ID   I4EPD4_HUMAN            Unreviewed;       183 AA.
AC   I4EPD4;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   02-SEP-2026, entry version 46.
DE   SubName: Full=MHC class II antigen {ECO:0000313|EMBL:CCH35804.1};
DE   Flags: Fragment;
GN   Name=HLA-DQB1 {ECO:0000313|EMBL:CCH35804.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CCH35804.1};
RN   [1] {ECO:0000313|EMBL:CCH35804.1}
RP   NUCLEOTIDE SEQUENCE.
RA   BGI H.;
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CCH35804.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23826662; DOI=10.1111/tan.12167;
RA   Zhang C., Wang Y., Huang C., Zhang M., Chen C., Cao H., Chai X., Li J.;
RT   "Characterization of 27 novel HLA class II alleles from China marrow donor
RT   program.";
RL   Tissue Antigens 82:201-202(2013).
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004352}.
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|ARBA:ARBA00007394}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00114}.
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DR   EMBL; HE804185; CCH35804.1; -; Genomic_DNA.
DR   AlphaFoldDB; I4EPD4; -.
DR   SMR; I4EPD4; -.
DR   OrthoDB; 10043043at2759; -.
DR   ChiTaRS; HLA-DQB1; human.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:InterPro.
DR   GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd21001; IgC1_MHC_II_beta_HLA-DQ_I-A; 1.
DR   FunFam; 2.60.40.10:FF:000116; HLA class II histocompatibility antigen, DRB1-1 beta chain; 1.
DR   FunFam; 3.10.320.10:FF:000001; HLA class II histocompatibility antigen, DRB1-1 beta chain; 1.
DR   Gene3D; 3.10.320.10; Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR050160; MHC/Immunoglobulin.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   PANTHER; PTHR19944:SF101; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ BETA 1 CHAIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Immunoglobulin domain {ECO:0000256|PROSITE-ProRule:PRU00114};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   MHC II {ECO:0000256|ARBA:ARBA00023182};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          92..180
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CCH35804.1"
FT   NON_TER         183
FT                   /evidence="ECO:0000313|EMBL:CCH35804.1"
SQ   SEQUENCE   183 AA;  21426 MW;  56D0DB492EA6B72E CRC64;
     DFVYQFKGMC YFTNGTERVR LVSRSIYNRE EIVRFDSDVG EFRAVTLLGL PAAEYWNSQK
     DILERKRAAV DRVCRHNYQL ELRTTLQRRV EPTVTISPSR TEALNHHNLL VCSVTDFYPA
     QIKVRWFRND QEETAGVVST PLIRNGDWTF QILVMLEMTP QRGDVYTCHV EHPSLQSPIT
     VEW
//