ID O58151_PYRHO Unreviewed; 336 AA. AC O58151; DT 01-AUG-1998, integrated into UniProtKB/TrEMBL. DT 01-AUG-1998, sequence version 1. DT 04-NOV-2026, entry version 146. DE RecName: Full=UDP-glucose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00067046}; DE EC=4.2.1.76 {ECO:0000256|ARBA:ARBA00067046}; GN OrderedLocusNames=PH0414 {ECO:0000313|EMBL:BAA29500.1}; OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC OS 100139 / OT-3). OC Archaea; Methanobacteriati; Methanobacteriota; Thermococci; Thermococcales; OC Thermococcaceae; Pyrococcus. OX NCBI_TaxID=70601 {ECO:0000313|EMBL:BAA29500.1, ECO:0000313|Proteomes:UP000000752}; RN [1] {ECO:0000313|EMBL:BAA29500.1, ECO:0000313|Proteomes:UP000000752} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3 RC {ECO:0000313|Proteomes:UP000000752}; RX PubMed=9679194; DOI=10.1093/dnares/5.2.55; RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., RA Otuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T., RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Nakamura Y., RA Robb T.F., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.; RT "Complete sequence and gene organization of the genome of a hyper- RT thermophilic archaebacterium, Pyrococcus horikoshii OT3."; RL DNA Res. 5:55-76(1998). RN [2] {ECO:0007829|PDB:2HUN} RP X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS) IN COMPLEX WITH NAD(+). RA Yamamoto H., Kunishima N.; RT "Crystal structure of hypothetical protein PH0414 from Pyrococcus RT horikoshii OT3."; RL Submitted (JUL-2006) to the PDB data bank. CC -!- COFACTOR: CC Name=NAD(+); Xref=ChEBI:CHEBI:57540; CC Evidence={ECO:0000256|ARBA:ARBA00001911}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BA000001; BAA29500.1; -; Genomic_DNA. DR PIR; G71151; G71151. DR PDB; 2HUN; X-ray; 2.07 A; A/B=1-336. DR AlphaFoldDB; O58151; -. DR SMR; O58151; -. DR STRING; 70601.gene:9377345; -. DR EnsemblBacteria; BAA29500; BAA29500; BAA29500. DR KEGG; pho:PH0414; -. DR eggNOG; arCOG01371; Archaea. DR OMA; AACKFEV; -. DR EvolutionaryTrace; O58151; -. DR Proteomes; UP000000752; Chromosome. DR GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:InterPro. DR GO; GO:0050377; F:UDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC. DR GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro. DR CDD; cd05246; dTDP_GD_SDR_e; 1. DR FunFam; 3.40.50.720:FF:000304; UDP-glucose 4,6-dehydratase; 1. DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1. DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1. DR InterPro; IPR005888; dTDP_Gluc_deHydtase. DR InterPro; IPR016040; NAD(P)-bd_dom. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR NCBIfam; TIGR01181; dTDP_gluc_dehyt; 1. DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1. DR Pfam; PF16363; GDP_Man_Dehyd; 1. DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:2HUN}; Lyase {ECO:0000256|ARBA:ARBA00023239}; KW NAD {ECO:0000256|ARBA:ARBA00023027}; KW Nucleotide-binding {ECO:0007829|PDB:2HUN}; KW Reference proteome {ECO:0000313|Proteomes:UP000000752}. FT DOMAIN 7..307 FT /note="NAD(P)-binding" FT /evidence="ECO:0000259|Pfam:PF16363" FT BINDING 14 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" FT BINDING 15 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" FT BINDING 36 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" FT BINDING 39 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" FT BINDING 62 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" FT BINDING 63 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" FT BINDING 82 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" FT BINDING 84 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" FT BINDING 86 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" FT BINDING 101 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" FT BINDING 155 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" FT BINDING 181 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0007829|PDB:2HUN" SQ SEQUENCE 336 AA; 38928 MW; FEA88AD528DDBE86 CRC64; MHSMKLLVTG GMGFIGSNFI RYILEKHPDW EVINIDKLGY GSNPANLKDL EDDPRYTFVK GDVADYELVK ELVRKVDGVV HLAAESHVDR SISSPEIFLH SNVIGTYTLL ESIRRENPEV RFVHVSTDEV YGDILKGSFT ENDRLMPSSP YSATKAASDM LVLGWTRTYN LNASITRCTN NYGPYQFPEK LIPKTIIRAS LGLKIPIYGT GKNVRDWLYV EDHVRAIELV LLKGESREIY NISAGEEKTN LEVVKIILRL MGKGEELIEL VEDRPGHDLR YSLDSWKITR DLKWRPKYTF DEGIKKTIDW YLKNEWWWKP LVDERILHPT PWKLKW //