ID   CLD5_HUMAN              Reviewed;         218 AA.
AC   O00501; B3KS11; Q53XW2; Q8WUW3;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   02-SEP-2026, entry version 191.
DE   RecName: Full=Claudin-5;
DE   AltName: Full=Transmembrane protein deleted in VCFS;
DE            Short=TMDVCF;
GN   Name=CLDN5; Synonyms=AWAL, TMVCF;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9192844; DOI=10.1006/geno.1997.4734;
RA   Sirotkin H., Morrow B., St Jore B., Puech A., Das Gupta R., Patanjali S.,
RA   Skoultchi A., Weissman S.M., Kucherlapati R.;
RT   "Identification, characterization, and precise mapping of a human gene
RT   encoding a novel membrane-spanning protein from the 22q11 region deleted in
RT   velo-cardio-facial syndrome.";
RL   Genomics 42:245-251(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA   Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA   Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA   Beare D.M., Dunham I.;
RT   "A genome annotation-driven approach to cloning the human ORFeome.";
RL   Genome Biol. 5:R84.1-R84.11(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   SUBCELLULAR LOCATION.
RX   PubMed=30734065; DOI=10.1007/s00018-019-03030-7;
RA   Berndt P., Winkler L., Cording J., Breitkreuz-Korff O., Rex A., Dithmer S.,
RA   Rausch V., Blasig R., Richter M., Sporbert A., Wolburg H., Blasig I.E.,
RA   Haseloff R.F.;
RT   "Tight junction proteins at the blood-brain barrier: far more than claudin-
RT   5.";
RL   Cell. Mol. Life Sci. 76:1987-2002(2019).
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
CC       Interacts with MPDZ (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       O00501; P29972: AQP1; NbExp=3; IntAct=EBI-18400628, EBI-745213;
CC       O00501; Q6UX41-6: BTNL8; NbExp=3; IntAct=EBI-18400628, EBI-17442596;
CC       O00501; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-18400628, EBI-9083477;
CC       O00501; A0PK11: CLRN2; NbExp=3; IntAct=EBI-18400628, EBI-12813623;
CC       O00501; Q9BT09: CNPY3; NbExp=3; IntAct=EBI-18400628, EBI-2835965;
CC       O00501; Q9Y5Q5: CORIN; NbExp=3; IntAct=EBI-18400628, EBI-17876114;
CC       O00501; P40313: CTRL; NbExp=3; IntAct=EBI-18400628, EBI-7883667;
CC       O00501; Q07325: CXCL9; NbExp=3; IntAct=EBI-18400628, EBI-3911467;
CC       O00501; Q8NBI2: CYB561A3; NbExp=3; IntAct=EBI-18400628, EBI-10269179;
CC       O00501; P52803: EFNA5; NbExp=3; IntAct=EBI-18400628, EBI-1753674;
CC       O00501; Q08426: EHHADH; NbExp=3; IntAct=EBI-18400628, EBI-2339219;
CC       O00501; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-18400628, EBI-711490;
CC       O00501; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-18400628, EBI-10976398;
CC       O00501; P02724: GYPA; NbExp=3; IntAct=EBI-18400628, EBI-702665;
CC       O00501; O43561-2: LAT; NbExp=3; IntAct=EBI-18400628, EBI-8070286;
CC       O00501; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-18400628, EBI-2820517;
CC       O00501; P30301: MIP; NbExp=3; IntAct=EBI-18400628, EBI-8449636;
CC       O00501; Q04941: PLP2; NbExp=3; IntAct=EBI-18400628, EBI-608347;
CC       O00501; Q96GM1: PLPPR2; NbExp=3; IntAct=EBI-18400628, EBI-12955265;
CC       O00501; Q01453: PMP22; NbExp=3; IntAct=EBI-18400628, EBI-2845982;
CC       O00501; Q9NS64: RPRM; NbExp=3; IntAct=EBI-18400628, EBI-1052363;
CC       O00501; P11686: SFTPC; NbExp=3; IntAct=EBI-18400628, EBI-10197617;
CC       O00501; Q13326: SGCG; NbExp=3; IntAct=EBI-18400628, EBI-5357343;
CC       O00501; Q969S0: SLC35B4; NbExp=3; IntAct=EBI-18400628, EBI-10281213;
CC       O00501; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-18400628, EBI-741850;
CC       O00501; Q9NZ01: TECR; NbExp=3; IntAct=EBI-18400628, EBI-2877718;
CC       O00501; P02787: TF; NbExp=3; IntAct=EBI-18400628, EBI-714319;
CC       O00501; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-18400628, EBI-10694905;
CC       O00501; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-18400628, EBI-2844246;
CC       O00501; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-18400628, EBI-2339195;
CC       O00501; Q6ZP80: TMEM182; NbExp=3; IntAct=EBI-18400628, EBI-10255122;
CC       O00501; Q8WZ59: TMEM190; NbExp=3; IntAct=EBI-18400628, EBI-10278423;
CC       O00501; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-18400628, EBI-347385;
CC       O00501; O60636: TSPAN2; NbExp=3; IntAct=EBI-18400628, EBI-3914288;
CC       O00501; O95183: VAMP5; NbExp=3; IntAct=EBI-18400628, EBI-10191195;
CC       O00501; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-18400628, EBI-7850136;
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000269|PubMed:30734065}. Cell membrane
CC       {ECO:0000250|UniProtKB:O54942}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR   EMBL; AF000959; AAC51364.1; -; mRNA.
