ID   G1PS57_MYOLU            Unreviewed;      4859 AA.
AC   G1PS57;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   10-JUN-2026, entry version 91.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   Name=HERC1 {ECO:0000313|Ensembl:ENSMLUP00000013989.2};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013989.2, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000013989.2, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000013989.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; AAPE02026412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02026413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02026414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02026415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02026416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02026417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000013989; -.
DR   Ensembl; ENSMLUT00000015354.2; ENSMLUP00000013989.2; ENSMLUG00000015305.2.
DR   eggNOG; KOG1426; Eukaryota.
DR   GeneTree; ENSGT00940000155907; -.
DR   HOGENOM; CLU_000091_0_0_1; -.
DR   InParanoid; G1PS57; -.
DR   OMA; LAICCQN; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-EC.
DR   CDD; cd00078; HECTc; 1.
DR   CDD; cd12881; SPRY_HERC1; 1.
DR   CDD; cd14401; UBA_HERC1; 1.
DR   FunFam; 2.130.10.30:FF:000001; LOW QUALITY PROTEIN: probable E3 ubiquitin-protein ligase HERC1; 2.
DR   FunFam; 2.60.120.920:FF:000015; LOW QUALITY PROTEIN: probable E3 ubiquitin-protein ligase HERC1; 1.
DR   FunFam; 2.130.10.10:FF:000148; probable E3 ubiquitin-protein ligase HERC1 isoform X1; 1.
DR   FunFam; 3.30.2410.10:FF:000006; probable E3 ubiquitin-protein ligase HERC1 isoform X2; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR058923; RCC1-like_dom.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   InterPro; IPR051625; Signaling_Regulatory_Domain.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035768; SPRY_HERC1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR22872; BTK-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR22872:SF6; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR   Pfam; PF00632; HECT; 1.
DR   Pfam; PF00415; RCC1; 3.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF00400; WD40; 3.
DR   Pfam; PF25390; WD40_RLD; 2.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SMART; SM00119; HECTc; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS00626; RCC1_2; 4.
DR   PROSITE; PS50012; RCC1_3; 14.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          372..421
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          422..476
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          477..529
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          530..579
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          581..632
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          633..683
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          684..736
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   DOMAIN          2001..2192
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   REPEAT          3423..3464
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          3621..3652
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          3741..3782
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          3995..4043
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          4044..4098
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          4099..4150
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          4151..4202
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          4204..4255
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          4256..4307
