ID   F6CRW3_MARPP            Unreviewed;       577 AA.
AC   F6CRW3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   02-SEP-2026, entry version 57.
DE   SubName: Full=Dihydroxy-acid dehydratase {ECO:0000313|EMBL:AEF54966.1};
DE            EC=4.2.1.9 {ECO:0000313|EMBL:AEF54966.1};
GN   OrderedLocusNames=Mar181_1928 {ECO:0000313|EMBL:AEF54966.1};
OS   Marinomonas posidonica (strain CECT 7376 / NCIMB 14433 / IVIA-Po-181).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Oceanospirillales; Oceanospirillaceae; Marinomonas.
OX   NCBI_TaxID=491952 {ECO:0000313|EMBL:AEF54966.1, ECO:0000313|Proteomes:UP000009230};
RN   [1] {ECO:0000313|EMBL:AEF54966.1, ECO:0000313|Proteomes:UP000009230}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 7376 / NCIMB 14433 / IVIA-Po-181
RC   {ECO:0000313|Proteomes:UP000009230};
RX   PubMed=23458837; DOI=10.4056/sigs.2976373;
RA   Lucas-Elio P., Goodwin L., Woyke T., Pitluck S., Nolan M., Kyrpides N.C.,
RA   Detter J.C., Copeland A., Lu M., Bruce D., Detter C., Tapia R., Han S.,
RA   Land M.L., Ivanova N., Mikhailova N., Johnston A.W., Sanchez-Amat A.;
RT   "Complete genome sequence of Marinomonas posidonica type strain (IVIA-Po-
RT   181(T)).";
RL   Stand. Genomic Sci. 7:31-43(2012).
CC   -!- SIMILARITY: Belongs to the IlvD/Edd family.
CC       {ECO:0000256|ARBA:ARBA00006486}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP002771; AEF54966.1; -; Genomic_DNA.
DR   RefSeq; WP_013796441.1; NC_015559.1.
DR   AlphaFoldDB; F6CRW3; -.
DR   STRING; 491952.Mar181_1928; -.
DR   KEGG; mpc:Mar181_1928; -.
DR   eggNOG; COG0129; Bacteria.
DR   HOGENOM; CLU_014271_3_1_6; -.
DR   OrthoDB; 9807077at2; -.
DR   Proteomes; UP000009230; Chromosome.
DR   GO; GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:UniProtKB-EC.
DR   FunFam; 3.50.30.80:FF:000001; Dihydroxy-acid dehydratase; 1.
DR   Gene3D; 3.50.30.80; IlvD/EDD C-terminal domain-like; 1.
DR   InterPro; IPR042096; Dihydro-acid_dehy_C.
DR   InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR   InterPro; IPR056740; ILV_EDD_C.
DR   InterPro; IPR000581; ILV_EDD_N.
DR   InterPro; IPR037237; IlvD/EDD_N.
DR   InterPro; IPR052352; Sugar_Degrad_Dehydratases.
DR   NCBIfam; NF004784; PRK06131.1; 1.
DR   NCBIfam; NF009560; PRK13017.1; 1.
DR   PANTHER; PTHR43183:SF1; HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED; 1.
DR   PANTHER; PTHR43183; HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED; 1.
DR   Pfam; PF24877; ILV_EDD_C; 1.
DR   Pfam; PF00920; ILVD_EDD_N; 1.
DR   SUPFAM; SSF143975; IlvD/EDD N-terminal domain-like; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR   PROSITE; PS00886; ILVD_EDD_1; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:AEF54966.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009230}.
FT   DOMAIN          44..354
FT                   /note="Dihydroxy-acid/6-phosphogluconate dehydratase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00920"
FT   DOMAIN          365..559
FT                   /note="Dihydroxy-acid/6-phosphogluconate dehydratase C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF24877"
SQ   SEQUENCE   577 AA;  62455 MW;  02A2F9368CD0B790 CRC64;
     MSDDNKNKKP LRSQEWYGKL DKDGFIHRSW MKNQGLPDHS FDGRPIIGIC NSWSELTPCN
     AHLRELAEYV KRGVWEAGGV PLEFPVMSLG ETQMKPTAML FRNLMSMDVE ESIRAYGMDG
     VVLLGGCDKT TPAQLMGACS VDLPAIVVSS GPMLNGKYRG QDIGSGTDVW KFSEAVRGGK
     MSLDEFMRAE SGMSRSRGTC MTMGTASTMS CLTEALGMSL PENGTLPAVD ARRQALAHLT
     GMRIVEMVKE DLKPSDILTK SAFENAIRAN AAIGGSTNAV VHLLAIAGRV GVELTLDDWD
     RIGAEIPCLV DLMPSGRFLM EDFHYAGGFP ALIQRLQHEF DMQAMTVAGS SLSDVTKEAE
     CFNDEVIRPL DKPLREKAGI AVLKGNLCPQ GAIIKPSAAT PALLQHTGKA VVFENIEDYK
     ARIDTPELDV DKDSILVLKG CGPKGYPGMP EVGNMALPSK LLEQGITDMV RISDARMSGT
     AFGTVVLHVA PEATMGGPLA LVKNGDEITL DLAGRGLHLH ISDEEMASRQ AAWQAEDSDY
     QRGYAKLYID HVMQADSGAD LDFLVGKSGS KVSRESH
//