ID   F5XP78_MICPN            Unreviewed;       605 AA.
AC   F5XP78;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   28-JAN-2026, entry version 57.
DE   RecName: Full=Acyl-CoA synthetase {ECO:0000256|ARBA:ARBA00032875};
GN   Name=fadD {ECO:0000313|EMBL:BAK36718.1};
GN   OrderedLocusNames=MLP_37040 {ECO:0000313|EMBL:BAK36718.1};
OS   Microlunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC
OS   101784 / NCIMB 13414 / VKM Ac-1990 / NM-1).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Microlunatus.
OX   NCBI_TaxID=1032480 {ECO:0000313|EMBL:BAK36718.1, ECO:0000313|Proteomes:UP000007947};
RN   [1] {ECO:0000313|EMBL:BAK36718.1, ECO:0000313|Proteomes:UP000007947}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414
RC   / VKM Ac-1990 / NM-1 {ECO:0000313|Proteomes:UP000007947};
RA   Hosoyama A., Sasaki K., Harada T., Igarashi R., Kawakoshi A., Sasagawa M.,
RA   Fukada J., Nakamura S., Katano Y., Hanada S., Kamagata Y., Nakamura N.,
RA   Yamazaki S., Fujita N.;
RT   "Whole genome sequence of Microlunatus phosphovorus NM-1.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; AP012204; BAK36718.1; -; Genomic_DNA.
DR   RefSeq; WP_013864567.1; NC_015635.1.
DR   AlphaFoldDB; F5XP78; -.
DR   STRING; 1032480.MLP_37040; -.
DR   KEGG; mph:MLP_37040; -.
DR   eggNOG; COG1022; Bacteria.
DR   HOGENOM; CLU_000022_45_5_11; -.
DR   OrthoDB; 9803968at2; -.
DR   Proteomes; UP000007947; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR   GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:TreeGrafter.
DR   CDD; cd05907; VL_LC_FACS_like; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_synth/lig_dom.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43272:SF32; AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF23562; AMP-binding_C_3; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:BAK36718.1};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007947}.
FT   DOMAIN          23..431
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   605 AA;  65546 MW;  F0E61E328BF4C262 CRC64;
     MMPLEQQQEV LANRPSSVGA MLQDRVAASG PREAFRYLDG GRWISLTWNE TKTAVYEVAA
     GLLALGLQLE DRVAIASGTR MEWILADLGI MCAGGATTTV YPTTQHEDVA YILRDSESKV
     VFAEDDFQVA KVVDHLDELS VVKIVQFSGK ADHELVVSWT EFRELGRSHL VEQPGSVDNA
     IAATRPDTLA TLIYTSGTTG RPKGVRLTQD AWTYEGAAVE AYDIISPDDL QYLWLPLSHV
     FGKALIAIQL KIGFTTAVDG VIENIVDNLG VVKPTFMAGA PRIFEKVRAK VMTGAQSGVK
     GKIFNWAFSV GYKTIPGRLA GSEPAGLLGI QYALADKLVF SKLKARMGGN IKFFVSGSAA
     LSREVQEWFY AAGLLILEGY GLTETSAATF VNDPRATRFG TVGPAVPGTE VKIADDGEIL
     VRGAGVMSGY HGNDEATAEV LTADGWFSTG DIGELDDHGY LRITDRKKDL IKTSGGKYVA
     PQKVEAAVKA ASPYVSQVLV HGEGRKYISA LVTLDPEAIT TWAKENGQES ADLTALSASP
     AVKELINGQV AQANRKLERW ETIKKFEILP QEFTVDGGEV TPSLKIRRKA VEKKYGDTLN
     TLYED
//