -. DR KEGG; hsa:4513; -. DR CTD; 4513; -. DR DisGeNET; 4513; -. DR VEuPathDB; HostDB:ENSG00000198712; -. DR GeneCards; MT-CO2; -. DR GeneReviews; MT-CO2; -. DR HGNC; HGNC:7421; MT-CO2. DR AGR; HGNC:52028; -. DR AGR; HGNC:7421; -. DR HPA; ENSG00000198712; Tissue enhanced (heart). DR MalaCards; MT-CO2; -. DR MIM; 220110; phenotype. DR MIM; 516040; gene. DR OpenTargets; ENSG00000198712; -. DR Orphanet; 254905; Isolated cytochrome C oxidase deficiency. DR Orphanet; 550; MELAS. DR ClinPGx; PA31227; -. DR eggNOG; KOG4767; Eukaryota. DR GeneTree; ENSGT00390000017410; -. DR HOGENOM; CLU_036876_2_3_1; -. DR InParanoid; P00403; -. DR OMA; AAGFNWW; -. DR PhylomeDB; P00403; -. DR BioCyc; MetaCyc:HS00027-MONOMER; -. DR Reactome; R-HSA-5419276; Mitochondrial translation termination. DR Reactome; R-HSA-5628897; TP53 Regulates Metabolic Genes. DR Reactome; R-HSA-611105; Respiratory electron transport. DR Reactome; R-HSA-9707564; Cytoprotection by HMOX1. DR Reactome; R-HSA-9837999; Mitochondrial protein degradation. DR Reactome; R-HSA-9864848; Complex IV assembly. DR SignaLink; P00403; -. DR SIGNOR; P00403; -. DR ChiTaRS; MT-CO2; human. DR EvolutionaryTrace; P00403; -. DR Agora; ENSG00000198712; -. DR GeneWiki; MT-CO2; -. DR GenomeRNAi; 4513; -. DR PRO; PR:P00403; -. DR Bgee; ENSG00000198712; Expressed in metanephros cortex and 95 other cell types or tissues. DR ExpressionAtlas; P00403; baseline and differential. DR CDD; cd13912; CcO_II_C; 1. DR FunFam; 1.10.287.90:FF:000001; Cytochrome c oxidase subunit 2; 1. DR FunFam; 2.60.40.420:FF:000001; Cytochrome c oxidase subunit 2; 1. DR Gene3D; 1.10.287.90; -; 1. DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 1. DR InterPro; IPR045187; CcO_II. DR InterPro; IPR002429; CcO_II-like_C. DR InterPro; IPR034210; CcO_II_C. DR InterPro; IPR001505; Copper_CuA. DR InterPro; IPR008972; Cupredoxin. DR InterPro; IPR014222; Cyt_c_oxidase_su2. DR InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom. DR InterPro; IPR036257; Cyt_c_oxidase_su2_TM_sf. DR PANTHER; PTHR22888:SF9; CYTOCHROME C OXIDASE SUBUNIT 2; 1. DR PANTHER; PTHR22888; CYTOCHROME C OXIDASE, SUBUNIT II; 1. DR Pfam; PF00116; COX2; 1. DR Pfam; PF02790; COX2_TM; 1. DR PRINTS; PR01166; CYCOXIDASEII. DR SUPFAM; SSF49503; Cupredoxins; 1. DR SUPFAM; SSF81464; Cytochrome c oxidase subunit II-like, transmembrane region; 1. DR NCBIfam; TIGR02866; CoxB; 1. DR PROSITE; PS00078; COX2; 1. DR PROSITE; PS50857; COX2_CUA; 1. DR PROSITE; PS50999; COX2_TM; 1. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:CAFA. DR GO; GO:0005759; C:mitochondrial matrix; TAS:Reactome. DR GO; GO:0031966; C:mitochondrial membrane; IDA:ComplexPortal. DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB. DR GO; GO:0045277; C:respiratory chain complex IV; IDA:UniProtKB. DR GO; GO:0005507; F:copper ion binding; IEA:InterPro. DR GO; GO:0004129; F:cytochrome-c oxidase activity; ISS:UniProtKB. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IBA:GO_Central. DR GO; GO:0045333; P:cellular respiration; NAS:ComplexPortal. DR GO; GO:0007595; P:lactation; IEA:Ensembl. DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; ISS:FlyBase. DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl. DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl. DR Proteomes; UP000005640; Mitochondrion MT. DR PathwayCommons; P00403; -. DR Pharos; P00403; Tchem. DR DrugCentral; P00403; -. DR Antibodypedia; 4262; 305 antibodies from 37 providers. DR RNAct; P00403; protein. DR BioGRID-ORCS; 4513; 0 hits in 2 CRISPR screens. DR AlphaFoldDB; P00403; -. DR EMDB; EMD-52654; -. DR EMDB; EMD-52662; -. DR CD-CODE; 91857CE7; Nucleolus. DR CD-CODE; FB4E32DD; Presynaptic clusters and postsynaptic densities. DR FunCoup; P00403; 226. DR PAN-GO; P00403; 4 GO annotations based on evolutionary models. PE 1: Evidence at protein level; KW 3D-structure; Copper; Cytochrome c-type biogenesis; Disease variant; KW Electron transport; Magnesium; Membrane; Metal-binding; Mitochondrion; KW Mitochondrion inner membrane; Primary mitochondrial disease; KW Proteomics identification; Reference proteome; Respiratory chain; KW