ID   F7DTL6_HORSE            Unreviewed;       184 AA.
AC   F7DTL6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   04-NOV-2026, entry version 83.
DE   SubName: Full=C-type lectin domain family 2 member B {ECO:0000313|Ensembl:ENSECAP00000000240.1};
GN   Name=CLEC2B {ECO:0000313|Ensembl:ENSECAP00000000240.1,
GN   ECO:0000313|VGNC:VGNC:16602};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000000240.1, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000000240.1, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000240.1,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000000240.1}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000240.1};
RG   Ensembl;
RL   Submitted (JUL-2026) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00040}.
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DR   RefSeq; XP_003365218.1; XM_003365170.5.
DR   RefSeq; XP_014596211.1; XM_014740725.3.
DR   RefSeq; XP_023498878.1; XM_023643110.2.
DR   AlphaFoldDB; F7DTL6; -.
DR   SMR; F7DTL6; -.
DR   FunCoup; F7DTL6; 6.
DR   STRING; 9796.ENSECAP00000000240; -.
DR   PaxDb; 9796-ENSECAP00000000240; -.
DR   Ensembl; ENSECAT00000000312.3; ENSECAP00000000240.1; ENSECAG00000000382.3.
DR   GeneID; 100629907; -.
DR   KEGG; ecb:100629907; -.
DR   CTD; 9976; -.
DR   VGNC; VGNC:16602; CLEC2B.
DR   GeneTree; ENSGT00940000163321; -.
DR   HOGENOM; CLU_049894_8_4_1; -.
DR   InParanoid; F7DTL6; -.
DR   OMA; ADWLYHQ; -.
DR   OrthoDB; 8935730at2759; -.
DR   Proteomes; UP000002281; Chromosome 6.
DR   Bgee; ENSECAG00000000382; Expressed in blood and 18 other cell types or tissues.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR   GO; GO:0051132; P:NK T cell activation; IBA:GO_Central.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd03593; CLECT_NK_receptors_like; 1.
DR   Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR050828; C-type_lectin/matrix_domain.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR033992; NKR-like_CTLD.
DR   PANTHER; PTHR45710:SF15; C-TYPE LECTIN DOMAIN FAMILY 2 MEMBER B; 1.
DR   PANTHER; PTHR45710; C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180; 1.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00040};
KW   Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|PROSITE-
KW   ProRule:PRU00040}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          77..180
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000259|PROSITE:PS50041"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        158..171
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00040"
SQ   SEQUENCE   184 AA;  21468 MW;  91CB0DC7A7F8901B CRC64;
     MTQSRQVAAP AQGGPENDNS NQGKETQKKQ GIKNMKEKCI LIFIGLVLGI VLTILYFSIC
     LKGTETQHFC PHDWIGFQDK CYYFSKEEGD WNSSRYNCST QHTDLTMIDT VEEMHFLRRH
     KCTSDHWIGL EMTENQIRKW VNGTVFNKWF TVRGNEKCAY LNDDGVATAR CYTERKWICR
     KKVH
//