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          4308..4359
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   DOMAIN          4499..4846
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          125..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1322..1341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1348..1379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1397..1432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1509..1529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2256..2285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2406..2469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2616..2674
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2691..2751
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2797..2877
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3233..3254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1356..1367
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2261..2280
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2409..2418
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2419..2433
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2634..2668
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2700..2711
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2718..2729
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3234..3245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        4809
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   4859 AA;  532082 MW;  EEBBFC298E935882 CRC64;
     MATMVPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVLL PQQVLCLKGP
     QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK
     YHDKGKVKQQ QHSPESSSGS ADVHSVSERP RSSTDALIEM GVRTGLSLLF ALLRQSWMMP
     VSGPGLSLCN DVIHTAIEVV SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD
     TLGRRLASEL LLGLAAQRGS LRYLLEWIEM ALGASAVVNS MEKSKLLSSQ EGMISFDCFM
     TILMQMRRSL GSSADRSQWR EPTRTSDGLC SLYEAALCLF EEVCRMASDY SRTCASPDSI
     QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP SFSDAQTIEA GQYCTFVIST
     DGSVRACGKG SYGRLGLGDS NNQSTLKKLT FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF
     SWGDGDYGKL GHGNSSTQKY PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF
     GRLGHGDSNS RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN
     RVYKPKVIEA LQGMFIRKVC AGSQSSLSLT STGQVYAWGC GACLGCGSSE ATALRPKLIE
     ELAATRIVDI SIGDSHCLAL SHDNEVYAWG NNSMGQCGQG NSTGPITKPK KVSGLDGIAI
     QQISAGTSHS LAWTALPRDR QVVAWHRPYC VDLEESTFSH LRSFLERYCD KINSEIPPLP
     FPSSREHHSF LKLCLKLLSN HLALALAGGV ATSILGRQAG PLRNLLFRLM DSTVPDEIQE
     VVIETLSVGA TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA
     SLLGYSSPSD AADLSSVCTG YGNLSDQPYG TQSCHPDTHL AEILMKTLLR NLGFYTDQAF
     GELEKNSDKF LLGTSSSENS QPAHLHELLC SLQKQLLAFC HINNISENSS SVALLHKHLQ
     LLLPHATDIY SRSANLLKES PWNGSVGEKL RDVIYVSAAG SMLCQIVNSL LLLPVSVARP
     LLSYLLDLLP PLDCLNRLLP AAALLEDQEL QWPLHGGPEL IDPAGVPLPQ PAQSWVWLVD
     LERTIALLIG RCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA
     LSGNEEQKPF DYKLRPEIAV FVDLALGCSK EPARSLWISM QDYAVSKDWD SATLSNESLL
     DTVSRFVLAA LLKHTNLLSQ ACGESRYQPG KSLSEVYRCV YKVRSRLLAC KNLELIQTRS
     SSRDRWISEN QDSADVDPQE HSFTRTIDEE AEMEEQAERD REEGHPEPED EEEEREHEVM
     TAGKIFQCFL SAREVARSRD RDRMNSGAGS GARSDDPPPQ SQQERRVSTD LPEGQDVYTA
     ACNSVIHRCA LLILGVSPVI DELQKRREEG QLQQPSTSAS EGGGLMTRSE SLTAESRLVH
     TSPNYRLIKS RSESDLSQPE SDEEGYALNG RRNVDLDLAS SHRKRGPIHS QLEFRNDSWA
     RLKHSRDWLC NSSYSFESDF DLTKSLGVHT LIENVVSFVS GDVGNAPGFK EPEESMSTSP
     QASIIAMEQQ QLRAELRLEA LHQILILLSG MEEKGSISLA GSRLSSGFQS STLLTSVRLQ
     FLAGCFGLGT VGHAGAKGES GRLHHYQDGI RAAKRNIQIE IQVAVHKIYQ QLSATLERAL