DR   EMBL; CR456420; CAG30306.1; -; mRNA.
DR   EMBL; AK092561; BAG52573.1; -; mRNA.
DR   EMBL; BT007254; AAP35918.1; -; mRNA.
DR   EMBL; AC000082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC002404; AAH02404.1; -; mRNA.
DR   EMBL; BC019290; AAH19290.2; -; mRNA.
DR   EMBL; BC032363; AAH32363.1; -; mRNA.
DR   CCDS; CCDS93118.1; -.
DR   RefSeq; NP_001124333.1; NM_001130861.1.
DR   RefSeq; NP_001349995.1; NM_001363066.2.
DR   RefSeq; NP_001413331.1; NM_001426402.1.
DR   RefSeq; NP_003268.2; NM_003277.4.
DR   AlphaFoldDB; O00501; -.
DR   SMR; O00501; -.
DR   BioGRID; 112977; 49.
DR   FunCoup; O00501; 371.
DR   IntAct; O00501; 36.
DR   NDEx; IQUERY-CP-CLDN5; 6 NDEx IQuery Curated Pathways.
DR   STRING; 9606.ENSP00000385477; -.
DR   TCDB; 1.H.1.1.16; the claudin tight junction (claudin1) family.
DR   iPTMnet; O00501; -.
DR   PhosphoSitePlus; O00501; -.
DR   SwissPalm; O00501; -.
DR   BioMuta; CLDN5; -.
DR   MassIVE; O00501; -.
DR   PaxDb; 9606-ENSP00000385477; -.
DR   PeptideAtlas; O00501; -.
DR   ProteomicsDB; 47945; -.
DR   ABCD; O00501; 13 sequenced antibodies.
DR   Antibodypedia; 3615; 494 antibodies from 41 providers.
DR   DNASU; 7122; -.
DR   Ensembl; ENST00000618236.2; ENSP00000480623.1; ENSG00000184113.10.
DR   GeneID; 7122; -.
DR   KEGG; hsa:7122; -.
DR   MANE-Select; ENST00000618236.2; ENSP00000480623.1; NM_001363066.2; NP_001349995.1.
DR   UCSC; uc062bmp.1; human.
DR   AGR; HGNC:2047; -.
DR   ClinPGx; PA26573; -.
DR   CTD; 7122; -.
DR   DisGeNET; 7122; -.
DR   GeneCards; CLDN5; -.
DR   HGNC; HGNC:2047; CLDN5.
DR   HPA; ENSG00000184113; Tissue enhanced (adipose tissue, breast, choroid plexus, lung).
DR   MalaCards; CLDN5; -.
DR   MIM; 602101; gene.
DR   OpenTargets; ENSG00000184113; -.
DR   VEuPathDB; HostDB:ENSG00000184113; -.
DR   eggNOG; ENOG502QW5D; Eukaryota.
DR   GeneTree; ENSGT00940000161769; -.
DR   HOGENOM; CLU_076370_1_2_1; -.
DR   InParanoid; O00501; -.
DR   OrthoDB; 9423433at2759; -.
