ID   AK_CHLTR                Reviewed;         431 AA.
AC   O84367;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   04-NOV-2026, entry version 128.
DE   RecName: Full=Aspartokinase;
DE            EC=2.7.2.4;
DE   AltName: Full=Aspartate kinase;
GN   Name=lysC; OrderedLocusNames=CT_362;
OS   Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx).
OC   Bacteria; Pseudomonadati; Chlamydiota; Chlamydiia; Chlamydiales;
OC   Chlamydiaceae; Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-885 / DSM 19411 / UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-aspartate + ATP = 4-phospho-L-aspartate + ADP;
CC         Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC       pathway; L-homoserine from L-aspartate: step 1/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC       from L-aspartate: step 1/5.
CC   -!- SIMILARITY: Belongs to the aspartokinase family. {ECO:0000305}.
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DR   EMBL; AE001273; AAC67958.1; -; Genomic_DNA.
DR   PIR; G71524; G71524.
DR   RefSeq; NP_219871.1; NC_000117.1.
DR   RefSeq; WP_010725171.1; NC_000117.1.
DR   AlphaFoldDB; O84367; -.
DR   SMR; O84367; -.
DR   FunCoup; O84367; 62.
DR   STRING; 272561.CT_362; -.
DR   EnsemblBacteria; AAC67958; AAC67958; CT_362.
DR   GeneID; 884754; -.
DR   KEGG; ctr:CT_362; -.
DR   PATRIC; fig|272561.5.peg.391; -.
DR   HOGENOM; CLU_009116_6_0_0; -.
DR   InParanoid; O84367; -.
DR   OMA; AADNIHD; -.
DR   OrthoDB; 9799110at2; -.
DR   UniPathway; UPA00034; UER00015.
DR   UniPathway; UPA00050; UER00461.
DR   UniPathway; UPA00051; UER00462.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004072; F:aspartate kinase activity; IBA:GO_Central.
DR   GO; GO:0009090; P:L-homoserine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009085; P:L-lysine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009088; P:L-threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04243; AAK_AK-HSDH-like; 1.
DR   Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR   Gene3D; 1.20.120.1320; Aspartokinase, catalytic domain; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR001341; Asp_kinase.
DR   InterPro; IPR042199; AsparK_Bifunc_asparK/hSer_DH.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   NCBIfam; TIGR00657; asp_kinases; 1.
DR   NCBIfam; NF004579; PRK05925.1; 1.
DR   PANTHER; PTHR21499; ASPARTATE KINASE; 1.
DR   PANTHER; PTHR21499:SF3; ASPARTOKINASE; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   SUPFAM; SSF53633; Carbamate kinase-like; 1.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Diaminopimelate biosynthesis; Kinase;
KW   Lysine biosynthesis; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..431
FT                   /note="Aspartokinase"
FT                   /id="PRO_0000066675"
SQ   SEQUENCE   431 AA;  47648 MW;  170F9B7DB1DCC919 CRC64;
     MLRQETAPLV CKFGGTSVGT AQSIRRVCEI IQEERPSFVV VSAVAGVTDW LEEFCRLPKG
     KRAALTEKIR ERHESIAKEL GIEVSLAIFW EILEHFEDVE ELFSEDQARI LAIGEDLSST
     LICSYCCTYV LPLKRLEARQ VILTDSQFLR AVPDLALMQT AWGELALQED TIYLMQGFLG
     ATSSGKTTVL GRGGSDFSAS LIGELCKARE LRIYTDVCGV HTADPKILKD TQLIDSLTFE
     EMQELASSGA KVLHQDMLKP CVRAKVPIFV TSTFNVTKEG TWICASLNES TEGPVIKALS
     LKSNQALWFV EYNSPLVRLE DVLGCVRSLG FVPGVVMAQS LGVYFTIDWE EYPQTITKAL
     EAFGTVSCEG PLSLVALVGA KLASWSMSRV FEALHRTPVL CWSQTDTVIN LIINKDFGVA
     VTELLHDCLF K
//