     QANKHHIEAQ QRLLLVTVFA LSVHYQPVDV SLAISTGLLN VLSQLCGTDT MLGQPLQLLP
     KTGVSQLSTA LKVASTRLLQ ILAITTGTYA DKLSPKIVQS LLDLLCSQLK NLLSQTGVLL
     MASFGEGEED GEEEEKKLDS SGETEKRDFR AALRKQHAAE LHLGDFLVFL RRVVSSKAIQ
     SKMASPKWTE VLLNIASQKC SAGIPLVGNL RTRLLALHVL EAVLPACESG VEDDQMAQVV
     ERLFSLLSDC MWETPIAQAK HAIQIKEKEQ EIKLQKQGEL EEEDENLPIQ EVSFDPEKAQ
     CCLVENGQIL THGSGGKGYG LASTGVTSGC YQWKFYIVKE NRGNEGTCVG VSRWPVHDFN
     HRTTSDMWLY RAYSGNLYHN GEQTLTLSSF TQGDFITCVL DMEARTISFG KNGEEPKLAF
     EDVDAAELYP CVMFYSSNPG EKVKICDMQM RGTPRDLLPG DPICSPVAAV LAEATIQLIR
     ILHRTDRWTY CINKKMMERL HKIKICIKES GQKLKKSRSV QSREENEMRE EKESKEEEKS
     KHNRHGLADL SELQLRTLCI EVWPVLAVIG GVDAGLRVGG RCVHRQTGRH ATLLGVVKEG
     STSAKVQWDE AEITISFPTF WSPSDTPLYN LEPCEPLPFD VARFRGLTAS VLLDLTYLTG
     IHEDMGKQST KRHEKKHRHE SEEKGDIEQK TESESALDMR TGLTSDDVKS QGTTSSKSEG
     EIASFSLDPT LPGVEYQHQI TEGKRKNHEH MSKIHDIPQT EIRAVQLSYL YLGAMKSLSA
     LLGCSKYAEL LLIPKVLAEN GHNSDCASSP VVHEDVEMRA ALQFLMRHMV KRAVMRSPIK
     RALGLADLER AQAMIYKLVV SGLLEDQFGG KIKQEIDQQA EESDPAQQAQ TPVTTSPSAS
     STTSFMSSSL EDTTTATTPV TDTETVPASE SPGVMPLSLL RQMFSSYPTT TVLPTRRAQT
     PPISSLPTSP SDEVGRRQSL TSPDSQSARP ANRTALSDPS SRLSTSPPPP AIAVPLLEMG
     FSLRQIAKAM EATGARGEAD AQNITVLAMW MIEHPGHEDE EEPQSGSTAD SRHGAAVLGS
     AGKSNDPCYL QSPGDIPSAD AAEMEEGFSE SPDNLDHTEN AASGSGPPTR GRSAVTRRHK
     FDLAARTLLA RAAGLYRSVQ AHRNQSRREG ISLQQDPGAL YDFNLDEELE IDLDDEAMEA
     MFGQDLTSEN DILGMWIPEV LDWPTWHVCE SEDREEVVVC ELCECSVVSF NQHMKRNHPG
     CGRSANRQGY RSNGSYVDGW FGGECGSGNP YYLLCGSCRE KYLALKTKSK TTSSERYKGQ
     APDLIGKQDS VYEEDWDMLD VDEDEKLTGE EEFELLAGPL GLNDRRIVPE PVQFPDSDPL
     GASVAMVTAT NSMEETLMQI GCHGSVEKSS SGRITLGEQA AALANPHDRV VALRRVTAAA
     QVLLSRTMVM RALSLLSVSG SSCSLAAGLE SLGLTDIRTL VRLMCLAAAG RAGLSTSPSA
     MGSTTERSRG GHSKANKPIS CLAYLSTAVG CLASNTPSAA KLLVQLCTQN LISAATGVNL
     TTVDDPIQRK FLPSFLRGIA EENKLVTSPN FVVTQALVAL LADKGAKLRP NYDKSEVEKK
     GPLELANALA ACCLSSRLSS QHRQWAAQQL VRTLAAHDRD NQTTPQTLAD MGGDLRKCSF
     IKLEAHQNRV MTCVWCNKKG LLATSGNDGT IRVWNVTKKQ YSLQQTCVFN RLEGDAEESL
     GSPSDPSFLP VSWSISGKYL AGALEKMVNI WQVNGGKGLV DIQPHWVSSL AWPEEGPATA
     WSGESPELLL VGRMDGSLGL IEVVDVSTMH RQELEHCYRK DVSVTCIAWF SEDRPFAVGY
     FDGKLLLGTK EPLEKGGIVL IDAHKDTLVS MKWDPTGHIL MTCAKEENVK LWGPISGCWC
     CLHSLCHPSI VNGIAWCSLP GKGSKLHLLM GGCQSGLVCV WRIPQDTTQT SVATSEGWWD
     QESNCQDGYR KPSGAKCVYQ LRGHITPVRT VAFSSDGLAL VSGGLGGLMN IWSLRDGSVL
     QTVVIGSGAI QATVWIPDVG VAACSNRSKD VLVVNCTTEW AAANHVLATC RTALKQQGVL
     GLNMAPCMRA FLERLPMMLQ EQYAYEKPHV VCGDQLVHSP YMQCLASLAV GLHLDQLLCN
     PPVPPHHQNC LPDPASWNPN EWAWLECFST TIKAAEALTN GAQFPESFTV PDLEPVPEDE
     LVLLMDNSKW INGMDEQIMS WATSRPEDWH LGGKCDVYLW GAGRHGQLAE AGRNVMVPAA
     APSFSQAQQV ICGQNCTFVI QANGTVLACG EGSYGRLGQG NSDDLHVLTV ISALQGFVVT
     QLVTSCGSDG HSMALTESGE VFSWGDGDYG KLGHGNSDRQ RRPRQIEALQ GEEVVQMSCG
     FKHSAVVTSD GKLFTFGNGD YGRLGLGNTS NKKLPERVTA LEGYQIGQVA CGLNHTLAVS
     ADGSMVWAFG DGDYGKLGLG NSTAKSSPQK VDVLCGIGIK KVACGTQFSV ALTKDGQVYT
     FGQDRLIGLP EGRARNHNRP QQVPVLAGVV IEDVAVGAEH TLALTSAGDI YAWGSNSEGQ
     LGLGHTNHVR EPTLVTVLQG KSVRQISAGR CHSAAWTAPP VPPRAPGVSV PLQLGLPDAV
     PPQYGALREV SIHTARARLR LLYHFSDLMY SSWRLLNLSP NNQNSTSHYN AGTWGIVQGQ
     LRPLLAPRVY TLPMVRSIGK TMVQGKNYGP QITVKRISTR GRKCKPIFVQ IARQVVKLNA
     SDLRLPSRAW KVKLVGEGAD DAGGVFDDTI TEMCQELETG SVDLLIPSPN ATAEVGYNRD
     RFLFNPSACL DEHLMQFKFL GILMGVAIRT KKPLDLHLAP LVWKQLCCVP LALEDLEEVD
     LLYVQTLHSI LHLEDSGITE ESFHEMIPLD SFVGQSADGK MVPIIPGGNS IPLTFSNRKE
     YVERAIEYRL HEMDRQVAAV REGMSWIIPV PLLSLLTAKQ LEQMVCGMPE ISVEVLKKVV
     RYREVDEQHQ LVQWFWHTLE EFSNEERVLF MRFVSGRSRL PANTADISQR FQIMKVDRPY
     DSLPTSQTCF FQLRLPPYSS QLVMAERLRY AINNCRSIDM DNYMLSRNVD NTEGSDTDY
//