ID   J7IX44_DESMD            Unreviewed;       395 AA.
AC   J7IX44;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   08-OCT-2025, entry version 69.
DE   SubName: Full=Alanine racemase {ECO:0000313|EMBL:AFQ46387.1};
GN   OrderedLocusNames=Desmer_4583 {ECO:0000313|EMBL:AFQ46387.1};
OS   Desulfosporosinus meridiei (strain ATCC BAA-275 / DSM 13257 / KCTC 12902 /
OS   NCIMB 13706 / S10).
OC   Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales;
OC   Desulfitobacteriaceae; Desulfosporosinus.
OX   NCBI_TaxID=768704 {ECO:0000313|EMBL:AFQ46387.1, ECO:0000313|Proteomes:UP000005262};
RN   [1] {ECO:0000313|EMBL:AFQ46387.1, ECO:0000313|Proteomes:UP000005262}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-275 / DSM 13257 / NCIMB 13706 / S10
RC   {ECO:0000313|Proteomes:UP000005262};
RX   PubMed=23105050; DOI=10.1128/jb.01392-12;
RA   Pester M., Brambilla E., Alazard D., Rattei T., Weinmaier T., Han J.,
RA   Lucas S., Lapidus A., Cheng J.F., Goodwin L., Pitluck S., Peters L.,
RA   Ovchinnikova G., Teshima H., Detter J.C., Han C.S., Tapia R., Land M.L.,
RA   Hauser L., Kyrpides N.C., Ivanova N.N., Pagani I., Huntmann M., Wei C.L.,
RA   Davenport K.W., Daligault H., Chain P.S., Chen A., Mavromatis K.,
RA   Markowitz V., Szeto E., Mikhailova N., Pati A., Wagner M., Woyke T.,
RA   Ollivier B., Klenk H.P., Spring S., Loy A.;
RT   "Complete genome sequences of Desulfosporosinus orientis DSM765T,
RT   Desulfosporosinus youngiae DSM17734T, Desulfosporosinus meridiei DSM13257T,
RT   and Desulfosporosinus acidiphilus DSM22704T.";
RL   J. Bacteriol. 194:6300-6301(2012).
RN   [2] {ECO:0000313|Proteomes:UP000005262}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-275 / DSM 13257 / NCIMB 13706 / S10
RC   {ECO:0000313|Proteomes:UP000005262};
RA   Huntemann M., Wei C.-L., Han J., Detter J.C., Han C., Davenport K.,
RA   Daligault H., Erkkila T., Gu W., Munk A.C.C., Teshima H., Xu Y., Chain P.,
RA   Tapia R., Chen A., Krypides N., Mavromatis K., Markowitz V., Szeto E.,
RA   Ivanova N., Mikhailova N., Ovchinnikova G., Pagani I., Pati A., Goodwin L.,
RA   Peters L., Pitluck S., Woyke T., Pester M., Spring S., Ollivier B.,
RA   Rattei T., Klenk H.-P., Wagner M., Loy A.;
RT   "Finished genome of Desulfosporosinus meridiei DSM 13257.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR600821-50};
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DR   EMBL; CP003629; AFQ46387.1; -; Genomic_DNA.
DR   RefSeq; WP_014905291.1; NC_018515.1.
DR   AlphaFoldDB; J7IX44; -.
DR   STRING; 768704.Desmer_4583; -.
DR   KEGG; dmi:Desmer_4583; -.
DR   eggNOG; COG0787; Bacteria.
DR   HOGENOM; CLU_028393_2_2_9; -.
DR   OrthoDB; 9813814at2; -.
DR   Proteomes; UP000005262; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0008784; F:alanine racemase activity; IEA:InterPro.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:TreeGrafter.
DR   GO; GO:0030632; P:D-alanine biosynthetic process; IEA:TreeGrafter.
DR   CDD; cd00430; PLPDE_III_AR; 1.
DR   FunFam; 3.20.20.10:FF:000002; Alanine racemase; 1.
DR   Gene3D; 3.20.20.10; Alanine racemase; 1.
DR   Gene3D; 2.40.37.10; Lyase, Ornithine Decarboxylase, Chain A, domain 1; 1.
DR   InterPro; IPR000821; Ala_racemase.
DR   InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR   InterPro; IPR011079; Ala_racemase_C.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR020622; Ala_racemase_pyridoxalP-BS.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   NCBIfam; TIGR00492; alr; 1.
DR   PANTHER; PTHR30511; ALANINE RACEMASE; 1.
DR   PANTHER; PTHR30511:SF0; ALANINE RACEMASE, CATABOLIC-RELATED; 1.
DR   Pfam; PF00842; Ala_racemase_C; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PRINTS; PR00992; ALARACEMASE.
DR   SMART; SM01005; Ala_racemase_C; 1.
DR   SUPFAM; SSF50621; Alanine racemase C-terminal domain-like; 1.
DR   SUPFAM; SSF51419; PLP-binding barrel; 1.
DR   PROSITE; PS00395; ALANINE_RACEMASE; 1.
PE   4: Predicted;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR600821-50};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005262}.
FT   DOMAIN          241..371
FT                   /note="Alanine racemase C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01005"
FT   BINDING         133
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600821-52"
FT   BINDING         335
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600821-52"
FT   MOD_RES         35
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600821-50"
SQ   SEQUENCE   395 AA;  43927 MW;  6E6F39B81342A875 CRC64;
     MSGTWIEVDL DAIVNNYQEI IKRLHPKARC MAVVKADAYG LGAVQVALAL EQAGCEAFAV
     TKVEEGLILR KSGIKGLILV LGPTTQEEWP EAIKSQLQLT ITELSLIPKL NEVCLGLHQD
     VHVQLKLETG MGRTGFRSAE LGELSKLLGN ADRLKVRGVY THFARAAQRD KRYTSEQYAT
     FKALITRLEE LGIDPEWKHV CNSAAYLDYP EWHLDFVRIG TLLIGHYPGP GFSGKLSLED
     PWIAKSRIVH LRQVPKGTYV GYQSIYRTKS VTQLAVIPVG YADGLGVAPH FVPQGWVDFI
     KIVIKNFAAL IGIFLGQERV ELGGRTVRVA GKIGMQLTVL DVGMQDCTLG DEVRIPLRRT
     LANPRIHRKY KQGGRILSER TIEEGLSTTN TEYSR
//