ID   O67390_AQUAE            Unreviewed;       501 AA.
AC   O67390;
DT   01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 1.
DT   04-NOV-2026, entry version 138.
DE   SubName: Full=NADH dehydrogenase I chain M {ECO:0000313|EMBL:AAC07353.1};
GN   Name=nuoM2 {ECO:0000313|EMBL:AAC07353.1};
GN   OrderedLocusNames=aq_1382 {ECO:0000313|EMBL:AAC07353.1};
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Pseudomonadati; Aquificota; Aquificia; Aquificales; Aquificaceae;
OC   Aquifex.
OX   NCBI_TaxID=224324 {ECO:0000313|EMBL:AAC07353.1, ECO:0000313|Proteomes:UP000000798};
RN   [1] {ECO:0000313|EMBL:AAC07353.1, ECO:0000313|Proteomes:UP000000798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5 {ECO:0000313|EMBL:AAC07353.1,
RC   ECO:0000313|Proteomes:UP000000798};
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olson G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4 family.
CC       {ECO:0000256|ARBA:ARBA00009025}.
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DR   EMBL; AE000657; AAC07353.1; -; Genomic_DNA.
DR   PIR; C70420; C70420.
DR   RefSeq; WP_010880892.1; NC_000918.1.
DR   AlphaFoldDB; O67390; -.
DR   FunCoup; O67390; 135.
DR   STRING; 224324.aq_1382; -.
DR   EnsemblBacteria; AAC07353; AAC07353; aq_1382.
DR   KEGG; aae:aq_1382; -.
DR   PATRIC; fig|224324.8.peg.1081; -.
DR   eggNOG; COG1008; Bacteria.
DR   HOGENOM; CLU_007100_4_4_0; -.
DR   InParanoid; O67390; -.
DR   OMA; AAFKFFV; -.
DR   OrthoDB; 9807568at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0045271; C:respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0048039; F:ubiquinone binding; IBA:GO_Central.
DR   GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR   InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_TM.
DR   NCBIfam; TIGR01972; NDH_I_M; 1.
DR   PANTHER; PTHR43507; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1.
DR   PANTHER; PTHR43507:SF1; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000798};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000320};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        35..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        88..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        118..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        171..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        212..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        283..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        311..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        342..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        380..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        418..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        458..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          137..429
FT                   /note="NADH:quinone oxidoreductase/Mrp antiporter
FT                   transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF00361"
SQ   SEQUENCE   501 AA;  56526 MW;  B12172EBF819C47A CRC64;
     MEKVGFEFPI ISVSLAIPAV FAVLILFFKE KFAKYIALLG TGLTFLVSLI ALFKFDFARD
     NVIQFYEEYT ILKELGVKLS LGMDGLSLLM YFLTTLVSLI AVIWSIGDEK IKHRLKEYYI
     AFLLTESFVI GVFTTFNLIV FYVFYELTLL PMLFVIGIWG YKLRLYSAYK FFVYIFISSL
     FLLLGIASIS TYHYKMNGSF TFEYLELLNL NIPNGFEIFL FLLFFIAFAV KTPIVPFHTW
     LPDAHGEAPT AGSVVLAAIL LKMGTYALVR FNIGLFPDAA LELSPYLVAL GIYSIIMASW
     MTISQTNIKR FVAYSSVSHM GFVVTAAFLL NMEGLRASII EMFAHGLTSA GLFMVAGYIY
     NKLHTFNFAS LRGAIKFMPL FATITAATAF AAMGLPGGSS FWGKFLTILA AREYSTPLAF
     LVVFAAFFSA AYVLYFLKTL YLDVREESVL IHFKDVSGYP LVAFLMIVIP VLLVGFVPFI
     FFAFYNEFLV HLLKYVLKLP F
//