ID   G1LII5_AILME            Unreviewed;       427 AA.
AC   G1LII5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   04-NOV-2026, entry version 77.
DE   SubName: Full=Serpin family A member 4 {ECO:0000313|Ensembl:ENSAMEP00000006738.1};
GN   Name=SERPINA4 {ECO:0000313|Ensembl:ENSAMEP00000006738.1};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000006738.1, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000006738.1, ECO:0000313|Proteomes:UP000008912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000006738.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2026) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|RuleBase:RU000411}.
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DR   RefSeq; XP_002920530.3; XM_002920484.4.
DR   RefSeq; XP_019656562.1; XM_019801003.2.
DR   AlphaFoldDB; G1LII5; -.
DR   STRING; 9646.ENSAMEP00000006738; -.
DR   Ensembl; ENSAMET00000007022.2; ENSAMEP00000006738.1; ENSAMEG00000006405.2.
DR   GeneID; 100481675; -.
DR   KEGG; aml:100481675; -.
DR   CTD; 5267; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   GeneTree; ENSGT00940000160877; -.
DR   HOGENOM; CLU_023330_2_1_1; -.
DR   InParanoid; G1LII5; -.
DR   OMA; ACSYSCT; -.
DR   OrthoDB; 671595at2759; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   FunFam; 3.30.497.10:FF:000001; Serine protease inhibitor; 1.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461:SF194; KALLISTATIN; 1.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..427
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003414640"
FT   DOMAIN          60..424
FT                   /note="Serpin"
FT                   /evidence="ECO:0000259|SMART:SM00093"
FT   REGION          26..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   427 AA;  48375 MW;  C1A5EE2BFEFCDA9A CRC64;
     MRLADCPLLL LAGLLVLSHG QLHPERYRQG HTSSPHREAS STGEGSPSLK IAPGNTAFAL
     HFYHLLASQS PGSNIFFSPL SISASYAMLS LGAHSHSQTQ ILEGLGFNLT ELSAWDIHRG
     FQHLLHTVRL PGDGLEMRMG SALFLSQDLL VLPAFLNDIE AFYESKLFPT NFHNSVGTTQ
     LINDHIKEET QGKIVDLVSP LSTDISMVLV NYIYFKALWE KPFVPSMTMP QDFHVDKNTV
     VKVPMMLQDT QHHWYLHDRR LPCSVLRMDY QGNMTAFFIL PDRGKMKQVE EVLTPEMLTR
     WKNLLQKRYF YKKLELHFPK FSISGSYQLD QILPKMGFMH LFSKQVDLSG ITKERKLQVS
     KSLHKAILEM DEVGAQAAVA TGSFTTFMSA QHNRRVLRFN RPFLVVIFST NTQSILFLGK
     VVNPTNS
//