ID   F6RWL0_HORSE            Unreviewed;       345 AA.
AC   F6RWL0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   04-NOV-2026, entry version 78.
DE   SubName: Full=Cysteinyl leukotriene receptor 2 {ECO:0000313|Ensembl:ENSECAP00000003194.3};
GN   Name=CYSLTR2 {ECO:0000313|Ensembl:ENSECAP00000003194.3,
GN   ECO:0000313|VGNC:VGNC:50472};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003194.3, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000003194.3, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003194.3,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000003194.3}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003194.3};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC   -!- SIMILARITY: Belongs to the G protein-coupled receptor 1 family.
CC       {ECO:0000256|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00521}.
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DR   RefSeq; XP_023477354.1; XM_023621586.2.
DR   RefSeq; XP_070095809.1; XM_070239708.1.
DR   AlphaFoldDB; F6RWL0; -.
DR   STRING; 9796.ENSECAP00000003194; -.
DR   PaxDb; 9796-ENSECAP00000003194; -.
DR   Ensembl; ENSECAT00000004606.4; ENSECAP00000003194.3; ENSECAG00000004678.4.
DR   Ensembl; ENSECAT00000090055.1; ENSECAP00000082906.1; ENSECAG00000004678.4.
DR   Ensembl; ENSECAT00000113907.1; ENSECAP00000078209.1; ENSECAG00000004678.4.
DR   Ensembl; ENSECAT00000114787.1; ENSECAP00000064465.1; ENSECAG00000004678.4.
DR   Ensembl; ENSECAT00000125664.1; ENSECAP00000065213.1; ENSECAG00000004678.4.
DR   Ensembl; ENSECAT00000129263.1; ENSECAP00000061925.1; ENSECAG00000004678.4.
DR   Ensembl; ENSECAT00000143582.1; ENSECAP00000069802.1; ENSECAG00000004678.4.
DR   Ensembl; ENSECAT00000144477.1; ENSECAP00000071254.1; ENSECAG00000004678.4.
DR   GeneID; 100056882; -.
DR   CTD; 57105; -.
DR   VGNC; VGNC:50472; CYSLTR2.
DR   GeneTree; ENSGT01160000290794; -.
DR   HOGENOM; CLU_009579_8_2_1; -.
DR   InParanoid; F6RWL0; -.
DR   OMA; AANACFN; -.
DR   Proteomes; UP000002281; Chromosome 17.
DR   Bgee; ENSECAG00000004678; Expressed in chorionic villus and 16 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001631; F:cysteinyl leukotriene receptor activity; IBA:GO_Central.
DR   GO; GO:0004966; F:galanin receptor activity; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   CDD; cd15157; 7tmA_CysLTR2; 1.
DR   FunFam; 1.20.1070.10:FF:000017; lysophosphatidic acid receptor 4; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR013311; CLT2_recept.
DR   InterPro; IPR004071; Cyst_leuk_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24231:SF48; G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24231; PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR01903; CYSLT2RECPTR.
DR   PRINTS; PR01533; CYSLTRECPTR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   G protein-coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW   ECO:0000256|PROSITE-ProRule:PRU00521};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00521};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PROSITE-
KW   ProRule:PRU00521}; Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00521};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        77..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        156..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        246..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        287..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          56..306
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  39405 MW;  4492E71B8943A39A CRC64;
     MERKLMSSVP SVSSSETEPN GTFSSNDSHR NCTIENFKRE FYPIIYLIIF VWGALGNGFS
     IYVFLQPYKK CTSVNVFMLN LAISDLLFTS TLPFRADYYL RGSNWIFGDL ACRIMSYSLY
     VNMYSSIYFL TVLSVVRFLA TVHPFRLLHV TSIRSAWILC GIIWIFIMAS SAVLLKNGSE
     QDGNVTLCLE LNLNKVIKLQ ALNYLALVVG FLLPFCTLSI CYLLIIRALL MVKVSETGLR
     VSHRKALTTI IISLVIFLLC FLPYHVLRTL HLVMWEVGTC IDWLHKAVVI TLALAATNSC
     FNPLLYYFAG ENFKDRLRSA VRKCHLQKIK CSFPVCVWLK KETRV
//