Translocase; Transmembrane; Transmembrane helix; Transport. FT CHAIN 1..227 FT /note="Cytochrome c oxidase subunit 2" FT /id="PRO_0000183610" FT TOPO_DOM 1..14 FT /note="Mitochondrial intermembrane" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 15..45 FT /note="Helical; Name=I" FT /evidence="ECO:0000250|UniProtKB:P68530" FT TOPO_DOM 46..59 FT /note="Mitochondrial matrix" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 60..87 FT /note="Helical; Name=II" FT /evidence="ECO:0000250|UniProtKB:P68530" FT TOPO_DOM 88..227 FT /note="Mitochondrial intermembrane" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 161 FT /ligand="Cu cation" FT /ligand_id="ChEBI:CHEBI:23378" FT /ligand_label="A1" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 196 FT /ligand="Cu cation" FT /ligand_id="ChEBI:CHEBI:23378" FT /ligand_label="A1" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 196 FT /ligand="Cu cation" FT /ligand_id="ChEBI:CHEBI:23378" FT /ligand_label="A2" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 198 FT /ligand="Cu cation" FT /ligand_id="ChEBI:CHEBI:23378" FT /ligand_label="A2" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 198 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_note="ligand shared with MT-CO1" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 200 FT /ligand="Cu cation" FT /ligand_id="ChEBI:CHEBI:23378" FT /ligand_label="A1" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 200 FT /ligand="Cu cation" FT /ligand_id="ChEBI:CHEBI:23378" FT /ligand_label="A2" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 204 FT /ligand="Cu cation" FT /ligand_id="ChEBI:CHEBI:23378" FT /ligand_label="A2" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 207 FT /ligand="Cu cation" FT /ligand_id="ChEBI:CHEBI:23378" FT /ligand_label="A1" FT /evidence="ECO:0000269|PubMed:30030519" FT VARIANT 11 FT /note="D -> A" FT /evidence="ECO:0000269|PubMed:1757091" FT /id="VAR_008863" FT VARIANT 29 FT /note="M -> K (in MT-C4D; affect the stability of the COX FT complex; dbSNP:rs199474827)" FT /evidence="ECO:0000269|PubMed:10486321" FT /id="VAR_035085" FT VARIANT 30 FT /note="I -> V (in dbSNP:rs1569484167)" FT /evidence="ECO:0000269|PubMed:8277847" FT /id="VAR_011344" FT VARIANT 123 FT /note="L -> P" FT /evidence="ECO:0000269|PubMed:1757091" FT /id="VAR_008571" FT VARIANT 142 FT /note="V -> M (in colorectal cancer; dbSNP:rs199474826)" FT /evidence="ECO:0000269|PubMed:9806551" FT /id="VAR_008390" FT VARIANT 148 FT /note="A -> T (in dbSNP:rs1116904)" FT /evidence="ECO:0000269|PubMed:8277847" FT /id="VAR_011345" FT VARIANT 187 FT /note="T -> M" FT /evidence="ECO:0000269|PubMed:1757091" FT /id="VAR_008572" FT HELIX 9..12 FT /evidence="ECO:0007829|PDB:9I6F" FT HELIX 15..46 FT /evidence="ECO:0007829|PDB:9I6F" FT HELIX 62..84 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 94..102 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 105..110 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 112..114 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 116..120 FT /evidence="ECO:0007829|PDB:9I6F" FT HELIX 125..127 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 134..136 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 138..140 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 142..144 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 146..148 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 150..159 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 161..165 FT /evidence="ECO:0007829|PDB:9I6F" FT TURN 166..169 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 170..174 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 180..184 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 190..195 FT /evidence="ECO:0007829|PDB:9I6F" FT TURN 202..205 FT /evidence="ECO:0007829|PDB:9I6F" FT STRAND 208..213 FT /evidence="ECO:0007829|PDB:9I6F" FT HELIX 216..219 FT /evidence="ECO:0007829|PDB:9I6F" SQ SEQUENCE 227 AA; 25565 MW; 402A3145241DDEE6 CRC64; MAHAAQVGLQ DATSPIMEEL ITFHDHALMI IFLICFLVLY ALFLTLTTKL TNTNISDAQE METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL //