ID   F1SQU9_PIG              Unreviewed;       856 AA.
AC   F1SQU9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2022, sequence version 3.
DT   04-NOV-2026, entry version 68.
DE   SubName: Full=FA complementation group B {ECO:0000313|Ensembl:ENSSSCP00000012913.4};
GN   Name=FANCB {ECO:0000313|Ensembl:ENSSSCP00000012913.4,
GN   ECO:0000313|VGNC:VGNC:88002};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000012913.4, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000012913.4, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000012913.4,
RC   ECO:0000313|Proteomes:UP000008227};
RX   PubMed=32543654;
RA   Warr A., Affara N., Aken B., Beiki H., Bickhart D.M., Billis K., Chow W.,
RA   Eory L., Finlayson H.A., Flicek P., Giron C.G., Griffin D.K., Hall R.,
RA   Hannum G., Hourlier T., Howe K., Hume D.A., Izuogu O., Kim K., Koren S.,
RA   Liu H., Manchanda N., Martin F.J., Nonneman D.J., O'Connor R.E.,
RA   Phillippy A.M., Rohrer G.A., Rosen B.D., Rund L.A., Sargent C.A.,
RA   Schook L.B., Schroeder S.G., Schwartz A.S., Skinner B.M., Talbot R.,
RA   Tseng E., Tuggle C.K., Watson M., Smith T.P.L., Archibald A.L.;
RT   "An improved pig reference genome sequence to enable pig genetics and
RT   genomics research.";
RL   Gigascience 9:giaa051-giaa051(2020).
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000012913.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2026) to UniProtKB.
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DR   AlphaFoldDB; F1SQU9; -.
DR   FunCoup; F1SQU9; 758.
DR   GlyGen; F1SQU9; 1 site.
DR   Ensembl; ENSSSCT00000013269.5; ENSSSCP00000012913.4; ENSSSCG00000012130.6.
DR   VGNC; VGNC:88002; FANCB.
DR   GeneTree; ENSGT00390000009885; -.
DR   Reactome; R-SSC-6783310; Fanconi Anemia Pathway.
DR   Reactome; R-SSC-9833482; PKR-mediated signaling.
DR   Proteomes; UP000008227; Chromosome X.
DR   Bgee; ENSSSCG00000012130; Expressed in oocyte and 24 other cell types or tissues.
DR   ExpressionAtlas; F1SQU9; baseline and differential.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0043240; C:Fanconi anaemia nuclear complex; IBA:GO_Central.
DR   GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR   GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IBA:GO_Central.
DR   InterPro; IPR033333; FANCB.
DR   InterPro; IPR060027; FANCB_C.
DR   InterPro; IPR060177; FANCB_middle.
DR   InterPro; IPR060178; FANCB_N.
DR   PANTHER; PTHR28450; FANCONI ANEMIA GROUP B PROTEIN; 1.
DR   PANTHER; PTHR28450:SF1; FANCONI ANEMIA GROUP B PROTEIN; 1.
DR   Pfam; PF28318; FANCB_C; 1.
DR   Pfam; PF28312; FANCB_middle; 1.
DR   Pfam; PF28327; FANCB_N; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN          13..363
FT                   /note="Fanconi anemia group B protein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF28327"
FT   DOMAIN          468..746
FT                   /note="Fanconi anaemia group B protein middle"
FT                   /evidence="ECO:0000259|Pfam:PF28312"
FT   DOMAIN          748..855
FT                   /note="Fanconi anaemia group B protein C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF28318"
SQ   SEQUENCE   856 AA;  97348 MW;  96D87C41ABF7FE01 CRC64;
     MSSNEQERLL CYNGEVLVFC LSKGNFVDKG PAKITMIHVR RMTFDRGTGV FVQKSTGSFS
     IKEEYSHLKI MCCNSVSDFR TGINLPYVMI QCNKENNIFR YFLLFLHSTN KFEKRLSFRL
     GYELKDSIRV LNGPLVLWRH VQTFFYISSQ TGRVVTVSFN FSSIDWVGEI ENLGIVLLGL
     KRYYLSEEGC TPKPSKSDYA TWNTPFCVYS LEREEVLSDT YLIPPVYSSV VTCVHVCATE
     IVDNQLRLSL IALTQKNQLI SFQNGTPKSV CQLPFEDPCA VHLMDSGGGN LHFIVSFRSN
     DACAVRAKNF QVVDKWEKMS SILVDDFLGT GTEQVLLLFK DSLSSDCLSS FKITNLDNIN
     YSSQPVDCSQ DDLFDNEQDN CSLMIPPLER RLKVSVYVCF QELQQNLLLK EKILSKSYKA
     FTNLFQGKDD STPSAKEDYL VTLCGKEENP VCTSDEKLSE NFQDSKQLVE KIWYRVIEDS
     LVVGVKTTSS LKVSLSHVTL SLSMHRACNS SFPGIKCQNR VLQLNRNSSP PPCLVPYEVR
     SEVKRIKLSV DSEQEEEKKE SLVCEQPSEK DCVQMITAVT SLSPLLAFSN FCCIVLLQIR
     ERENANYSKV HYVHCGRIFL SLEDLSSGKY LLTFPKKKPL EHMEDLFALL AVLHRACFQI
     TSRSYALTSV KSWLLEHMEC EVIKEFPEVC FCKRPGNFYG TFFSWKERTP FEGILIVYFR
     NQTVLFQCLH NLSRVLPVNS FFKNLKLGSE DILIDHLTLA LEKELVTLGS LSSASAKVES
     NLVQSSEASE EKSSNVAASS DREERIHLYR EELQREKQQT LGTNLNVSGA LYREMTLKLA
     EVQLKSDLAA QKLTDL
//