DR   PAN-GO; O00501; 3 GO annotations based on evolutionary models.
DR   PhylomeDB; O00501; -.
DR   PathwayCommons; O00501; -.
DR   Reactome; R-HSA-420029; Tight junction interactions.
DR   Reactome; R-HSA-8935964; RUNX1 regulates expression of components of tight junctions.
DR   SignaLink; O00501; -.
DR   SIGNOR; O00501; -.
DR   Agora; ENSG00000184113; -.
DR   BioGRID-ORCS; 7122; 11 hits in 1145 CRISPR screens.
DR   ChiTaRS; CLDN5; human.
DR   GeneWiki; CLDN5; -.
DR   GenomeRNAi; 7122; -.
DR   Pharos; O00501; Tbio.
DR   PRO; PR:O00501; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; O00501; protein.
DR   Bgee; ENSG00000184113; Expressed in right lung and 192 other cell types or tissues.
DR   ExpressionAtlas; O00501; baseline and differential.
DR   GO; GO:0016327; C:apicolateral plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005923; C:bicellular tight junction; IDA:UniProtKB.
DR   GO; GO:0030054; C:cell junction; TAS:Reactome.
DR   GO; GO:0005911; C:cell-cell junction; IDA:UniProtKB.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; TAS:UniProtKB.
DR   GO; GO:0033270; C:paranode region of axon; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR   GO; GO:0043220; C:Schmidt-Lanterman incisure; IEA:Ensembl.
DR   GO; GO:0070160; C:tight junction; IDA:ARUK-UCL.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0016338; P:calcium-independent cell-cell adhesion; ISS:UniProtKB.
DR   GO; GO:0007043; P:cell-cell junction assembly; IMP:UniProtKB.
DR   GO; GO:1990963; P:establishment of blood-retinal barrier; IMP:ARUK-UCL.
DR   GO; GO:0060325; P:face morphogenesis; TAS:UniProtKB.
DR   GO; GO:0007612; P:learning; TAS:UniProtKB.
DR   GO; GO:0035633; P:maintenance of blood-brain barrier; IMP:ARUK-UCL.
DR   GO; GO:0042552; P:myelination; IEA:Ensembl.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IMP:ARUK-UCL.
DR   GO; GO:0030336; P:negative regulation of cell migration; IMP:ARUK-UCL.
DR   GO; GO:0010629; P:negative regulation of gene expression; IMP:ARUK-UCL.
DR   GO; GO:0043116; P:negative regulation of vascular permeability; IMP:ARUK-UCL.
DR   GO; GO:0003151; P:outflow tract morphogenesis; TAS:UniProtKB.
DR   GO; GO:1903348; P:positive regulation of bicellular tight junction assembly; IMP:ARUK-UCL.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:ARUK-UCL.
DR   GO; GO:1903142; P:positive regulation of establishment of endothelial barrier; IMP:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:ARUK-UCL.
DR   GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR   GO; GO:0060021; P:roof of mouth development; TAS:UniProtKB.
DR   GO; GO:0120192; P:tight junction assembly; ISS:ARUK-UCL.
DR   GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
DR   FunFam; 1.20.140.150:FF:000001; Claudin; 1.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR003551; Claudin5.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; CLAUDIN; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01077; CLAUDIN.
DR   PRINTS; PR01380; CLAUDIN5.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Membrane; Proteomics identification;
KW   Reference proteome; Tight junction; Transmembrane; Transmembrane helix.
FT   CHAIN           1..218
FT                   /note="Claudin-5"
FT                   /id="PRO_0000144745"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..218
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          217..218
FT                   /note="Interactions with TJP1, TJP2 and TJP3"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   218 AA;  23147 MW;  9F7F9E194D25425F CRC64;
     MGSAALEILG LVLCLVGWGG LILACGLPMW QVTAFLDHNI VTAQTTWKGL WMSCVVQSTG
     HMQCKVYDSV LALSTEVQAA RALTVSAVLL AFVALFVTLA GAQCTTCVAP GPAKARVALT
     GGVLYLFCGL LALVPLCWFA NIVVREFYDP SVPVSQKYEL GAALYIGWAA TALLMVGGCL
     LCCGAWVCTG RPDLSFPVKY SAPRRPTATG DYDKKNYV
//